Glyceraldehyde-3-phosphate dehydrogenase as a target for small-molecule disease-modifying therapies in human neurodegenerative disorders

Journal of Psychiatry and Neuroscience

Volumn 29, Issue 5, 2004, Pages 337-345

  Berry, Mark D ^a,b  

^a ALviva Biopharmaceuticals Inc   (Canada)

^b BRANDON UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

1 [N (4 CHLOROBENZYL)SUCCINAMOYL]PROLINAL; 10 (N METHYL N PROPARGYLAMINOMETHYL)DIBENZO[B,F]OXEPIN; ALIPHATIC COMPOUND; APOPTOSIS INHIBITOR; DONEPEZIL; ESTRADIOL; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; ISOENZYME; N (2 HEPTYL) N METHYLPROPARGYLAMINE; NORSELEGILINE; POLYGLUTAMINE; SELEGILINE; TACRINE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; APOPTOSIS; AUTOPSY; CELL NUCLEUS; CLINICAL TRIAL; DEGENERATIVE DISEASE; DEMENTIA; GLAUCOMA; GLYCOLYSIS; HUMAN; HUNTINGTON CHOREA; MOLECULE; NONHUMAN; PARKINSON DISEASE; POLYGLUTAMINE REPEAT DISORDER; PROTEIN FUNCTION; PROTEIN SYNTHESIS; PROTEIN TRANSPORT; REVIEW; SMALL MOLECULE DISEASE MODIFYING THERAPY; THERAPY;

APOPTOSIS; ENZYME INHIBITORS; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASES; HUMANS; NEURODEGENERATIVE DISEASES; PROTEIN TRANSPORT;

EID: 9644270583     PISSN: 11804882     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (57)

