메뉴 건너뛰기




Volumn 7, Issue 4, 1996, Pages 551-563

Phase I study to the immunotherapy of metastatic malignant melanoma by a cancer vaccine consisting of autologous cancer cells transfected with the human IL-2 gene
[No Author Info available]

Author keywords

[No Author keywords available]

Indexed keywords

CANCER VACCINE; CYTOKINE; INTERLEUKIN 2; VACCINE;

EID: 0029872770     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.1996.7.4-551     Document Type: Article
Times cited : (49)

References (60)
  • 4
    • 0027165558 scopus 로고
    • The tyrosinase gene codes for an antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas
    • Brichard, V., Van Pel, A., Wölfel, T., Wölfel, C., De Plaen, E., Lethé, B., Coulie P, and Boon, T. (1993). The tyrosinase gene codes for an antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas. J. Exp. Med. 178, 489-495.
    • (1993) J. Exp. Med. , vol.178 , pp. 489-495
    • Brichard, V.1    Van Pel, A.2    Wölfel, T.3    Wölfel, C.4    De Plaen, E.5    Lethé, B.6    Coulie, P.7    Boon, T.8
  • 6
    • 0027439005 scopus 로고
    • Costimulation of T cells for tumor immunity
    • Chen, L., Linsley, P.S., and Hellström, K.E. (1993). Costimulation of T cells for tumor immunity. Immunol. Today 14, 483-486.
    • (1993) Immunol. Today , vol.14 , pp. 483-486
    • Chen, L.1    Linsley, P.S.2    Hellström, K.E.3
  • 9
    • 0023893547 scopus 로고
    • Autologous lymph node cell derived tumor-specific cytotoxic T cells for use in adoptive immunotherapy of human melanoma
    • Darrow, T.L., Slingluff, C.L., and Seigler, H.F. (1988). Autologous lymph node cell derived tumor-specific cytotoxic T cells for use in adoptive immunotherapy of human melanoma. Cancer 62, 84-91.
    • (1988) Cancer , vol.62 , pp. 84-91
    • Darrow, T.L.1    Slingluff, C.L.2    Seigler, H.F.3
  • 10
    • 0025102464 scopus 로고
    • Antigens recognized on a melanoma line by autologous cytotoxic T lymphocytes are also expressed on freshly collected tumor cells
    • Degiovanni, G., Hainaut, P., Lahaye, T., Weynants, P., and Boon, T. (1990). Antigens recognized on a melanoma line by autologous cytotoxic T lymphocytes are also expressed on freshly collected tumor cells. Eur. J. Immunol. 20, 1865-68.
    • (1990) Eur. J. Immunol. , vol.20 , pp. 1865-1868
    • Degiovanni, G.1    Hainaut, P.2    Lahaye, T.3    Weynants, P.4    Boon, T.5
  • 11
    • 0027538181 scopus 로고
    • Vaccination with irradiated tumor cells engineered to secret murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity
    • Dranoff, G., Jaffee, E., Lazenby, A., Golumbek, P., Levitsky, H.L., Brose, K., Jackson, V., Hamada, H., Pardoll, D.M., and Mulligan, R.C. (1993). Vaccination with irradiated tumor cells engineered to secret murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity. Proc Natl. Acad. Sci. USA 90, 3539-3543.
    • (1993) Proc Natl. Acad. Sci. USA , vol.90 , pp. 3539-3543
    • Dranoff, G.1    Jaffee, E.2    Lazenby, A.3    Golumbek, P.4    Levitsky, H.L.5    Brose, K.6    Jackson, V.7    Hamada, H.8    Pardoll, D.M.9    Mulligan, R.C.10
  • 12
    • 0019188259 scopus 로고
    • Melanoma. An ultrastructural study of the host inflammatory and vascular responses
    • Dvorak, A.M., Mihm, M.C., Osage, J.E., and Dvorak, H.F. (1980). Melanoma. An ultrastructural study of the host inflammatory and vascular responses. J. Invest. Dermatol. 75, 388-393.
