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Volumn 2, Issue 6, 2004, Pages 831-843

Gemifloxacin: A new, potent fluoroquinolone for the therapy of lower respiratory tract infections

Author keywords

Acute exacerbation of chronic bronchitis; Community acquired pneumonia; Fluoroquinolone; Gemifloxacin; Respiratory tract infection; Streptococcus pneumoniae

Indexed keywords

ALUMINUM MAGNESIUM HYDROXIDE; AMOXICILLIN; AMOXICILLIN PLUS CLAVULANIC ACID; AZITHROMYCIN; CEFTRIAXONE; CEFUROXIME; CEFUROXIME AXETIL; CEPHALOSPORIN; CIPROFLOXACIN; CLARITHROMYCIN; COTRIMOXAZOLE; DIGOXIN; ERYTHROMYCIN; FERROUS SULFATE; GATIFLOXACIN; GEMIFLOXACIN; GREPAFLOXACIN; LEVOFLOXACIN; LIVER ENZYME; MACROLIDE; MOXIFLOXACIN; OFLOXACIN; PENICILLIN G; QUINOLINE DERIVED ANTIINFECTIVE AGENT; SPARFLOXACIN; SUCRALFATE; TELITHROMYCIN; TETRACYCLINE; TROVAFLOXACIN; UNINDEXED DRUG;

EID: 9944233493     PISSN: 14787210     EISSN: None     Source Type: Journal    
DOI: 10.1586/14789072.2.6.831     Document Type: Article
Times cited : (11)

References (55)
  • 1
    • 0242362709 scopus 로고    scopus 로고
    • A profile of gemifloxacin, a new respiratory fluoroquinolone
    • File TM Jr, Iannini PB. A profile of gemifloxacin, a new respiratory fluoroquinolone. Today's Therapeutic Trends 21, 415-435 (2003).
    • (2003) Today's Therapeutic Trends , vol.21 , pp. 415-435
    • File Jr., T.M.1    Iannini, P.B.2
  • 2
    • 0031894382 scopus 로고    scopus 로고
    • Community acquired pneumonia in adults: Guidelines for management The
    • Infectious Diseases Society of America
    • Bartlett JG, Breiman RF, Mandell LA, File TM Jr. Community acquired pneumonia in adults: guidelines for management. The Infectious Diseases Society of America. Clin. Infect. Dis. 26(4), 811-838 (1998).
    • (1998) Clin. Infect. Dis. , vol.26 , Issue.4 , pp. 811-838
    • Bartlett, J.G.1    Breiman, R.F.2    Mandell, L.A.3    File Jr., T.M.4
  • 3
    • 0030031642 scopus 로고    scopus 로고
    • Prognosis and outcomes of patients with community acquired pneumonia. A meta-analysis
    • Fine MJ, Smith MA, Carson CA et al. Prognosis and outcomes of patients with community acquired pneumonia. A meta-analysis J. Am. Med. Assoc. 275(2), 134-141 (1996).
    • (1996) J. Am. Med. Assoc. , vol.275 , Issue.2 , pp. 134-141
    • Fine, M.J.1    Smith, M.A.2    Carson, C.A.3
  • 4
    • 0035871188 scopus 로고    scopus 로고
    • Microbial etiology of community acquired pneumonia in the adult population of four municipalities in eastern Finland
    • Jokinen C, Heiskanen L, Jouvonen H et al. Microbial etiology of community acquired pneumonia in the adult population of four municipalities in eastern Finland. Clin. Infect. Dis. 32, 1141-1154 (2001).
    • (2001) Clin. Infect. Dis. , vol.32 , pp. 1141-1154
    • Jokinen, C.1    Heiskanen, L.2    Jouvonen, H.3
  • 5
    • 0347364864 scopus 로고    scopus 로고
    • Community acquired pneumonia
    • File TM Jr. Community acquired pneumonia. Lancet 362, 1991-2001 (2003).
