Retinoic acid-mediated growth inhibition of small cell lung cancer cells is associated with reduced myc and increased p27(Kip1) expression

International Journal of Cancer

Volumn 80, Issue 6, 1999, Pages 935-943

  Weber, Erich ^a,b,e   Ravi, Rajani K ^a   Knudsen, Erik S ^b   Williams, Jerry R ^a   Dillehay, Larry E ^a   Nelkin, Barry D ^a   Kalemkerian, Gregory P ^c   Feramisco, James R ^b   Mabry, Mack ^a,d  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d Matrix Pharmaceutical Inc   (United States)

^e ETH ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P27; RECEPTOR SUBTYPE; RETINOIC ACID; RETINOIC ACID RECEPTOR; VIRUS VECTOR;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CANCER RESISTANCE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; GENETIC TRANSDUCTION; GROWTH REGULATION; HUMAN; HUMAN CELL; LUNG CARCINOGENESIS; LUNG SMALL CELL CANCER; NONHUMAN; ONCOGENE MYC; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; REACTION ANALYSIS; REGULATORY MECHANISM; RNA ANALYSIS;

ANTINEOPLASTIC AGENTS; CARCINOMA, SMALL CELL; CDC2-CDC28 KINASES; CELL CYCLE PROTEINS; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLIN-DEPENDENT KINASES; DRUG RESISTANCE, NEOPLASM; ENZYME ACTIVATION; G1 PHASE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, MYC; GROWTH INHIBITORS; HUMANS; LUNG NEOPLASMS; MICROTUBULE-ASSOCIATED PROTEINS; NEOPLASM PROTEINS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-MYC; RECEPTORS, RETINOIC ACID; RECOMBINANT FUSION PROTEINS; TRANSFECTION; TRETINOIN; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS;

EID: 0033559524     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19990315)80:6<935::AID-IJC21>3.0.CO;2-E     Document Type: Article

References (31)