    • (1980) J. Invest. Dermatol. , vol.75 , pp. 388-393
    • Dvorak, A.M.1    Mihm, M.C.2    Osage, J.E.3    Dvorak, H.F.4
  • 13
    • 0023943438 scopus 로고
    • Induction in a murine tumor of immunogenic tumor variants by transfection with a foreign gene
    • Fearon, E.R., Itaya, T., Hunt, B., Vogelstein, B., and Frost, P. (1988). Induction in a murine tumor of immunogenic tumor variants by transfection with a foreign gene. Cancer Res. 48, 2975-2980.
    • (1988) Cancer Res. , vol.48 , pp. 2975-2980
    • Fearon, E.R.1    Itaya, T.2    Hunt, B.3    Vogelstein, B.4    Frost, P.5
  • 15
    • 0027531749 scopus 로고
    • Analysis of T cell receptor variability in tumor-infiltrating lymphocytes from a human regressive melanoma
    • Ferradini, L., Mackensen, A., Genevée, C., Bosq, J., Duvilland, P., Avril, M.F., and Hercend, T. (1993). Analysis of T cell receptor variability in tumor-infiltrating lymphocytes from a human regressive melanoma. J Clin. Invest. 91, 1183-1190.
    • (1993) J Clin. Invest. , vol.91 , pp. 1183-1190
    • Ferradini, L.1    Mackensen, A.2    Genevée, C.3    Bosq, J.4    Duvilland, P.5    Avril, M.F.6    Hercend, T.7
  • 16
    • 0021345863 scopus 로고
    • The augmentation of tumor-specific immunity by virus help: I. Demonstration of vaccinia virus-reactive helper T cell activity involved in enhanced induction of cytotoxic T lymphocyte and antibody responses
    • Fujiwara, H., Shimizu, Y., Takai, Y., Wakamiya, N., Ueda, S., Karo, S., and Hamaoka, T. (1984). The augmentation of tumor-specific immunity by virus help: I. Demonstration of vaccinia virus-reactive helper T cell activity involved in enhanced induction of cytotoxic T lymphocyte and antibody responses. Eur. J. Immunol. 14, 171-175.
    • (1984) Eur. J. Immunol. , vol.14 , pp. 171-175
    • Fujiwara, H.1    Shimizu, Y.2    Takai, Y.3    Wakamiya, N.4    Ueda, S.5    Karo, S.6    Hamaoka, T.7
  • 17
    • 0025000864 scopus 로고
    • Interleukin 2 gene transfer into tumor cells abrogates tumorigenicity and induces protective immunity
    • Gansbacher, B., Zier, K., Daniels, B., Cronin, K., Bannerji, R., and Gilboa, E. (1990a). Interleukin 2 gene transfer into tumor cells abrogates tumorigenicity and induces protective immunity. J. Exp. Med. 172, 1217-1224.
    • (1990) J. Exp. Med. , vol.172 , pp. 1217-1224
    • Gansbacher, B.1    Zier, K.2    Daniels, B.3    Cronin, K.4    Bannerji, R.5    Gilboa, E.6
  • 18
    • 0025604195 scopus 로고
    • Retroviral vector-mediated γ-interferon gene transfer into tumor cells generates potent and long lasting antitumor immunity
    • Gansbacher, B., Bannerji, R., Daniels, B., Zier, K., and Gilboa, E. (1990b). Retroviral vector-mediated γ-interferon gene transfer into tumor cells generates potent and long lasting antitumor immunity. Cancer Res. 50, 7820-7825.
    • (1990) Cancer Res. , vol.50 , pp. 7820-7825
    • Gansbacher, B.1    Bannerji, R.2    Daniels, B.3    Zier, K.4    Gilboa, E.5
  • 20
    • 0002950402 scopus 로고
    • The worldwide incidence of malignant melanoma
    • C.M. Balch, A.N. Houghton, G.W. Milton, A.J. Sober, and S.J. Soong, eds. (Philadelphia: J.B. Lippincott Company)
    • Grin-Jorgensen, C.M., Rigel, D.S., and Friedman, R.J. (1992). The worldwide incidence of malignant melanoma. In Cutaneous melanoma. C.M. Balch, A.N. Houghton, G.W. Milton, A.J. Sober, and S.J. Soong, eds. (Philadelphia: J.B. Lippincott Company), pp. 27-39.