    • (2003) Lancet , vol.362 , pp. 1991-2001
    • File Jr., T.M.1
  • 6
    • 4444220828 scopus 로고    scopus 로고
    • Antibacterial susceptibility among Streptococcus pneumoniae isolated from pediatric and adult patients as part of the PROTEKT US study in 2001-2002
    • Brown SD, Farrell DJ. Antibacterial susceptibility among Streptococcus pneumoniae isolated from pediatric and adult patients as part of the PROTEKT US study in 2001-2002. J. Antimicrob. Chemother. 54(Suppl. 1), I23-I29 (2004).
    • (2004) J. Antimicrob. Chemother. , vol.54 , Issue.SUPPL. 1
    • Brown, S.D.1    Farrell, D.J.2
  • 7
    • 0033761135 scopus 로고    scopus 로고
    • Antimicrobial resistance in Streptococcus pneumoniae: Implications for patients with community acquired pneumonia
    • Chenoweth CE, Saint S, Martinez F, Lynch JP 3rd, Fendrick AM. Antimicrobial resistance in Streptococcus pneumoniae: implications for patients with community acquired pneumonia. Mayo Clin. Proc. 75(11), 1161-1168 (2000).
    • (2000) Mayo Clin. Proc. , vol.75 , Issue.11 , pp. 1161-1168
    • Chenoweth, C.E.1    Saint, S.2    Martinez, F.3    Lynch III, J.P.4    Fendrick, A.M.5
  • 8
    • 0034959819 scopus 로고    scopus 로고
    • Guidelines for the management of adults with community acquired pneumonia. Diagnosis, assessment of severity, antimicrobial therapy, and prevention
    • American Thoracic Society
    • Niederman MS, Mandell LA, Anzueto A et al. American Thoracic Society. Guidelines for the management of adults with community acquired pneumonia. Diagnosis, assessment of severity, antimicrobial therapy, and prevention. Am. J. Respir. Crit. Care Med. 163(7), 1730-1754 (2001).
    • (2001) Am. J. Respir. Crit. Care Med. , vol.163 , Issue.7 , pp. 1730-1754
    • Niederman, M.S.1    Mandell, L.A.2    Anzueto, A.3
  • 9
    • 0345550450 scopus 로고    scopus 로고
    • Update of practice guidelines for the management of community acquired pneumonia in immunocompetent adults
    • Infectious Diseases Society of America
    • Mandell LA, Bartlett JG, Dowell SF, File TM Jr, Musher DM, Whitney C. Infectious Diseases Society of America. Update of practice guidelines for the management of community acquired pneumonia in immunocompetent adults. Clin. Infect. Dis. 37(11), 1405-1433 (2003).
    • (2003) Clin. Infect. Dis. , vol.37 , Issue.11 , pp. 1405-1433
    • Mandell, L.A.1    Bartlett, J.G.2    Dowell, S.F.3    File Jr., T.M.4    Musher, D.M.5    Whitney, C.6
  • 10
    • 0031466263 scopus 로고    scopus 로고
    • Guidelines for the treatment of acute exacerbations of chronic bronchitis
    • Grossman RG. Guidelines for the treatment of acute exacerbations of chronic bronchitis. Chest 112(Suppl. 6), S310-S313 (1997).
    • (1997) Chest , vol.112 , Issue.SUPPL. 6
    • Grossman, R.G.1
  • 11
    • 0036384110 scopus 로고    scopus 로고
    • Global initiative for chronic Obstructive Lung Diseases (GOLD)
    • Hurd S, Pauwels R. Global initiative for chronic Obstructive Lung Diseases (GOLD). Pulm. Pharmacol. Ther. 15(4), 353-355 (2002 ).