1. Sirover MA. Emerging new functions of the glycolytic protein, glyceraldehyde-3-phosphate dehydrogenase, in mammalian cells. Life Sci 1996;58:2271-7.
2. Sirover MA. Role of the glycolytic protein, glyceraldehyde-3-phosphate dehydrogenase in normal cell function and in cell pathology. J Cell Biochem 1997;66:133-40.
3. Sirover MA. New insights into an old protein: the functional diversity of mammalian glyceraldehyde-3-phosphate dehydrogenase. Biochim Biophys Acta 1999;1432:159-84.
4. Berry MD, Boulton AA. Glyceraldehyde-3-phosphate dehydrogenase and apoptosis. J Neurosci Res 2000;60:150-4.
5. Lev N, Melamed E, Offen D. Apoptosis and Parkinson's disease. Prog Neuropsychopharmacol Biol Psychiatry 2003;27:245-50.
6. Raina A, Hochman A, Ickes H II, Zhu X, Ogawa O, Cash AD, et al. Apoptotic promoters and inhibitors in Alzheimer's disease: Who wins out? Prog Neuropsychopharmacol Biol Psychiatry 2003;27:251-4.
7. Hickey MA, Chesselet MF. Apoptosis in Huntington's disease. Prog Neuropsychopharmacol Biol Psychiatry 2003;27:255-65.
8. Love S. Apoptosis and brain ischaemia. Prog Neuropsychopharmacol Biol Psychiatry 2003;27:267-82.
9. Barber AJ. A new view of diabetic retinopathy: a neurodegenerative disease of the eye. Prog Neuropsychopharmacol Biol Psychiatry 2003;27:283-90.
10. Waldmeier PC. Prospects for antiapoptotic drug therapy of neurodegenerative diseases. Prog Neuropsychopharmacol Biol Psychiatry 2003;27:303-21.
11. Berry MD, Ashe PC. Glyceraldehyde-3-phosphate dehydrogenase as a target for antiapoptotic drugs. In: LeBlanc AC, editor. Neuromethods: apoptosis techniques and protocols. Vol. 37. 2nd ed. Totowa (NJ): Humana Press; 2002. p. 149-61.
12. Burke JR, Enghild JJ, Martin ME, Jou YS, Myers RM, Roses AD, et al. Huntingtin and DRLPA proteins selectively interact with the enzyme GAPDH. Nat Med 1996;2:347-50.
13. Klement IA, Skinner PJ, Kaytor MD, Yi H, Hersch SM, Clark HB, et al. Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice. Cell 1998;95:41-53.
14. Saudou F, Finkbeiner S, Devys D, Greenberg ME. Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions. Cell 1998;95:55-66.
15. Ishitani R, Fushiki S, Tatton NA, Tsuchiya K, Kuwae T, Yamada M, et al. Pro-apoptotic GAPDH protein: implications in the pathogenesis of neurodegenerative disorders [poster]. Soc Neurosci Abstr Vol. 27, Program No. 572.14, 2001. Available: http://sfn.scholarone.com/itin2001/index.html (accessed 2004 Aug. 18).
16. Ishitani R, Tajima H, Takata H, Tsuchiya K, Kuwae T, Yamada M, et al. Proapoptotic protein glyceraldehyde-3-phosphate dehydrogenase: a possible site of action of antiapoptotic drugs. Prog Neuropsychopharmacol Biol Psychiatry 2003;27:291-301.
17. Shiozawa M, Fukutani Y, Arai N, Cairns NJ, Mizutani T, Isaki K, et al. Glyceraldehyde 3-phosphate dehydrogenase and endothelin-1 immunoreactivity is associated with cerebral white matter damage in dentatorubral-pallidoluysian atrophy. Neuropathology 2003;23:36-43.
18. Mazzola JL, Sirover MA. Alteration of nuclear glyceraldehyde-3-phosphate dehydrogenase structure in Huntington's disease fibroblasts. Mol Brain Res 2002;100:95-101.
19. Tatton NA. Increased caspase 3 and Bax immunoreactivity accompany nuclear GAPDH translocation and neuronal apoptosis in Parkinson's disease. Exp Neurol 2000;166:29-43.
20. Fukuhara Y, Takeshima T, Kashiyawa Y, Mishima K, Ishitani R, Nakashima K. GAPDH antisense oligonucleotide protects dopaminergic neuronal death occurring with exposure of the cerebrospinal fluid from PD patients [poster]. Soc Neurosci Abstr Vol. 27, Program No. 198.17, 2001. Available: http://sfn.scholarone.com/ itin20021/index.html (accessed 2004 Aug. 18).
