메뉴 건너뛰기




Volumn 17, Issue 3, 1999, Pages 1047-1060

Cancer vaccines

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA FETOPROTEIN; BACTERIAL VACCINE; BETA CATENIN; CANCER VACCINE; CARCINOEMBRYONIC ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; FREUND ADJUVANT; GANGLIOSIDE ANTIBODY; GANGLIOSIDE GM2; GENE PRODUCT; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HEAT SHOCK PROTEIN; HLA ANTIGEN; IMMUNOGLOBULIN; IMMUNOLOGICAL ADJUVANT; INTERLEUKIN 2; MAJOR HISTOCOMPATIBILITY ANTIGEN; MELANIN; MELANOMA ANTIGEN; MONOPHENOL MONOOXYGENASE; PROTEIN P53; T LYMPHOCYTE RECEPTOR; TUMOR ANTIGEN; VIRUS VACCINE;

EID: 0000023712     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/jco.1999.17.3.1047     Document Type: Article
Times cited : (148)

References (148)
  • 1
    • 0000161413 scopus 로고
    • The treatment of malignant tumors by repeated inoculations of erysipelas: With a report of ten original cases
    • Coley WB: The treatment of malignant tumors by repeated inoculations of erysipelas: With a report of ten original cases. Am J Med Sci 105:487-511, 1893
    • (1893) Am J Med Sci , vol.105 , pp. 487-511
    • Coley, W.B.1
  • 2
    • 0022002253 scopus 로고
    • Prospectively randomized trial of adjuvant active-specific immunotherapy for human colorectal cancer
    • Hoover HJ, Surdyke M, Dangel RB, et al: Prospectively randomized trial of adjuvant active-specific immunotherapy for human colorectal cancer. Cancer 55:1236-1243, 1985
    • (1985) Cancer , vol.55 , pp. 1236-1243
    • Hoover, H.J.1    Surdyke, M.2    Dangel, R.B.3
  • 3
    • 0027512782 scopus 로고
    • Adjuvant active specific immunotherapy for human colorectal cancer: 6.5-Year median follow-up of a phase III prospectively randomized trial
    • Hoover HJ, Brandhorst JS, Peters LC, et al: Adjuvant active specific immunotherapy for human colorectal cancer: 6.5-Year median follow-up of a phase III prospectively randomized trial. J Clin Oncol 11:390-399, 1993
    • (1993) J Clin Oncol , vol.11 , pp. 390-399
    • Hoover, H.J.1    Brandhorst, J.S.2    Peters, L.C.3
  • 4
    • 0025147441 scopus 로고
    • Treatment of metastatic melanoma with an autologous tumor-cell vaccine: Clinical and immunologic results in 64 patients
    • Berd D, Maguire HCJ, McCue P, et al: Treatment of metastatic melanoma with an autologous tumor-cell vaccine: Clinical and immunologic results in 64 patients. J Clin Oncol 8:1858-1867, 1990
    • (1990) J Clin Oncol , vol.8 , pp. 1858-1867
    • Berd, D.1    Maguire, H.C.J.2    McCue, P.3
  • 5
    • 0025782710 scopus 로고
    • Corynebacterium parvum versus Bacille Calmette-Guérin adjuvant immunotherapy of stage II malignant melanoma
    • Lipton A, Harvey HA, Balch CM, et al: Corynebacterium parvum versus Bacille Calmette-Guérin adjuvant immunotherapy of stage II malignant melanoma. J Clin Oncol 9:1151-1156, 1991
    • (1991) J Clin Oncol , vol.9 , pp. 1151-1156
    • Lipton, A.1    Harvey, H.A.2    Balch, C.M.3
  • 6
    • 0025642936 scopus 로고
    • Renal cell carcinoma treated by vaccines for active specific immunotherapy: Correlation of survival with skin testing by autologous tumor cell -Bacillus Calmette-Guérin vaccine
    • McCune CS, O'Donnell RW, Marquis DM, et al: Renal cell carcinoma treated by vaccines for active specific immunotherapy: Correlation of survival with skin testing by autologous tumor cell -Bacillus Calmette-Guérin vaccine. Cancer Immunol Immunother 32:62-66, 1990
    • (1990) Cancer Immunol Immunother , vol.32 , pp. 62-66
    • McCune, C.S.1    O'Donnell, R.W.2    Marquis, D.M.3
  • 7
    • 0028908324 scopus 로고
    • Paracrine cytokine adjuvants in cancer immunotherapy
    • Pardoll DM: Paracrine cytokine adjuvants in cancer immunotherapy. Annu Rev Immunol 13:399-415, 1995
    • (1995) Annu Rev Immunol , vol.13 , pp. 399-415
    • Pardoll, D.M.1
  • 8
    • 0027538181 scopus 로고
    • Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity
    • Dranoff G, Jaffee E, Lazenby A, et al: Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity. Proc Natl Acad Sci U S A 90:3539-3543, 1993
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 3539-3543
    • Dranoff, G.1    Jaffee, E.2    Lazenby, A.3
  • 9
    • 0026331269 scopus 로고
    • Treatment of established renal cancer by tumor cells engineered to secrete interleukin-4
    • Golumbek PT, Lazenby AJ, Levitsky HI, et al: Treatment of established renal cancer by tumor cells engineered to secrete interleukin-4. Science 254:713-716, 1991
    • (1991) Science , vol.254 , pp. 713-716
    • Golumbek, P.T.1    Lazenby, A.J.2    Levitsky, H.I.3
  • 10
    • 0023054680 scopus 로고
    • Immunology: The ins and outs of antigen processing and presentation
    • Germain RN: Immunology: The ins and outs of antigen processing and presentation. Nature 322:687-689, 1986
    • (1986) Nature , vol.322 , pp. 687-689
    • Germain, R.N.1
  • 11
    • 0025918153 scopus 로고
    • Helper T-cell subsets: Phenotype, function and the role of lymphokines in regulating their development
    • Swain SL, Bradley LM, Croft M, et al: Helper T-cell subsets: Phenotype, function and the role of lymphokines in regulating their development. Immunol Rev 123:1115-1144, 1991
    • (1991) Immunol Rev , vol.123 , pp. 1115-1144
    • Swain, S.L.1    Bradley, L.M.2    Croft, M.3
  • 12
    • 0027302705 scopus 로고
    • Immunological memory
    • Mackay C: Immunological memory. Adv Immunol 53:217-265, 1993
    • (1993) Adv Immunol , vol.53 , pp. 217-265
    • Mackay, C.1
  • 14
    • 0023143676 scopus 로고
    • Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo
    • Jenkins MK, Schwartz RH: Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo. J Exp Med 165:302-319, 1987
    • (1987) J Exp Med , vol.165 , pp. 302-319
    • Jenkins, M.K.1    Schwartz, R.H.2
  • 15
    • 0027087331 scopus 로고
    • Costimulation of T lymphocytes: The role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy
    • Schwartz RH: Costimulation of T lymphocytes: The role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy. Cell 71:1065-1068, 1992
    • (1992) Cell , vol.71 , pp. 1065-1068
    • Schwartz, R.H.1
  • 16
    • 0028201732 scopus 로고
    • Tolerance, danger, and the extended family
    • Matzinger P: Tolerance, danger, and the extended family. Annu Rev Immunol 12:991-1045, 1994
    • (1994) Annu Rev Immunol , vol.12 , pp. 991-1045
    • Matzinger, P.1
  • 17
    • 0032477815 scopus 로고    scopus 로고
    • Induction of antigen-specific T cell anergy: An early event in the course of tumor progression
    • Staveley-O'Carroll K, Sotomayor E, Montgomery J, et al: Induction of antigen-specific T cell anergy: An early event in the course of tumor progression. Proc Natl Acad Sci US A95:1178-1183, 1998
    • (1998) Proc Natl Acad Sci US A , vol.95 , pp. 1178-1183
    • Staveley-O'Carroll, K.1    Sotomayor, E.2    Montgomery, J.3
  • 18
    • 0030807565 scopus 로고    scopus 로고
    • Antigenic cancer cells grow progressively in immune hosts without evidence for T cell exhaustion or systemic anergy
    • Wick M, Dubey P, Koeppen H, et al: Antigenic cancer cells grow progressively in immune hosts without evidence for T cell exhaustion or systemic anergy. J Exp Med 186:229-238, 1997
    • (1997) J Exp Med , vol.186 , pp. 229-238
    • Wick, M.1    Dubey, P.2    Koeppen, H.3
  • 19
    • 0030848578 scopus 로고    scopus 로고
    • Self antigens expressed by solid tumors do not efficiently stimulate naive or activated T cells: Implications for immunotherapy
    • Speiser DE, Miranda R, Zakarian A, et al: Self antigens expressed by solid tumors do not efficiently stimulate naive or activated T cells: Implications for immunotherapy. J Exp Med 186:645-653, 1997
    • (1997) J Exp Med , vol.186 , pp. 645-653
    • Speiser, D.E.1    Miranda, R.2    Zakarian, A.3
  • 20
    • 0028179056 scopus 로고
    • Role of bone marrow-derived cells in presenting MHC class I-restricted tumor antigens
    • Huang AY, Golumbek P, Ahmadzadeh M, et al: Role of bone marrow-derived cells in presenting MHC class I-restricted tumor antigens. Science 264:961-965, 1994
    • (1994) Science , vol.264 , pp. 961-965
    • Huang, A.Y.1    Golumbek, P.2    Ahmadzadeh, M.3
  • 21
    • 0032485487 scopus 로고    scopus 로고
    • Dendritic cells acquire antigen from apoptotic cells and induce class I restricted CTLs
    • Albert ML, Sauter B, Bhardwaj N: Dendritic cells acquire antigen from apoptotic cells and induce class I restricted CTLs. Nature 392:86-89, 1998
    • (1998) Nature , vol.392 , pp. 86-89
    • Albert, M.L.1    Sauter, B.2    Bhardwaj, N.3
