Auto iris pigment epithelial cell transplantation in patients with age-related macular degeneration: Short-term results

Tohoku Journal of Experimental Medicine

Volumn 191, Issue 1, 2000, Pages 7-20

  Abe, Toshiaki ^a   Yoshida, Madoka ^a   Tomita, Hiroshi ^a   Kano, Tetsuya ^a   Sato, Masami ^a   Wada, Yuko ^a   Fuse, Nobuo ^a   Yamada, Tasuku ^a   Tamai, Makoto ^a  

^a TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Age related macular degeneration; Auto iris pigment epithelium; Rejection; Transplantation

Indexed keywords

AGED; AGING; ARTICLE; AUTOMATION; CELL TRANSPLANTATION; CYTOLOGY; ELECTROPHYSIOLOGY; EPITHELIUM CELL; FEMALE; HUMAN; IRIS; MALE; METHODOLOGY; MIDDLE AGED; PATHOPHYSIOLOGY; PHYSIOLOGY; PIGMENT EPITHELIUM; RETINA MACULA DEGENERATION; TIME; VISUAL ACUITY; VISUAL FIELD;

AGED; AGED, 80 AND OVER; AGING; AUTOMATION; CELL TRANSPLANTATION; ELECTROPHYSIOLOGY; EPITHELIAL CELLS; FEMALE; HUMANS; IRIS; MACULAR DEGENERATION; MALE; MIDDLE AGED; PIGMENT EPITHELIUM OF EYE; TIME FACTORS; VISUAL ACUITY; VISUAL FIELDS;

EID: 0034186383     PISSN: 00408727     EISSN: None     Source Type: Journal    
DOI: 10.1620/tjem.191.7     Document Type: Article

References (27)

