Improvement of warfarin biopharmaceutics by conjugation with poly(ethylene glycol)

European Journal of Pharmaceutical Sciences

Volumn 23, Issue 4-5, 2004, Pages 379-384

  Zacchigna, Marina ^a   Di Luca, Gabriella ^a   Cateni, Francesca ^a   Maurich, Venerando ^a  

^a UNIVERSITY OF TRIESTE   (Italy)

Author keywords

Macromolecular prodrugs; Pharmacokinetic; Poly(ethylene glycol); Warfarin

Indexed keywords

MACROGOL; WARFARIN;

ARTICLE; CONJUGATION; DRUG RELEASE; HYDROLYSIS; PH MEASUREMENT; PRIORITY JOURNAL; ROOM TEMPERATURE; SOLUBILITY;

ADMINISTRATION, ORAL; ANIMALS; CALIBRATION; ELECTROCHEMISTRY; INJECTIONS, INTRAPERITONEAL; INTUBATION, GASTROINTESTINAL; MALE; POLYETHYLENE GLYCOLS; RABBITS; WARFARIN;

EID: 9644266599     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2004.09.001     Document Type: Article

References (13)

1. AA.VV. K. Parfitt Martindale. The Complete Drug Reference 32nd ed. 1999 Pharmaceutical Press London 964 971
2. H.O. Ammar, M. Ghorab, S.A. el-Nahhas, and T.S. Makram Improvement of biological performance of oral anticoagulant drugs. 1. Warfarin Pharmazie 52 1997 627 631
3. S.A. Babhair, M.A. Tariq, and A.A. Al-Bard Warfarin. K. Florey Analytical Profiles of Drugs Substances vol. 14 1985 Academic Press Inc. 423 449
4. T.D. Bjornsson, T.F. Blasche, and P.J. Meffin High-pressure liquid chromatographic analysis of drugs in biological fluids I: Warfarin J. Pharm. Sci. 66 1977 142 145
5. G. Gasic, T.B. Gasic, and C.C. Steward Antimetastatic effects associated with platelet reduction Proc. Natl. Acad. Sci. U.S.A. 61 1968 46 52
6. R.B. Greenwald, Y.H. Choe, J. McGuire, and C.D. Conover Effective drug delivery by PEGylated drug conjugates Adv. Drug Deliv. Rev. 55 2003 217 250
7. S.A. Smith, S.L. Kraft, D.C. Lewis, and L.C. Freeman Plasma pharmacokinetics of warfarin enantiomers in cats J. Vet. Pharmacol. Ther. 23 2000 329 337
8. S.A. Smith, S.L. Kraft, D.C. Lewis, S. Melethil, and L.C. FKreeman Pharmacodynamics of warfarin in cats J. Vet. Pharmacol. Ther. 23 2000 339 344
9. J. Stangier, C.A. Su, M.G. Hendriks, J.J. van Lier, F.A. Sollie, B. Oosterhius, and J.H. Jonkman Steady-state pharmacodynamics of warfarin in presence and absence of telmisartan in healthy male volunteers J. Clin. Pharmacol. 40 2000 1331 1337
10. P.G. Welling, and M.R. Dobrinska R.J. Robinson V.H.L. Lee Controlled drug delivery: Fundamentals and Applications vol. 29 1987 Marcel Dekker Inc. New York 253 291
11. M. Zacchigna, G. Di Luca, F. Cateni, S. Zorzet, and V. Maurich Improvement of physicochemical and biopharmaceutical properties of theophylline by poly(ethylene glycol) conjugates Il Farmaco. 58 2003 1307 1312
12. M. Zacchigna, G. Di Luca, V. Maurich, and E. Boccù Syntheses, chemical and enzymatic stability of new poly(ethylene glycol)-acyclovir prodrugs Il Farmaco. 57 2002 207 214
13. S. Zalipsky, C. Gilon, and A. Zilkha Attachment of drugs to polyethylene glycols Eur. Polym. J. 19 1983 1177 1183