Growth limiting substrate affects antibiotic production and associated metabolic fluxes in Streptomyces clavuligerus

Biotechnology Letters

Volumn 22, Issue 22, 2000, Pages 1803-1809

  Kirk, Samantha ^a   Avignone Rossa, Claudio A ^a   Bushell, Michael E ^a  

^a UNIVERSITY OF SURREY   (United Kingdom)

Author keywords

Chemostat culture; Clavulanic acid; Fermentation technology; Metabolic flux analysis

Indexed keywords

AMINO ACID; ANTIBIOTIC AGENT; CLAVULANIC ACID; GLUTAMIC ACID; NITROGEN;

ARTICLE; BIOREACTOR; BIOSYNTHESIS; CHEMOSTAT; CITRIC ACID CYCLE; GROWTH RATE; METABOLISM; NUTRIENT; STREPTOMYCES CLAVULIGERUS;

EID: 0033668863     PISSN: 01415492     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1005670603596     Document Type: Article

References (29)

1. Regulation of nitrogen catabolic enzymes in Streptomyces clavuligerus
2. Alpha-oxogutarate
3. The application of materials balancing to the characterisation of sequential secondary metabolite formation in Streptomyces cattleya NRRL 8057
4. A physiological control model for erythromycin production in batch and cyclic fed batch culture
5. Oxygen limitation can induce microbial secondary metabolite formation: Investigations with miniature electrodes in shaker and bioreactor culture
6. Activity of phosphoenolpyruvate carboxylase of an anthracycline-producing streptomycete
7. New type of hexameric ornithine carbamoyltransferase with arginase activity in the cephamycin producers Streptomyces clavuligerus and Nocardia lactamdurans
8. Metabolic control of secondary biosynthetic pathways
9. The identification of three new biosynthetic intermediates and one further biosynthetic enzyme in the clavulanic acid pathway
10. Assay of Amoxicillin and clavulanic acid, the components of Augmentin, in biological fluids with high performance liquid chromatography
11. Fatty acid composition of Streptomyces hygroscopicus strains producing antibiotics
12. Clavulanic acid biosynthesis in Streptomyces clavuligerus: Gene cloning and characterization
13. Flux analysis and control of the central metabolic pathways in Escherichia coli
14. Manipulation of the physiology of clavulanic acid production in Streptomyces clavuligerus
15. Biosynthesis and molecular genetics of clavulanic acid
16. The physiology of erythromycin biosynthesis in cyclic fed batch culture
17. Estimation of the kinetic constants and elucidation of trends in growth and erythromycin production in batch and continuous cultures of Saccharopolyspora erythraea using curve fitting techniques
18. Importance of stored triacylglycerols in Streptomyces: Possible carbon source for antibiotics
19. Clavulanic acid: A β-lactamase-inhibiting β-lactam from Streptomyces clavuligerus Antimicrobiol
20. Pathways of glucose catabolism during germination of Streptomyces spores
21. Growth rate control of protein and nucleic acid content in Streptomyces coelicolor A3(2) and Escherichia coli B/r
22. Studies on the biosynthesis of clavulanic acid. II Chemical degradations of (14)C-Iabelled clavulanic acid
23. 5 unit
24. Evidence that arginine is a later metabolic intermediate than ornithine in the biosynthesis of clavulanic acid by Streptomyces clavuligerus
25. Application of metabolic flux analysis for the identification of metabolic bottlenecks in the biosynthesis of Penicillin G
26. Oxaloacetate
27. The induction of antibiotic synthesis in Saccharopolyspora erythraea and Streptomyces hygroscopicus by growth rate decrease is accompanied by a down-regulation of protein synthesis rate