Localization of constitutive isoforms of nitric oxide synthase in the gastric glandular mucosa of the rat

Cell and Tissue Research

Volumn 285, Issue 1, 1996, Pages 157-163

  Price, Kenneth J ^a   Hanson, Peter J ^a   Whittle, Brendan J R ^b  

^a ASTON UNIVERSITY   (United Kingdom)

^b WELLCOME RESEARCH LABORATORIES   (United Kingdom)

Author keywords

Gastric mucosa; Immunohistochemistry; Nitric oxide; Nitric oxide synthase; Rat (Wistar); Stomach

Indexed keywords

NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ANIMAL TISSUE; ARTICLE; BRAIN; ENZYME LOCALIZATION; IMMUNOHISTOCHEMISTRY; MALE; MUCUS SECRETION; NONHUMAN; PRIORITY JOURNAL; STOMACH MUCOSA;

ANIMALS; ANTIBODY SPECIFICITY; GASTRIC MUCOSA; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; ISOENZYMES; MALE; NADPH DEHYDROGENASE; NITRIC OXIDE SYNTHASE; RATS; RATS, WISTAR;

ANIMALIA;

EID: 0030017982     PISSN: 0302766X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004410050631     Document Type: Article

References (25)

1. Allen A, Flemstrom G, Garner A, Kivilaakso E (1993) Gastroduodenul mucosal protection. Physiol Rev 73:823-857
2. Alm P, Larsson B, Ekblad E, Sundler F, Andersson, K-E (1993) Immunohistochemical localization of peripheral nitric oxide synthase-containing nerves using antibodies raised against synthesized C- and N-terminal fragments of a cloned enzyme from rat brain. Acta Physiol Scand 148:421-429
3. Brown JF, Hanson PJ, Whittle BJR (1992a) Nitric oxide donors increase mucus gel thickness in rat stomach. Eur J Pharmacol 223:103-104
4. Brown JF, Tepperman BL, Hanson PJ, Whittle BJR, Moncada S (1992b) Differential distribution of nitric oxide synthase between cell fractions isolated from the rat gastric mucosa. Biochem Biophys Res Commun 184:680-685
5. Brown JF, Keates AC, Hanson PJ, Whittle BJR (1993) Nitric oxide generators and cGMP stimulate mucus secretion by rat gastric mucosal cells. Am J Physiol 265:G418-G442
6. 2+-independent nitric oxide synthase activity in rat gastric mucosal cells. Eur J Pharmacol 292:111-114
7. Cho HJ, Xie Q-W, Calaycay J, Mumford RA, Swiderek KM, Lee TD, Nathan C (1992) Calmodulin is a subunit of nitric oxide synthase from macrophages. J Exp Med 176:599-604
8. Dinerman JL, Dawson TM, Schell MJ, Snowman A, Snyder SH (1994) Endothelial nitric oxide synthase localized to hippocampal pyramidal cells: implications for synaptic plasticity. Proc Natl Acad Sci USA 91:4214-4218
9. Flemstrom G. (1994) Gastric and duodenal mucosal secretion of bicarbonate. In: Johnson LR (ed) The physiology of the gastrointestinal tract. Raven, New York, pp 1285-1309
10. Konturek SJ, Brzozowski T, Majka J, Szlachcic A, Pytko-Polonczyk J (1993) Implications of nitric oxide in the action of cytoprotective drugs on gastric mucosa. J Clin Gastroenterol 17 [Suppl 1]:S140-S145
11. Kugler P, Hofer D, Mayer B, Drenckhahn D (1994) Nitric oxide synthase and NADP-linked glucose-6-phosphate dehydrogenase are co-localized in brush cells of rat stomach and pancreas. J Histochem Cytochem 42:1317-1321
12. Matsumoto T, Nakane M, Pollock JS, Kuk JE, Forstermann U (1993) A correlation between soluble brain nitric oxide synthase and NADPH diaphorase activity is only seen after exposure of the tissue to fixative. Neurosci Lett 155:61-64
13. McKee M, Scavone C, Nathanson JA (1994) Nitric oxide, cGMP, and hormone regulation of active sodium transport. Proc Natl Acad Sci USA91:2056-12060
14. Nichols K, Staines W, Krantis A (1993) Nitric oxide synthase distribution in the rat intestine: a histochemical analysis. Gastroenterology 105:1651-1661
15. Pollock JS, Nakane M, Buttery LDK, Martinez A, Springall D, Polak JM, Forstermann U, Murad F (1993) Characterization and localization of endothelial nitric oxide synthase using specific monoclonal antibodies. Am J Physiol 265:C1379-C1387
16. Price KJ, Hanson PJ, Whittle BJR (1994) Stimulation by carbachol of mucus gel thickness in rat stomach involves nitric oxide. Eur J Pharmacol 263:199-202
17. Schmidt HHHW, Gagne GD, Nakane M, Pollock JS, Miller MF, Murad F (1992) Mapping of neural nitric oxide synthase in the rat suggests frequent co-localization with NADPH diaphorase but not with soluble guanylyl cyclase, and novel paraneural functions for nitrigergic signal transduction. J Histochem Cytochem 40:1439-1456
18. Spessert R, Layes E (1994) Fixation conditions affect the intensity but not the pattern of NADPH-diaphorase staining as a marker for neuronal nitric oxide synthase in rat olfactory bulb. J Histochem Cytochem 42:1309-1315
19. Takeuchi K, Ohuchi T, Okabe S (1994) Endogenous nitric oxide in gastric alkaline response in the rat stomach after damage. Gastroenterology 106:367-374
20. Tomimoto H, Akiguchi I, Wakita H, Nakamura S, Kimura J, (1994) Histochemical demonstration of membranous localization of endothelial nitric oxide synthase in endothelial-cells of the rat-brain. Brain Res 667:107-110
21. Tracey WR, Nakane M, Pollock JS, Forstermann U (1993) Nitricoxide synthases in neuronal cells, macrophages and endothelium are NADPH diaphorases, but represent only a fraction of total cellular NADPH diaphorase activity. Biochem Biophys Res Commun 195:1035-1040
22. Tracey WR, Pollock JS, Murad F, Nakane M, Forstermann U (1994) Identification of an endothelial-like type III NO synthase in LLC-PK1 kidney epithelial cells. Am J Physiol 266:C22-C28
23. Whittle BJR (1994) Nitric oxide in gastrointestinal physiology and pathology. In: Johnson LR (ed) The physiology of the gastrointestinal tract. Raven, New York, pp 267-294
24. Whittle BJR, Lopez-Belmonte J, Moncada S (1990) Regulation of gastric mucosal integrity by endogenous nitric oxide: interactions with prostanoids and sensory neuropeptides in the rat. Br J Pharmacol 99:607-611
25. Wood J, Garthwaite J (1994) Models for diffusional spread of nitric oxide: implications for neural nitric oxide signalling and its pharmacological properties. Neuropharmacology 33:1235-1244