Monomerization as a prerequisite for intramolecular cleavage and shedding of the thyrotropin receptor

Endocrinology

Volumn 145, Issue 12, 2004, Pages 5580-5588

  Latif, R ^a   Ando, T ^a   Davies, T F ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN G; MONOCLONAL ANTIBODY; RECEPTOR SUBUNIT; THYROTROPIN RECEPTOR; THYROTROPIN RECEPTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL SURFACE; CHO CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CROSS LINKING; DOUBLE ANTIBODY SANDWICH ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; FLUORESCENCE; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; RECEPTOR DOWN REGULATION;

ANIMALS; ANTIBODIES, MONOCLONAL; BINDING SITES; CRICETINAE; CROSS-LINKING REAGENTS; FLOW CYTOMETRY; FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; IODINE RADIOISOTOPES; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, THYROTROPIN; THYROTROPIN;

EID: 9444277288     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2004-0797     Document Type: Article

References (49)

1. Milgrom E, de Roux N, Ghinea N, Beau I, Loosfelt H, Vannier B, Savouret JF, Misrahi M 1997 Gonadotrophin and thyrotrophin receptors. Horm Res 48(Suppl 4):33-37
2. Rapoport B, Chazenbalk GD, Jaume JC, McLachlan SM 1998 The thyrotropin (TSH) receptor: interaction with TSH and autoantibodies. Endocr Rev 19:673-716
3. Vassart G, Dumont JE 1992 The thyrotropin receptor and the regulation of thyrocyte function and growth. Endocr Rev 13:596-611
4. Loosfelt H, Pichon C, Jolivet A, Misrahi M, Caillou B, Jamous M, Vannier B, Milgrom E 1992 Two-subunit structure of the human thyrotropin receptor. Proc Natl Acad Sci USA 89:3765-3769
5. Rees Smith B, McLachlan SM, Furmaniak J 1988 Autoantibodies to the thyrotropin receptor. Endocr Rev 9:106-121
6. Couet J, Sar S, Jolivet A, Hai M-TV, Milgrom E, Misrahi M 1996 Shedding of human TSH receptor ectodomain: involvement of a matrix metalloprotease. J Biol Chem 271:4545-4552
7. Couet J, de Bernard S, Loosfelt H, Saunier B, Milgrom E, Misrahi M 1996 Cell surface protein disulfide-isomerase is involved in the shedding of human thyrotropin receptor ectodomain. Biochem 35:14800-14805
8. Misrahi M, Milgrom E 1997 Cleavage and shedding of the TSH receptor. Eur J Endocrinol 137:599-602
9. Chazenbalk GD, Tanaka K, Nagayama Y, Kakinuma A, Jaume JC, McLachlan S, Rapoport B 1997 Evidence that the TSH receptor ectodomain contains not one, but two, cleavage sites. Endocrinology 138:2893-2899
10. Graves P, Pritsker A, Davies TF 1999 Post-translational processing of the natural human TSH receptor: demonstration of more than two cleavage sites. Endocrinology 84:2177-2181
11. de Bernard S, Misrahi M, Huet JC, Beau I, Desroches A, Loosfelt H, Pichon C, Pernollet JC, Milgrom E 1999 Sequential cleavage and excision of a segment of the thyrotropin receptor ectodomain. J Biol Chem 274:101-107
12. Misrahi M, Ghinea N, Sar S, Saunier B, Jolivet A, Loosfelt H, Cerutti M, Devauchelle G, Milgrom E 1994 Processing of the precursors of the human thyroid-stimulating hormone receptor in various eukaryotic cells (human thyrocytes, transfected L cells and baculovirus-infected insect cells). Eur J Biochem 222:711-719
13. Ando T, Latif R, Pritsker A, Moran T, Nagayama Y, Davies TF 2002 A monoclonal thyroid-stimulating antibody. J Clin Invest 110:1667-1674
14. Chazenbalk GD, Tanaka K, McLachlan SM, Rapoport B 1999 On the functional importance of thyrotropin receptor intramolecular cleavage. Endocrinology 140:4516-4520
15. Quellari M, Desroches A, Beau I, Beaudeux E, Misrahi M 2003 Role of cleavage and shedding in human thyrotropin receptor function and trafficking. Eur J Biochem 270:3486-3497
16. Chazenbalk GD, Pichurin P, Chen CR, Latrofa F, Johnstone AP, McLachlan SM, Rapoport B 2002 Thyroid-stimulating autoantibodies in Graves disease preferentially recognize the free A subunit, not the thyrotropin holoreceptor. J Clin Invest 110:209-217
17. Vassart G, Costagliola S 2004 A physiological role for the posttranslational cleavage of the thyrotropin receptor? Endocrinology 145:1-3
18. Latif R, Graves P, Davies TF 2001 Oligomerization of the human thyrotropin receptor: fluorescent protein-tagged hTSHR reveals post-translational complexes. J Biol Chem 276:45217-45224
19. Graves PN, Vlase H, Bobovnikova Y, Davies TF 1996 Multimeric complex formation by the natural TSH receptor. Endocrinology 137:3915-3920
20. Latif R, Graves P, Davies TF 2002 Ligand-dependent inhibition of oligomerization at the human thyrotropin receptor. J Biol Chem 277:45059-45067
21. Ciullo I, Latif R, Graves P, Davies TF 2003 Functional assessment of the thyrotropin receptor-β subunit. Endocrinology 144:3176-3181
22. Chazenbalk GD, Chen CR, McLachlan SM, Rapoport B 2004 Does thyrotropin cleave its cognate receptor? Endocrinology 145:4-10
