Optimisation of medium composition for clavulanic acid production by Streptomyces clavuligerus

Biotechnology Letters

Volumn 23, Issue 2, 2001, Pages 157-161

  Gouveia, Ester R ^a   Baptista Neto, Alvaro ^a   Badino Jr , Alberto C ^a   Hokka, Carlos O ^a  

^a FEDERAL UNIVERSITY OF SÃO CARLOS   (Brazil)

Author keywords

Clavulanic acid; Empirical model; Experimental design; Medium composition; Streptomyces clavuligerus

Indexed keywords

CLAVULANIC ACID; GLYCEROL; NITROGEN;

ANTIBIOTIC BIOSYNTHESIS; ARTICLE; BACTERIUM CULTURE; CONTROLLED STUDY; CULTURE MEDIUM; DRUG MANUFACTURE; DRUG SYNTHESIS; NONHUMAN; SOYBEAN; STATISTICAL MODEL; STREPTOMYCES CLAVULIGERUS;

EID: 0035138488     PISSN: 01415492     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1010356231673     Document Type: Article

References (11)

1. Clavulanic acid: Properties, biosynthesis and fermentation
2. Assay of amoxicillin and clavulanic acid, the components of Augmentin, in biological fluids with HPLC
3. Improvement of clavulanic acid production by Streptomyces clavuligerus in medium containing soybean derivatives
4. Manipulation of the physiology of clavulanic acid production in Streptomyces clavuligerus
5. Economic improvement of the fermentative production of gallidermin by Staphylococcus gallinarum
6. Phosphate repression of cephamycin and clavulanic acid production by Streptomyces clavuligerus
7. Production of clavulanic acid and cephamycin C by Streptomyces clavuligerus
8. Simultaneous production and decomposition of clavulanic acid during Streptomyces clavuligerus cultivation
9. Clavulanic acid: A β-lactam from Streptomyces clavuligerus
10. Regulation of lysine ε-aminotransferase by carbon source and lack of control by phosphate in Streptomyces clavuligerus