1. BERARD, J., LABOUNE, F., MUKUNA, M., MASSE, S., KOTHARY, R. and BRADLEY, W.E., Lung tumors in mice expressing an antisense RARbeta2 transgene. FASEB J., 10, 1091-1097 (1996).
2. BIRRER, M.J., SEGAL, S., DEGREVE, J.S., KAYE, F., SAUSVILLE, E.A. and MINNA, J.D., L-myc cooperates with ras to transform primary rat embryo fibroblasts. Mol. cell. Biol., 8, 2668-2673 (1988).
3. CHAMBON, P., A decade of molecular biology of retinoic acid receptors. FASEB J., 10, 940-954 (1996).
4. CHYTIL, F., Retinoids in lung development. FASEB J., 10, 986-992 (1996).
5. DOSAKA-AKITA, H., AKIE, K., HIROUMI, H., KINOSHITA, I., KAWAKAMI, Y. and MURAKAMI, A., Inhibition of proliferation by L-myc antisense DNA for the translational initiation site in human small cell lung cancer. Cancer Res., 55, 1559-1564 (1995).
6. GEBERT, J.F., MOGHAL, N., FRANGIONI, J.V. SUGARBAKER, D.J. and NEEL, B.G., High frequency of retinoic acid receptor beta abnormalities in human lung cancer. Oncogene, 6, 1859-1868 (1991).
7. GERADTS, J., CHEN, J.Y., RUSSELL, E.K., YANKASKAS, J.R., NIEVES, L. and MINNA, J.D., Human lung cancer cell lines exhibit resistance to retinoic acid treatment. Cell Growth Differentiation, 4, 799-809 (1993).
8. HARBOUR, J.W., LAI, S.L., WHANG-PENG, J., GAZDAR, A.F., MINNA, J.D. and KAYE, F.J., Abnormalities in structure and expression of the human retinoblastoma gene in SCLC. Science, 241, 353-357 (1988).
9. HENRIKSSON, M. and LUESCHER, B., Proteins of the myc network: essential regulators of cell growth and differentiation. Adv. Cancer Res., 68, 109-182 (1996).
10. HOULE, B., ROCHETTE-EGLY, C. and BRADLEY, W.E., Tumor-suppressive effect of the retinoic acid receptor beta in human epidermoid lung cancer cells. Proc. nat. Acad. Sci. (Wash.), 90, 985-989 (1993).
11. JOHNSON, B.E., BATTEY, J., LINNOILA, I., BECKER, K.L., MAKUCH, R.W., SNIDER, R.H., CARNEY, D.N. and MINNA, J.D., Changes in the phenotype of human small cell lung cancer cell lines after transfection and expression of the c-myc proto-oncogene. J. clin. Invest., 78, 525-532 (1986).
12. JOHNSON, B.E., BRENNAN, J.F., IHDE, D.C. and GAZDAR, A.F., myc Family DNA amplification in tumors and tumor cell lines from patients with small-cell lung cancer. Monogr. nat. Cancer Inst., 13, 39-43 (1992).
13. KALEMKERIAN, G.P., JASTI, R.K., CELANO, P., NELKIN, B.D. and MABRY, M., All-trans-retinoic acid alters myc gene expression and inhibits in vitro progression in small cell lung cancer. Cell Growth Differentiation, 5, 55-60 (1994).
14. KALEMKERIAN, G.P., SLUSHER, R., RAMALINGAM, S., GADGEEL, S. and MABRY, M., Growth inhibition and induction of apoptosis by fenretinide in small-cell lung cancer cell lines. J. nat. Cancer Inst., 87, 1674-1680 (1995).
15. KANDA, T., SULLIVAN, K.F. and WAHL, G.M., Histone-GFP fusion protein enables sensitive analysis of chromosome dynamics in living mammalian cells. Curr. Biol., 8, 377-385 (1998).
16. Kipl: a key mediator of retinoic acid induced growth arrest in the SMS-KCNR human neuroblastoma cell line. Oncogene, 16, 3337-3343 (1998).
17. MINNA, J.D., SEKIDO, Y. and FONG, K., Molecular biology of lung cancer. In: V.T.J. De Vita, S. Hellman and S.A. Rosenberg (eds.), Cancer: principles and practice of oncology (5th ed.), pp. 849-857, Lippincott-Raven, Philadelphia (1997).
18. MORGENSTERN, J.P. and LAND, H., Advanced mammalian gene transfer: high titer retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line. Nucleic Acids Res., 18, 3587-3596 (1990).
19. MUELLER, D., BOUCHARD, C., RUDOLPH, B., STEINER, P., STUCKMANN, I., SAFFRICH, R., ANSORGE, W., HUTTNER, W. and EILERS, M., Cdk2-dependent phosphorylation of p27 facilitates its Myc-induced release from cyclin E/cdk2 complexes. Oncogene, 15, 2561-2576 (1997).
20. NAGY, L., THOMAZY, V.A., HEYMAN, R.A. and DAVIES, P.J.A., Retinoid-induced apoptosis in normal and neoplastic tissues. Cell Death Differentiation, 5, 11-19 (1998).
21. PARKER, S.L., TONG, T., BOLDEN, S. and WINGO, P.A., Cancer statistics, 1997. CA Cancer J. Clin., 46, 5-27 (1997).
22. PARRY, D., BATES, S., MANN, D.J. and PETERS, G., Lack of cyclin D-Cdk complexes in Rb-negative cells correlates with high levels of p16INK4/ MTS1 tumour suppressor gene product. EMBO J., 14, 503-511 (1995).
23. RAVI, R.K., SCOTT, F.M., CUTTITA, F., WEBER, E., KALEMKERIAN, G.P., NELKIN, B.D. and MABRY, M., Induction of gastrin releasing peptide by all-trans retinoic acid in small cell lung cancer cells. Oncology Rep., 5, 497-501 (1998a).
24. RAVI, R.K., WEBER, E., MCMAHON, M., WILLIAMS, J.R., BAYLIN, S., MAI, A., HARTER, M.L., DILLEHAY, L.E., CLAUDIO, P.P., GIORDANO, A., NELKIN, B.D. and MABRY, M., Activated Raf-1 causes growth arrest in human small cell lung cancer cells. J. clin. Invest., 101, 153-159 (1998b).
25. SCHAUER, I.E., SIRIWARDANA, S., LANGAN, T.A. and SCLAFANI, R.A., Cyclin D1 overexpression vs. retinoblastoma inactivation: implications for growth control evasion in non-small cell and small cell lung cancer. Proc. nat. Acad. Sci. (Wash.), 91, 7827-7831 (1994).
26. SCUDIERO, D.A., SHOEMAKER, R.H., PAULL, R.H., MONKS, A., TIERNEY, S., NOFZIGER, T.H., CURRENS, M.J., SENIFF, D. and BOYD, M.R., Evaluation of a soluble tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines. Cancer Res., 48, 4827-4833 (1988).
27. SEEWALDT, V.L., JOHNSON, B.S., PARKER, M.B., COLLINS, S.J. and SWISSHELM, K., Expression of retinoic acid receptor beta mediates retinoic acid-induced growth arrest and apoptosis in breast cancer cells. Cell Growth Differentiation, 6, 1077-1088 (1995).
28. SHERR, C.J., Cancer cell cycles. Science, 274, 1672-167 (1996).
29. SIMMS, E., GAZDAR, A.F., ABRAMS, P.G. and MINNA, J.D., Growth of human small cell (oat cell) carcinoma of the lung in serum-free growth factor-supplemented medium. Cancer Res., 40, 4356-4363 (1980).
30. THORBURN, A.M., WALTON, P.A. and FERAMISCO, J.R., MyoD induced cell cycle arrest is associated with increased nuclear affinity of the Rb protein. Mol. Biol. Cell, 4, 705-713 (1993).
31. Kipl is abrogated by c-Myc. EMBO J., 15, 6595-6604 (1996).