"Hijacking" the thyrotropin receptor: A chimeric receptor-lysosome associated membrane protein enhances deoxyribonucleic acid vaccination and induces Graves' hyperthyroidism

Endocrinology

Volumn 145, Issue 12, 2004, Pages 5504-5514

  Pichurin, Pavel N ^a   Chazenbalk, Gregorio D ^a   Aliesky, Holly ^a   Pichurina, Oxana ^a   Rapoport, Basil ^a   McLachlan, Sandra M ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARDIOTOXIN; CHIMERIC PROTEIN; DNA VACCINE; GAMMA INTERFERON; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1 THYROTROPIN RECEPTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; SIGNAL PEPTIDE; THYROTROPIN RECEPTOR; THYROTROPIN RECEPTOR ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY DETECTION; ANTIBODY PRODUCTION; ANTIGEN PRESENTATION; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FIBROBLAST; GOITER; GRAVES DISEASE; HORMONE BINDING; MACROPHAGE; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPLEEN CELL; T LYMPHOCYTE; THYROXINE BLOOD LEVEL; VACCINATION; WILD TYPE;

ANIMALS; AUTOANTIBODIES; CELL ADHESION MOLECULES, NEURONAL; CHO CELLS; CRICETINAE; FEMALE; GRAVES DISEASE; IMMUNOLOGIC MEMORY; INJECTIONS, INTRAMUSCULAR; LYSOSOMES; MICE; MICE, INBRED BALB C; PLASMIDS; RECEPTORS, THYROTROPIN; RECOMBINANT FUSION PROTEINS; SPLEEN; T-LYMPHOCYTES; VACCINES, DNA;

EID: 9444296052     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2004-0530     Document Type: Article

References (37)

