Protective effects of a free radical scavenger, MCI-186, on high-glucose-induced dysfunction of human dermal microvascular endothelial cells

Wound Repair and Regeneration

Volumn 12, Issue 6, 2004, Pages 607-612

  Jiaojun, Dong ^a,b   Takami, Yoshihiro ^a,c   Tanaka, Hideharu ^a   Yamaguchi, Ryo ^a   Jingping, Guo ^a   Chun, Qing ^b   Shuliang, Lu ^b   Shimazaki, Shuji ^a   Ogo, Ken ^a  

^a KYORIN UNIVERSITY   (Japan)

^b SHANGHAI SECOND MEDICAL UNIVERSITY   (China)

^c KYORIN UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; GLUCOSE; GROWTH FACTOR; MANNITOL; MITOGEN ACTIVATED PROTEIN KINASE; NORPHENAZONE; SCAVENGER; TUMOR NECROSIS FACTOR ALPHA;

APOPTOSIS; ARTICLE; CELL CULTURE; CELL DAMAGE; CELL PROLIFERATION; CELL PROTECTION; CONTROLLED STUDY; CULTURE MEDIUM; DIABETES MELLITUS; DRUG MECHANISM; ENZYME ACTIVATION; HUMAN; HUMAN CELL; HYPERGLYCEMIA; OSMOSIS; PRIORITY JOURNAL; STRESS; VASCULAR ENDOTHELIUM;

ANTIPYRINE; APOPTOSIS; BLOTTING, WESTERN; CASPASE 3; CASPASES; CELL PROLIFERATION; CELLS, CULTURED; ENDOTHELIAL CELLS; FREE RADICAL SCAVENGERS; HUMANS; HYPERGLYCEMIA; MICROCIRCULATION; MITOGEN-ACTIVATED PROTEIN KINASE 3; SKIN; TUMOR NECROSIS FACTOR-ALPHA;

EID: 9644254050     PISSN: 10671927     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1067-1927.2004.12607.x     Document Type: Article

References (29)