  • 22
    • 0032482474 scopus 로고    scopus 로고
    • T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions
    • Schoenberger SP, Toes RE, van der Voort EI, et al: T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions. Nature 393:480-483, 1998
    • (1998) Nature , vol.393 , pp. 480-483
    • Schoenberger, S.P.1    Toes, R.E.2    Van Der Voort, E.I.3
  • 23
    • 0032482337 scopus 로고    scopus 로고
    • A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell
    • Ridge JP, Di Rosa F, Matzinger P: A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell. Nature 393:474-478, 1998
    • (1998) Nature , vol.393 , pp. 474-478
    • Ridge, J.P.1    Di Rosa, F.2    Matzinger, P.3
  • 24
    • 0032482356 scopus 로고    scopus 로고
    • Help for cytotoxic-T-cell responses is mediated by CD40 signalling
    • Bennett SR, Carbone FR, Karamalis F, et al: Help for cytotoxic-T-cell responses is mediated by CD40 signalling. Nature 393:478-480, 1998
    • (1998) Nature , vol.393 , pp. 478-480
    • Bennett, S.R.1    Carbone, F.R.2    Karamalis, F.3
  • 25
    • 0032503016 scopus 로고    scopus 로고
    • Enhanced tumor protection by granulocyte-macrophage colony-stimulating factor expression at the site of an allogeneic vaccine
    • Thomas MC, Greten TF, Pardoll DM, et al: Enhanced tumor protection by granulocyte-macrophage colony-stimulating factor expression at the site of an allogeneic vaccine. Hum Gene Ther 9:835-843, 1998
    • (1998) Hum Gene Ther , vol.9 , pp. 835-843
    • Thomas, M.C.1    Greten, T.F.2    Pardoll, D.M.3
  • 26
    • 0029783148 scopus 로고    scopus 로고
    • Protective antitumor immunity induced by immunization with completely allogeneic tumor cells
    • Toes RE, Blom RJ, van Voort E, et al: Protective antitumor immunity induced by immunization with completely allogeneic tumor cells. Cancer Res 56:3782-3787, 1996
    • (1996) Cancer Res , vol.56 , pp. 3782-3787
    • Toes, R.E.1    Blom, R.J.2    Van Voort, E.3
  • 27
    • 0024121486 scopus 로고
    • Immunogenic (tum-) variants of mouse tumor P815: Cloning of the gene of turn-antigen P91A and identification of the turn- Mutation
    • De Plaen E, Lurquin C, Van Pel A, et al: Immunogenic (tum-) variants of mouse tumor P815: Cloning of the gene of turn-antigen P91A and identification of the turn- mutation. Proc Natl Acad Sci U S A 85:2274-2278, 1988
    • (1988) Proc Natl Acad Sci U S A , vol.85 , pp. 2274-2278
    • De Plaen, E.1    Lurquin, C.2    Van Pel, A.3
  • 28
    • 0024316157 scopus 로고
    • Structure of the gene of tum- Transplantation antigen P91 A: The mutated exon encodes a peptide recognized with Ld by cytolytic T cells
    • Lurquin C, Van Pel A, Mariame B, et al: Structure of the gene of tum- transplantation antigen P91 A: The mutated exon encodes a peptide recognized with Ld by cytolytic T cells. Cell 58:293-303, 1989
    • (1989) Cell , vol.58 , pp. 293-303
    • Lurquin, C.1    Van Pel, A.2    Mariame, B.3
  • 30
    • 0028304337 scopus 로고
    • Identification of a peptide recognized by five melanoma-specific human cytotoxic T cell lines
    • Cox AL, Skipper J, Chen Y, et al: Identification of a peptide recognized by five melanoma-specific human cytotoxic T cell lines. Science 264:716-719, 1994
    • (1994) Science , vol.264 , pp. 716-719
    • Cox, A.L.1    Skipper, J.2    Chen, Y.3
  • 31
    • 9544221745 scopus 로고    scopus 로고
    • The immunodominant major histocompatibility complex class I-restricted antigen of a murine colon tumor derives from an endogenous retroviral gene product
    • Huang AYC, Gulden PH, Woods AS, et al: The immunodominant major histocompatibility complex class I-restricted antigen of a murine colon tumor derives from an endogenous retroviral gene product. Proc Natl Acad Sci U S A 93:9730-9735, 1996
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 9730-9735
    • Huang, A.Y.C.1    Gulden, P.H.2    Woods, A.S.3
  • 32
    • 0028326766 scopus 로고
    • CTL induction by a tumor-associated antigen octapeptide derived from a murine lung carcinoma
    • Mandelboim O, Berke G, Fridkin M, et al: CTL induction by a tumor-associated antigen octapeptide derived from a murine lung carcinoma. Nature 369:67-71, 1994
    • (1994) Nature , vol.369 , pp. 67-71
    • Mandelboim, O.1    Berke, G.2    Fridkin, M.3
  • 33
    • 13344282077 scopus 로고
    • Human neoplasms elicit multiple specific immune responses in the autologous host
    • Sahin U, Tureci O, Schmitt H, et al: Human neoplasms elicit multiple specific immune responses in the autologous host. Proc Natl Acad Sci U S A 92:11810-11813, 1995
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 11810-11813
    • Sahin, U.1    Tureci, O.2    Schmitt, H.3
  • 34
    • 0342940792 scopus 로고    scopus 로고
    • Serological identification of human tumor antigens
    • Sahin U, Tureci O, Pfreundschuh M: Serological identification of human tumor antigens. Curr Opin Immunol 9:709-716, 1997
    • (1997) Curr Opin Immunol , vol.9 , pp. 709-716
    • Sahin, U.1    Tureci, O.2    Pfreundschuh, M.3
  • 35
    • 2642683198 scopus 로고    scopus 로고
    • Simultaneous humoral and cellular immune response against cancer-testis antigen Ny-Eso-1: Definition of human histocompatibility leukocyte antigen (HLA)-A2-binding peptide epitopes
    • Jager E, Chen YT, Drijfhout JW, et al: Simultaneous humoral and cellular immune response against cancer-testis antigen Ny-Eso-1: Definition of human histocompatibility leukocyte antigen (HLA)-A2-binding peptide epitopes. J Exp Med 187:265-270, 1998
    • (1998) J Exp Med , vol.187 , pp. 265-270
    • Jager, E.1    Chen, Y.T.2    Drijfhout, J.W.3
  • 36
    • 12644276375 scopus 로고    scopus 로고
    • A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening
    • Chen YT, Scanlan MJ, Sahin U, et al: A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening. Proc Natl Acad Sci U S A 94:1914-1918, 1997
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 1914-1918
    • Chen, Y.T.1    Scanlan, M.J.2    Sahin, U.3
  • 37
    • 0032499710 scopus 로고    scopus 로고
    • Identification of multiple cancer/testis antigens by allogeneic antibody screening of a melanoma cell line library
    • Chen YT, Cure AO, Tsang S, et al: Identification of multiple cancer/testis antigens by allogeneic antibody screening of a melanoma cell line library. Proc Natl Acad Sci U S A 95:6919-6923, 1998
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 6919-6923
    • Chen, Y.T.1    Cure, A.O.2    Tsang, S.3
  • 38
    • 0028947046 scopus 로고
    • A unique tumor antigen produced by a single amino acid substitution
    • Monach PA, Meredith SC, Siegel CT, et al: A unique tumor antigen produced by a single amino acid substitution. Immunity 2:45-59, 1995
    • (1995) Immunity , vol.2 , pp. 45-59
    • Monach, P.A.1    Meredith, S.C.2    Siegel, C.T.3
  • 39
    • 0027165558 scopus 로고
    • The tyrosinase gene codes for an antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas
    • Brichard V, Van Pel A, Wolfel T, et al: The tyrosinase gene codes for an antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas. J Exp Med 178:489-495, 1993
    • (1993) J Exp Med , vol.178 , pp. 489-495
    • Brichard, V.1    Van Pel, A.2    Wolfel, T.3
  • 40
    • 0028303166 scopus 로고
    • A new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas
    • Coulie PG, Brichard V, Van Pel A, et al: A new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas. J Exp Med 180:35-42, 1994
    • (1994) J Exp Med , vol.180 , pp. 35-42
    • Coulie, P.G.1    Brichard, V.2    Van Pel, A.3
  • 41
    • 0028316911 scopus 로고
    • Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor
    • Kawakami Y, Eliyahu S, Delgado CH, et al: Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor. Proc Natl Acad Sci U S A 91:3515-3519, 1994
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 3515-3519
    • Kawakami, Y.1    Eliyahu, S.2    Delgado, C.H.3
  • 42
    • 0027958312 scopus 로고
    • Melanocyte lineage-specific antigen gp100 is recognized by melanoma-derived tumor-infiltrating lymphocytes
    • Bakker AB, Schreurs MW, de Boer AJ, et al: Melanocyte lineage-specific antigen gp100 is recognized by melanoma-derived tumor-infiltrating lymphocytes. J Exp Med 179:1005-1009, 1994
    • (1994) J Exp Med , vol.179 , pp. 1005-1009
    • Bakker, A.B.1    Schreurs, M.W.2    De Boer, A.J.3
  • 43
    • 0028906594 scopus 로고
    • Identification of a gene encoding a melanoma tumor antigen recognized by HLA-A31-restricted tumor-infiltrating lymphocytes
    • published erratum appears in J Exp Med 181:1261, 1995.
