Role for NKG2-A and NKG2-C surface receptors in chronic CD4+ T-cell responses

Immunology and Cell Biology

Volumn 82, Issue 6, 2004, Pages 587-595

  Ortega, Consuelo ^a   Romero, Pilar ^a   Palma, Agustín ^a   Orta, Teresa ^a   Peña, José ^a   García Vinuesa, Amaya ^a   Molina, Ignacio J ^b   Santamarí, Manuel ^a,c  

^a UNIVERSITY OF CÓRDOBA   (Spain)

^b UNIVERSITY OF GRANADA   (Spain)

^c HOSPITAL UNIVERSITARIO REINA SOFÍA   (Spain)

Author keywords

C type lectin receptors; Cytokine regulation; Interleukin 10; Tumour growth factor ; Tumour necrosis factor

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CD94 ANTIGEN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; LECTIN RECEPTOR; LYMPHOCYTE MEMBRANE RECEPTOR; MESSENGER RNA; NATURAL KILLER CELL RECEPTOR NKG2A; NATURAL KILLER CELL RECEPTOR NKG2C; SUPERANTIGEN; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR VBETA2; TOXIC SHOCK SYNDROME TOXIN 1; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANTIGEN EXPRESSION; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOLYSIS; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE INDUCTION; HUMAN; HUMAN CELL; IMMUNOREGULATION; LYMPHOCYTE ACTIVATION; MULTIGENE FAMILY; NATURAL KILLER CELL; PERIPHERAL LYMPHOCYTE; RECEPTOR OCCUPANCY; RNA ANALYSIS; T LYMPHOCYTE SUBPOPULATION;

ANTIGENS, CD; ANTIGENS, CD94; CD4-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; CELLS, CULTURED; CYTOKINES; GENE EXPRESSION REGULATION; HUMANS; LECTINS, C-TYPE; MUROMONAB-CD3; RECEPTORS, IMMUNOLOGIC; SUPERANTIGENS; TIME FACTORS;

EID: 9444285009     PISSN: 08189641     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0818-9641.2004.01284.x     Document Type: Article

References (27)

