Mexiletine protects myocardium during acute ischemia by opening sarcolemmal K-ATP channel: Studies in closed-chest acute ischemia model in rabbits

Journal of Cardiovascular Pharmacology

Volumn 44, Issue 6, 2004, Pages 639-644

  Niwano, Shinichi ^a   Inuo, Kimiatsu ^a   Morohoshi, Yasuo ^a   Nakayama, Shigenobu ^a   Yuge, Masaru ^a   Imaki, Ryuta ^a   Izumi, Tohru ^a  

^a KITASATO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Antiarrhythmic agents; Ischemia; K ATP channel; Pre conditioning; Sarcolemma

Indexed keywords

5 HYDROXYDECANOIC ACID; ADENOSINE TRIPHOSPHATE; ANTIARRHYTHMIC AGENT; CLAMIKALANT; MEXILETINE; PILSICAINIDE; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT;

ANIMAL MODEL; ARTERY OCCLUSION; ARTICLE; CAROTID ARTERY; CONTROLLED STUDY; HEART HEMODYNAMICS; HEART INFARCTION SIZE; HEART LEFT VENTRICLE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART MUSCLE; HEART MUSCLE FIBER MEMBRANE; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HEART VENTRICLE ARRHYTHMIA; LEFT CORONARY ARTERY; NONHUMAN; PRIORITY JOURNAL; RABBIT;

ACUTE DISEASE; ANIMALS; ANTI-ARRHYTHMIA AGENTS; ATP-BINDING CASSETTE TRANSPORTERS; DISEASE MODELS, ANIMAL; ELECTROCARDIOGRAPHY; HEMODYNAMIC PROCESSES; LIDOCAINE; MEXILETINE; MYOCARDIAL INFARCTION; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; POTASSIUM CHANNELS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; RABBITS; SARCOLEMMA; SODIUM CHANNEL BLOCKERS; STROKE VOLUME; VENTRICULAR FUNCTION, LEFT;

EID: 9744228620     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-200412000-00003     Document Type: Article

References (39)