23. Chazenbalk GD, Rapoport B 1994 Cleavage of the thyrotropin receptor does not occur at a classical subtilisin-related proprotein convertase endoproteolytic site. J Biol Chem 269:32209-32213
24. Costagliola S, Swillens S, Niccoli P, Dumont JE, Vassart G, Ludgate M 1992 Binding assay for thyrotropin receptor autoantibodies using the recombinant receptor protein. J Clin Endocrinol Metab 75:1540-1544
25. Chazenbalk GD, Kakinuma A, Jaume JC, McLachlan SM, Rapoport B 1996 Evidence for negative cooperativity among human thyrotropin receptors overexpressed in mammalian cells. Endocrinology 137:4586-4591
26. Oda Y, Sanders J, Roberts S, Maruyama M, Kato R, Perez M, Petersen VB, Wedlock N, Furmaniak J, Rees SB 1998 Binding characteristics of antibodies to the TSH receptor. J Mol Endocrinol 20:233-244
27. Johnstone AP, Cridland JC, DaCosta CR, Harfst E, Shepherd PS 1994 Monoclonal antibodies that recognize the native human thyrotropin receptor. Mol Cell Endocrinol 105:R1-R9
28. Zhang M, Tong KP, Fremont V, Chen J, Narayan P, Puett D, Weintraub BD, Szkudlinski MW 2000 The extracellular domain suppresses constitutive activity of the transmembrane domain of the human TSH receptor: implications for hormone-receptor interaction and antagonist design. Endocrinology 141:3514-3517
29. Harlow E, Lane D 1998 Antibodies: a laboratory manual. Long Island, NY: Cold Spring Harbor Laboratory
30. Tanimura N, Nagafuku M, Liddicoat DR, Hamaoka T, Kosugi A 2003 Analysis of the mobility of signaling molecules in lymphocytes using fluorescence photobleaching techniques. Sci STKE 2003:p110
31. Jeffreys J, Depraetere H, Sanders J, Oda Y, Evans M, Kiddie A, Richards T, Furmaniak J, Rees SB 2002 Characterization of the thyrotropin binding pocket. Thyroid 12:1051-1061
32. Kawakami N, Miyoshi K, Horio S, Fukui H 2004 β(2)-Adrenergic receptor-mediated histamine h(1) receptor down-regulation: another possible advantage of β(2) agonists in asthmatic therapy. J Pharmacol Sci 94:449-458
33. Singh SP, McDonald D, Hope TJ, Prabhakar BS 2004 Upon thyrotropin binding the thyrotropin receptor is internalized and localized to endosome. Endocrinology 145:1003-1010
34. Von Zastrow M 2001 Role of endocytosis in signalling and regulation of G-protein-coupled receptors. Biochem Soc Trans 29:500-504
35. Azpiazu I, Gautam N 2004 A FRET based sensor indicates that receptor access to a G protein is unrestricted in a living mammalian cell. J Biol Chem 279:27709-27718
36. Lippincott-Schwartz J, Snapp E, Kenworthy A 2001 Studying protein dynamics in living cells. Nat Rev Mol Cell Biol 2:444-456
37. Schaaf MJ, Cidlowski JA 2003 Molecular determinants of glucocorticoid receptor mobility in living cells: the importance of ligand affinity. Mol Cell Biol 23:1922-1934
38. Tanaka K, Chazenbalk GD, McLachlan SM, Rapoport B 1998 Thyrotropin receptor cleavage at site 1 does not involve a specific amino acid motif but instead depends on the presence of the unique, 50 amino acid insertion. J Biol Chem 273:1959-1963
39. Tanaka K, Chazenbalk GD, McLachlan SM, Rapoport B 1999 Subunit structure of thyrotropin receptors expressed on the cell surface. J Biol Chem 274:33979-33984
40. Graves PN, Davies TF 2000 New insights into the thyroid-stimulating hormone receptor. The major antigen of Graves' disease. Endocrinol Metab Clin North Am 29:267-286
41. Mui AL, Kay RJ, Humphries RK, Krystal G 1992 Ligand-induced phosphorylation of the murine interleukin 3 receptor signals its cleavage. Proc Natl Acad Sci USA 89:10812-10816
42. Pandiella A, Massague J 1991 Multiple signals activate cleavage of the membrane transforming growth factor-α precursor. J Biol Chem 266:5769-5773
43. Tedder TF 1991 Cell-surface receptor shedding: a means of regulating function. Am J Respir Cell Mol Biol 5:305-306
44. Tanaka K, Nagayama Y, Yamasaki H, Hayashi H, Namba H, Yamashita S, Niwa M 1996 Epitope-tagging of a functional thyrotropin receptor: detection of the native receptor on intact cells. Biochem Biophys Res Commun 228:21-28
45. Baratti-Elbaz C, Ghinea N, Lahuna O, Loosfelt H, Pichon C, Milgrom E 1999 Internalization and recycling pathways of the thyrotropin receptor. Mol Endocrinol 13:1751-1765
46. Kajita Y, Rickards CR, Buckland PR, Howells RD, Rees SB 1985 Analysis of thyrotropin receptors by photoaffinity labelling. Orientation of receptor subunits in the cell membrane. Biochem J 227:413-420
47. Chazenbalk GD, Nagayama Y, Russo D, Wadsworth HL, Rapoport B 1990 Functional analysis of the cytoplasmic domains of the human thyrotropin receptor by site-directed mutagenesis. J Biol Chem 265:20970-20975
48. Tanaka K, Chazenbalk GD, McLachlan SM, Rapoport B 1999 The shed thyrotropin receptor is primarily a carboxyl terminal truncated form of the A subunit, not the entire A subunit. Mol Cell Endocrinol 150:113-119
49. Baumann G 2002 When should we measure growth hormone binding protein? J Pediatr Endocrinol Metab 15:959-961