21. Fukuhara Y, Takeshima T, Kashiwaya Y, Mishima K, Ishitani R, Nakashima K. (-)-Deprenyl and GAPDH antisense oligonucleotides rescue mesencephalic dopaminergic neurons from neuronal death induced by cerebrospinal fluid from PD patients (poster). Program no. 361.14. 2002 Abstract Viewer/Itinerary Planner. Washington: Society for Neuroscience; 2002. Available: http://sfn.scholarone. com/itin2002/index.html (accessed 2004 Aug. 18).
22. Sunaga K, Takahashi H, Chuang DM, Ishitani R. Glyceraldehyde-3-phosphate dehydrogenase is over-expressed during apoptotic death of neuronal cultures and is recognized by a monoclonal antibody against amyloid plaques from Alzheimer's brain. Neurosci Lett 1995;200:133-6.
23. Schulze H, Schuler A, Stuber D, Dobeli H, Langen H, Huber G. Rat brain glyceraldehyde-3-phosphate dehydrogenase interacts with the recombinant cytoplasmic domain of Alzheimer's β-amyloid precursor protein. J Neurochem 1993;60:1915-22.
24. Mazzola JL, Sirover MA. Subcellular alteration of glyceraldehyde-3- phosphate dehydrogenase in Alzheimer's disease fibroblasts. J Neurosci Res 2003;71:279-85.
25. Mittag TW, Tatton NA, Wax M, Edward D, Chalmers-Redman RME, Tatton WG. Increased retinal ganglion cell (RGC) GAPDH, Bax and activated caspase 3 in a rat model and in human glaucoma [poster]. Association for Research in Vision and Ophthalmology meeting; 2001 Apr 25-May 4; Fort Lauderdale, Fla.
26. Tanaka R, Mochizuki H, Suzuki A, Katsube N, Ishitani R, Mizuno Y, et al. Induction of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) expression in rat brain after focal ischemia/reperfusion. J Cereb Blood Flow Metab 2002;22:280-8.
27. Meyer-Siegler K, Mauro DJ, Seal G, Wurzer J, DeRiel JK, Sirover MA. A human nuclear uracil DNA glycosylase is the 37kDa subunit of glyceraldehyde-3-phosphate dehydrogenase. Proc Natl Acad Sci USA 1991;88:8460-4.
28. Saunders PA, Chen RW, Chuang DM. Nuclear translocation of glyceraldehyde-3-phosphate dehydrogenase isoforms during neuronal apoptosis. J Neurochem 1999;72:925-32.
29. Sawa A, Khan AA, Hester LD, Snyder SH. Glyceraldehyde-3-phosphate dehydrogenase: nuclear translocation participates in neuronal and nonneuronal cell death. Proc Natl Acad Sci U S A 1997;94:11669-74.
30. Dastoor Z, Dreyer JL. Potential role of nuclear translocation of glyceraldehyde-3-phosphate dehydrogenase in apoptosis and oxidative stress. J Cell Sci 2001;114:1643-53.
31. Maruyama W, Oya-Ito T, Shamoto-Nagai M, Osawa T, Naoi M. Glyceraldehyde-3-phosphate dehydrogenase is translocated into nuclei through Golgi apparatus during apoptosis induced by 6-hydroxydopamine in human dopaminergic SH-SY5Y cells. Neurosci Lett 2002;321:29-32.
32. Shashidharan P, Chalmers-Redman RME, Carlile GW, Rodic V, Gurvich N, Yuen T, et al. Nuclear translocation of GAPDH-GFP fusion protein during apoptosis. NeuroReport 1999;10:1149-53.
33. Ishitani R, Chuang DM. Glyceraldehyde-3-phosphate dehydrogenase antisense oligodeoxynucleotides protect against cytosine arabinonucleoside-induced apoptosis in cultured cerebellar neurons. Proc Natl Acad Sci USA 1996;93:9937-41.
34. +-induced apoptosis but not necrosis of cultured cerebellar granule cells. Mol Pharmacol 1997;51:542-50.
35. Chen RW, Saunders PA, Wei H, Li Z, Seth P, Chuang DM. Involvement of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and p53 in neuronal apoptosis: evidence that GAPDH is upregulated by p53. J Neurosci 1999;19:9654-62.
36. Saunders PA, Chalecka-Franaszek E, Chuang DM. Subcellular distribution of glyceraldehyde-3-phosphate dehydrogenase in cerebellar granule cells undergoing cytosine arabinoside-induced apoptosis. J Neurochem 1997;69:1820-8.
37. +-induced apoptosis. Neuroreport 2001;12:2049-52.
38. Ishitani R, Tanaka M, Sunaga K, Katsube N, Chuang DM. Nuclear localization of overexpressed glyceraldehyde-3-phosphate dehydrogenase in cultured cerebellar neurons undergoing apoptosis. Mol Pharmacol 1998;53:701-7.