    • (2002) Pulm. Pharmacol. Ther. , vol.15 , Issue.4 , pp. 353-355
    • Hurd, S.1    Pauwels, R.2
  • 12
    • 0029084854 scopus 로고
    • Epidemiology and treatment of chronic bronchitis and its exacerbations
    • Ball P. Epidemiology and treatment of chronic bronchitis and its exacerbations. Chest 108(Suppl. 2), S43-S52 (1995).
    • (1995) Chest , vol.108 , Issue.SUPPL. 2
    • Ball, P.1
  • 14
    • 0141670266 scopus 로고    scopus 로고
    • Canadian guidelines for the management of acute exacerbations of chronic bronchitis
    • Chronic Bronchitis Working Group
    • Balter MS, La Forge J, Low DE, Mandell LA, Grossman RF, Chronic Bronchitis Working Group. Canadian guidelines for the management of acute exacerbations of chronic bronchitis. Canadian Resp. J. 10, B3-B32 (2003).
    • (2003) Canadian Resp. J. , vol.10
    • Balter, M.S.1    La Forge, J.2    Low, D.E.3    Mandell, L.A.4    Grossman, R.F.5
  • 15
    • 0028918620 scopus 로고
    • Antibiotics in chronic obstructive pulmonary disease exacerbations. A meta-analysis
    • Saint S, Bent S, Vittinghoff E, Grady D. Antibiotics in chronic obstructive pulmonary disease exacerbations. A meta-analysis. J. Am. Med. Assoc. 273(12), 957-960 (1995).
    • (1995) J. Am. Med. Assoc. , vol.273 , Issue.12 , pp. 957-960
    • Saint, S.1    Bent, S.2    Vittinghoff, E.3    Grady, D.4
  • 16
    • 0034920257 scopus 로고    scopus 로고
    • Management of acute exacerbations of COPD: A summary and appraisal of published evidence
    • McCrory DC, Brown C, Gelfand SE, Bach PB. Management of acute exacerbations of COPD: a summary and appraisal of published evidence. Chest 119(4), 1190-1209 (2001).
    • (2001) Chest , vol.119 , Issue.4 , pp. 1190-1209
    • McCrory, D.C.1    Brown, C.2    Gelfand, S.E.3    Bach, P.B.4
  • 17
    • 1842552109 scopus 로고    scopus 로고
    • Standards for the diagnosis and treatment of patients with COPD: A summary of the ATS/ERS position paper
    • Celli BR, MacNee W. Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper. Eur. Respir. J. 23(6), 932-946 (2004).
    • (2004) Eur. Respir. J. , vol.23 , Issue.6 , pp. 932-946
    • Celli, B.R.1    MacNee, W.2
  • 18
    • 0043156138 scopus 로고    scopus 로고
    • The Alexander Project 1998 to 2000: Susceptibility of pathogens isolated from community acquired respiratory tract infection to commonly used antimicrobial agents
    • The Alexander Project Group
    • Jacobs MR, Felmingham D, Appelbaum PC, Gruneberg RN, The Alexander Project Group. The Alexander Project 1998 to 2000: susceptibility of pathogens isolated from community acquired respiratory tract infection to commonly used antimicrobial agents. J. Antimicrob. Chemother. 52(2), 229-246 (2003).
    • (2003) J. Antimicrob. Chemother. , vol.52 , Issue.2 , pp. 229-246
    • Jacobs, M.R.1    Felmingham, D.2    Appelbaum, P.C.3    Gruneberg, R.N.4
  • 19
    • 0346656808 scopus 로고    scopus 로고
    • Antibacterial resistance among children with community acquired respiratory tract infections (PROTEKT 1999-2000)
    • Felmingham D, Farrell DJ, Reinert RR, Morrissey I. Antibacterial resistance among children with community acquired respiratory tract infections (PROTEKT 1999-2000) J. Infect. 48(1), 39-55 (2004).
