Iris pigment epithelium attachment to aged submacular human Bruch's membrane

Investigative Ophthalmology and Visual Science

Volumn 45, Issue 12, 2004, Pages 4520-4528

  Itaya, Hiroshi ^a   Gullapalli, Vamsi ^a   Sugino, Ilene K ^a   Tamai, Makoto ^b   Zarbin, Marco A ^a  

^a INSTITUTE OF OPHTHALMOLOGY AND VISUAL SCIENCE   (United States)

^b TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; INTEGRIN; LIGAND;

ADULT; AGED; ARTICLE; BASEMENT MEMBRANE; BRUCH MEMBRANE; CELL ADHESION; CELL AGGREGATION; CELL CULTURE; CELL DIFFERENTIATION; CELL ISOLATION; CELL STRUCTURE; CELL SURFACE; CELL SURVIVAL; CLINICAL ARTICLE; CONTROLLED STUDY; EXTRACELLULAR MATRIX; GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; INTEGRIN GENE; INTEGRIN SUBUNIT ALPHA1 GENE; INTEGRIN SUBUNIT ALPHA2 GENE; INTEGRIN SUBUNIT ALPHA3 GENE; INTEGRIN SUBUNIT ALPHA4 GENE; INTEGRIN SUBUNIT ALPHA5 GENE; INTEGRIN SUBUNIT ALPHA6 GENE; INTEGRIN SUBUNIT BETA1 GENE; IRIS; IRIS PIGMENTED LAYER; LIGAND BINDING; ORGAN CULTURE; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETINA MACULA AGE RELATED DEGENERATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION;

AGED; AGED, 80 AND OVER; AGING; BRUCH MEMBRANE; CELL DIVISION; HUMANS; IMMUNOHISTOCHEMISTRY; INTEGRIN ALPHA CHAINS; IRIS; MICROSCOPY, ELECTRON, SCANNING; MIDDLE AGED; PIGMENT EPITHELIUM OF EYE; PROTEIN ISOFORMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TIME FACTORS; TISSUE CULTURE TECHNIQUES;

EID: 9644252640     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.04-0684     Document Type: Article

References (61)

