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Volumn 15, Issue 16, 2004, Pages 2447-2450

FMRP and its target RNAs: Fishing for the specificity

Author keywords

BC1; Fragile X mental retardation protein; G quartet; Micro RNAs; Translational regulation

Indexed keywords

FRAGILE X MENTAL RETARDATION PROTEIN; MESSENGER RNA;

EID: 9644300809     PISSN: 09594965     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001756-200411150-00002     Document Type: Review
Times cited : (10)

References (42)
  • 1
    • 0029816723 scopus 로고    scopus 로고
    • The fragile X mental retardation protein is a ribonucleoprotein containing both nuclear localization and nuclear export signals
    • Eberhart DE, Malter HE, Feng Y and Warren ST. The fragile X mental retardation protein is a ribonucleoprotein containing both nuclear localization and nuclear export signals. Hum Mol Genet 1996; 5:1083-1091.
    • (1996) Hum Mol Genet , vol.5 , pp. 1083-1091
    • Eberhart, D.E.1    Malter, H.E.2    Feng, Y.3    Warren, S.T.4
  • 2
    • 0031445652 scopus 로고    scopus 로고
    • Analysis of domains affecting intracellular localization of the FMRP protein
    • Bardoni B, Sittler A, Shen Y and Mandel JL. Analysis of domains affecting intracellular localization of the FMRP protein. Neurobiol Dis 1997; 4: 329-336.
    • (1997) Neurobiol Dis , vol.4 , pp. 329-336
    • Bardoni, B.1    Sittler, A.2    Shen, Y.3    Mandel, J.L.4
  • 4
    • 0036301947 scopus 로고    scopus 로고
    • A decade of molecular studies of fragile X syndrome
    • O'Donnell WT and Warren ST. A decade of molecular studies of fragile X syndrome. Annu Rev Neurosci 2002; 25:315-338.
    • (2002) Annu Rev Neurosci , vol.25 , pp. 315-338
    • O'Donnell, W.T.1    Warren, S.T.2
  • 6
    • 0345107245 scopus 로고    scopus 로고
    • Understanding the biological underpinnings of fragile X syndrome
    • Chiurazzi P, Neri G and Oostra BA. Understanding the biological underpinnings of fragile X syndrome. Curr Opin Pediatr 2003; 15:559-566.
    • (2003) Curr Opin Pediatr , vol.15 , pp. 559-566
    • Chiurazzi, P.1    Neri, G.2    Oostra, B.A.3
  • 7
  • 8
    • 0033797832 scopus 로고    scopus 로고
    • Dendritic spine structural anomalies in fragile-X mental retardation syndrome
    • Irwin SA, Galvez R and Greenough WT. Dendritic spine structural anomalies in fragile-X mental retardation syndrome. Cerebr Cortex 2000; 10:1038-1044.
    • (2000) Cerebr Cortex , vol.10 , pp. 1038-1044
    • Irwin, S.A.1    Galvez, R.2    Greenough, W.T.3
  • 9
    • 0028246435 scopus 로고
    • Fmr1 knockout mice: A model to study fragile X mental retardation
    • The Dutch-Belgian Fragile X Consortium
    • Bakker CE, Verheij C, Willemsen R, van der Helm R, Oerlemans F, Vermey M et al. Fmr1 knockout mice: a model to study fragile X mental retardation. The Dutch-Belgian Fragile X Consortium. Cell 1994; 78:23-33.
    • (1994) Cell , vol.78 , pp. 23-33
    • Bakker, C.E.1    Verheij, C.2    Willemsen, R.3    Van Der Helm, R.4    Oerlemans, F.5    Vermey, M.6
  • 11
    • 0033802736 scopus 로고    scopus 로고
    • FMRP involvement in formation of synapses among cultured hippocampal neurons
    • Braun K and Segal M. FMRP involvement in formation of synapses among cultured hippocampal neurons. Cerebr Cortex 2000; 10:1045-1052.
    • (2000) Cerebr Cortex , vol.10 , pp. 1045-1052
    • Braun, K.1    Segal, M.2
  • 12
    • 0027273728 scopus 로고
    • The pre-mRNA binding K protein contains a novel evolutionarily conserved motif