    • (1992) Cutaneous Melanoma , pp. 27-39
    • Grin-Jorgensen, C.M.1    Rigel, D.S.2    Friedman, R.J.3
  • 21
    • 0027787055 scopus 로고
    • Adenoviral interleukin-2 gene transfer into P815 tumor cells abrogates tumorigenicity and induces antitumoral immunity in mice
    • Haddada, H., Ragot, T., Cordier, L., Duffour, M.T., and Perricaudet, M. (1993). Adenoviral interleukin-2 gene transfer into P815 tumor cells abrogates tumorigenicity and induces antitumoral immunity in mice. Hum. Gene Ther. 4, 703-711.
    • (1993) Hum. Gene Ther. , vol.4 , pp. 703-711
    • Haddada, H.1    Ragot, T.2    Cordier, L.3    Duffour, M.T.4    Perricaudet, M.5
  • 22
    • 0023552308 scopus 로고
    • Evidence that treatment with vaccinia melanoma cell lysates (VMCL) may improve survival of patients with stage II melanoma
    • Hersey, P., Edwards, A., Coates, A., Shaw, H., McCarthy, W.H., and Milton, G.W. (1987). Evidence that treatment with vaccinia melanoma cell lysates (VMCL) may improve survival of patients with stage II melanoma. Cancer Immunol. Immunother. 25, 257-265.
    • (1987) Cancer Immunol. Immunother. , vol.25 , pp. 257-265
    • Hersey, P.1    Edwards, A.2    Coates, A.3    Shaw, H.4    McCarthy, W.H.5    Milton, G.W.6
  • 24
    • 0000747851 scopus 로고
    • Treatment of advanced melanoma
    • C.M. Balch, A.N. Houghton, G.W. Milton, A.J. Sober, and S.J. Soong, eds. (Philadelphia: J.B. Lippincott Company)
    • Houghton, A.N. and Balch, C.M. (1992). Treatment of advanced melanoma. In Cutaneous melanoma. C.M. Balch, A.N. Houghton, G.W. Milton, A.J. Sober, and S.J. Soong, eds. (Philadelphia: J.B. Lippincott Company), pp. 468-497.
    • (1992) Cutaneous Melanoma , pp. 468-497
    • Houghton, A.N.1    Balch, C.M.2
  • 25
    • 0023754537 scopus 로고
    • Autologous tumor-specific cytotoxic T lymphocyts in the infiltrate of human metastatic melanomas. Activation by interleukin 2 and autologous tumor cells, and involvement of the T cell receptor
    • Itoh, K., Platsoucas, C.D., and Balch, C.M. (1988). Autologous tumor-specific cytotoxic T lymphocyts in the infiltrate of human metastatic melanomas. Activation by interleukin 2 and autologous tumor cells, and involvement of the T cell receptor. J. Exp. Med. 168, 1419-1441.
    • (1988) J. Exp. Med. , vol.168 , pp. 1419-1441
    • Itoh, K.1    Platsoucas, C.D.2    Balch, C.M.3
  • 27
    • 0025608955 scopus 로고
    • Post-operative active specific immunization in curatively resected colorectal cancer patients with a virus-modified autologous tumor cell vaccine
    • Lehner, B., Schlag, P., Liebrich, W., and Schirrmacher, V. (1990). Post-operative active specific immunization in curatively resected colorectal cancer patients with a virus-modified autologous tumor cell vaccine. Cancer Immunol. Immunother. 32, 173-178.
    • (1990) Cancer Immunol. Immunother. , vol.32 , pp. 173-178
    • Lehner, B.1    Schlag, P.2    Liebrich, W.3    Schirrmacher, V.4
  • 28
    • 0026033391 scopus 로고
    • Interleukin 2-dependent activation of tumor-specific cytotoxic T lymphocytes in vivo
    • Ley, V., Langlade-Demoyen, P., Kourilsky, P., and Larsson-Sciard, E.L. (1991). Interleukin 2-dependent activation of tumor-specific cytotoxic T lymphocytes in vivo. Eur. J. Immunol. 21, 851-854.