1. Ferris FL III, Fine SL, Hyman L. Age-related macular degeneration and blindness due to neovascular maculopathy. Arch Ophthalmol. 1984;102:1640-1642.
2. Thomas MA, Grand MG, Williams DF, Lee CM, Pesin SR, Lowe MA. Surgical management of subfoveal choroidal neovascularization. Ophthalmology. 1992;99:952-968; discussion 975-976.
3. Nasir MA, Sugino I, Zarbin MA. Decreased choriocapillaris perfusion following surgical excision of choroidal neovascular membranes in age-related macular degeneration. Br J Ophthalmol. 1997;81:481-489.
4. Merrill PT, LoRusso FJ, Lomeo MD, Saxe SJ, Khan MM, Lambert HM. Surgical removal of subfoveal choroidal neovascularization in age-related macular degeneration. Ophthalmology. 1999;106:782-789.
5. Castellarin AA, Nasir MA, Sugino IK, Zarbin MA. Clinicopathological correlation of primary and recurrent choroidal neovascularisation following surgical excision in age related macular degeneration. Br J Ophthalmol. 1998;82:480-487.
6. Rosa RH, Thomas MA, Green WR. Clinicopathologic correlation of submacular membranectomy with retention of good vision in a patient with age-related macular degeneration. Arch Ophthalmol. 1996;114:480-487.
7. Hsu JK, Thomas MA, Ibanez H, Green WR. Clinicopathologic studies of an eye after submacular membranectomy for choroidal neovascularization. Retina. 1995;15:43-52.
8. Grossniklaus HE, Green WR. Histopathologic and ultrastructural findings of surgically excised choroidal neovascularization. Submacular Surgery Trials Research Group. Arch Ophthalmol. 1998;116:745-749.
9. Dorey CK, Wu G, Ebenstein D, Garsd A, Weiter JJ. Cell loss in the aging retina: relationship to lipofuscin accumulation and macular degeneration. Invest Ophthalmol Vis Sci. 1989;30:1691-1699.
10. Del Priore LV, Kaplan HJ, Hornbeck R, Jones Z, Swinn M. Retinal pigment epithelial debridement as a model for the pathogenesis and treatment of macular degeneration. Am J Ophthalmol. 1996;122:629-643.
11. Leonard DS, Zhang XG, Panozzo G, Sugino IK, Zarbin MA. Clinicopathologic correlation of localized retinal pigment epithelium debridement. Invest Ophthalmol Vis Sci. 1997;38:1094-1109.
12. Li LX, Turner JE. Inherited retinal dystrophy in the RCS rat: prevention of photoreceptor degeneration by pigment epithelial cell transplantation. Exp Eye Res. 1988;47:911-917.
13. Little CW, Castillo B, DiLoreto DA, et al. Transplantation of human fetal retinal pigment epithelium rescues photoreceptor cells from degeneration in the Royal College of Surgeons rat retina. Invest Ophthalmol Vis Sci. 1996;37:204-211.
14. Gouras P, Kong J, Tsang SH. Retinal degeneration and RPE transplantation in Rpe65(-/-) mice. Invest Ophthalmol Vis Sci. 2002;43:3307-3311.
15. Peyman GA, Blinder KJ, Paris CL, Alturki W, Nelson NC Jr, Desai UR. A technique for retinal pigment epithelium transplantation for age-related macular degeneration secondary to extensive subfoveal scarring. Ophthalmic Surg. 1991;22:102-108.
16. Binder S, Stolba U, Krebs I, et al. Transplantation of autologous retinal pigment epithelium in eyes with foveal neovascularization resulting from age-related macular degeneration: a pilot study. Am J Ophthalmol. 2002;133:215-225.
17. Del Priore LV, Kaplan HJ, Tezel TH, Hayashi N, Berger AS, Green WR. Retinal pigment epithelial cell transplantation after subfoveal membranectomy in age-related macular degeneration: Clinicopathologic correlation. Am J Ophthalmol. 2001;131:472-480.
18. Algvere PV, Gouras P, Dafgard Kopp E. Long-term outcome of RPE allografts in non-immunosuppressed patients with AMD. Eur J Ophthalmol. 1999;9:217-230.
19. Majji AB, de Juan E Jr. Retinal pigment epithelial autotransplantation: morphological changes in retina and choroid. Graefes Arch Clin Exp Ophthalmol. 2000;238:779-791.
20. Tezel TH, Del Priore LV. Reattacnment to a substrate prevents apoptosis of human retinal pigment epithelium. Graefes Arch Clin Exp Ophthalmol. 1997;235:41-47.
21. Castellarin AA, Sugino IK, Vargas JA, Parolini B, Lui GM, Zarbin MA. In vitro transplantation of fetal human retinal pigment epithelial cells onto human cadaver Bruch's membrane. Exp Eye Res. 1998;66:49-67.
22. Tezel TH, Kaplan HJ, Del Priore LV. Fate of human retinal pigment epithelial cells seeded onto layers of human Bruch's membrane. Invest Ophthalmol Vis Sci. 1999;40;467-476.
23. Tsukahara I, Ninomiya S, Castellarin A, Yagi F, Sugino IK, Zarbin MA. Early attachment of uncultured retinal pigment epithelium from aged donors onto Bruch's membrane explants. Exp Eye Res. 2002;74:255-266.
24. Zarbin MA. Analysis of retinal pigment epithelium integrin expression and adhesion to aged submacular human Bruch's membrane. Trans Am Ophthalmol Soc. 2003;101:499-520.
25. Tamai M. Retinal pigment epithelial cell transplantation: perspective (in Japanese). Nippon Ganka Gakkai Zasshi. 1996;100:982-1006.
26. Rezai KA, Kohen L, Wiedemann P, Heimann K. Iris pigment epithelium transplantation. Graefes Arch Clin Exp Ophthalmol. 1997;235:558-562.
27. Abe T, Tomita H, Kano T, et al. Autologous iris pigment epithelial cell transplantation in monkey subretinal region. Curr Eye Res. 2000;20:268-275.
28. Abe T, Yoshida M, Tomita H, et al. Auto iris pigment epithelial cell transplantation in patients with age-related macular degeneration: short-term results. Tohoku J Exp Med. 2000;191:7-20.
29. Lappas A, Weinberger AW, Foerster AM, Kube T, Rezai KA, Kirchhof B. Iris pigment epithelial cell translocation in exudative age-related macular degeneration: a pilot study in patients. Graefes Arch Clin Exp Ophthalmol. 2000;238:631-641.