1. McKinlay J, Marceau L. US public health and the 21st century: diabetes mellitus. Lancet 2000;356:757-61.
2. McMurry JF Jr. Wound healing with diabetes mellitus. Better glucose control for better wound healing in diabetes. Surg Clin North Am 1984;64:769-78.
3. Mudge BP, Harris C, Gilmont RR, Adamson BS, Rees RS. Role of glutathione redox dysfunction in diabetic wounds. Wound Rep Reg 2002;10:53-8.
4. King GL. The role of hyperglycemia and hyperinsulinaemia in causing vascular dysfunction in diabetes. Ann Med 1996;28: 427-32.
5. Ishibashi T, Inomata H. Ultrastructure of retinal vessels in diabetic patients. Br J Ophtalmol 1993;77:574-8.
6. Inoguchi T, Battan R, Handler E, Sportsman R, Heath W, King GL. Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation. Proc Natl Acad Sci USA 1992;89:11059-63.
7. Koya D, King GL. Protein kinase C activation and the development of diabetic complications. Diabetes 1998;47:859-66.
8. Vlassara H, Palace MR. Diabetes and advanced glycation endproducts. J Intern Med 2002;251:87-101.
9. Baynes JW. Role of oxidative stress in development of complications in diabetes. Diabetes 1991;40:405-12.
10. Giugliano D, Ceriello A, Paolisso G. Oxidative stress and diabetic vascular complications. Diabetes Care 1996;19:257-67.
11. Uemura S, Matsushita H, Li W, Glassford AJ, Asagami T, Lee KH, Harrison DG, Taso PS. Diabetes mellitus enhances vascular matrix metalloproteinase activity: role of oxidative stress. Circ Res 2001;88:1291-8.
12. Soriano FG, Virag L, Szabo C. Diabetic endothelial dysfunction: role of reactive oxygen and nitrogen species production and poly (ADP-ribose) polymerase activation. J Mol Med 2001;79: 437-48.
13. Abe K, Yuki S, Kogure K. Strong attenuation of ischemic and postischemic brain edema in rats by a novel free radical scavenger. Stroke 1988;19:480-5.
14. Watanabe T, Morita I, Nishi H, Murota SI. Preventive effect of MCI-186 on 15-HPETE induced vascular endothelial cell injury in vitro. Prostaglandins Leukot Essent Fatty Acids 1988;33:81-7.
15. Watanabe T, Yuki S, Egawa M, Nishi H. Protective effects of MCI-186 on cerebral ischemia: possible involvenment of free radical scavenging and antioxidant actions. J Pharmacol Exp Ther 1994;268:1597-604.
16. Kawai H, Nakai H, Suga M, Yuki S, Watanabe T, Saito KI. Effects of novel free radical scavenger, MCI-186, on ischemic brain damage in the rat distal middle cerebral artery occlusion model. J Pharmacol Exp Ther 1997;281:921-7.
17. Abe A, Inokuchi J, Jimbo M, Shimeno H, Nagamatsu A, Shayman JA, Shukla GS, Radin NS. Improved inhibitors of glucosylceramide synthase. J Biochem 1992;111:191-6.
18. Morishita R, Nakamura S, Nakamura Y, Aoki Motokuni Moriguchi A, Kida I, Yo Y, Matsumoto K, Nakamura T, Higaki N, Ogihara T. Potential role of an endothelium-specific growth factor, hepatocyte growth factor, on endothelial damage in diabetes. Diabetes 1997;46:138-42.
19. Lynch K, Fernandes A, Pappalardo A, Peruso JJ. Basic fibroblast growth factor inhibits apoptosis of spontaneously immortalized granuloma cells by regulating intracellular free calcium levels through a protein kinase C-dependent pathway. Endocrinology 2000;141:4209-17.
20. Petrache I, Verin AD, Crow MT, Birukova A, Liu F, Garcia JG. Differential effect of MLC kinase in TNF-alpha-induced endothelial cell apoptosis and barrier dysfunction. Am J Physiol Lung Cell Mol Physiol 2001;280:L1168-78.
21. Stull ND, Polan DP, Iacovitti L. Antioxidant compounds protect dopamine neurons from death due to oxidative stress in vitro. Brain Res 2002;931:181-5.
22. Giardino I, Edelstein D, Brownlee M. Nonenzymatic glycosylation in vitro and in bovine endothelial cells alters basic fibroblast growth factor activity. J Clin Invest 1994;94:110-7.
23. Nakagami H, Morishita R, Yamamoto K, Yoshimura S, Taniyama Y, Aoki M, Matsubara H, Kim S, Kaneda Y, Ogihara T. Phosphorylation of p38 mitogen-activated protein kinase downstream of bax-caspase-3 pathway leads to cell death induced by high D-glucose in human endothelial cells. Diabetes 2001;50:1472-81.
24. Nakagami H, Morishita R, Yamamoto K, Taniyama Y, Aoki M, Yamasaki K, Matsumoto K, Nakamura T, Kaneda Y, Ogihrara T. Hepatocyte growth factor prevents endothelial cell death through inhibition of bax translocation from cytosol to mitochondrial membrane. Diabetes 2002;51:2604-11.
25. Haunstetter A, Izumo S. Apoptosis basic mechanism and implications for cardiovascular disease. Circ Res 1998;82:1111-29.
26. Choy JC, Granville DJ, Hunt DWC, McManus BM. Endothelial cell apoptosis: biochemical characteristics and potential implications for atherosclerosis. J Mol Cell Cardiol 2001;33:1673-90.
27. Liu W, Schoenkerman A, Lowe WL Jr. Activation of members of the mitogen-activated protein kinase family by glucose in endothelial cells. Am J Physiol Endocrinol Metab 2000;279: E782-90.
28. Werle M, Schmal U, Hanna K, Kreuzer J. MCP-1 induces activation of MAP-kinases ERK, JUK and p38 MAPK in human endothelial cells. Cardiovasc Res 2002;56:284-92.
29. Yates S, Rayner TE. Transcription factor activation in response to cutaneous injury: role of AP-1 reepithelialization. Wound Rep Reg 2002;10:5-15.