1. Costagliola S, Many MC, Denef JF, Pohlenz J, Refetoff S, Vassart G 2000 Genetic immunization of outbred mice with thyrotropin receptor cDNA provides a model of Graves' disease. J Clin Invest 105:803-811
2. Flynn JC, Rao PV, Gora M, Alsharabi G, Wei W, Giraldo AA, David CS, Banga JP, Kong YM 2004 Graves' hyperthyroidism and thyroiditis in HLA-DRB1*0301 (DR3) transgenic mice after immunization with thyrotropin receptor DNA. Clin Exp Immunol 135:35-40
3. Pichurin P, Chen CR, Pichurina O, David C, Rapoport B, McLachlan SM 2003 Thyrotropin receptor-DNA vaccination of transgenic mice expressing HLA-DR3 or HLA-DQ6b. Thyroid 13:911-917
4. Costagliola S, Rodien P, Many M-C, Ludgate M, Vassart G 1998 Genetic immunization against the human thyrotropin receptor causes thyroiditis and allows production of monoclonal antibodies recognizing the native receptor. J Immunol 160:1458-1465
5. Pichurin P, Yan X-M, Farilla L, Guo J, Chazenbalk G, Rapoport B, McLachlan SM 2001 Naked thyrotropin receptor DNA vaccination: A TH1 T cell response in which interferon-γ production, rather than antibody, dominates the immune response in mice. Endocrinology 142:3530-3536
6. Pichurin P, Pichurina O, Chazenbalk GD, Paras C, Chen CR, Rapoport B, McLachlan SM 2002 Immune deviation away from Th1 in interferon-γ knockout mice does not enhance TSH receptor antibody production after naked DNA vaccination. Endocrinology 143:1182-1189
7. Nagayama Y, Kita-Furuyama M, Ando T, Nakao K, Mizuguchi H, Hayakawa T, Eguchi K, Niwa M 2002 A novel murine model of Graves' hyperthyroidism with intramuscular injection of adenovirus expressing the thyrotropin receptor. J Immunol 168:2789-2794
8. Rao PV, Watson PF, Weetman AP, Carayanniotis G, Banga JP 2003 Contrasting activities of thyrotropin receptor antibodies in experimental models of Graves' disease induced by injection of transfected fibroblasts or deoxyribonucleic acid vaccination. Endocrinology 144:260-266
9. Pan CH, Chen HW, Tao MH 1999 Modulation of immune responses to DNA vaccines by codelivery of cytokine genes. J Formos Med Assoc 98:722-729
10. Heemels MT, Ploegh H 1995 Generation, translocation, and presentation of MHC class I-restricted peptides. Annu Rev Biochem 64:463-491
11. Bona C 2004 Processing and presentation of self antigens. In: Theofilopoulos AN, Bona CA, eds. The molecular pathology of autoimmune diseases. New York: Taylor and Francis; 184-191
12. Pichurin P, Schwarz-Lauer L, Braley-Mullen H, Paras C, Pichurina O, Morris JC, Rapoport B, McLachlan SM 2002 Peptide scanning for thyrotropin receptor T-cell epitopes in mice vaccinated with naked DNA. Thyroid 12:755-764
13. Guarnieri FG, Arterburn LM, Penno MB, Cha Y, August JT 1993 The motif Tyr-X-X-hydrophobic residue mediates lysosomal membrane targeting of lysosome-associated membrane protein 1. J Biol Chem 268:1941-1946
14. Wu JM, Wu B, Guarnieri F, August JT, Drachman DB 2000 Targeting antigen-specific T cells by genetically engineered antigen presenting cells. A strategy for specific immunotherapy of autoimmune disease. J Neuroimmunol 106:145-153
15. Boyle JS, Silva A, Brady JL, Lew AM 1997 DNA immunization: induction of higher avidity antibody and effect of route on T cell cytotoxicity. Proc Natl Acad Sci USA 94:14626-14631
16. Nagayama Y, Kaufman KD, Seto P, Rapoport B 1989 Molecular cloning, sequence and functional expression of the cDNA for the human thyrotropin receptor. Biochem Biophys Res Commun 165:1184-1190
17. Chen C-R, Tanaka K, Chazenbalk GD, McLachlan SM, Rapoport B 2001 A full biological response to autoantibodies in Graves' disease requires a disulfide-bond loop in the thyrotropin N-terminus homologous to a laminin EGF-like domain. J Biol Chem 276:14767-14772
18. Chazenbalk GD, Jaume JC, McLachlan SM, Rapoport B 1997 Engineering the human thyrotropin receptor ectodomain from a nonsecreted form to a secreted, highly immunoreactive glycoprotein that neutralizes autoantibodies in Graves' patients' sera. J Biol Chem 272:18959-18965
19. Chazenbalk G, McLachlan S, Pichurin P, Rapoport B 2001 A "prion-like" shift between two conformational forms of a recombinant thyrotropin receptor A subunit module: purification and stabilization using chemical chaperones of the form reactive with Graves' autoantibodies. J Clin Endocrinol Metab 86:1287-1293
20. Morris JC, Bergert ER, McCormick DJ 1993 Structure-function studies of the human thyrotropin receptor. Inhibition of binding of labeled thyrotropin (TSH) by synthetic human TSH receptor peptides. J Biol Chem 268:10900-10905
21. Shewring GA, Rees Smith B 1982 An improved radioreceptor assay for TSH receptor antibodies. Clin Endocrinol (Oxf) 17:409-417
22. Chert C-R, Pichurin P, Nagayama Y, Latrofa F, Rapoport B, McLachlan SM 2003 The thyrotropin receptor autoantigen in Graves' disease is the culprit as well as the victim. J Clin Invest 111:1897-1904
23. Costagliola S, Franssen JD, Bonomi M, Urizar E, Willnich M, Bergmann A, Vassart G 2002 Generation of a mouse monoclonal TSH receptor antibody with stimulating activity. Biochem Biophys Res Commun 299:891-896
24. Raviprakash K, Marques E, Ewing D, Lu Y, Phillips I, Porter KR, Kochel TJ, August TJ, Hayes CG, Murphy GS 2001 Synergistic neutralizing antibody response to a dengue virus type 2 DNA vaccine by incorporation of lysosome-associated membrane protein sequences and use of plasmid expressing GM-CSF. Virology 290:74-82
25. Kim JW, Hung CF, Juang J, He L, Kim TW, Armstrong DK, Pai SI, Chen PJ, Lin CT, Boyd DA, Wu TC 2004 Comparison of HPV DNA vaccines employing intracellular targeting strategies. Gene Ther 11:1011-1118
26. Chen CH, Wang TL, Hung CF, Pardoll DM, Wu TC 2000 Boosting with recombinant vaccinia increases HPV-16 E7-specific T cell precursor frequencies of HPV-16 E7-expressing DNA vaccines. Vaccine 18:2015-2022
27. Moreno J, Vignali DA, Nadimi F, Fuchs S, Adorini L, Hammerling GJ 1991 Processing of an endogenous protein can generate MHC class II-restricted T cell determinants distinct from those derived from exogenous antigen. J Immunol 147:3306-3313
28. Bonifaz LC, Arzate S, Moreno J 1999 Endogenous and exogenous forms of the same antigen are processed from different pools to bind MHC class II molecules in endocytic compartments. Eur J Immunol 29:119-131
29. Fernandes DM, Vidard L, Rock KL 2000 Characterization of MHC class II-presented peptides generated from an antigen targeted to different endocytic compartments. Eur J Immunol 30:2333-2343
30. Rapoport B, Chazenbalk GD, Jaume JC, McLachlan SM 1998 The thyrotropin receptor: interaction with thyrotropin and autoantibodies. Endocr Rev 19:673-716
31. Carlsson SR, Fukuda M 1992 The lysosomal membrane glycoprotein lamp-1 is transported to lysosomes by two alternative pathways. Arch Biochem Biophys 296:630-639
32. Prasad DV, Parekh W, Joshi BN, Banerjee PP, Parab PB, Chattopadhyay S, Kumar A, Mishra GC 2002 The Th1-specific costimulatory molecule, m150, is a posttranslational isoform of lysosome-associated membrane protein-1. J Immunol 169:1801-1809
33. Bergstresser PR, Fletcher CR, Streilein JW 1980 Surface densities of Langerhans cells in relation to rodent epidermal sites with special immunologic properties. J Invest Dermatol 74:77-80
34. Barrett K, Liakata E, Rao PV, Watson PF, Weetman AP, Lymberi P, Banga JP, Carayanniotis G 2004 Induction of hyperthyroidism in mice by intradermal immunization with DNA encoding the thyrotropin receptor. Clin Exp Immunol 136:413-422
35. Chazenbalk GD, Pichurin P, Chen CR, Latrofa F, Johnstone AP, McLachlan SM, Rapoport B 2002 Thyroid-stimulating autoantibodies in Graves disease preferentially recognize the free A subunit, not the thyrotropin holoreceptor. J Clin Invest 110:209-217
36. Geutskens SB, van der Eb MM, Plomp AC, Jonges LE, Cramer SJ, Ensink NG, Kuppen PJ, Hoeben RC 2000 Recombinant adenoviral vectors have adjuvant activity and stimulate T cell responses against tumor cells. Gene Ther 7:1410-1416
37. Krieg AM, Yi AK, Matson S, Waldschmidt TJ, Bishop GA, Teasdale R, Koretzky GA, Klinman DM 1995 CpG motifs in bacterial DNA trigger direct B cell activation. Nature 374:546-549