    • Wang RF, Robbins PF, Kawakami Y, et al: Identification of a gene encoding a melanoma tumor antigen recognized by HLA-A31-restricted tumor-infiltrating lymphocytes [published erratum appears in J Exp Med 181:1261, 1995]. J Exp Med 181:799-804, 1995
    • (1995) J Exp Med , vol.181 , pp. 799-804
    • Wang, R.F.1    Robbins, P.F.2    Kawakami, Y.3
  • 44
    • 0030472678 scopus 로고    scopus 로고
    • Identification of TRP-2 as a human tumor antigen recognized by cytotoxic T lymphocytes
    • Wang RF, Appella E, Kawakami Y, et al: Identification of TRP-2 as a human tumor antigen recognized by cytotoxic T lymphocytes. J Exp Med 184:2207-2216, 1996
    • (1996) J Exp Med , vol.184 , pp. 2207-2216
    • Wang, R.F.1    Appella, E.2    Kawakami, Y.3
  • 45
    • 0028347940 scopus 로고
    • Two tyrosinase nonapeptides recognized on HLA-A2 melanomas by autologous cytolytic T lymphocytes
    • Wolfel T, Van Pel A, Brichard V, et al: Two tyrosinase nonapeptides recognized on HLA-A2 melanomas by autologous cytolytic T lymphocytes. Eur J Immunol 24:759-764, 1994
    • (1994) Eur J Immunol , vol.24 , pp. 759-764
    • Wolfel, T.1    Van Pel, A.2    Brichard, V.3
  • 46
    • 0029028642 scopus 로고
    • Identification of a novel peptide derived from the melanocyte-specific gp100 antigen as the dominant epitope recognized by an HLA-A2.1- Restricted anti-melanoma CTL line
    • Bakker AB, Schreurs MW, Tafazzul G, et al: Identification of a novel peptide derived from the melanocyte-specific gp100 antigen as the dominant epitope recognized by an HLA-A2.1- restricted anti-melanoma CTL line. Int J Cancer 62:97-102, 1995
    • (1995) Int J Cancer , vol.62 , pp. 97-102
    • Bakker, A.B.1    Schreurs, M.W.2    Tafazzul, G.3
  • 47
    • 0026322151 scopus 로고
    • A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma
    • Van der Bruggen P, Traversari C, Chomez P, et al: A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma. Science 254:1643-1647, 1991
    • (1991) Science , vol.254 , pp. 1643-1647
    • Van Der Bruggen, P.1    Traversari, C.2    Chomez, P.3
  • 48
    • 0028952240 scopus 로고
    • BAGE: A new gene encoding an antigen recognized on human melanomas by cytolytic T lymphocytes
    • Boel P, Wildmann C, Sensi ML, et al: BAGE: A new gene encoding an antigen recognized on human melanomas by cytolytic T lymphocytes. Immunity 2:167-175, 1995
    • (1995) Immunity , vol.2 , pp. 167-175
    • Boel, P.1    Wildmann, C.2    Sensi, M.L.3
  • 49
    • 0029085917 scopus 로고
    • A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma
    • Van den Eynde B, Peeters O, De Backer O, et al: A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma. J Exp Med 182:689-698, 1995
    • (1995) J Exp Med , vol.182 , pp. 689-698
    • Van Den Eynde, B.1    Peeters, O.2    De Backer, O.3
  • 50
    • 0028978274 scopus 로고
    • A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma
    • Wolfel T, Hauer M, Schneider J, et al: A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma. Science 269:1281-1284, 1995
    • (1995) Science , vol.269 , pp. 1281-1284
    • Wolfel, T.1    Hauer, M.2    Schneider, J.3
  • 51
    • 0025882042 scopus 로고
    • T cell recognition of transforming proteins encoded by mutated ras proto-oncogenes
    • Peace DJ, Chen W, Nelson H, et al: T cell recognition of transforming proteins encoded by mutated ras proto-oncogenes. J Immunol 146:2059-2065, 1991
    • (1991) J Immunol , vol.146 , pp. 2059-2065
    • Peace, D.J.1    Chen, W.2    Nelson, H.3
  • 52
    • 0026074766 scopus 로고
    • Human T lymphocytes recognize a peptide of single point-mutated, oncogenic ras proteins
    • Jung S, Schluesener HJ: Human T lymphocytes recognize a peptide of single point-mutated, oncogenic ras proteins. J Exp Med 173:273-276, 1991
    • (1991) J Exp Med , vol.173 , pp. 273-276
    • Jung, S.1    Schluesener, H.J.2
  • 53
    • 0028961520 scopus 로고
    • Cytotoxic T cells overcome BCR-ABL-mediated resistance to apoptosis
    • Fuchs EJ, Bedi A, Jones RJ, et al: Cytotoxic T cells overcome BCR-ABL-mediated resistance to apoptosis. Cancer Res 55:463-469, 1995
    • (1995) Cancer Res , vol.55 , pp. 463-469
    • Fuchs, E.J.1    Bedi, A.2    Jones, R.J.3
  • 55
    • 0030221850 scopus 로고    scopus 로고
    • Epstein-Barr virus as a therapeutic target in Hodgkin's disease and nasopharyngeal carcinoma
    • Ambinder RF, Robertson KD, Moore SM, et al: Epstein-Barr virus as a therapeutic target in Hodgkin's disease and nasopharyngeal carcinoma. Semin Cancer Biol 7:217-226, 1996
    • (1996) Semin Cancer Biol , vol.7 , pp. 217-226
    • Ambinder, R.F.1    Robertson, K.D.2    Moore, S.M.3
  • 56
    • 0028109547 scopus 로고
    • Immunology of the human papilloma virus in relation to cancer
    • Wu TC: Immunology of the human papilloma virus in relation to cancer. Curr Opin Immunol 6:746-754, 1994
    • (1994) Curr Opin Immunol , vol.6 , pp. 746-754
    • Wu, T.C.1
  • 57
    • 0030965103 scopus 로고    scopus 로고
    • Universal hepatitis B vaccination in Taiwan and the incidence of hepatocellular carcinoma in children: Taiwan Childhood Hepatoma Study Group
    • Chang MH, Chen CJ, Lai MS, et al: Universal hepatitis B vaccination in Taiwan and the incidence of hepatocellular carcinoma in children: Taiwan Childhood Hepatoma Study Group. N Engl J Med 336:1855-1859, 1997
    • (1997) N Engl J Med , vol.336 , pp. 1855-1859
    • Chang, M.H.1    Chen, C.J.2    Lai, M.S.3
  • 58
    • 0028023727 scopus 로고
    • Human CD4+ T cells specifically recognize a shared melanoma-associated antigen encoded by the tyrosinase gene
    • Topalian SL, Rivoltini L, Mancini M, et al: Human CD4+ T cells specifically recognize a shared melanoma-associated antigen encoded by the tyrosinase gene. Proc Natl Acad Sci USA 91:9461-9465, 1994
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 9461-9465
    • Topalian, S.L.1    Rivoltini, L.2    Mancini, M.3
  • 59
    • 0027362823 scopus 로고
    • B70 antigen is a second ligand for CTLA-4 and CD28
    • Azuma M, Ito D, Yagita H, et al: B70 antigen is a second ligand for CTLA-4 and CD28. Nature 366:76-79, 1993
    • (1993) Nature , vol.366 , pp. 76-79
    • Azuma, M.1    Ito, D.2    Yagita, H.3
  • 60
    • 0027729845 scopus 로고
    • Uncovering of functional alternative CTLA-4 counter-receptor in B7-deficient mice
    • Freeman GJ, Borriello F, Hodes RJ, et al: Uncovering of functional alternative CTLA-4 counter-receptor in B7-deficient mice. Science 262:907-909, 1993
    • (1993) Science , vol.262 , pp. 907-909
    • Freeman, G.J.1    Borriello, F.2    Hodes, R.J.3
  • 61
    • 0027767762 scopus 로고
    • Cloning of B7-2: A CTLA-4 counter-receptor that costimulates human T cell proliferation
    • Freeman GJ, Gribben JG, Boussiotis VA, et al: Cloning of B7-2: A CTLA-4 counter-receptor that costimulates human T cell proliferation. Science 262:909-911, 1993
    • (1993) Science , vol.262 , pp. 909-911
    • Freeman, G.J.1    Gribben, J.G.2    Boussiotis, V.A.3
  • 62
    • 0025830902 scopus 로고
    • CTLA-4 is a second receptor for the B cell activation antigen B7
    • Linsley PS, Brady W, Urnes M, et al: CTLA-4 is a second receptor for the B cell activation antigen B7. J Exp Med 174:561-569, 1991
    • (1991) J Exp Med , vol.174 , pp. 561-569
    • Linsley, P.S.1    Brady, W.2    Urnes, M.3
  • 63
    • 0027078670 scopus 로고
    • Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4
    • Chen L, Ashe S, Brady WA, et al: Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4. Cell 71:1093-1102, 1992