    • (2004) J. Infect. , vol.48 , Issue.1 , pp. 39-55
    • Felmingham, D.1    Farrell, D.J.2    Reinert, R.R.3    Morrissey, I.4
  • 20
    • 0346025671 scopus 로고    scopus 로고
    • Antimicrobial susceptibility among community acquired respiratory tract pathogens in the USA: Data from PROTEKT US 2000-2001
    • Doern GV, Brown SD. Antimicrobial susceptibility among community acquired respiratory tract pathogens in the USA: data from PROTEKT US 2000-2001. J. Infect. 48(1), 56-65 (2004).
    • (2004) J. Infect. , vol.48 , Issue.1 , pp. 56-65
    • Doern, G.V.1    Brown, S.D.2
  • 21
    • 0042927965 scopus 로고    scopus 로고
    • Comparison of Streptococcus pneumoniae and Haemophilus influenzae susceptibilities from community acquired respiratory tract infections and hospitalized patients with pneumonia: 5-year results for the SENTRY Antimicrobial Surveillance Program
    • Gordon KA, Biedenbach DJ, Jones RN. Comparison of Streptococcus pneumoniae and Haemophilus influenzae susceptibilities from community acquired respiratory tract infections and hospitalized patients with pneumonia: 5-year results for the SENTRY Antimicrobial Surveillance Program. Diagn. Microbiol. Infect. Dis. 46(4), 285-289 (2003).
    • (2003) Diagn. Microbiol. Infect. Dis. , vol.46 , Issue.4 , pp. 285-289
    • Gordon, K.A.1    Biedenbach, D.J.2    Jones, R.N.3
  • 22
    • 0033595136 scopus 로고    scopus 로고
    • Decreased susceptibility of Streptococcus pneumoniae to fluoroquinolones in Canada
    • Chen DK, McGeer A, De Azavedo J, Low DE. Decreased susceptibility of Streptococcus pneumoniae to fluoroquinolones in Canada. N. Engl. J. Med. 341, 233-239 (1999).
    • (1999) N. Engl. J. Med. , vol.341 , pp. 233-239
    • Chen, D.K.1    McGeer, A.2    De Azavedo, J.3    Low, D.E.4
  • 23
    • 0032908242 scopus 로고    scopus 로고
    • Emergence of fluoroquinolone resistance among multiple resistant strains of Streptococcus pneumoniae in Hong Kong
    • Ho PL, Que TL, Tsang DN, Ng TY, Chow KH, Seto WH. Emergence of fluoroquinolone resistance among multiple resistant strains of Streptococcus pneumoniae in Hong Kong. Antimicrob. Agents Chemother. 43, 1310-1313 (1999).
    • (1999) Antimicrob. Agents Chemother. , vol.43 , pp. 1310-1313
    • Ho, P.L.1    Que, T.L.2    Tsang, D.N.3    Ng, T.Y.4    Chow, K.H.5    Seto, W.H.6
  • 24
    • 0033547373 scopus 로고    scopus 로고
    • Fluoroquinolone resistance in Streptecoccus pneumoniae
    • Linares J, de la Campa AG, Pallares R. Fluoroquinolone resistance in Streptecoccus pneumoniae. N. Engl. J. Med. 341, 1546-1547 (1999).
    • (1999) N. Engl. J. Med. , vol.341 , pp. 1546-1547
    • Linares, J.1    de la Campa, A.G.2    Pallares, R.3
  • 25
    • 0032856370 scopus 로고    scopus 로고
    • Mechanism of fluoroquinolone action
    • Drlica K. Mechanism of fluoroquinolone action. Curr. Opin. Microbiol. 2, 504-508 (1999).
    • (1999) Curr. Opin. Microbiol. , vol.2 , pp. 504-508
    • Drlica, K.1
  • 28
    • 9944231235 scopus 로고    scopus 로고
    • Gemifloxacin mesylate (Factive®), prescribing information. Oscient Pharmaceuticals, MA, USA
    • Gemifloxacin mesylate (Factive®), prescribing information. Oscient Pharmaceuticals, MA, USA (2003).