1. + channel in cardiac muscle. Nature. 1983;305:147-148.
2. Gross GJ, Peart JN. K-ATP channels and myocardial preconditioning: an update. Am J Physiol Heart Circ Physiol. 2003;285:H921-H930.
3. Gross GJ, Auchampach JA. Blockade of ATP-sensitive potassium channels prevents myocardial preconditioning in dogs. Circ Res. 1992;70:223-233.
4. ATP channel opener bimakalim on coronary blood flow, monophasic action potential duration, and infarct size in dogs. Circulation. 1994;89:1769-1775.
5. Grover GJ, D'Alonzo AJ, Phaham CS, et al. Cardioprotection with the K-ATP opener cromakalim is not correlated with ischemic myocardial action potential duration. J Cardiovasc Pharmacol. 1995;26:145-152.
6. + blocker dofetilide. Am J Physiol Heart Circ Physiol 1996;271:H1207-H1214.
7. Armstrong SC, Liu GS, Downey JM, et al. Potassium channels and preconditioning of isolated rabbit cardiomyocytes: effects of glyburide and pinacidil. J Mol Cell Cardiol. 1995;27:1765-1774.
8. - channels. Possible mechanism of cardioprotection. Circ Res. 1997;81:1072-1082.
9. Sasaki N, Murata M, Guo Y, et al. MCC-134, a single pharmacophore, opens surface ATP-sensitive potassium channels, blocks mitochondrial ATP-sensitive potassium channels, and suppresses preconditioning. Circulation. 2003;107:1183-1188.
10. Schwartz LM, Welch TS, Crago MS. Cardioprotection by multiple preconditioning cycles does not require mitochondrial K-ATP channels in pig. Am J Physiol Heart Circ Physiol. 2002;283:H1538-H1544.
11. + channels and myocardial preconditioning. Circ Res. 1999;84:973-979.
12. ATP channel. Am J Physiol. 1994;266:H 829-H 839.
13. + channels in early phase of reperfusion and its protection role against myocardial stunning. Circulation. 1995;92:2266-2275.
14. Yasuda T, Hashimura K, Matsuura Y, et al. Nicorandil, a hybrid between nitrate and ATP-sensitive potassium channel opener, preconditions human heart to ischemia during percutaneous transluminal coronary angioplasty. Jpn Circ J. 2001;65:526-530.
15. Kitakaze M, Minamino T, Node K, et al. Adenosine and cardioprotection in the diseased heart. Jpn Circ J. 1999;63:231-243.
16. + channels induced by angiotensin II type 1 receptor antagonist on metabolism, contraction and relaxation in ischemia-reperfused rabbit heart. Jpn Circ J. 2001;65:451-456.
17. Sato T, Sakaki N, O'Rouker B, et al. Nicorandil, a potent cardioprotective agent, acts by opening mitochondrial ATP-dependent potassium channels. J Am Coll Cardiol. 2000;35:514-518.
18. ATP channels. Clin Exp Pharmacol Physiol. 2000;27:810-817.
19. Zhu BM, Miyamoto S, Nagasawa Y, et al. Effect of sarcolemmal K(ATP) channel blocker HMR1098 on arrhythmias induced by programmed electrical stimulation in canine old myocardial infarction model: comparison with glibenclamide. J Pharmacol Sci. 2003;93:106-113.
20. + channels protect the myocardium against ischemia/reperfusion damage. Circ Res. 1991;69:571-581.
21. Yao Z, Gross GJ. Activation of ATP-sensitive potassium channels lowers threshold for ischemic preconditioning in dogs. Am J Physiol Heart Circ Physiol. 1994;267:H1888-H1894.
22. Schulz R, Rose J, Heusch G. Involvement of activation of ATP-dependent potassium channels in ischemic preconditioning in swine. Am J Physiol Heart Circ Physiol. 1994;267:H1341-H1352.
23. Suzuki M, Sasaki N, Miki T, et al. Role of sarcolemmal K-ATP channels in cardioprotection against ischemia/reperfusion injury in mice. J Clin Invest. 2002;109:509-516.
24. + channel subunits confer resistance to chemical hypoxia-reoxidation injury. Circulation. 1998;98:1548-1555.
25. Janovic N, Janovic S, Janovic A, et al. Gene delivery of Kir6.2/SUR2A in conjunction with pinacidil handles intracellular Ca homeostasis under metabolic stress. FASEB J. 1999;13:923-939.
26. Rajashree R, Koster JC, Markova KP, et al. Contractility and ischemic response of hearts from transgenic mice with altered sarcolemmal K-ATP channels. Am J Physiol Heart Circ Physiol. 2002;283:H584-H590.
27. Inuo K, Niwano S, Morohoshi Y, et al. Cardioprotective effect of mexiletine in acute myocardial ischemia. Studies in the rabbit closed chest ischemia model. Circ J. 2002;66:403-410.
28. Niwano S, Yoshizawa N, Inuo K, et al. Evaluation of post-reporalization refractoriness for conduction block in cardiac muscle. Studies in an artificial isthmus in canine right atrium. Jpn Circ J. 2001;65:40-45.
29. Ito WD, Schaarschmid S, Klask R, et al. Infarct size measurment by triphenyltetorazolium chloride staining versus in vivo injection of propidium iodide. J Mol Cell Cardiol. 1997;29:2169-2175.
30. Hale SL, Kloner RA. Myocardial temperature attenuates necrosis after prolonged ischemia in rabbits. Cardiovasc Res. 1998;40:502-507.
31. Duncker DJ, Klassen CL, Ishibashi Y, Herrlinger SH, Pavek TJ, Bache RJ. Effect of temperature on myocardial infarction in swine. Am J Physiol. 1996;270:H1189-H1199.
32. + channel opening property and nitrate property. Clin Exp Pharmacol Physiol. 1993;20:595-602.
33. Gross GJ, Auchampach JA, Maruyama M, et al. Cardioprotective effects of nicorandil. J Cardiovasc Pharmacol. 1992;20:S22-S28.
34. Mitani A, Kinoshita K, Fukamachi K, et al. Effects of glibenclamide and nicorandil on cardiac function during ischemia and reperfusion in isolated perfused rat hearts. Am J Physiol. 1991;261:H1864-H1871.
35. Auchampach JA, Cavero I, Gross GJ. Nicorandil attenuates myocardial dysfunction associated with transient ischemia by opening ATP-dependent potassium channels. J Cardiovasc Pharmacol. 1992;20:765-771.
36. + channels. Br J Pharmacol. 1995;115:381-382.
37. +channels in guinea-pig ventricular muscles. Naunyn Schmiedebergs Arch Pharmacol. 1998;357:283-290.
38. Gaudette GR, Krukenkamp IB, Saltman AE, et al. Preconditioning with PKC and the ATP-sensitive potassium channels: a codependent relationship. Ann Thorac Surg. 2000;70:602-608.
39. ATP channels. Clin Exp Pharmacol Physiol. 2000;27:810-817.