    • (1992) Cell , vol.71 , pp. 1093-1102
    • Chen, L.1    Ashe, S.2    Brady, W.A.3
  • 64
    • 0027211058 scopus 로고
    • Constitutive expression of B7 restores immunogenicity of tumor cells expressing truncated major histocompatibility complex class II molecules
    • Baskar S, Ostrand-Rosenberg S, Nabavi N, et al: Constitutive expression of B7 restores immunogenicity of tumor cells expressing truncated major histocompatibility complex class II molecules. Proc Natl Acad Sci U S A 90:5687-5690, 1993
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 5687-5690
    • Baskar, S.1    Ostrand-Rosenberg, S.2    Nabavi, N.3
  • 65
    • 0027392843 scopus 로고
    • Tumor rejection after direct costimulation of CD8+ T cells by B7- Transfected melanoma cells
    • Townsend SE, Allison JP: Tumor rejection after direct costimulation of CD8+ T cells by B7- transfected melanoma cells [see comments]. Science 259:368-370, 1993
    • (1993) Science , vol.259 , pp. 368-370
    • Townsend, S.E.1    Allison, J.P.2
  • 66
    • 0029914307 scopus 로고    scopus 로고
    • Coexpression of interleukin-4 and B7.1 in murine tumor cells leads to improved tumor rejection and vaccine effect compared to single gene transfectants and a classical adjuvant
    • Cayeux S, Beck C, Dorken B, et al: Coexpression of interleukin-4 and B7.1 in murine tumor cells leads to improved tumor rejection and vaccine effect compared to single gene transfectants and a classical adjuvant. Hum Gene Ther 7:525-529, 1996
    • (1996) Hum Gene Ther , vol.7 , pp. 525-529
    • Cayeux, S.1    Beck, C.2    Dorken, B.3
  • 67
    • 0029101821 scopus 로고
    • Tumor cells cotransfected with interleukin-7 and B7.1 genes induce CD25 and CD28 on tumor-infiltrating T lymphocytes and are strong vaccines
    • Cayeux S, Beck C, Aicher A, et al: Tumor cells cotransfected with interleukin-7 and B7.1 genes induce CD25 and CD28 on tumor-infiltrating T lymphocytes and are strong vaccines. Eur J Immunol 25:2325-2331, 1995
    • (1995) Eur J Immunol , vol.25 , pp. 2325-2331
    • Cayeux, S.1    Beck, C.2    Aicher, A.3
  • 68
    • 0032546352 scopus 로고    scopus 로고
    • Dendritic cells and the control of immunity
    • Banchereau J, Steinman RM: Dendritic cells and the control of immunity. Nature 392:245-252, 1998
    • (1998) Nature , vol.392 , pp. 245-252
    • Banchereau, J.1    Steinman, R.M.2
  • 69
    • 0028914976 scopus 로고
    • Serological response patterns of melanoma patients immunized with a GM2 ganglioside conjugate vaccine
    • Kitamura K, Livingston PO, Fortunato SR, et al: Serological response patterns of melanoma patients immunized with a GM2 ganglioside conjugate vaccine. Proc Natl Acad Sci U S A 92:2805-2809, 1995
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 2805-2809
    • Kitamura, K.1    Livingston, P.O.2    Fortunato, S.R.3
  • 70
    • 0028981087 scopus 로고
    • GM2-KLH conjugate vaccine: Increased immunogenicity in melanoma patients after administration with immunological adjuvant QS-21
    • Helling F, Zhang S, Shang A, et al: GM2-KLH conjugate vaccine: Increased immunogenicity in melanoma patients after administration with immunological adjuvant QS-21. Cancer Res 55:2783-2788, 1995
    • (1995) Cancer Res , vol.55 , pp. 2783-2788
    • Helling, F.1    Zhang, S.2    Shang, A.3
  • 71
    • 0031007771 scopus 로고    scopus 로고
    • Tumor-specific idiotype vaccines in the treatment of patients with B-cell lymphoma: Long-term results of a clinical trial
    • Hsu FJ, Caspar CB, Czerwinski D, et al: Tumor-specific idiotype vaccines in the treatment of patients with B-cell lymphoma: Long-term results of a clinical trial. Blood 89:3129-3135, 1997
    • (1997) Blood , vol.89 , pp. 3129-3135
    • Hsu, F.J.1    Caspar, C.B.2    Czerwinski, D.3
  • 72
    • 0031801808 scopus 로고    scopus 로고
    • Idiotypic immunization induces immunity to mutated p53 and tumor rejection
    • Ruiz JP, Wolkowicz R, Waisman A, et al: Idiotypic immunization induces immunity to mutated p53 and tumor rejection. Nat Med 4:710-712, 1998
    • (1998) Nat Med , vol.4 , pp. 710-712
    • Ruiz, J.P.1    Wolkowicz, R.2    Waisman, A.3
  • 73
    • 84988098462 scopus 로고
    • Tumor-specific immunity can be enhanced by transfection of tumor cells with syngeneic MHC-class-II genes or allogeneic MHC-class-I genes
    • Ostrand-Rosenberg S, Roby C, Clements VK, et al: Tumor-specific immunity can be enhanced by transfection of tumor cells with syngeneic MHC-class-II genes or allogeneic MHC-class-I genes. Int J Cancer Suppl 6:61-68, 1991
    • (1991) Int J Cancer Suppl , vol.6 , pp. 61-68
    • Ostrand-Rosenberg, S.1    Roby, C.2    Clements, V.K.3
  • 74
    • 0021815478 scopus 로고
    • Abrogation of metastatic properties of tumour cells by de novo expression of H-2K antigens following H-2 gene transfection
    • Wallich R, Bulbuc N, Hammerling GJ, et al: Abrogation of metastatic properties of tumour cells by de novo expression of H-2K antigens following H-2 gene transfection. Nature 315:301-305, 1985
    • (1985) Nature , vol.315 , pp. 301-305
    • Wallich, R.1    Bulbuc, N.2    Hammerling, G.J.3
  • 75
    • 0027280569 scopus 로고
    • Immunotherapy of malignancy by in vivo gene transfer into tumors
    • Plautz GE, Yang ZY, Wu BY, et al: Immunotherapy of malignancy by in vivo gene transfer into tumors. Proc Natl Acad Sci USA 90:4645-4649, 1993
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 4645-4649
    • Plautz, G.E.1    Yang, Z.Y.2    Wu, B.Y.3
  • 76
    • 0027295140 scopus 로고
    • Interleukin 3 enhances development of tumor-reactive cytotoxic cells by a CD4-dependent mechanism
    • Pulaski BA, McAdam AJ, Hutter EK, et al: Interleukin 3 enhances development of tumor-reactive cytotoxic cells by a CD4-dependent mechanism. Cancer Res 53:2112-2117, 1993
    • (1993) Cancer Res , vol.53 , pp. 2112-2117
    • Pulaski, B.A.1    McAdam, A.J.2    Hutter, E.K.3
  • 77
    • 0025000864 scopus 로고
    • Interleukin 2 gene transfer into tumor cells abrogates tumorigenicity and induces protective immunity
    • Gansbacher B, Zier K, Daniels B, et al: Interleukin 2 gene transfer into tumor cells abrogates tumorigenicity and induces protective immunity. J Exp Med 172:1217-1224, 1990
    • (1990) J Exp Med , vol.172 , pp. 1217-1224
    • Gansbacher, B.1    Zier, K.2    Daniels, B.3
  • 78
    • 0025806563 scopus 로고
    • Murine tumor cells transduced with the gene for tumor necrosis factor-a
    • Asher M, Mule J, Kasid A: Murine tumor cells transduced with the gene for tumor necrosis factor-a. J Immunol 146:3227-3229, 1991
    • (1991) J Immunol , vol.146 , pp. 3227-3229
    • Asher, M.1    Mule, J.2    Kasid, A.3
  • 79
    • 0025604195 scopus 로고
    • Retroviral vector-mediated gamma-interferon gene transfer into tumor cells generates potent and long lasting antitumor immunity
    • Gansbacher B, Bannerji R, Daniels B: Retroviral vector-mediated gamma-interferon gene transfer into tumor cells generates potent and long lasting antitumor immunity. Cancer Res 50:7820-7826, 1990
    • (1990) Cancer Res , vol.50 , pp. 7820-7826
    • Gansbacher, B.1    Bannerji, R.2    Daniels, B.3
  • 80
    • 0025837199 scopus 로고
    • Interleukin 7 induces CD4+ T cell-dependent tumor rejection
    • Hock H, Dorsch M, Diamantstein T, et al: Interleukin 7 induces CD4+ T cell-dependent tumor rejection. J Exp Med 174:1291-1298, 1991
    • (1991) J Exp Med , vol.174 , pp. 1291-1298