    • (1991) Eur. J. Immunol. , vol.21 , pp. 851-854
    • Ley, V.1    Langlade-Demoyen, P.2    Kourilsky, P.3    Larsson-Sciard, E.L.4
  • 29
    • 0025763446 scopus 로고
    • In vitro and clinical characterization of a Newcastle disease virus-modified autologous tumor cell vaccine for treatment of colorectal patients
    • Liebrich, W., Schlag, P., Manasterski, M., Lehner, B., Stöhr, M., Möller, P., and Schirrmacher, V. (1991). In vitro and clinical characterization of a Newcastle disease virus-modified autologous tumor cell vaccine for treatment of colorectal patients. Eur. J. Cancer 27, 703-710.
    • (1991) Eur. J. Cancer , vol.27 , pp. 703-710
    • Liebrich, W.1    Schlag, P.2    Manasterski, M.3    Lehner, B.4    Stöhr, M.5    Möller, P.6    Schirrmacher, V.7
  • 30
    • 0014106471 scopus 로고
    • Viral oncolysis: Increased immunogenicity of host cell antigen associated with influenza virus
    • Lindenmann, J. and Klein, P.A. (1967). Viral oncolysis: Increased immunogenicity of host cell antigen associated with influenza virus. J. Exp. Med. 126, 93-108.
    • (1967) J. Exp. Med. , vol.126 , pp. 93-108
    • Lindenmann, J.1    Klein, P.A.2
  • 31
    • 0010436707 scopus 로고
    • Ultraviolet radiation and other putative causes of melanoma
    • C.M. Balch, A.N. Houghton, G.W. Milton, A.J. Sober, and S.J. Soong, eds. (Philadelphia: J.B. Lippincott Company)
    • Longstreth, J.D., Lea, C.S., and Kripke, M.L. (1992). Ultraviolet radiation and other putative causes of melanoma. In Cutaneous melanoma. C.M. Balch, A.N. Houghton, G.W. Milton, A.J. Sober, and S.J. Soong, eds. (Philadelphia: J.B. Lippincott Company), pp. 46-58.
    • (1992) Cutaneous Melanoma , pp. 46-58
    • Longstreth, J.D.1    Lea, C.S.2    Kripke, M.L.3
  • 32
    • 0029076718 scopus 로고
    • Priming of tumor-specific T cells in the draining lymph nodes after immunization with IL-2-secreting tumor cells: Three consecutive stages may be required for successful tumor vaccination
    • Maass, G., Schmidt, W., Berger, M., Schilcher, F., Koszik, F., Schneeberger, A., Stingl, G., Birnstiel, M.L., and Schweighoffer, T. (1995). Priming of tumor-specific T cells in the draining lymph nodes after immunization with IL-2-secreting tumor cells: three consecutive stages may be required for successful tumor vaccination. Proc. Natl. Acad. Sci. USA 92, 5540-5544.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 5540-5544
    • Maass, G.1    Schmidt, W.2    Berger, M.3    Schilcher, F.4    Koszik, F.5    Schneeberger, A.6    Stingl, G.7    Birnstiel, M.L.8    Schweighoffer, T.9
  • 35
    • 0025044674 scopus 로고
    • Predominant expression of T cell receptor Vα7 in tumor-infiltrating lymphocytes of uveal melanoma
    • Nitta, T., Oksenberg, J.R., Rao, N.A., and Steinman, L. (1990). Predominant expression of T cell receptor Vα7 in tumor-infiltrating lymphocytes of uveal melanoma. Science 249, 672.
    • (1990) Science , vol.249 , pp. 672
    • Nitta, T.1    Oksenberg, J.R.2    Rao, N.A.3    Steinman, L.4
  • 37
    • 0025978347 scopus 로고
    • Weekly 24-hour continuous infusion interleukin-2 for metastatic and renal cell carcinoma: A phase I study
    • Perez, E.A., Scudder, S.A., Meyers, F.A., Tanaka, M.S., Paradise, C., and Gandara, D.R. (1991). Weekly 24-hour continuous infusion interleukin-2 for metastatic and renal cell carcinoma: A phase I study. J. Immunother. 10,57-62.