    • Siomi H, Matunis MJ, Michael WM and Dreyfuss G. The pre-mRNA binding K protein contains a novel evolutionarily conserved motif. Nucleic Acids Res 1993; 21:1193-1198.
    • (1993) Nucleic Acids Res , vol.21 , pp. 1193-1198
    • Siomi, H.1    Matunis, M.J.2    Michael, W.M.3    Dreyfuss, G.4
  • 14
    • 0032847774 scopus 로고    scopus 로고
    • Dissecting FMR1, the protein responsible for fragile X syndrome, in its structural and functional domains
    • Adinolfi S, Bagni C, Musco G, Gibson T, Mazzarella L and Pastore A. Dissecting FMR1, the protein responsible for fragile X syndrome, in its structural and functional domains. RNA 1999; 9:1248-1258.
    • (1999) RNA , vol.9 , pp. 1248-1258
    • Adinolfi, S.1    Bagni, C.2    Musco, G.3    Gibson, T.4    Mazzarella, L.5    Pastore, A.6
  • 15
    • 0041817560 scopus 로고    scopus 로고
    • The N-terminus of the fragile X mental retardation protein contains a novel domain involved in dimerization and RNA-binding
    • Adinolfi S, Ramos A, Martin SR, Dal Piaz F, Pucci P, Bardoni B et al. The N-terminus of the fragile X mental retardation protein contains a novel domain involved in dimerization and RNA-binding. Biochemistry 2003; 42:10437-10444.
    • (2003) Biochemistry , vol.42 , pp. 10437-10444
    • Adinolfi, S.1    Ramos, A.2    Martin, S.R.3    Dal Piaz, F.4    Pucci, P.5    Bardoni, B.6
  • 16
    • 0027377580 scopus 로고
    • FMR1 protein: Conserved RNP family domains and selective RNA binding
    • Ashley CT, Jr. Wilkinson KD, Reines D and Warren ST. FMR1 protein: conserved RNP family domains and selective RNA binding. Science 1993; 262:563-566.
    • (1993) Science , vol.262 , pp. 563-566
    • Ashley, C.T.1    Wilkinson Jr., K.D.2    Reines, D.3    Warren, S.T.4
  • 17
    • 1942467797 scopus 로고    scopus 로고
    • Molecular insights into mental retardation: Multiple functions for the fragile X mental retardation protein?
    • Zalfa F and Bagni C. Molecular insights into mental retardation: multiple functions for the fragile X mental retardation protein? Curr Issues Mol Biol 2004; 6:73-88.
    • (2004) Curr Issues Mol Biol , vol.6 , pp. 73-88
    • Zalfa, F.1    Bagni, C.2
  • 18
    • 0035801393 scopus 로고    scopus 로고
    • The fragile X mental retardation protein binds specifically to its mRNA via a purine quartet motif
    • Schaeffer C, Bardoni B, Mandel JL, Ehresmann B, Ehresmann C and Moine H. The fragile X mental retardation protein binds specifically to its mRNA via a purine quartet motif. EMBO J 2001; 20:4803-4813.
    • (2001) EMBO J , vol.20 , pp. 4803-4813
    • Schaeffer, C.1    Bardoni, B.2    Mandel, J.L.3    Ehresmann, B.4    Ehresmann, C.5    Moine, H.6
  • 19
    • 0035900649 scopus 로고    scopus 로고
    • Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function
    • Darnell JC, Jensen KB, Jin P, Brown V, Warren ST and Darnell RB. Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function. Cell 2001; 107:489-499.
    • (2001) Cell , vol.107 , pp. 489-499
    • Darnell, J.C.1    Jensen, K.B.2    Jin, P.3    Brown, V.4    Warren, S.T.5    Darnell, R.B.6
  • 20
    • 0141631894 scopus 로고    scopus 로고
    • G-quartet-dependent recognition between the FMRP RGG box and RNA
    • Ramos A, Hollingworth D and Pastore A. G-quartet-dependent recognition between the FMRP RGG box and RNA. RNA 2003; 9:1198-1207.
    • (2003) RNA , vol.9 , pp. 1198-1207
    • Ramos, A.1    Hollingworth, D.2    Pastore, A.3
  • 21
    • 0042624778 scopus 로고    scopus 로고
    • The fragile X mental retardation protein binds and regulates a novel class of mRNAs containing U rich target sequences