    • Hock, H.1    Dorsch, M.2    Diamantstein, T.3
  • 81
    • 0026772066 scopus 로고
    • Interleukin 6 gene transfection into Lewis lung carcinoma tumor cells suppresses the malignant phenotype and confers immunotherapeutic competence against parental metastatic cells
    • Porgador A, Tzehoval E, Katz A, et al: Interleukin 6 gene transfection into Lewis lung carcinoma tumor cells suppresses the malignant phenotype and confers immunotherapeutic competence against parental metastatic cells. Cancer Res 52:3679-3686, 1992
    • (1992) Cancer Res , vol.52 , pp. 3679-3686
    • Porgador, A.1    Tzehoval, E.2    Katz, A.3
  • 82
    • 0025849163 scopus 로고
    • Tumor suppression after tumor cell-targeted tumor necrosis factor via gene transfer
    • Blankenstein T, Qin Z, Uberla K: Tumor suppression after tumor cell-targeted tumor necrosis factor via gene transfer. J Exp Med 173:1047-1052, 1991
    • (1991) J Exp Med , vol.173 , pp. 1047-1052
    • Blankenstein, T.1    Qin, Z.2    Uberla, K.3
  • 83
    • 0030944023 scopus 로고    scopus 로고
    • Bioactivity of autologous irradiated renal cell carcinoma vaccines generated by ex vivo granulocyte-macrophage colony-stimulating factor gene transfer
    • Simons JW, Jaffee EM, Weber CE, et al: Bioactivity of autologous irradiated renal cell carcinoma vaccines generated by ex vivo granulocyte-macrophage colony-stimulating factor gene transfer. Cancer Res 57:1537-1546, 1997
    • (1997) Cancer Res , vol.57 , pp. 1537-1546
    • Simons, J.W.1    Jaffee, E.M.2    Weber, C.E.3
  • 84
    • 0027141113 scopus 로고
    • Controlled release, biodegradable cytokine depots: A new approach in cancer vaccine design
    • Golumbek PT, Azhari R, Jaffee EM, et al: Controlled release, biodegradable cytokine depots: A new approach in cancer vaccine design. Cancer Res 53:1-4, 1993
    • (1993) Cancer Res , vol.53 , pp. 1-4
    • Golumbek, P.T.1    Azhari, R.2    Jaffee, E.M.3
  • 85
    • 17144451105 scopus 로고    scopus 로고
    • Cytokine gene therapy of cancer using interleukin-12: Murine and clinical trials
    • Lotze MT, Zitvogel L, Campbell R, et al: Cytokine gene therapy of cancer using interleukin-12: Murine and clinical trials. Ann N Y Acad Sei 795:440-454, 1996
    • (1996) Ann N Y Acad Sei , vol.795 , pp. 440-454
    • Lotze, M.T.1    Zitvogel, L.2    Campbell, R.3
  • 86
    • 0028589416 scopus 로고
    • Experimental and clinical studies of cytokine gene-modified tumor cells
    • Tepper RI, Mule JJ: Experimental and clinical studies of cytokine gene-modified tumor cells. Hum Gene Ther 5:153-164, 1994
    • (1994) Hum Gene Ther , vol.5 , pp. 153-164
    • Tepper, R.I.1    Mule, J.J.2
  • 87
    • 0030635670 scopus 로고    scopus 로고
    • Clinical Trials Referral Resource: Trials using tumor vaccines
    • Cheson BD, Phillips PH, Sznol M: Clinical Trials Referral Resource: Trials using tumor vaccines. Oncology 11:81-82, 84, 90, 1997
    • (1997) Oncology , vol.11 , pp. 81-82
    • Cheson, B.D.1    Phillips, P.H.2    Sznol, M.3
  • 88
    • 19244363863 scopus 로고    scopus 로고
    • Limited antitumor T cell response in melanoma patients vaccinated with interleukin-2 gene-transduced allogeneic melanoma cells
    • Arienti F, Sule-Suso J, Belli F, et al: Limited antitumor T cell response in melanoma patients vaccinated with interleukin-2 gene-transduced allogeneic melanoma cells. Hum Gene Ther 7:1955-1963, 1996
    • (1996) Hum Gene Ther , vol.7 , pp. 1955-1963
    • Arienti, F.1    Sule-Suso, J.2    Belli, F.3
  • 89
    • 0030820018 scopus 로고    scopus 로고
    • A phase I clinical trial of immunotherapy with interferon-gamma gene-modified autologous melanoma cells: Monitoring the humoral immune response
    • Abdel-Wahab Z, Weltz C, Hester D, et al: A phase I clinical trial of immunotherapy with interferon-gamma gene-modified autologous melanoma cells: Monitoring the humoral immune response. Cancer 80:401-412, 1997
    • (1997) Cancer , vol.80 , pp. 401-412
    • Abdel-Wahab, Z.1    Weltz, C.2    Hester, D.3
  • 90
    • 0025231388 scopus 로고
    • Direct gene transfer into mouse muscle in vivo
    • Wolff JA, Malone RW, Williams P, et al: Direct gene transfer into mouse muscle in vivo. Science 247:1465-1468, 1990
    • (1990) Science , vol.247 , pp. 1465-1468
    • Wolff, J.A.1    Malone, R.W.2    Williams, P.3
  • 91
    • 0029820526 scopus 로고    scopus 로고
    • DNA-based immunization by in vivo transfection of dendritic cells
    • Condon C, Watkins SC, Celluzzi CM, et al: DNA-based immunization by in vivo transfection of dendritic cells. Nat Med 2:1122-1128, 1996
    • (1996) Nat Med , vol.2 , pp. 1122-1128
    • Condon, C.1    Watkins, S.C.2    Celluzzi, C.M.3
  • 92
    • 0026579897 scopus 로고
    • Genetic immunization is a simple method for eliciting an immune response
    • Tang DC, DeVit M, Johnston SA: Genetic immunization is a simple method for eliciting an immune response. Nature 356:152-154, 1992
    • (1992) Nature , vol.356 , pp. 152-154
    • Tang, D.C.1    DeVit, M.2    Johnston, S.A.3
  • 94
    • 0029080474 scopus 로고
    • Exposing the immunology of naked DNA vaccines
    • Pardoll DM, Beckerleg AM: Exposing the immunology of naked DNA vaccines. Immunity 3:165-169, 1995
    • (1995) Immunity , vol.3 , pp. 165-169
    • Pardoll, D.M.1    Beckerleg, A.M.2
  • 95
    • 0029737350 scopus 로고    scopus 로고
    • Induction of cytotoxic T lymphocytes by intramuscular immunization with plasmid DNA is facilitated by bone marrow-derived cells
    • Doe B, Selby M, Barnett S, et al: Induction of cytotoxic T lymphocytes by intramuscular immunization with plasmid DNA is facilitated by bone marrow-derived cells. Proc Natl Acad Sci U S A 93:8578-8583, 1996
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 8578-8583
    • Doe, B.1    Selby, M.2    Barnett, S.3
  • 96
    • 0029956512 scopus 로고    scopus 로고
    • Gene vaccination with naked plasmidDNA: Mechanism of CTL priming
    • Corr M, Lee DJ, Carson DA, et al: Gene vaccination with naked plasmidDNA: Mechanism of CTL priming. J Exp Med 184:1555-1560, 1996
    • (1996) J Exp Med , vol.184 , pp. 1555-1560
    • Corr, M.1    Lee, D.J.2    Carson, D.A.3
  • 97
    • 0028930719 scopus 로고
    • Minimal determinant expressed by a recombinant vaccinia virus elicits therapeutic antitumor cytolytic T lymphocyte responses
    • McCabe B, Irvine K, Nishimura M, et al: Minimal determinant expressed by a recombinant vaccinia virus elicits therapeutic antitumor cytolytic T lymphocyte responses. Cancer Res 55:1741-1757, 1995
    • (1995) Cancer Res , vol.55 , pp. 1741-1757
    • McCabe, B.1    Irvine, K.2    Nishimura, M.3
  • 98
    • 0029057976 scopus 로고
    • Antigen processing in vivo and the elicitation of primary CTL responses
    • Restifo NP, Bacik I, Irvine KR, et al: Antigen processing in vivo and the elicitation of primary CTL responses. J Immunol 154:4414-4422, 1995
    • (1995) J Immunol , vol.154 , pp. 4414-4422
    • Restifo, N.P.1    Bacik, I.2    Irvine, K.R.3
  • 99
    • 0029071787 scopus 로고
    • Synthetic oligonucleotide expressed by a recombinant vaccinia virus elicits therapeutic CTL
    • Irvine K, McCabe B, Rosenberg S, et al: Synthetic oligonucleotide expressed by a recombinant vaccinia virus elicits therapeutic CTL. J Immunol 154:4651-4657, 1995
    • (1995) J Immunol , vol.154 , pp. 4651-4657
    • Irvine, K.1    McCabe, B.2    Rosenberg, S.3
  • 100
    • 0029007260 scopus 로고
    • Active immunotherapy of cancer with a nonreplicating recombinant fowlpox virus encoding a model tumor-associated antigen