1. Lopez-Botet M, Bellon T. Natural killer cell activation and inhibition by receptors for MHC class I. Curr. Opin. Immunol. 1999; 11: 301-7.
2. Lanier LL. On guard - activating NK cell receptors. Nat. Immunol. 2001; 2: 23-7.
3. Natarajan K, Dimasi N, Wang J, Mariuzza RA, Margulies DH. Structure and function of natural killer cell receptors: multiple molecular solutions to self, nonself discrimination. Annu. Rev. Immunol. 2002; 20: 853-85.
4. Chang C, Rodriguez A, Carretero M, Lopez-Botet M, Phillips JH, Lanier LL. Molecular characterization of human CD94: a type II membrane glycoprotein related to the C-type lectin superfamily. Eur. J. Immunol. 1995; 25: 2433-7.
5. Renedo M, Arce I, Rodriguez A et al. The human natural killer gene complex is located on chromosome 12p12-p13. Immunogenetics 1997; 46: 307-11.
6. Carretero M, Cantoni C, Bellon T et al. The CD94 and NKG2-A C-type lectins covalently assemble to form a natural killer cell inhibitory receptor for HLA class I molecules. Eur. J. Immunol. 1997; 27: 563-7.
7. Leibson PJ. Signal transduction during natural killer cell activation: inside the mind of a killer. Immunity 1997; 6: 655-61.
8. Houchins JP, Lanier LL, Niemi EC, Phillips JH, Ryan JC. Natural killer cell cytolytic activity is inhibited by NKG2-A and activated by NKG2-C. J. Immunol. 1997; 158: 3603-9.
9. Borrego F, Ulbrecht M, Weiss EH, Coligan JE, Brooks AG. Recognition of human histocompatibility leukocyte antigen (HLA)-E complexed with HLA class I signal sequence-derived peptides by CD94/NKG2 confers protection from natural killer cell-mediated lysis. J. Exp. Med. 1998; 187: 813-18.
10. Moretta A, Biassoni R, Bottino C et al. Major histocompatibility complex class I-specific receptors on human natural killer and T lymphocytes. Immunol. Rev. 1997; 155: 105-17.
11. Halary F, Peyrat MA, Champagne E et al. Control of self-reactive cytotoxic T lymphocytes expressing gamma delta T cell receptors by natural killer inhibitory receptors. Eur. J. Immunol. 1997; 27: 2812-21.
12. Brumbaugh KM, Perez-Villar JJ, Dick CJ, Schoon RA, Lopez-Botet M, Leibson PJ. Clonotypic differences in signaling from CD94 (kp43) on NK cells lead to divergent cellular responses. J. Immunol. 1996; 157: 2804-12.
13. Cantoni C, Biassoni R, Pende D et al. The activating form of CD94 receptor complex: CD94 covalently associates with the Kp39 protein that represents the product of the NKG2-C gene. Eur. J. Immunol. 1998; 28: 327-38.
14. Mingari MC, Ponte M, Bertone S et al. HLA class I-specific inhibitory receptors in human T lymphocytes: interleukin 15-induced expression of CD94/NKG2A in superantigen- or alloantigen-activated CD8+ T cells. Proc. Natl Acad. Sci. USA 1998; 95: 1172-7.
15. Derre L, Corvaisier M, Pandolfino MC, Diez E, Jotereau F, Gervois N. Expression of CD94/NKG2-A on human T lymphocytes is induced by IL-12: implications for adoptive immunotherapy. J. Immunol. 2002; 168: 4864-70.
16. Bertone S, Schiavetti F, Bellomo R et al. Transforming growth factor-beta-induced expression of CD94/NKG2A inhibitory receptors in human T lymphocytes. Eur. J. Immunol. 1999; 29: 23-9.
17. Galiani MD, Aguado E, Tarazona R et al. Expression of killer inhibitory receptors on cytotoxic cells from HIV-1- infected individuals. Clin. Exp. Immunol. 1999; 115: 472-6.
18. Romero P, Ortega C, Palma A, Molina IJ, Pena J, Santamaria M. Expression of CD94 and NKG2 molecules on human CD4(+) T cells in response to CD3-mediated stimulation. J. Leukoc. Biol. 2001; 70: 219-24.
19. Lian RH, Maeda M, Lohwasser S et al. Orderly and non-stochastic acquisition of CD94/NKG2 receptors by developing NK cells derived from embryonic stem cells in vitro. J. Immunol. 2002; 168: 4980-7.
20. Jabri B, Selby JM, Negulescu H et al. TCR Specificity Dictates CD94/NKG2A Expression by Human CTL. Immunity 2002; 17: 487-99.
21. Lahm HW, Stein S. Characterization of recombinant human interleukin-2 with micromethods. J. Chromatogr. 1985; 326: 357-61.
22. Uhrberg M, Valiante NM, Shum BP et al. Human diversity in killer cell inhibitory receptor genes. Immunity 1997; 7: 753-63.
23. de Mattos AM, Meyer MM, Norman DJ, Bennett WM, Sprague J, Bakke AC. Interleukin-12 p40 m-RNA expression in human kidney allograft biopsies. Transpl. Immunol. 1997; 5: 199-203.
24. Aguado E, Santamaria M, Gallego MD, Pena J, Molina IJ. Functional expression of CD43 on human natural killer cells. J. Leukoc. Biol. 1999; 66: 923-9.
25. 2 in toxic shock syndrome. J. Exp. Med. 1990; 172: 981-4.
26. Eichler W, Ruschpler P, Wobus M, Drossler K. Differentially induced expression of C-type lectins in activated lymphocytes. J. Cell Biochem. Suppl. 2001; 36: 201-8.
27. Meyers JH, Ryu A, Monney L et al. CD94/NKG2 Is Expressed on Th1 But Not Th2 Cells and Costimulates Th1 Effector Functions. J. Immunol. 2002; 169: 5382-6.