    • Chen L, Yun SW, Seto J, Liu W and Toth M. The fragile X mental retardation protein binds and regulates a novel class of mRNAs containing U rich target sequences. Neuroscience 2003; 120:1005-1017.
    • (2003) Neuroscience , vol.120 , pp. 1005-1017
    • Chen, L.1    Yun, S.W.2    Seto, J.3    Liu, W.4    Toth, M.5
  • 22
    • 0037423293 scopus 로고    scopus 로고
    • The fragile X syndrome protein FMRP associates with BC1 RNA and regulates the translation of specific mRNAs at synapses
    • Zalfa F, Giorgi M, Primerano B, Moro A, Di Penta A, Reis S et al. The fragile X syndrome protein FMRP associates with BC1 RNA and regulates the translation of specific mRNAs at synapses. Cell 2003; 112:317-327.
    • (2003) Cell , vol.112 , pp. 317-327
    • Zalfa, F.1    Giorgi, M.2    Primerano, B.3    Moro, A.4    Di Penta, A.5    Reis, S.6
  • 23
    • 18044379515 scopus 로고    scopus 로고
    • Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome
    • Brown V, Jin P, Ceman S, Darnell JC, O'Donnell WT, Tenenbaum SA et al. Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome. Cell 2001; 107: 477-487.
    • (2001) Cell , vol.107 , pp. 477-487
    • Brown, V.1    Jin, P.2    Ceman, S.3    Darnell, J.C.4    O'Donnell, W.T.5    Tenenbaum, S.A.6
  • 24
    • 0037421721 scopus 로고    scopus 로고
    • RNA cargoes associating with FMRP reveal deficits in cellular functioning in Fmr1 null mice
    • Miyashiro KY, Beckel-Mitchener A, Purk TP, Becker KG, Barret T, Liu L et al. RNA cargoes associating with FMRP reveal deficits in cellular functioning in Fmr1 null mice. Neuron 2003; 37: 417-431.
    • (2003) Neuron , vol.37 , pp. 417-431
    • Miyashiro, K.Y.1    Beckel-Mitchener, A.2    Purk, T.P.3    Becker, K.G.4    Barret, T.5    Liu, L.6
  • 25
    • 0035977134 scopus 로고    scopus 로고
    • Drosophila fragile X-related gene regulates the MAP1B homolog Futsch to control synaptic structure and function
    • Zhang YQ, Bailey AM, Matthies HJ, Renden RB, Smith MA, Speese SD et al. Drosophila fragile X-related gene regulates the MAP1B homolog Futsch to control synaptic structure and function. Cell 2001; 107:591-603.
    • (2001) Cell , vol.107 , pp. 591-603
    • Zhang, Y.Q.1    Bailey, A.M.2    Matthies, H.J.3    Renden, R.B.4    Smith, M.A.5    Speese, S.D.6
  • 26
    • 0026740718 scopus 로고
    • Primary structure the binding activity of the hnRNP U protein: Binding through the RGG box
    • Kiledjian M and Dreyfuss G. Primary structure the binding activity of the hnRNP U protein: binding through the RGG box. EMBO J 1992; 11: 2655-2664.
    • (1992) EMBO J , vol.11 , pp. 2655-2664
    • Kiledjian, M.1    Dreyfuss, G.2
  • 28
    • 0035046796 scopus 로고    scopus 로고
    • Neuronal BC1 RNA structure: Evolutionary conversion of a tRNA(Ala) domain into an extended stem-loop structure
    • Rozhdestvensky TS, Kopylov AM, Brosius J and Huttenhofer A. Neuronal BC1 RNA structure: evolutionary conversion of a tRNA(Ala) domain into an extended stem-loop structure. RNA 2001; 7: 722-730.
    • (2001) RNA , vol.7 , pp. 722-730
    • Rozhdestvensky, T.S.1    Kopylov, A.M.2    Brosius, J.3    Huttenhofer, A.4
  • 29
    • 2342564387 scopus 로고    scopus 로고
    • The fragile X mental retardation protein has nucleic acid chaperone properties
    • Gabus C, Mazroui R, Tremblay S, Khandjian EW and Darlix JL. The fragile X mental retardation protein has nucleic acid chaperone properties. Nucleic Acid Res 2004; 32:2129-2137.
    • (2004) Nucleic Acid Res , vol.32 , pp. 2129-2137
