The spatial and temporal expression patterns of integrin α9β1 and one of its ligands, the EIIIA segment of fibronectin, in cutaneous wound healing

Journal of Investigative Dermatology

Volumn 123, Issue 6, 2004, Pages 1176-1181

  Singh, Purva ^a   Reimer, Corinne L ^b   Peters, John H ^c,d   Stepp, Mary Ann ^e   Hynes, Richard O ^f   Van De Water, Livingston ^a  

^a ALBANY MEDICAL COLLEGE   (United States)

^b MILLENNIUM PHARMACEUTICALS INC   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

^e GEORGE WASHINGTON UNIVERSITY MEDICAL CENTER   (United States)

^f MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Cutaneous wound healing; Fibronectin; Integrin 9 1; Keratinocytes

Indexed keywords

ALPHA INTEGRIN; FIBRONECTIN; INTEGRIN ALPHA 9 BETA 1; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BASAL CELL; CELL FUNCTION; CONTROLLED STUDY; DERMIS; EPIDERMIS; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; KERATINOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RAT; TIME; WOUND HEALING;

EID: 9744274523     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0022-202X.2004.23485.x     Document Type: Article

References (32)

1. Brown LF, Dubin D, Lavigne L, Logan B, Dvorak HF, Van De Water L: Macrophages and fibroblasts express embryonic fibronectins during cutaneous wound healing. Am J Pathol 142:793-801, 1993
2. Brown LF, Yeo KT, Berse B, Yeo TK, Senger DR, Dvorak HF, Van De Water L: Expression of vascular permeability factor (vascular endothelial growth factor) by epidermal keratinocytes during wound healing. J Exp Med 176:1375-1379, 1992
3. Clark RA, Lanigan JM, DellaPelle P, Manseau E, Dvorak HF, Colvin RB: Fibronectin and fibrin provide a provisional matrix for epidermal cell migration during wound reepithelialization. J Invest Dermatol 79:264-269, 1982
4. DiPersio CM, Hodivala-Dilke KM, Jaenisch R, Kreidberg JA, Hynes RO: α3β11 integrin is required for normal development of the epidermal basement membrane. J Cell Biol 137:729-742, 1997
5. ffrench-Constant C, Van De Water L, Dvorak HF, Hynes RO: Reappearance of an embryonic pattern of fibronectin splicing during wound healing in the adult rat. J Cell Biol 109:903-914, 1989
6. Fukuda T, Yoshida N, Kataoka Y, et al: Mice lacking the EDB segment of fibronectin develop normally but exhibit reduced cell growth and fibronectin matrix assembly in vitro. Cancer Res 62:5603-5610, 2002
7. Gailit J, Pierschbacher M, Clark RA: Expression of functional α4β1 integrin by human dermal fibroblasts. J Invest Dermatol 100:323-328, 1993
8. Grinnell F, Billingham RE, Burgess L: Distribution of fibronectin during wound healing in vivo. J Invest Dermatol 76:181-189, 1981
9. Grose R, Hutter C, Bloch W, et al: A crucial role of β1 integrins for keratinocyte migration in vitro and during cutaneous wound repair. Development 129:2303-2315, 2002
10. Hakkinen L, Hildebrand HC, Berndt A, Kosmehl H, Larjava H: Immunolocalization of tenascin-C, α9 integrin subunit, and αvβ6 integrin during wound healing in human oral mucosa. J Histochem Cytochem 48:985-998, 2000
11. Huang XZ, Wu JF, Ferrando R, Lee JH, Wang YL, Farese RV Jr, Sheppard D: Fatal bilateral chylothorax in mice lacking the integrin α9β1. Mol Cell Biol 20:5208-5215, 2000
12. Hynes R: Fibronectins. New York: Springer-Verlag, 1990
13. Iglesia DD, Gala PH, Qiu T, Stepp MA: Integrin expression during epithelial migration and restratification in the tenascin-C-deficient mouse cornea. J Histochem Cytochem 48:363-376, 2000
14. Kubo M, Van de Water L, Plantefaber LC, et al: Fibrinogen and fibrin are anti-adhesive for keratinocytes: A mechanism for fibrin eschar slough during wound repair. J Invest Dermatol 117:1369-1381, 2001