    • (1991) J. Immunother. , vol.10 , pp. 57-62
    • Perez, E.A.1    Scudder, S.A.2    Meyers, F.A.3    Tanaka, M.S.4    Paradise, C.5    Gandara, D.R.6
  • 38
    • 0027511213 scopus 로고
    • Phagocytic processing of bacterial antigens for class I MHC presentation to T cells
    • Pfeifer, J.D., Wick, M.J., Roberts, R.L., Findlay, K., Normark, S.J., and Harding, C.V. (1993). Phagocytic processing of bacterial antigens for class I MHC presentation to T cells. Nature 361, 359-362.
    • (1993) Nature , vol.361 , pp. 359-362
    • Pfeifer, J.D.1    Wick, M.J.2    Roberts, R.L.3    Findlay, K.4    Normark, S.J.5    Harding, C.V.6
  • 39
    • 0026772066 scopus 로고
    • Interleukin 6 gene transfection into Lewis lung carcinoma tumor cells suppresses the malignant phenotype and confers immunotherapeutic competence against parental metastatic cells
    • Porgador, A., Tzehoval E, Katz, A., Vadai, E., Revel, M., Feldman, M., and Eisenbach, L. (1992). Interleukin 6 gene transfection into Lewis lung carcinoma tumor cells suppresses the malignant phenotype and confers immunotherapeutic competence against parental metastatic cells. Cancer Res. 52, 3679-3686.
    • (1992) Cancer Res. , vol.52 , pp. 3679-3686
    • Porgador, A.1    Tzehoval, E.2    Katz, A.3    Vadai, E.4    Revel, M.5    Feldman, M.6    Eisenbach, L.7
  • 40
    • 0023097234 scopus 로고
    • Immunohistological analysis of the lymphoid infiltrate in cutaneous malignant melanomas
    • Ralfkiaer, E., Hou-Jensen, K., Gatter, K.C., Drzewiecki, D.T., and Mason, D.Y. (1987). Immunohistological analysis of the lymphoid infiltrate in cutaneous malignant melanomas. Virchows Arch. 410, 355-361.
    • (1987) Virchows Arch. , vol.410 , pp. 355-361
    • Ralfkiaer, E.1    Hou-Jensen, K.2    Gatter, K.C.3    Drzewiecki, D.T.4    Mason, D.Y.5
  • 41
    • 0023620585 scopus 로고
    • Prognosis for recurrent stage I malignant melanoma
    • Reintgen, S., Vollmer, R., Tso, C.Y., and Seigler, H.F. (1987). Prognosis for recurrent stage I malignant melanoma. Arch. Surg. 122, 1338-1342.
    • (1987) Arch. Surg. , vol.122 , pp. 1338-1342
    • Reintgen, S.1    Vollmer, R.2    Tso, C.Y.3    Seigler, H.F.4
  • 42
    • 0025030522 scopus 로고
    • Presentation of exogenous antigen with class I major histocompatibility complex molecules
    • Rock, K.L., Gamble S., and Rothstein, L. (1990). Presentation of exogenous antigen with class I major histocompatibility complex molecules. Science 249, 918-921.
    • (1990) Science , vol.249 , pp. 918-921
    • Rock, K.L.1    Gamble, S.2    Rothstein, L.3
  • 46
    • 0022534622 scopus 로고
    • Extravasation of intervascular fluid mediated by the systemic administration of recombinant Interleukin-2
    • Rosenstein, M., Ettinghausen, S.E., and Rosenberg, S.A. (1986). Extravasation of intervascular fluid mediated by the systemic administration of recombinant Interleukin-2. J. Immunol. 137, 1735-1742.
    • (1986) J. Immunol. , vol.137 , pp. 1735-1742
    • Rosenstein, M.1    Ettinghausen, S.E.2    Rosenberg, S.A.3
  • 48
    • 0027199885 scopus 로고
    • T cell receptor (TCR) structure of autologous melanoma-reactive cytotoxic T lymphocyte (CTL) clones: Tumor-infiltrating lymphocytes overexpress in vivo the TCR β chain sequence used by an HLA-A2-restricted and melanocyte-lineage-specific CTL clone
    • Sensi, M., Salvi, S., Castelli, C., Maccalli, C., Mazzocchi, A., Mortarini, R., Nicolini, G., Herlyn, M., Parmiani, G., and Anichini, A. (1993). T cell receptor (TCR) structure of autologous melanoma-reactive cytotoxic T lymphocyte (CTL) clones: tumor-infiltrating lymphocytes overexpress in vivo the TCR β chain sequence used by an HLA-A2-restricted and melanocyte-lineage-specific CTL clone. J. Exp. Med. 178, 1231-1246.