    • Wang M, Bronte V, Chen PW, et al: Active immunotherapy of cancer with a nonreplicating recombinant fowlpox virus encoding a model tumor-associated antigen. J Immunol 154:4685-4692, 1995
    • (1995) J Immunol , vol.154 , pp. 4685-4692
    • Wang, M.1    Bronte, V.2    Chen, P.W.3
  • 101
    • 0029070112 scopus 로고
    • IL-2 enhances the function of recombinant poxvirus-based vaccines in the treatment of established pulmonary metastases
    • Bronte V, Tsung K, Rao JB, et al: IL-2 enhances the function of recombinant poxvirus-based vaccines in the treatment of established pulmonary metastases. J Immunol 154:5282-5292, 1995
    • (1995) J Immunol , vol.154 , pp. 5282-5292
    • Bronte, V.1    Tsung, K.2    Rao, J.B.3
  • 102
    • 0029583864 scopus 로고
    • Engineer-ing an intracellular pathway for major histocompatibility complex class I! presentation of antigens
    • Wu TC, Guarnieri FG, Staveley-O'Carroll KF, et al: Engineer-ing an intracellular pathway for major histocompatibility complex class I! presentation of antigens. Proc Natl Acad Sci U S A 92:11671-11675, 1995
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 11671-11675
    • Wu, T.C.1    Guarnieri, F.G.2    Staveley-O'Carroll, K.F.3
  • 103
    • 0030068375 scopus 로고    scopus 로고
    • Treatment of established tumors with a novel vaccine that enhances major histocompatibility class II presentation of tumor antigen
    • Lin KY, Guarnieri FG, Staveley-O'Carroll K, et al: Treatment of established tumors with a novel vaccine that enhances major histocompatibility class II presentation of tumor antigen. Cancer Res 56:21-26, 1996
    • (1996) Cancer Res , vol.56 , pp. 21-26
    • Lin, K.Y.1    Guarnieri, F.G.2    Staveley-O'Carroll, K.3
  • 104
    • 15844365301 scopus 로고    scopus 로고
    • A recombinant vaccinia virus encoding human papillomavirus types 16 and 18, E6 and E7 proteins as immunotherapy for cervical cancer
    • Borysiewicz LK, Fiander A, Nimako M, et al: A recombinant vaccinia virus encoding human papillomavirus types 16 and 18, E6 and E7 proteins as immunotherapy for cervical cancer [see comments]. Lancet 347:1523-1527, 1996
    • (1996) Lancet , vol.347 , pp. 1523-1527
    • Borysiewicz, L.K.1    Fiander, A.2    Nimako, M.3
  • 106
    • 0029047262 scopus 로고
    • A recombinant Listeria monocytogenes vaccine expressing a model tumour antigen protects mice against lethal tumour cell challenge and causes regression of established tumours
    • Pan ZK, Ikonomidis G, Lazenby A, et al: A recombinant Listeria monocytogenes vaccine expressing a model tumour antigen protects mice against lethal tumour cell challenge and causes regression of established tumours. Nat Med 1:471-477, 1995
    • (1995) Nat Med , vol.1 , pp. 471-477
    • Pan, Z.K.1    Ikonomidis, G.2    Lazenby, A.3
  • 107
    • 0024466940 scopus 로고
    • Eradication of adenovirus El-induced tumors by ElA-specific cytotoxic T lymphocytes
    • Kast WM, Offringa R, Peters PJ, et al: Eradication of adenovirus El-induced tumors by ElA-specific cytotoxic T lymphocytes. Cell 59:603-614, 1989
    • (1989) Cell , vol.59 , pp. 603-614
    • Kast, W.M.1    Offringa, R.2    Peters, P.J.3
  • 108
    • 0028884728 scopus 로고
    • Regression of established murine carcinoma metastases following vaccination with tumour-associated antigen peptides
    • Mandelboim O, Vadai E, Fridkin M, et al: Regression of established murine carcinoma metastases following vaccination with tumour-associated antigen peptides [see comments]. Nat Med 1:1179-1183, 1995
    • (1995) Nat Med , vol.1 , pp. 1179-1183
    • Mandelboim, O.1    Vadai, E.2    Fridkin, M.3
  • 109
    • 0029935569 scopus 로고    scopus 로고
    • Enhanced tumor outgrowth after peptide vaccination: Functional deletion of tumor-specific CTL induced by peptide vaccination can lead to the inability to reject tumors
    • Toes RE, Blom RJ, Offringa R, et al: Enhanced tumor outgrowth after peptide vaccination: Functional deletion of tumor-specific CTL induced by peptide vaccination can lead to the inability to reject tumors. J Immunol 156:3911-3918, 1996
    • (1996) J Immunol , vol.156 , pp. 3911-3918
    • Toes, R.E.1    Blom, R.J.2    Offringa, R.3
  • 110
    • 0029642252 scopus 로고
    • Tumor regression responses in melanoma patients treated with a peptide encoded by gene MAGE-3
    • Marchand M, Weynants P, Rankin E, et al: Tumor regression responses in melanoma patients treated with a peptide encoded by gene MAGE-3. Int J Cancer 63:883-885, 1995
    • (1995) Int J Cancer , vol.63 , pp. 883-885
    • Marchand, M.1    Weynants, P.2    Rankin, E.3
  • 111
    • 0041485051 scopus 로고    scopus 로고
    • Granulocyte-macrophage-colony-stimulating factor enhances immune responses to melanoma-associated peptides in vivo
    • Jager E, Ringhoffer M, Dienes HP, et al: Granulocyte-macrophage-colony-stimulating factor enhances immune responses to melanoma-associated peptides in vivo. Int J Cancer 67:54-62, 1996
    • (1996) Int J Cancer , vol.67 , pp. 54-62
    • Jager, E.1    Ringhoffer, M.2    Dienes, H.P.3
  • 112
    • 0030587077 scopus 로고    scopus 로고
    • Improved induction of melanoma-reactive CTL with peptides from the melanoma antigen gp100 modified at HLA-A*0201-binding residues
    • Parkhurst MR, Salgaller ML, Southwood S, et al: Improved induction of melanoma-reactive CTL with peptides from the melanoma antigen gp100 modified at HLA-A*0201-binding residues. J Immunol 157:2539-2548, 1996
    • (1996) J Immunol , vol.157 , pp. 2539-2548
    • Parkhurst, M.R.1    Salgaller, M.L.2    Southwood, S.3
  • 113
    • 0031890206 scopus 로고    scopus 로고
    • Immunologic and therapeutic evaluation of a synthetic peptide vaccine for the treatment of patients with metastatic melanoma
    • Rosenberg SA, Yang JC, Schwartzentruber DJ, et al: Immunologic and therapeutic evaluation of a synthetic peptide vaccine for the treatment of patients with metastatic melanoma. Nat Med 4:321-327, 1998
    • (1998) Nat Med , vol.4 , pp. 321-327
    • Rosenberg, S.A.1    Yang, J.C.2    Schwartzentruber, D.J.3
  • 114
    • 0030820099 scopus 로고    scopus 로고
    • Immunotherapy of tumors with autologous tumor-derived heat shock protein preparations
    • Tamura Y, Peng P, Liu K, et al: Immunotherapy of tumors with autologous tumor-derived heat shock protein preparations. Science 278:117-120, 1997
    • (1997) Science , vol.278 , pp. 117-120
    • Tamura, Y.1    Peng, P.2    Liu, K.3
  • 115
    • 0030775140 scopus 로고    scopus 로고
    • Heat shock protein-peptide complexes, reconstituted in vitro, elicit peptide-specific cytotoxic T lymphocyte response and tumor immunity
    • Blachere NE, Li Z, Chandawarkar RY, et al: Heat shock protein-peptide complexes, reconstituted in vitro, elicit peptide-specific cytotoxic T lymphocyte response and tumor immunity. J Exp Med 186:1315-1322, 1997
    • (1997) J Exp Med , vol.186 , pp. 1315-1322
    • Blachere, N.E.1    Li, Z.2    Chandawarkar, R.Y.3
  • 116
    • 0015619335 scopus 로고
    • Identification of a novel cell type in peripheral lymphoid organs of mice: I. Morphology, quantitation, tissue distribution
    • Steinman RM, Cohn ZA: Identification of a novel cell type in peripheral lymphoid organs of mice: I. Morphology, quantitation, tissue distribution. J Exp Med 137:1142-1162, 1973
    • (1973) J Exp Med , vol.137 , pp. 1142-1162
    • Steinman, R.M.1    Cohn, Z.A.2
  • 117
    • 0026481133 scopus 로고