15. Larjava H, Salo T, Haapasalmi K, Kramer RH, Heino J: Expression of integrins and basement membrane components by wound keratinocytes. J Clin Invest 92:1425-1435, 1993
16. Liao YF, Gotwals PJ, Koteliansky VE, Sheppard D, Van De Water L: The EIIIA segment of fibronectin is a ligand for integrins α9β1 and α4β1 providing a novel mechanism for regulating cell adhesion by alternative splicing. J Biol Chem 277:14467-14474, 2002
17. Liaw L, Birk DE, Ballas CB, Whitsitt JS, Davidson JM, Hogan BL: Altered wound healing in mice lacking a functional osteopontin gene (ssp1). J Clin Invest 101:1468-1478, 1998
18. Mackie EJ, Hlafter W, Liverani D: Induction of tenascin in healing wounds. J Cell Biol 107:2757-2767, 1988
19. Massia SP, Hubbell JA: Vascular endothelial cell adhesion and spreading promoted by the peptide REDV of the IIICS region of plasma fibronectin is mediated by integrin α4β1. J Biol Chem 267:14019-14026, 1992
20. Muro AF, Chauhan AK, Gajovic S, Iaconcig A, Porro F, Stanta G, Baralle FE: Regulated splicing of the fibronectin EDA exon is essential for proper skin wound healing and normal lifespan. J Cell Biol 162:149-160, 2003
21. Nguyen BP, Ryan MC, Gil SG, Carter WG: Deposition of laminin 5 in epidermal wounds regulates integrin signaling and adhesion. Curr Opin Cell Biol 12:554-562, 2000
22. Pal-Ghosh S, Pajoohesh-Ganji A, Brown M, Stepp MA: A mouse model for the study of recurrent corneal epithelial erosions demonstrates a role for α9β1 integrin in the progression of the disease. Invest Ophthal Vis Sci 45:1775-1788, 2004
23. Palmer EL, Ruegg C, Ferrando R, Pytela R, Sheppard D: Sequence and tissue distribution of the integrin α9 subunit, a novel partner of β1 that is widely distributed in epithelia and muscle. J Cell Biol 123:1289-1297, 1993
24. Peters JH, Chen GE, Hynes RO: Fibronectin isoform distribution in the mouse. II. Differential distribution of the alternatively spliced EIIIB, EIIIA, and V segments in the adult mouse. Cell Adhes Commun 4:127-148, 1996
25. Peters JH, Hynes RO: Fibronectin isoform distribution in the mouse. I. The alternatively spliced EIIIB, EIIIA, and V segments show widespread co-distribution in the developing mouse embryo. Cell Adhes Commun 4:103-125, 1996
26. Raghavan S, Bauer C, Mundschau G, Li Q, Fuchs E: Conditional ablation of β1 integrin in skin. Severe defects in epidermal proliferation, basement membrane formation, and hair follicle invagination. J Cell Biol 150:1149-1160, 2000
27. Sakai T, Johnson KJ, Murozono M, et al: Plasma fibronectin supports neuronal survival and reduces brain injury following transient focal cerebral ischemia but is not essential for skin-wound healing and hemostasis. Nat Med 7:324-330, 2001
28. Serini G, Bochaton-Piallat ML, Ropraz P, Geinoz A, Borsi L, Zardi L, Gabbiani G: The fibronectin domain ED-A is crucial for myofibroblastic phenotype induction by transforming growth factor-β1. J Cell Biol 142:873-881, 1998
29. Stepp MA, Gibson HE, Gala PH, et al: Defects in keratinocyte activation during wound healing in the syndecan-1-deficient mouse. J Cell Sci 115:4517-4531, 2002
30. Stepp MA, Zhu L: Upregulation of α9 integrin and tenascin during epithelial regeneration after debridement in the cornea. J Histochem Cytochem 45:189-201, 1997
31. Taooka Y, Chen J, Yednock T, Sheppard D: The integrin α9β1 mediates adhesion to activated endothelial cells and transendothelial neutrophil migration through interaction with vascular cell adhesion molecule-1. J Cell Biol 145:413-420, 1999
32. Wang A, Patrone L, McDonald JA, Sheppard D: Expression of the integrin subunit α9 in the murine embryo. Dev Dyn 204:421-431, 1995