1. Abe, T., Sato, M. & Tamai, M. (1998) Dedifferentiation of the retinal pigment epithelium compared to the proliferative membranes of proliferative vitreoretinopathy. Curr. Eye Res., 17, 1103-1109.
2. Algvere, P.V., Berglin, L., Gouras, P., Sheng, Y. & Kopp, E.D. (1997) Transplantation of RPE in age-related macular degeneration: Observations in disciform lesions and dry RPE atrophy. Graefes Arch. Clin. Exp. Ophthalmol., 235, 149-158.
3. Bok, D. & Hall, M.O. (1971) The role of the pigment epithelium in the etiology of inherited retinal dystrophy in the rat. J. Cell Biol., 49, 664-682.
4. Bynoe, L.A., Chang, T.S., Funata, M., Del Priore, L.V., Kaplan, H.J. & Green, W.R. (1994) Histopathologic examination of vascular patterns in subfoveal neovascular membranes. Ophthalmology, 101, 1112-1117.
5. Ishida, M., Lui, G.M., Yamani, A., Sugino, I.K. & Zarbin, M.A. (1998) Culture of human retinal pigment epithelial cells from peripheral scleral flap biopsies. Curr. Eye Res., 17, 392-402.
6. Jiang, L.Q., Jorquera, M. & Streilein, J.W. (1993) Subretinal space and vitreous cavity as immunologically privileged sites for retinal allografts. Invest. Ophthalmol. Vis. Sci., 34, 3347-3354.
7. Kodama, R. & Eguchi, G. (1995) From lens regeneration in the newt to in-vitro transdifferentiation of vertebrate pigmented epithelial cells. Seminar Cell Biol., 6, 143-149.
8. LaVail, M.M., Li, L., Turner, J.E. & Yasumura, D. (1992) Retinal pigment epithelial cell transplantation in RCS rats: Normal metabolism in rescued photoreceptors. Exp. Eye Res., 55, 555-562.
9. Li, L. & Turner, J.E. (1991) Optimal conditions for long-term photoreceptor cell rescue in RCS rats: The necessity for healthy RPE transplants. Exp. Eye Res., 52, 669-679.
10. Lopez, R., Gouras, P., Kjeldbye, H., Sullivan, B., Reppucci, V., Brittis, M., Wapner, F. & Goluboff, E. (1989) Transplanted retinal pigment epithelium modifies the retinal degeneration in the RCS rat. Invest. Ophthalmol. Vis. Sci., 30, 586-588.
11. Lopez, P.F., Grossniklaus, H.E., Lambert, H.M., Aaberg, T.M., Capone, A., Jr., Sternberg, P., Jr. & L'Hernault, N. (1991) Pathologic features of surgically excised subretinal neovascular membranes in age-related macular degeneration. Am. J. Ophthalmol., 112, 647-656.
12. McDonnel, J.M. (1989) Ocular embryology and anatomy. In: Retina, edited by S.J. Ryan & T.E. Ogden, Vol. 1, St. Louis, CV Mosby, 5-15.
13. Niederkorn, J.Y. & Streilein, J.W. (1986) Lymphoma allografts abrogate immune privilege within the anterior chamber of the eye. Invest. Ophthalmol. Vis. Sci., 27, 1235-1243.
14. Peyman, G.A., Blinder, K.J., Paris, C.L., Alturki, W., Nelson, N.C., Jr. & Desai, U. (1991) A technique for retinal pigment epithelium transplantation for age-related macular degeneration secondary to extensive subfoveal scarring. Ophthalmic Surg., 22, 102-108.
15. Rezai, K.A., Kohen, L., Wiedemann, P. & Heimann, K. (1997a) Iris pigment epithelium transplantation. Graefes Arch. Clin. Exp. Ophthalmol., 235, 558-562.
16. Rezai, K.A., Lappas, A., Farrokh-siar, L., Kohen, L., Wiedemann, P. & Heimann, K. (1997b) Iris pigment epithelial cells of long evans rats demonstrate phagocytic activity. Exp. Eye Res., 65, 23-29.
17. Rezai, K.A., Lappas, A., Kohen, L., Wiedemann, P. & Heimann, K. (1997c) Comparison of tight junction permeability for albumin in iris pigment epithelium and retinal pigment epithelium in vitro. Graefes Arch. Clin. Exp. Ophthalmol., 235, 48-55.
18. Schraermeyer, U., Kociok, N. & Heimann, K. (1999) Rescue effects of IPE transplants in RCS rats: Short-term results. Invest. Ophthalmol. Vis. Sci., 40, 1545-1556.
19. Seiler, M.J. & Aramant, R.B. (1998) Intact sheets of fetal retina transplanted to restore damaged rat retinas. Invest. Ophthalmol. Vis. Sci., 39, 2121-2131.
20. Sheedlo, H.J., Li, L. & Turner, J.E. (1991) Photoreceptor cell rescue at early and late RPE-cell transplantation periods during retinal disease in RCS dystrophic rats. J. Neural Trans. Plast., 2, 55-63.
21. Sheng, Y., Gouras, P., Cao, H., Berglin, L., Kjeldbye, H., Lopez, R. & Rosskothen, H. (1995) Patch transplants of human fetal retinal pigment epithelium in rabbit and monkey retina. Invest. Ophthalmol. Vis. Sci., 36, 381-390.
22. Streilein, J.W. (1990) Anterior chamber associated immune deviation: The privilege of immunity in the eye. Surv. Ophthalmol., 35, 67-73.
23. Tamai, M. (1996) Retinal pigment epithelial cell transplantation: Perspective. Acta Soc. Ophthamol. Jpn., 100, 982-1006.
24. Tamai, M., Takeda, Y., Yamada, K., Tomita, H., Abe, T., Kojima, S. & Ishigura, S. (1997) bFGF transfected iris PE may rescue photoreceptor cell degeneration in RCS rat. In: Retinal Degeneration, edited by M.M. LaVail, R.E. Anderson & J.G. Hollyfield, Plenum Press, New York, 323-328.
25. Thumann, G., Schraermeyer, U., Bartz-Schmidt, K.U. & Heimann, K. (1997) Descemet's membrane as membranous support in RPE/IPE transplantation. Curr. Eye Res., 16, 1236-1238.
26. Wongpichedchai, S., Weiter, J.J., Weber, P. & Dorey, C.K. (1992) Comparison of external and internal approaches for transplantation of autologous retinal pigment epithelium. Invest. Ophthalmol. Vis. Sci., 33, 3341-3352.
27. Zhang, X. & Bok, D. (1998) Transplantation of retinal pigment epithelial cells and immune response in the subretinal space. Invest. Ophthalmol. Vis. Sci., 39, 1012-1027.