    • Generation of large numbers of dendritic cells from mouse bone marrow cultures supple-mented with granulocyte/macrophage colony-stimulating factor
    • Inaba K, Inaba M, Romani N, et al: Generation of large numbers of dendritic cells from mouse bone marrow cultures supple-mented with granulocyte/macrophage colony-stimulating factor. J Exp Med 176:1693-1702, 1992
    • (1992) J Exp Med , vol.176 , pp. 1693-1702
    • Inaba, K.1    Inaba, M.2    Romani, N.3
  • 118
    • 0026446156 scopus 로고
    • GM-CSF and TNF-alpha cooperate in the generation of dendritic Langerhans cells
    • Caux C, Dezutter-Dambuyant C, Schmitt D, et al: GM-CSF and TNF-alpha cooperate in the generation of dendritic Langerhans cells. Nature 360:258-261, 1992
    • (1992) Nature , vol.360 , pp. 258-261
    • Caux, C.1    Dezutter-Dambuyant, C.2    Schmitt, D.3
  • 119
    • 0028289244 scopus 로고
    • Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/ macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha
    • Sallusto F, Lanzavecchia A: Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/ macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J Exp Med 179:1109-1118, 1994
    • (1994) J Exp Med , vol.179 , pp. 1109-1118
    • Sallusto, F.1    Lanzavecchia, A.2
  • 120
    • 0028285230 scopus 로고
    • Proliferating dendritic cell progenitors in human blood
    • Romani N, Gruner S, Brang D, et al: Proliferating dendritic cell progenitors in human blood. J Exp Med 180:83-93, 1994
    • (1994) J Exp Med , vol.180 , pp. 83-93
    • Romani, N.1    Gruner, S.2    Brang, D.3
  • 121
    • 0029610608 scopus 로고
    • Massive ex vivo generation of functional dendritic cells from mobilized CD34+ blood progenitors for anticancer therapy
    • Siena S, Di Nicola M, Bregni M, et al: Massive ex vivo generation of functional dendritic cells from mobilized CD34+ blood progenitors for anticancer therapy. Exp Hematol 23:1463-1471, 1995
    • (1995) Exp Hematol , vol.23 , pp. 1463-1471
    • Siena, S.1    Di Nicola, M.2    Bregni, M.3
  • 122
    • 0025735629 scopus 로고
    • The dendritic cell system and its role in immunogenicity
    • Steinman RM: The dendritic cell system and its role in immunogenicity. Annu Rev Immunol 9:271-296, 1991
    • (1991) Annu Rev Immunol , vol.9 , pp. 271-296
    • Steinman, R.M.1
  • 123
    • 0345020478 scopus 로고    scopus 로고
    • A dendritic-cell-derived C-C chemokine that preferentially attracts naive T cells
    • Adema GJ, Hartgers F, Verstraten R, et al: A dendritic-cell-derived C-C chemokine that preferentially attracts naive T cells. Nature 387:713-717, 1997
    • (1997) Nature , vol.387 , pp. 713-717
    • Adema, G.J.1    Hartgers, F.2    Verstraten, R.3
  • 124
    • 0030058647 scopus 로고    scopus 로고
    • Therapy of murine tumors with tumor peptide-pulsed dendritic cells: Dependence on T cells, B7 costimulation, and T helper cell 1 -associated cytokines
    • Zitvogel L, Mayordomo JI, Tjandrawan T, et al: Therapy of murine tumors with tumor peptide-pulsed dendritic cells: Dependence on T cells, B7 costimulation, and T helper cell 1 -associated cytokines [see comments]. J Exp Med 183:87-97, 1996
    • (1996) J Exp Med , vol.183 , pp. 87-97
    • Zitvogel, L.1    Mayordomo, J.I.2    Tjandrawan, T.3
  • 125
    • 0028793675 scopus 로고
    • Bone marrow-derived dendritic cells pulsed with synthetic tumour peptides elicit protective and therapeutic antitumour immunity
    • Mayordomo JI, Zorina T, Storkus WJ, et al: Bone marrow-derived dendritic cells pulsed with synthetic tumour peptides elicit protective and therapeutic antitumour immunity. Nat Med 1:1297-1302, 1995
    • (1995) Nat Med , vol.1 , pp. 1297-1302
    • Mayordomo, J.I.1    Zorina, T.2    Storkus, W.J.3
  • 126
    • 0030028770 scopus 로고    scopus 로고
    • Murine dendritic cells loaded in vitro with soluble protein prime cytotoxic T lymphocytes against tumor antigen in vivo
    • Paglia P, Chiodoni C, Rodolfo M, et al: Murine dendritic cells loaded in vitro with soluble protein prime cytotoxic T lymphocytes against tumor antigen in vivo. J Exp Med 183:317-322, 1996
    • (1996) J Exp Med , vol.183 , pp. 317-322
    • Paglia, P.1    Chiodoni, C.2    Rodolfo, M.3
  • 127
    • 0030904482 scopus 로고    scopus 로고
    • Induction of antitumor activity immunization with fusion of dendritic and carcinoma cells
    • Gong J, Chen D, Kashiwaba M, et al: Induction of antitumor activity immunization with fusion of dendritic and carcinoma cells. Nat Med 3:558-561, 1997
    • (1997) Nat Med , vol.3 , pp. 558-561
    • Gong, J.1    Chen, D.2    Kashiwaba, M.3
  • 128
    • 0029839058 scopus 로고    scopus 로고
    • Dendritic cells pulsed with RNA are potent antigen-presenting cells in vitro and in vivo
    • Boczkowski D, Nair SK, Snyder D, et al: Dendritic cells pulsed with RNA are potent antigen-presenting cells in vitro and in vivo. J Exp Med 184:465-472, 1996
    • (1996) J Exp Med , vol.184 , pp. 465-472
    • Boczkowski, D.1    Nair, S.K.2    Snyder, D.3
  • 129
    • 0030781054 scopus 로고    scopus 로고
    • Dendritic cells retrovirally transduced with a model tumor antigen gene are therapeutically effective against established pulmonary metastases
    • Specht JM, Wang G, Do MT, et al: Dendritic cells retrovirally transduced with a model tumor antigen gene are therapeutically effective against established pulmonary metastases. J Exp Med 186:1213-1221, 1997
    • (1997) J Exp Med , vol.186 , pp. 1213-1221
    • Specht, J.M.1    Wang, G.2    Do, M.T.3
  • 130
    • 0030856119 scopus 로고    scopus 로고
    • Dendritic cells genetically modified with an adenovirus vector encoding the cDNa for a model tumor antigen induce protective and therapeutic antitumor immunity
    • Song W, Kong H, Carpenter H, et al: Dendritic cells genetically modified with an adenovirus vector encoding the cDNA for a model tumor antigen induce protective and therapeutic antitumor immunity. J Exp Med 186:1247-1256, 1997
    • (1997) J Exp Med , vol.186 , pp. 1247-1256
    • Song, W.1    Kong, H.2    Carpenter, H.3
  • 131
    • 0031941423 scopus 로고    scopus 로고
    • Vaccination of melanoma patients with peptide- Or tumor lysate-pulsed dendritic cells
    • Nestle FO, Alijagic S, Gilliet M, etal: Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells. Nat Med 4:328-332, 1998
    • (1998) Nat Med , vol.4 , pp. 328-332
    • Nestle, F.O.1    Alijagic, S.2    Gilliet, M.3
  • 132
    • 0030026776 scopus 로고    scopus 로고
    • Vaccination of patients with B-cell lymphoma using autologous antigen-pulsed dendritic cells
    • Hsu FJ, Benike C, Fagnoni F, et al: Vaccination of patients with B-cell lymphoma using autologous antigen-pulsed dendritic cells. Nat Med 2:52-58, 1996
    • (1996) Nat Med , vol.2 , pp. 52-58
    • Hsu, F.J.1    Benike, C.2    Fagnoni, F.3
  • 133
    • 0027015406 scopus 로고
    • A pilot study of immunization with HLA-A2 matched allogeneic melanoma cells that secrete interleukin-2 in patients with metastatic melanoma
    • Gansbacher B, Houghton A, Livingston P, et al: A pilot study of immunization with HLA-A2 matched allogeneic melanoma cells that secrete interleukin-2 in patients with metastatic melanoma. Hum Gene Ther 3:677-690, 1992
    • (1992) Hum Gene Ther , vol.3 , pp. 677-690
    • Gansbacher, B.1    Houghton, A.2    Livingston, P.3
  • 134
    • 0027032428 scopus 로고
    • A pilot study of immunization with interleukin-2 secreting allogeneic HLA-A2 matched renal cell carcinoma cells in patients with advanced renal cell carcinoma