39. Edwards YH, Clark P, Harris H. Isozymes of glyceraldehyde-3-phosphate dehydrogenase in man and other mammals. Ann Hum Genet 1976;40:67-77.
40. Soukri A, Valverde F, Hafid N, Elkebbaj MS, Serrano A. Characterization of muscle glyceraldehyde-3-phosphate dehydrogenase isoforms from euthermic and induced hibernating Jaculus orientalis. Biochim Biophys Acta 1995;1243:161-8.
41. Mezquita J, Pau M, Mezquita C. Several novel transcripts of glyceraldehyde-3-phosphate dehydrogenase expressed in adult chicken testis. J Cell Biochem 1998;71:127-39.
42. Piechaczyk M, Blanchard JM, Riaad-El Sabouty S, Dani C, Marty L, Jeanteur P. Unusual abundance of vertebrate 3-phosphate dehydrogenase pseudogenes. Nature 1984;312:469-71.
43. Graven KK, Yu Q, Pan D, Roncarati JS, Farber HW. Identification of an oxygen responsive enhancer element in the glyceraldehyde-3-phosphate dehydrogenase gene. Biochim Biophys Acta 1999;1447:208-18.
44. Lu S, Gu X, Hoestje S, Epner DE. Identification of an additional hypoxia responsive element in the glyceraldehyde-3-phosphate dehydrogenase gene promoter. Biochim Biophys Acta 2002;1574:152-6.
45. Morgenegg G, Winkler GC, Hubscher U, Heizmann CW, Mous J, Kuenzle CC. Glyceraldehyde-3-phosphate dehydrogenase is a nonhistone protein and a possible activator of transcription in neurons. J Neurochem 1986;47:54-62.
46. Tatton WG. Apoptotic mechanisms in neurodegeneration: possible relevance to glaucoma. Eur J Ophthalmol 1999;9(Suppl 1):S22-9.
47. Ramirez VD, Kipp JL, Joe I. Estradiol, in the CNS, targets several physiologically relevant membrane-associated proteins. Brain Res Brain Res Rev 2001;37:141-52.
48. Carlile GW, Chalmers-Redman RME, Tatton NA, Pong A, Borden KE, Tatton WG. Reduced apoptosis after nerve growth factor and serum withdrawal: conversion of tetrameric glyceraldehyde-3-phosphate dehydrogenase to a dimer. Mol Pharmacol 2000;57:2-12.
49. Kragten E, Lalande I, Zimmermann K, Roggo S, Schindler P, Muller D, et al. Glyceraldehyde-3-phosphate dehydrogenase, the putative target of the antiapoptotic compounds CGP 3466 and R-(-)-deprenyl. J Biol Chem 1998;273:5821-8.
50. Berry MD. R-2HMP: an orally active agent combining independent antiapoptotic and MAO-B-inhibitory activities. CNS Drug Rev 1999;5:105-24.
51. Suresh S, Bressi JC, Kennedy KJ, Verlinde CL, Gelb MH, Hol WG. Conformational changes in Leishmania mexicana glyceraldehyde-3-phosphate dehydrogenase induced by designed inhibitors. J Mol Biol 2001;309:423-35.
52. Zhang D. Anti-apoptotic actions of R-2HMP in cerebellar granule cells: changes of mitochondrial membrane potential and sub-cellular GAPDH protein [dissertation]. Saskatoon (SK): University of Saskatchewan; 2001.
53. Kusner LL, Sarthy VP, Mohr S. Nuclear translocation of glyceraldehyde-3-phosphate dehydrogenase: a role in high glucose-induced apoptosis in retinal Muller cells. Invest Ophthalmol Vis Sci 2004;45(5):1553-61.
54. Takasaki Y, Kaneda K, Matsushita M, Yamada H, Nawata M, Matsudaira R, et al. Glyceraldehyde 3-phosphate dehydrogenase is a novel autoantigen leading autoimmune responses to proliferating cell nuclear antigen multiprotein complexes in lupus patients. Int Immunol 2004;16(9):1295-304.
55. Mazzola JL, Sirover MA. Subcellular analysis of aberrant protein structure in age-related neurodegenerative disorders. J Neurosci Methods 2004;137(2):241-6.
56. Brown VM, Krynetski EY, Krynetskaia NF, Grieger D, Mukatira ST, Murti KG, et al. A novel CRM1-mediated nuclear export signal governs nuclear accumulation of glyceraldehyde-3-phosphate dehydrogenase following genotoxic stress. J Biol Chem 2004;279(7):5984-92.
57. Kanai H, Sawa A, Chen RW, Leeds P, Chuang DM. Valproic acid inhibits histone deacetylase activity and suppresses excitotoxicity-induced GAPDH nuclear accumulation and apoptotic death in neurons. Pharmacogenomics J 2004;Aug 3 (electonic publication ahead of print).