    • (2003)
  • 29
    • 0033926264 scopus 로고    scopus 로고
    • Quinolone generations: Natural history or natural selection?
    • Ball P. Quinolone generations: natural history or natural selection? J. Antimicrob. Chemother. 46, 17-24 (2000).
    • (2000) J. Antimicrob. Chemother. , vol.46 , pp. 17-24
    • Ball, P.1
  • 31
    • 0028316927 scopus 로고
    • Structure - Activity and structure-side effect relationships for the quinolone antibacterials
    • Domagala J. Structure - activity and structure-side effect relationships for the quinolone antibacterials. J. Antimicrob. Chemother. 33, 685-706 (1994).
    • (1994) J. Antimicrob. Chemother. , vol.33 , pp. 685-706
    • Domagala, J.1
  • 32
    • 0033753211 scopus 로고    scopus 로고
    • Intracellular penetration and activity of gemifloxacin in human polymorphonuclear leukocytes
    • Garcia I, Pascual A, Ballesta S, Joyanes P, Perea EJ. Intracellular penetration and activity of gemifloxacin in human polymorphonuclear leukocytes. Antimicrob Agents Chemother. 44, 3193-3195 (2000).
    • (2000) Antimicrob Agents Chemother. , vol.44 , pp. 3193-3195
    • Garcia, I.1    Pascual, A.2    Ballesta, S.3    Joyanes, P.4    Perea, E.J.5
  • 33
    • 0000853149 scopus 로고    scopus 로고
    • Pharmacokinetics of LB20304, a new fluoroquinolone in rats and dogs
    • Seo SM, Lee SH, Choi YJ et al. Pharmacokinetics of LB20304, a new fluoroquinolone in rats and dogs. Arch. Pharmacol. Res. 19, 359-367 (1996).
    • (1996) Arch. Pharmacol. Res. , vol.19 , pp. 359-367
    • Seo, S.M.1    Lee, S.H.2    Choi, Y.J.3
  • 34
    • 0035050988 scopus 로고    scopus 로고
    • Pharmacokinetics and tissue penetration of gemifloxacin following a single oral dose
    • Gee T, Andrews JM, Ashby JP, Marshall G, Wise R. Pharmacokinetics and tissue penetration of gemifloxacin following a single oral dose. J. Antimicrob. Chemother. 47, 431-434 (2001).
    • (2001) J. Antimicrob. Chemother. , vol.47 , pp. 431-434
    • Gee, T.1    Andrews, J.M.2    Ashby, J.P.3    Marshall, G.4    Wise, R.5
  • 35
    • 0034043739 scopus 로고    scopus 로고
    • Comparative in vivo activity of gemifloxacin in a rat model of respiratory tract infection
    • Berry V, Page R, Satterfield J, Singley C, Straub R, Woodnutt G. Comparative in vivo activity of gemifloxacin in a rat model of respiratory tract infection. J. Antimicrob. Chemother. 45(Suppl. 1), 79-85 (2000).
    • (2000) J. Antimicrob. Chemother. , vol.45 , Issue.SUPPL. 1 , pp. 79-85
    • Berry, V.1    Page, R.2    Satterfield, J.3    Singley, C.4    Straub, R.5    Woodnutt, G.6
  • 37
    • 0034922168 scopus 로고    scopus 로고
    • In vitro activity of gemifloxacin (SB-265805, LB20304a) against Legionella pneumophila and its pharmacokinetics in guinea-pigs with L. pneumophila pneumonia
    • Edelstein PH, Shinzato T, Doyle E, Edelstein MA. In vitro activity of gemifloxacin (SB-265805, LB20304a) against Legionella pneumophila and its pharmacokinetics in guinea-pigs with L. pneumophila pneumonia. Antimicrob. Agents Chemother. 45, 2204-2209 (2001).
