Class I antiarrhythmic drugs alter the severity of myocardial stunning by modulating ATP-sensitive K+ channels in guinea pig ventricular muscles

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 357, Issue 3, 1998, Pages 283-290

  Shigematsu, S ^a   Sato, T ^a   Arita, M ^a  

^a OITA UNIVERSITY   (Japan)

Author keywords

Antiarrhythmic drugs; ATP sensitive potassium channels; Cibenzoline; Glibenclamide; Mexiletine; Myocardial stunning; Pilsicainide

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTIARRHYTHMIC AGENT; CIBENZOLINE; GLIBENCLAMIDE; MEXILETINE; PILSICAINIDE; POTASSIUM CHANNEL;

ACTION POTENTIAL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GUINEA PIG; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PROTECTION; NONHUMAN; REPOLARIZATION; STUNNED HEART MUSCLE;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; GLYBURIDE; GUINEA PIGS; HEART; HEART VENTRICLES; IMIDAZOLES; LIDOCAINE; MALE; MEXILETINE; MYOCARDIAL STUNNING; POTASSIUM CHANNELS;

EID: 0031915729     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00005169     Document Type: Article

References (35)

1. Bernardi P, Vassanelli S, Veronese P, Colonna R, Szabo I, Zoratti M (1992) Modulation of the mitochondrial permeability transition pore. Effect of protons and divalent cations. J Biol Chem 267:2934-2939
2. Bolli R (1990) Mechanism of myocardial "stunning". Circulation 82:723-738
3. + channels: An obligatory pathway for the cardioprotection afforded by ischemic and pharmacological preconditioning. In: Endoh M (ed) Molecular and cellular mechanisms of cardiovascular regulation. Springer, New York, pp 69-81
4. + channels protect the myocardium against ischemia/reperfusion damage. Circ Res 69:571-581
5. + concentration. J Biol Chem 256:8880-8885
6. 2+ responsiveness and altered diastolic function in intact ventricular muscle. Circ Res 76: 1036-1048
7. ATP channel as a receptor for potassium channel openers. J Biol Chem 271 :8796-8799
8. Grover GJ, McCullough JR, Henrry DE, Condor ML, Sleph PG (1989) Anti-ischemic effects of the potassium channel activators pinacidil and cromakalim and the reversal of these effects with the potassium channel blocker glyburide. J Pharmacol Exp Ther 251 :98-104
9. Grover GJ, Dzwonczyk S, Parham CS, Sleph PG (1990a) The protective effects of cromakalim and pinacidil on reperfusion function and infarct size in isolated perfused hearts and anesthetized dogs. Cardiovasc Drugs Ther 4 :465-474
10. Grover GJ, Sleph PG, Dzwonczyk S (1990b) Pharmacological profile of cromakalim in the treatment of myocardial ischemia in isolated rat hearts and anesthetized dogs. J Cardiovasc Pharmacol 16:853-864
11. ATP, opener cromakalim is not correlated with ischemic myocardial action potential duration. J Cardiovasc Phamiacol 26: 145-152
12. Hanaki Y, Sugiyama S, Hieda N, Taki K, Hayashi H, Ozawa T (1989) Cardioprotective effects of various class I antiarrhythmic drugs in canine hearts. J Am Coll Cardiol 14:219-224
13. Inomata N, Ishihara T, Akaike N (1987) SUN 1165: A new antiarrhylhniic Na current blocker in ventricular myocytes of guineapig. Comp Biochem Physiol 87C: 237-243
14. 2+ activation ot contraction as a consequence of reperfusion-induced cellular calcium overload in ferret hearts. J Clin Invest 79:950-961
15. Lamping KA, Gross GJ (1985) Improved recovery of myocardial segment function following a short coronary occlusion in dogs by nicorandil, a potential new antianginal agent, and nifedipine. J Cardiovasc Pharmacol 7: 158-166
16. Lazdunski M, Frelin C, Vigne P (1985) The sodium/hydrogen exchange system in cardiac cells: its biochemical and pharmacological properties and ils role in regulating internal concentrations of sodium and internal pH. J Mol Cell Cardiol 17: 1029-1042
17. Lee KS, Hume JR, Giles W, Brown AM (1981) Sodium current depressed by lidoeaine and quinidine in isolated ventricular cells. Nature 291 : 325-327
18. Liu Jian-Xun, Tanonaka K, Ohtsuka Y, Sakai Y, Takeo S (1993) Improvement of ischemia/reperfusion-induced contractile dysfunction of perfused hearts by class Ic antiarrhythmic agents. J Pharmacol Exp Ther 266: 1247-1254
19. 2+ homeostasis in hearts reperfused after prolonged episodes of ischemia. Ann NY Acad Sci 723: 38-50
20. McCullotigh JR, Normandin DE, Condor ML, Sleph PG, Dzwonczyk S, Grover GJ (1991) Specific block of the anti-ischemic actions of cromakalim by sodium 5-hydroxydecanoate. Circ Res 69:949-958
21. 31P-NMR magnetization transfer study of the isolated ferret heart. Circ Res 63:1-15
22. Przyklenk K, Kloner RA (1988) Effect of verapamil on postischemic "stunned" myocardium: importance of the timing of treatment. J Am Coll Cardiol 11 :614-623
23. Przyklenk K, Kloner RA (1991) Calcium antagonists and the stunned myocardium. J Cardiovasc Pharmacol 18 [Suppl 10]: S93-S101
24. Rolhbart ST, Saksena S (1986) Clinical electrophysiology efficacy and safety of chronic oral cibenzoline therapy in refractory ventricular tachycardia. Am J Cardiol 57:941-946
25. + channels. Br J Pharmacol 115: 381-382
26. Shattock MJ, Bers DM (1989) Rat vs, rabbit: Ca flux and intracellular Na assessed by ion-selective microeleclrodes. Am J Physiol 256:C813-C822
27. + channels in early phase of reperfusion and its protective role against myocardial stunning. Circulation 92: 2266-2275
28. 2+ exchange. Circ Res 65 : 1045-1056
29. 2+ overload and impairs function in anoxic rat heart. J Mol Cell Cardiol 22:52-72
30. Thormon JD, Thornton CS, Sterling DL, Downey JM (1993) Blockade of ATP-sensitive potassium channels increases infarct size hut does not prevent preconditioning in rabbit hearts. Circ Res 72:44-49
31. Wang DW, Sato T, Arita M (1995) Voltage dependent inhibition of ATP sensitive potassium channels by flecainide in guinea pig ventricular cells. Cardiovasc Res 29:520-525
32. Wu B, Sato T, Kiyosue T, Arita M (1992) Blockade of 2,4-dinitrophenol induced ATP sensitive potassium current in guinea pig ventricular myocytes by class I antiarrhythmic drugs. Cardiovasc Res 26: 1095-1101
33. ATP channel opener bimakalim on coronary blood flow, monophasic action potential duration, and infarct size in dogs. Circulation 89: 1769-1775
34. Yatani A, Akaike N (1985) Blockade of the sodium current in isolated single cells from rat ventricle with mexiletine and disopyramide. J Mol Cell Cardiol 17:467-476
35. Zipes DP, Troup PJ (1978) New antiarrhythmic agents. Am J Cardiol 41 : 1005-1024