    • Gabus, C.1    Mazroui, R.2    Tremblay, S.3    Khandjian, E.W.4    Darlix, J.L.5
  • 33
    • 0037164732 scopus 로고    scopus 로고
    • RNA interference: The fragile X syndrome connection
    • Carthew RW. RNA interference: the fragile X syndrome connection. Curr Biol 2002 12:R852-854.
    • (2002) Curr Biol , vol.12
    • Carthew, R.W.1
  • 34
    • 0036792769 scopus 로고    scopus 로고
    • Fragile X-related protein and VIG associate with the RNA interference machinery
    • Caudy AA, Myers M, Hannon GJ and Hammond SM. Fragile X-related protein and VIG associate with the RNA interference machinery. Genes Dev 2002; 16:2491-2496.
    • (2002) Genes Dev , vol.16 , pp. 2491-2496
    • Caudy, A.A.1    Myers, M.2    Hannon, G.J.3    Hammond, S.M.4
  • 35
    • 0036791671 scopus 로고    scopus 로고
    • A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins
    • Ishizuka A, Siomi MC and Siomi H. A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins. Genes Dev 2002; 16:2497-2508.
    • (2002) Genes Dev , vol.16 , pp. 2497-2508
    • Ishizuka, A.1    Siomi, M.C.2    Siomi, H.3
  • 36
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: Genomics, biogenesis, mechanism, and function
    • Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004; 116:281-297.
    • (2004) Cell , vol.116 , pp. 281-297
    • Bartel, D.P.1
  • 37
    • 1242296375 scopus 로고    scopus 로고
    • miRNP:mRNA association in polyribosomes in a human neuronal cell line
    • Nelson PT, Hatzigeorgiou AG and Mourelatos Z. miRNP:mRNA association in polyribosomes in a human neuronal cell line. RNA 2004; 10:387-394.
    • (2004) RNA , vol.10 , pp. 387-394
    • Nelson, P.T.1    Hatzigeorgiou, A.G.2    Mourelatos, Z.3
  • 38
    • 1642540373 scopus 로고    scopus 로고
    • Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway
    • Jin P, Zarnescu DC, Ceman S, Nakamoto M, Mowrey J, Jongens TA et al. Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway. Nature Neurosci 2004; 7:113-117.
    • (2004) Nature Neurosci , vol.7 , pp. 113-117
    • Jin, P.1    Zarnescu, D.C.2    Ceman, S.3    Nakamoto, M.4    Mowrey, J.5    Jongens, T.A.6
  • 39
    • 0027751663 scopus 로고
    • The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
    • Lee RC, Feinbaum RL and Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 1993; 75:843-854.
    • (1993) Cell , vol.75 , pp. 843-854
    • Lee, R.C.1    Feinbaum, R.L.2    Ambros, V.3
  • 40
    • 0027730383 scopus 로고
    • Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans
    • Wightman B, Ha I and Ruvkun G. Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. Cell 1993; 75:855-862.
    • (1993) Cell , vol.75 , pp. 855-862
    • Wightman, B.1    Ha, I.2    Ruvkun, G.3
  • 41
    • 0034708122 scopus 로고    scopus 로고
    • The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans
    • Reinhart BJ, Slack FJ, Basson M, Pasquinelli AE, Bettinger JC et al. The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature 2000; 403:901-906.
    • (2000) Nature , vol.403 , pp. 901-906
    • Reinhart, B.J.1    Slack, F.J.2    Basson, M.3    Pasquinelli, A.E.4    Bettinger, J.C.5
  • 42
    • 0037418839 scopus 로고    scopus 로고
    • Bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila
    • Brennecke J, Hipfner DR, Stark A, Russell RB and Cohen SM. Bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila. Cell 2003; 113:25-36.
    • (2003) Cell , vol.113 , pp. 25-36
    • Brennecke, J.1    Hipfner, D.R.2    Stark, A.3    Russell, R.B.4    Cohen, S.M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.