    • (2001) Antimicrob. Agents Chemother. , vol.45 , pp. 2204-2209
    • Edelstein, P.H.1    Shinzato, T.2    Doyle, E.3    Edelstein, M.A.4
  • 38
    • 0036239817 scopus 로고    scopus 로고
    • Gemifloxacin is efficacious against penicillin-resistant and quinolone-resistant pneumocci in experimental meningitis
    • Cottagnoud P, Acosta F, Cottagnoud M, Tauber MG. Gemifloxacin is efficacious against penicillin-resistant and quinolone-resistant pneumocci in experimental meningitis. Antimicrob. Agents Chemother. 46, 1607-1609 (2002).
    • (2002) Antimicrob. Agents Chemother. , vol.46 , pp. 1607-1609
    • Cottagnoud, P.1    Acosta, F.2    Cottagnoud, M.3    Tauber, M.G.4
  • 40
    • 0034901332 scopus 로고    scopus 로고
    • Efficacy and safety of gemifloxacin 320 mg once-daily for 7 days in the treatment of adult lower respiratory tract infections
    • 061 Study Group
    • Ball P, File TM Jr, Twynholm M, Henkel T, 061 Study Group. Efficacy and safety of gemifloxacin 320 mg once-daily for 7 days in the treatment of adult lower respiratory tract infections. Int. J. Antimicrob. Agents 18, 19-27 (2001).
    • (2001) Int. J. Antimicrob. Agents , vol.18 , pp. 19-27
    • Ball, P.1    File Jr., T.M.2    Twynholm, M.3    Henkel, T.4
  • 41
    • 3042589219 scopus 로고    scopus 로고
    • Gemifloxacin once daily for 7 days compared with amoxicillin/clavulanic acid thrice daily for 10 days for the treatment of community acquired pneumonia of suspected pneumococcal origin
    • Leophonte P, File TM, Feldman C. Gemifloxacin once daily for 7 days compared with amoxicillin/clavulanic acid thrice daily for 10 days for the treatment of community acquired pneumonia of suspected pneumococcal origin. Respir. Med. 98(8), 708-720 (2004).
    • (2004) Respir. Med. , vol.98 , Issue.8 , pp. 708-720
    • Leophonte, P.1    File, T.M.2    Feldman, C.3
  • 42
    • 0034916311 scopus 로고    scopus 로고
    • Efficacy and safety of gemifloxacin in the treatment of community acquired pneumonia: A randomized, double-blind comparison with trovafloxacin
    • 049 Clinical Study Group
    • File TM Jr, Schlemmer B, Garau J, Cupo M, Young C, 049 Clinical Study Group. Efficacy and safety of gemifloxacin in the treatment of community acquired pneumonia: a randomized, double-blind comparison with trovafloxacin. J. Antimicrob. Chemother. 48, 67-74 (2001).
    • (2001) J. Antimicrob. Chemother. , vol.48 , pp. 67-74
    • File Jr., T.M.1    Schlemmer, B.2    Garau, J.3    Cupo, M.4    Young, C.5
  • 43
    • 0036861678 scopus 로고    scopus 로고
    • Oral gemifloxacin versus sequential therapy with intravenous ceftriaxone/oral cefuroxime with or without a macrolide in the treatment of patients hospitalized with community acquired pneumonia: A randomized, open-label, multicenter study of clinical efficacy and tolerability
    • 185 Gemifloxacin Study Group
    • Lode H, File TM Jr, Mandell LA, Ball P, Pypstra R, Thomas M, 185 Gemifloxacin Study Group. Oral gemifloxacin versus sequential therapy with intravenous ceftriaxone/oral cefuroxime with or without a macrolide in the treatment of patients hospitalized with community acquired pneumonia: a randomized, open-label, multicenter study of clinical efficacy and tolerability. Clin. Ther. 24, 1915-1936 (2002).