    • Gansbacher B, Motzer R, Houghton A, et al: A pilot study of immunization with interleukin-2 secreting allogeneic HLA-A2 matched renal cell carcinoma cells in patients with advanced renal cell carcinoma. Hum Gene Ther 3:691-703, 1992
    • (1992) Hum Gene Ther , vol.3 , pp. 691-703
    • Gansbacher, B.1    Motzer, R.2    Houghton, A.3
  • 135
    • 0027304075 scopus 로고
    • Immunization with interleukin-2 transfected melanoma cells: A phase l-II study in patients with metastatic melanoma
    • Osanto S, Brouwenstyn N, Vaessen N, et al: Immunization with interleukin-2 transfected melanoma cells: A phase l-II study in patients with metastatic melanoma. Hum Gene Ther 4:323-330, 1993
    • (1993) Hum Gene Ther , vol.4 , pp. 323-330
    • Osanto, S.1    Brouwenstyn, N.2    Vaessen, N.3
  • 136
    • 0027517321 scopus 로고
    • A direct gene transfer with DNA-liposome complexes in melanoma: Expression, biologic activity, and lack of toxicity in humans
    • Nabel GJ, Nabel EG, Yang ZY, et al: A direct gene transfer with DNA-liposome complexes in melanoma: Expression, biologic activity, and lack of toxicity in humans. Proc Natl Acad Sci U S A 90:11307-11311, 1993
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 11307-11311
    • Nabel, G.J.1    Nabel, E.G.2    Yang, Z.Y.3
  • 137
    • 0028170348 scopus 로고
    • Gene therapy of cancer: A pilot study of IL-4-gene-modified fibroblasts admixed with autologous tumor to elicit an immune response
    • Lotze MT, Rubin JT, Carty S, et al: Gene therapy of cancer: A pilot study of IL-4-gene-modified fibroblasts admixed with autologous tumor to elicit an immune response. Hum Gene Ther 5:41 -55, 1994
    • (1994) Hum Gene Ther , vol.5 , pp. 41-55
    • Lotze, M.T.1    Rubin, J.T.2    Carty, S.3
  • 138
    • 0028101006 scopus 로고
    • Active immunization of metastatic melanoma patients with interleukin-4 transduced, allogeneic melanoma cells
    • Cascinelli N, Foa R, Parmiani G, et al: Active immunization of metastatic melanoma patients with interleukin-4 transduced, allogeneic melanoma cells. Hum Gene Ther 5:1059-1064, 1994
    • (1994) Hum Gene Ther , vol.5 , pp. 1059-1064
    • Cascinelli, N.1    Foa, R.2    Parmiani, G.3
  • 139
    • 0029101309 scopus 로고
    • Injection of colon carcinoma patients with autologous irradiated tumor cells and fibro-blasts genetically modified to secrete interleukin-2 (IL-2): A phase I study
    • Sobol RE, Royston I, Fakhrai H, et al: Injection of colon carcinoma patients with autologous irradiated tumor cells and fibro-blasts genetically modified to secrete interleukin-2 (IL-2): A phase I study. Hum Gene Ther 6:195-204, 1995
    • (1995) Hum Gene Ther , vol.6 , pp. 195-204
    • Sobol, R.E.1    Royston, I.2    Fakhrai, H.3
  • 140
    • 0029156407 scopus 로고
    • Phase I study of transfected cancer cells expressing the interleukin-2 gene product in limited stage small cell lung cancer
    • Cassileth PA, Podack E, Sridhar K, et al: Phase I study of transfected cancer cells expressing the interleukin-2 gene product in limited stage small cell lung cancer. Hum Gene Ther 6:369-383, 1995
    • (1995) Hum Gene Ther , vol.6 , pp. 369-383
    • Cassileth, P.A.1    Podack, E.2    Sridhar, K.3
  • 141
    • 0028982471 scopus 로고
    • Gene therapy of human melanoma: Immunization of patients with autologous tumor cells admixed with allogeneic melanoma cells secreting interleukin 6 and soluble interleukin 6 receptor
    • Mackiewicz A, Gomy A, Laciak M, et al: Gene therapy of human melanoma: Immunization of patients with autologous tumor cells admixed with allogeneic melanoma cells secreting interleukin 6 and soluble interleukin 6 receptor. Hum Gene Ther 6:805-811, 1995
    • (1995) Hum Gene Ther , vol.6 , pp. 805-811
    • Mackiewicz, A.1    Gomy, A.2    Laciak, M.3
  • 142
    • 0028905079 scopus 로고
    • Interleukin-2 gene therapy in a patient with glioblastoma
    • Sobol RE, Fakhrai H, Shawler D, et al: Interleukin-2 gene therapy in a patient with glioblastoma. Gene Ther 2:164-167, 1995
    • (1995) Gene Ther , vol.2 , pp. 164-167
    • Sobol, R.E.1    Fakhrai, H.2    Shawler, D.3
  • 143
    • 0027984920 scopus 로고
    • A phase I trial of human gamma interferon transduced autologous tumor cells in patients with disseminated malignant melanoma
    • Seigler HF, Darrow TL, Abdel-Wahab Z, et al: A phase I trial of human gamma interferon transduced autologous tumor cells in patients with disseminated malignant melanoma. Hum Gene Ther 5:761-777, 1994
    • (1994) Hum Gene Ther , vol.5 , pp. 761-777
    • Seigler, H.F.1    Darrow, T.L.2    Abdel-Wahab, Z.3
  • 144
    • 0029872770 scopus 로고    scopus 로고
    • Phase I study to the immunotherapy of metastatic malignant melanoma by a cancer vaccine consisting of autologous cancer cells transfected with the human IL-2 gene
    • Stingl G, Brocker EB, Mertelsmann R, et al: Phase I study to the immunotherapy of metastatic malignant melanoma by a cancer vaccine consisting of autologous cancer cells transfected with the human IL-2 gene. Hum Gene Ther 7:551-563, 1996
    • (1996) Hum Gene Ther , vol.7 , pp. 551-563
    • Stingl, G.1    Brocker, E.B.2    Mertelsmann, R.3
  • 145
    • 8544266091 scopus 로고    scopus 로고
    • Active immunization of metastatic melanoma patients with interleukin-2 transduced allogeneic melanoma cells: Evaluation of efficacy and tolerability
    • Belli F, Arienti F, Sule-Suso J, et al: Active immunization of metastatic melanoma patients with interleukin-2 transduced allogeneic melanoma cells: Evaluation of efficacy and tolerability. Cancer Immunol Immunother 44:197-203, 1997
    • (1997) Cancer Immunol Immunother , vol.44 , pp. 197-203
    • Belli, F.1    Arienti, F.2    Sule-Suso, J.3
  • 146
    • 16944364126 scopus 로고    scopus 로고
    • A phase I study of vaccination with autologous, irradiated melanoma cells engineered to secrete human granulocyte-macrophage colony stimulating factor
    • Dranoff G, Soiffer R, Lynch T, et al: A phase I study of vaccination with autologous, irradiated melanoma cells engineered to secrete human granulocyte-macrophage colony stimulating factor. Hum Gene Ther 8:111-123, 1997
    • (1997) Hum Gene Ther , vol.8 , pp. 111-123
    • Dranoff, G.1    Soiffer, R.2    Lynch, T.3
  • 147
    • 0012201556 scopus 로고    scopus 로고
    • A case report: Immune responses and clinical course of the first human use of granulocyte macrophage-colony-stimulating-factor-transduced autologous melanoma cells for immunotherapy
    • Ellem KA, O'Rourke MG, Johnson GR, et al: A case report: Immune responses and clinical course of the first human use of granulocyte macrophage-colony-stimulating-factor-transduced autologous melanoma cells for immunotherapy. Cancer Immunol Immunother 44:10-20, 1997
    • (1997) Cancer Immunol Immunother , vol.44 , pp. 10-20
    • Ellem, K.A.1    O'Rourke, M.G.2    Johnson, G.R.3
  • 148
    • 0031032759 scopus 로고    scopus 로고
    • Phase I study of direct gene transfer of an allogeneic histocompatibility antigen, HLA-B7, in patients with metastatic melanoma
    • Stopeck AT, Hersh EM, Akporiaye ET, et al: Phase I study of direct gene transfer of an allogeneic histocompatibility antigen, HLA-B7, in patients with metastatic melanoma. J CHn Oncol 15:341-346, 1997
    • (1997) J CHn Oncol , vol.15 , pp. 341-346
    • Stopeck, A.T.1    Hersh, E.M.2    Akporiaye, E.T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.