    • (1993) J. Exp. Med. , vol.178 , pp. 1231-1246
    • Sensi, M.1    Salvi, S.2    Castelli, C.3    Maccalli, C.4    Mazzocchi, A.5    Mortarini, R.6    Nicolini, G.7    Herlyn, M.8    Parmiani, G.9    Anichini, A.10
  • 49
    • 0021222897 scopus 로고
    • The augmentation of tumor-specific immunity by virus help: II. Enhanced induction of cytotoxic T lymphocyte and antibody responses to tumor antigens by vaccinia virus-reactive helper T-cells
    • Shimizu, Y., Fujiwara, H., Ueda, S., Wakamiya, N., Kato, S., and Hamaoka, T. (1984). The augmentation of tumor-specific immunity by virus help: II. Enhanced induction of cytotoxic T lymphocyte and antibody responses to tumor antigens by vaccinia virus-reactive helper T-cells. Eur. J. Immunol. 14, 839-843.
    • (1984) Eur. J. Immunol. , vol.14 , pp. 839-843
    • Shimizu, Y.1    Fujiwara, H.2    Ueda, S.3    Wakamiya, N.4    Kato, S.5    Hamaoka, T.6
  • 50
  • 52
    • 0025735629 scopus 로고
    • The dendritic cell system and its role in immunogenicity
    • Steinman, R.M. (1991). The dendritic cell system and its role in immunogenicity. Annu. Rev. Immunol. 9, 271-296.
    • (1991) Annu. Rev. Immunol. , vol.9 , pp. 271-296
    • Steinman, R.M.1
  • 53
    • 0028023477 scopus 로고
    • T-cell receptor repertoire of lymphocytes infiltrating cutaneous melanoma is predominated by V α specificities present in T-cells of normal human skin
    • Strohal, R., Paucz, L., Pehamberger, H., and Stingl, G. (1994). T-cell receptor repertoire of lymphocytes infiltrating cutaneous melanoma is predominated by V α specificities present in T-cells of normal human skin. Cancer Res. 54, 4734-4739.
    • (1994) Cancer Res. , vol.54 , pp. 4734-4739
    • Strohal, R.1    Paucz, L.2    Pehamberger, H.3    Stingl, G.4
  • 55
    • 0024390061 scopus 로고
    • Tumor-specific cytolysis by lymphocytes infiltrating human melanomas
    • Topalian, S.L., Solomon, D., and Rosenberg, S.A. (1989). Tumor-specific cytolysis by lymphocytes infiltrating human melanomas. J. Immunol. 142, 3714-3725.
    • (1989) J. Immunol. , vol.142 , pp. 3714-3725
    • Topalian, S.L.1    Solomon, D.2    Rosenberg, S.A.3
  • 57
    • 0027158507 scopus 로고
    • Usage of T-cell receptor Vβ chain genes in fresh and cultured tumor-infiltrating lymphocytes from human melanoma
    • Weidmann, E., Elder, E.M., Trucco, M., Lotze, M.T., and Whiteside, T.L. (1994). Usage of T-cell receptor Vβ chain genes in fresh and cultured tumor-infiltrating lymphocytes from human melanoma. Int. J. Cancer 54, 383-390.
    • (1994) Int. J. Cancer , vol.54 , pp. 383-390
    • Weidmann, E.1    Elder, E.M.2    Trucco, M.3    Lotze, M.T.4    Whiteside, T.L.5
  • 58
    • 0027729284 scopus 로고
    • Somatic gene therapy for cancer: The utility of transferrinfection in generating tumor vaccines
    • Zatloukal, K., Schmidt, W., Cotten, M., Wagner, E., Stingl, G., and Birnstiel, M.L. (1993). Somatic gene therapy for cancer: The utility of transferrinfection in generating tumor vaccines. Gene 135, 199-207.
    • (1993) Gene , vol.135 , pp. 199-207
    • Zatloukal, K.1    Schmidt, W.2    Cotten, M.3    Wagner, E.4    Stingl, G.5    Birnstiel, M.L.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.