    • (2002) Clin. Ther. , vol.24 , pp. 1915-1936
    • Lode, H.1    File Jr., T.M.2    Mandell, L.A.3    Ball, P.4    Pypstra, R.5    Thomas, M.6
  • 44
    • 1642286527 scopus 로고    scopus 로고
    • Timing of antibiotic administration and outcome for Medicare patients with community acquired pneumonia
    • Houck PM, Bratzler DW, Nsa W, Ma A, Bartlett JG. Timing of antibiotic administration and outcome for Medicare patients with community acquired pneumonia. Arch. Intern. Med. 164, 637-644 (2004).
    • (2004) Arch. Intern. Med. , vol.164 , pp. 637-644
    • Houck, P.M.1    Bratzler, D.W.2    Nsa, W.3    Ma, A.4    Bartlett, J.G.5
  • 45
    • 0036255914 scopus 로고    scopus 로고
    • A comparison of gemifloxacin and clarithromycin in acute exacerbations of chronic bronchitis and long-term clinical outcomes
    • 068 Study Group
    • Wilson R, Schentag JJ, Ball P, Mandell LA, 068 Study Group. A comparison of gemifloxacin and clarithromycin in acute exacerbations of chronic bronchitis and long-term clinical outcomes. Clin. Ther. 24, 639-652 (2002).
    • (2002) Clin. Ther. , vol.24 , pp. 639-652
    • Wilson, R.1    Schentag, J.J.2    Ball, P.3    Mandell, L.A.4
  • 46
    • 3042551134 scopus 로고    scopus 로고
    • A randomized double-blind study comparing 5 days oral with 7 days oral levofloxacin in patients with acute exacerbations of chronic bronchitis
    • Sethi S, Fulambarker A, Fogarty C. A randomized double-blind study comparing 5 days oral with 7 days oral levofloxacin in patients with acute exacerbations of chronic bronchitis. Respir. Med. 98(8 , 697-707 (2004).
    • (2004) Respir. Med. , vol.98 , Issue.8 , pp. 697-707
    • Sethi, S.1    Fulambarker, A.2    Fogarty, C.3
  • 47
    • 0034968690 scopus 로고    scopus 로고
    • Efficacy of gemifloxacin in acute exacerbations of chronic bronchitis: A randomized, double-blind comparison with trovafloxacin
    • 069 Clinical Study Group
    • Ball P, Wilson R, Mandell L, Brown J, Henkel T, 069 Clinical Study Group. Efficacy of gemifloxacin in acute exacerbations of chronic bronchitis: a randomized, double-blind comparison with trovafloxacin. J. Chemother. 13(3), 288-298 (2001).
    • (2001) J. Chemother. , vol.13 , Issue.3 , pp. 288-298
    • Ball, P.1    Wilson, R.2    Mandell, L.3    Brown, J.4    Henkel, T.5
  • 48
    • 0037370249 scopus 로고    scopus 로고
    • Oral gemifloxacin once daily for 5 days compared with sequential therapy with intravenous ceftriaxone/oral cefuroxime (maximum of 10 days) in the treatment of hospitalized patients with acute exacerbations of chronic bronchitis
    • Gemifloxacin 207 Clinical Study Group
    • Wilson R, Langan C, Ball P, Bateman K, Pypstra R, Gemifloxacin 207 Clinical Study Group. Oral gemifloxacin once daily for 5 days compared with sequential therapy with intravenous ceftriaxone/oral cefuroxime (maximum of 10 days) in the treatment of hospitalized patients with acute exacerbations of chronic bronchitis. Respir. Med. 97(3 , 242-249 (2003).
    • (2003) Respir. Med. , vol.97 , Issue.3 , pp. 242-249
    • Wilson, R.1    Langan, C.2    Ball, P.3    Bateman, K.4    Pypstra, R.5
  • 49
    • 0037100559 scopus 로고    scopus 로고
    • Cost-effectiveness of gemifloxacin: Results from the GLOBE study
    • Halpern MT, Palmer CS, Zodet M, Kirsch J. Cost-effectiveness of gemifloxacin: results from the GLOBE study. Am. J. Health Syst. Pharm. 59(14), 1357-1365 (2002).
