Plasma pharmacokinetics of warfarin enantiomers in cats

Journal of Veterinary Pharmacology and Therapeutics

Volumn 23, Issue 6, 2000, Pages 329-337

  Smith, S A ^a,d   Kraft, S L ^a,b   Lewis, D C ^a,c   Freeman, L C ^a  

^a KANSAS STATE UNIVERSITY   (United States)

^b USA   (United States)

^c ANTECH DIAGNOSTICS   (United States)

^d UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

WARFARIN;

AREA UNDER THE CURVE; ARTICLE; CAT; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DISPOSITION; DRUG HALF LIFE; DRUG PROTEIN BINDING; ENANTIOMER; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; PRIORITY JOURNAL;

ADMINISTRATION, ORAL; ANIMALS; ANTICOAGULANTS; AREA UNDER CURVE; CATS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; INJECTIONS, INTRAVENOUS; INTESTINAL ABSORPTION; MALE; PROTEIN BINDING; STEREOISOMERISM; TISSUE DISTRIBUTION; WARFARIN;

EID: 0034492498     PISSN: 01407783     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2885.2000.00269.x     Document Type: Article

References (30)

1. Risk factors, clinical signs, and survival in cats with a clinical diagnosis of idiopathic hypertrophic cardiomyopathy: 74 Cases (1985-1989)
2. Site I on human albumin: Differences in the binding of (R)- and (S)-warfarin
3. Location and characterization of the warfarin binding site of human serum albumin. A comparative study of two large fragments
4. A study of the relationship between the pharmacokinetics and the pharmacodynamics of the 4-hydroxycoumarin anticoagulants warfarin, difenacoum and brodifacoum in the rabbit
5. Species differences of the stereoselective binding of phenprocoumon and warfarin enantiomers to serum albumins
6. A simplified high-performance liquid chromatographic method for direct determination of warfarin enantiomers and their protein binding in stroke patients
7. Stereochemical aspects of warfarin drug interactions: Use of a combined pharmacokinetic-pharmacodynamic model
8. Disposition of warfarin enantiomers and metabolites in patients during multiple dosing with rac-warfarin
9. Comparative pharmacokinetics of coumarin anticoagulants. XLIX: Nonlinear tissue distribution of Swarfarin in rats
10. Warfarin therapy of the cat at risk of thromboembolism
11. Comparison of the rat liver microsomal metabolism of the enantiomers of warfarin and 4′-nitrowarfarin (acenocoumarol)
12. Plasma half-lives, plasma metabolites and anticoagulant efficacies of the enantiomers of warfarin in man
13. Kinetics of R and S warfarin enantiomers
14. Oral anticoagulant drugs
15. Prediction of pharmacokinetic drug/drug interactions from in vitro data: Interactions of the nonsteroidal anti-inflammatory drug lornoxicam with oral anticoagulants
16. A retrospective study of 100 cases of feline distal aortic thromboembolism: 1977-1993
17. Species-dependent enantioselective plasma protein binding of MK-571, a potent leukotriene D4 antagonist
18. Pharmacologic considerations in the cat
19. Measurement of the (R)- and (S)-isomers of warfarin in patients undergoing anticoagulant therapy
20. Feline hypertrophic cardiomyopathy
21. Development and validation of a high-performance liquid chromatographic method for the quantitation of warfarin enantiomers in human plasma
22. A comparison of drug binding sites on mammalian albumins
23. Warfarin: Metabolism and mode of action
24. Species differences and interindividual variation in liver microsomal cytochrome P450 2A enzymes: Effects on coumarin, dicumarol, and testosterone oxidation
25. The disposition of the enantiomers of warfarin following chronic administration to rats: Relationship to anticoagulant response
26. Characteristics of warfarin hydroxylation catalyzed by human liver microsomes
27. Pharmacodynamics of warfarin in cats
28. The warfarin-sulfinpyrazone interaction: Stereochemical considerations
29. Pharmacokinetics of the warfarin enantiomers in rats
30. Human liver cytochrome P450 enzymes involved in the 7-hydroxylation of R- and S-warfarin enantiomers