30. Hogan MJ, Alvarado JA, Weddell JE. Iris. Histology of the Human Eye. Philadelphia: WB Saunders; 1971:204-255.
31. Rezai KA, Lappas A, Farrokh-siar L, Kohen L, Wiedemann P, Heimann K. Iris pigment epithelial cells of long evans rats demonstrate phagocytic activity. Exp Eye Res. 1997;65:23-29.
32. Schraertneyer U, Enzmann V, Kohen L, Addicks K, Wiedemann P, Heimann K. Porcine iris pigment epithelial cells can take up retinal outer segments. Exp Eye Res. 1997;65:277-287.
33. Thumann G, Bartz-Schmidt KU, Heimann K, Schraermeyer U. Phagocytosis of rod outer segments by human iris pigment epithelial cells in vitro. Graefes Arch Clin Exp Ophthalmol. 1998;236:753-757.
34. Thumann G, Bartz-Schmidt KU, El Bakri H, et al. Transplantation of autologous iris pigment epithelium to the subretinal space in rabbits. Transplantation. 1999;68:195-201.
35. Schraermeyer U, Kayatz P, Thumann G, et al. Transplantation of iris pigment epithelium into the choroid slows down the degeneration of photoreceptors in the RCS rat. Graefes Arch Clin Exp Ophthalmol. 2000;238:979-984.
36. Abe T, Yoshida M, Tomita H, et al. Functional analysis after auto iris pigment epithelial cell transplantation in patients with age-related macular degeneration. Tohoku J Exp Med. 1999;189:295-305.
37. Thumann G, Aisenbrey S, Schraermeyer U, et al. Transplantation of autologous iris pigment epithelium after removal of choroidal neovascular membranes. Arch Ophthalmol. 2000;118:1350-1355.
38. Das A, Frank RN, Zhang NL, Turczyn TJ. Ultrastructural localization of extracellular matrix components in human retinal vessels and Bruch's membrane. Arch Ophthalmol. 1990;108:421-429.
39. Marshall J, Hussain AA, Starita C, Moore DJ, Patmore AL. Aging and Bruch's membrane. In: Wolfensberger TJ, ed. The Retinal Pigment Epithelium. New York: Oxford University Press; 1998:669-692.
40. Song MK, Lui GM. Propagation of fetal human RPE cells: preservation of original culture morphology after serial passage. J Cell Physiol. 1990;143:196-203.
41. Hu DN, McCormick SA, Ritch R. Isolation and culture of iris pigment epithelium from iridectomy specimens of eyes with and without exfoliation syndrome. Arch Ophthalmol. 1997;115:89-94.
42. Ishida M, Lui GM, Yamani A, Sugino IK, Zarbin MA. Culture of human retinal pigment epithelial cells from peripheral scleral flap biopsies. Curr Eye Res. 1998;17:392-402.
43. Curcio CA, Millican CL, Bailey T, Kruth HS. Accumulation of cholesterol with age in human Bruch's membrane. Invest Ophthalmol Vis Sci. 2001;42:265-274.
44. Ruberti JW, Curcio CA, Millican CL, Menco BP, Huang JD, Johnson M. Quick-freeze/deep-etch visualization of age-related lipid accumulation in Bruch's membrane. Invest Ophthalmol Vis Sci. 2003;44:1753-1759.
45. Handa JT, Verzijl N, Matsunaga H, et al. Increase in the advanced glycation end product pentosidine in Bruch's membrane with age. Invest Ophthalmol Vis Sci. 1999;40:775-779.
46. Delcommenne M, Streuli CH. Control of integrin expression by extracellular matrix. J Biol Chem. 1995;270:26794-26801.
47. Tian J, Ishibashi K, Handa JT. The expression of native and cultured RPE grown on different matrices. Physiol Genomics. 2004;17:170-182.
48. Lee JW, Juliano R. Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways. Mol Cells. 2004;17:188-202.
49. Stupack DG, Cheresh DA. Get a ligand, get a life: integrins, signaling and cell survival. J Cell Sci. 2002;115:3729-3738.
50. Giancotti FG, Ruoslahti E. Integrin signaling. Science. 1999;285:1028-1032.
51. Wayner EA, Carter WG. Identification of multiple cell adhesion receptors for collagen and fibronectin in human fibrosarcoma cells possessing unique alpha and common beta subunits. J Cell Biol. 1987;105:1873-1884.
52. Kirchhofer D, Languino LR, Ruoslahti E, Pierschbacher MD. Alpha 2 beta 1 integrins from different cell types show different binding specificities. J Biol Chem. 1990;265:615-618.
53. Languino LR, Gehlsen KR, Wayner E, Carter WG, Engvall E, Ruoslahti E. Endothelial cells use alpha 2 beta 1 integrin as a laminin receptor. J Cell Biol. 1989;109:2455-2462.
54. Wayner EA, Garcia-Pardo A, Humphries MJ, McDonald JA, Carter WG. Identification and characterization of the T lymphocyte adhesion receptor for an alternative cell attachment domain (CS-1) in plasma fibronectin. J Cell Biol. 1989;109:1321-1330.
55. Sawada H, Furthmayr H, Konomi H, Nagai Y. Immunoelectronmicroscopic localization of extracellular matrix components produced by bovine corneal endothelial cells in vitro. Exp Cell Res. 1987;171:94-109.
56. Pytela R, Pierschbacher MD, Ruoslahti E. Identification and isolation of a 140 kd cell surface glycoprotein with properties expected of a fibronectin receptor. Cell. 1985;40:191-198.
57. Guan JL, Hynes RO. Lymphoid cells recognize an alternatively spliced segment of fibronectin via the integrin receptor alpha 4 beta 1. Cell. 1990;60:53-61.
58. Marshall GE, Konstas AG, Reid GG, Edwards JG, Lee WR. Type IV collagen and laminin in Bruch's membrane and basal linear deposit in the human macula. Br J Ophthalmol. 1992;76:607-614.
59. Campochiaro PA, Jerdon JA, Glaser BM. The extracellular matrix of human retinal pigment epithelial cells in vivo and its synthesis in vitro. Invest Ophthalmol Vis Sci. 1986;27:1615-1621.
60. Thumann G, Kociok N, Bartz-Schmidt KU, Esser P, Schraermeyer U, Heimann K. Detection of mRNA for proteins involved in retinol metabolism in iris pigment epithelium. Graefes Arch Clin Exp Ophthalmol. 1999;237:1046-1051.
61. Thumann G. Development and cellular functions of the iris pigment epithelium. Surv Ophthalmol. 2001;45:345-354.