    • (2002) Am. J. Health Syst. Pharm. , vol.59 , Issue.14 , pp. 1357-1365
    • Halpern, M.T.1    Palmer, C.S.2    Zodet, M.3    Kirsch, J.4
  • 50
    • 0037240273 scopus 로고    scopus 로고
    • Maintaining fluoroquinolone class efficacy: Review of influencing factors
    • Scheld WM. Maintaining fluoroquinolone class efficacy: review of influencing factors. Emerg. Infect. Dis. 9, 1-9 (2000).
    • (2000) Emerg. Infect. Dis. , vol.9 , pp. 1-9
    • Scheld, W.M.1
  • 51
    • 0033843538 scopus 로고    scopus 로고
    • The effect of food on the bioavailability of oral gemifloxacin in healthy volunteers
    • Allen A, Bygate E, Clark D, Lewis A, Pay V. The effect of food on the bioavailability of oral gemifloxacin in healthy volunteers. Int. J. Antimicrob. Agents. 16(1), 45-50 (2000).
    • (2000) Int. J. Antimicrob. Agents. , vol.16 , Issue.1 , pp. 45-50
    • Allen, A.1    Bygate, E.2    Clark, D.3    Lewis, A.4    Pay, V.5
  • 52
    • 0033867094 scopus 로고    scopus 로고
    • The effect of ferrous sulfate and sucralfate on the bioavailability of oral gemifloxacin in healthy volunteers
    • Allen A, Bygate E, Faessel H, Isaac L, Lewis A. The effect of ferrous sulfate and sucralfate on the bioavailability of oral gemifloxacin in healthy volunteers. Int. J. Antimicrob. Agents. 15(4), 283-289 (2000).
    • (2000) Int. J. Antimicrob. Agents. , vol.15 , Issue.4 , pp. 283-289
    • Allen, A.1    Bygate, E.2    Faessel, H.3    Isaac, L.4    Lewis, A.5
  • 53
    • 0032737922 scopus 로고    scopus 로고
    • Lack of pharmacokinetic interaction between gemifloxacin and digoxin in healthy elderly volunteers
    • Vousden M, Allen A, Lewis A, Ehren N. Lack of pharmacokinetic interaction between gemifloxacin and digoxin in healthy elderly volunteers. Chemotherapy 45(6), 485-490 (1999).
    • (1999) Chemotherapy , vol.45 , Issue.6 , pp. 485-490
    • Vousden, M.1    Allen, A.2    Lewis, A.3    Ehren, N.4
  • 54
    • 0033220053 scopus 로고    scopus 로고
    • Effect of Maalox on the bioavailbility of oral gemifloxacin in healthy volunteers
    • Allen A, Vousden M, Porter A, Lewis A. Effect of Maalox on the bioavailbility of oral gemifloxacin in healthy volunteers. Chemotherapy 45(6), 504-511 (1999).
    • (1999) Chemotherapy , vol.45 , Issue.6 , pp. 504-511
    • Allen, A.1    Vousden, M.2    Porter, A.3    Lewis, A.4
  • 55
    • 0032736884 scopus 로고    scopus 로고
    • Lack of effect of gemifloxacin on the steady-state pharmacokinetics of theophylline in healthy volunteers
    • Davy M, Allen A, Bird N, Rost KL, Fuder H. Lack of effect of gemifloxacin on the steady-state pharmacokinetics of theophylline in healthy volunteers. Chemotherapy 45(6), 478-484 (1999).
    • (1999) Chemotherapy , vol.45 , Issue.6 , pp. 478-484
    • Davy, M.1    Allen, A.2    Bird, N.3    Rost, K.L.4    Fuder, H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.