Role of the 85-kilobase plasmid and plasmid-encoded virulence- associated protein A in intracellular survival and virulence of Rhodococcus equi

Infection and Immunity

Volumn 67, Issue 7, 1999, Pages 3548-3557

  Giguère, Steeve ^a   Hondalus, Mary K ^b   Yager, Julie A ^a   Darrah, Patricia ^c   Mosser, David M ^c   Prescott, John F ^a,d  

^a UNIVERSITY OF GUELPH   (Canada)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF GUELPH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN;

ANIMAL EXPERIMENT; ARTICLE; BACTERIAL GROWTH; BACTERIAL PNEUMONIA; BACTERIAL VIRULENCE; DNA REPLICATION; HORSE; MACROPHAGE; NONHUMAN; PHAGOCYTOSIS; PLASMID; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; RHODOCOCCUS EQUI;

EID: 18844480411     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.67.7.3548-3557.1999     Document Type: Article

References (37)

1. Arlotti, M., G. Zoboli, G. L. Moscatelli, G. Magnati, R. Maserati, V. Borghi, M. Andreoni, M. Libanore, L. Bonazzi, A. Piscina, and R. Ciammarughi. 1996. Rhodococcus equi infection in HIV-positive subjects: a retrospective analysis of 24 cases. Scand. J. Infect. Dis. 28:463-467.
2. Byrne, B. A., J. F. Prescott, G. H. Palmer, and S. A. Hines. 1998. Characterization of a virulence-associated gene family in Rhodococcus equi, abstr. P-63, p. 236. In Conference handbook of the 8th International Conference on Equine Infectious Diseases, Dubai, United Arab Emirates.
3. De la Pena-Moctezuma, A., and J. F. Prescott. 1995. Association with HeLa cells by Rhodococcus equi with and without the virulence plasmid. Vet. Microbiol. 46:383-392.
4. De la Pena-Moctezuma, A., and J. F. Prescott. 1996. Attempts to find phenotypic markers of the virulence plasmid of Rhodococcus equi. Can. J. Vet. Res. 60:29-33.
5. Donisi, A., M. G. Suardi, S. Casari, M. Longo, G. P. Cadeo, and G. Carosi. 1996. Rhodococcus equi infection in HIV-infected patients. AIDS 10:359-362.
6. Fernandez, A. S., J. F. Prescott, and V. M. Nicholson. 1997. Protective effect against Rhodococcus equi infection in mice of IgG purified from horses vaccinated with virulence associated protein (VapA)-enriched antigens. Vet. Microbiol. 56:187-192.
7. Giguère, S., and J. F. Prescott. 1997. Clinical manifestations, diagnosis, treatment, and prevention of Rhodococcus equi infections in foals. Vet. Microbiol. 56:313-334.
8. Giguère, S., and J. F. Prescott. 1998. Cytokine induction in murine macrophages infected with virulent and avirulent Rhodococcus equi. Infect. Immun. 66:1848-1854.
9. Gotoh, K., M. Mitsuyama, S. Imaizumi, I. Kawamura, and I. Yano. 1991. Mycolic acid-containing glycolipid as a possible virulence factor of Rhodococcus equi for mice. Microbiol. Immunol. 35:175-185.
10. Guiney, D. G., S. Libby, F. C. Fang, M. Krause, and J. Fierer. 1995. Growth-phase regulation of plasmid virulence genes in Salmonella. Trends Microbiol. 3:275-279.
11. Harvey, R. L., and J. C. Sunstrum. 1991. Rhodococcus equi infections in patients with and without human immunodeficiency virus infection. Rev. Infect. Dis. 13:139-145.
12. Hondalus, M. K., and D. M. Mosser. 1994. Survival and replication of Rhodococcus equi in macrophages. Infect. Immun. 62:4167-4175.
13. Johnson, J. A., J. F. Prescott, and R. J. F. Markham. 1983. The pathology of experimental Corynebacterium equi infection in foals following intrabronchial challenge. Vet. Pathol. 20:440-449.
14. Labidi, A., C. Dauget, K. S. Goh, and H. L. David. 1984. Plasmid profiles of Mycobacterium fortuitum complex isolates. Curr. Microbiol. 11:235-240.
15. Madarame, H., S. Takai, C. Matsumoto, K. Minamiyama, Y. Sasaki, S. Tsubaki, Y. Hasegawa, and A. Nakane. 1997. Virulent and avirulent Rhodococcus equi infection in T-cell deficient athymic nude mice: pathologic, bacteriologic and immunologic responses. FEMS Immunol. Med. Microbiol. 17:251-262.
16. Martens, R. J., R. A. Fiske, and H. W. Renshaw. 1982. Experimental sub-acute foal pneumonia induced by aerosol administration of Corynebacterium equi. Equine Vet. J. 14:111-116.
17. Mosser, D. M., and M. K. Hondalus. 1996. Rhodococcus equi: an emerging opportunistic pathogen. Trends Microbiol. 4:29-33.
18. Prescott, J. F. 1991. Rhodococcus equi: an animal and human pathogen. Clin. Microbiol. Rev. 4:20-34.
19. Prescott, J. F., A. S. Fernandez, V. M. Nicholson, M. A. Patterson, J. A. Yager, L. Viel, and G. Perkins. 1996. Use of a virulence-associated protein based enzyme-linked immunosorbent assay for Rhodococcus equi serology in horses. Equine Vet. J. 28:344-349.
20. Prescott, J. F., V. M. Nicholson, M. C. Patterson, M. C. Zandona Meleiro, A. Caterino de Araujo, J. A. Yager, and M. A. Holmes. 1997. Use of Rhodococcus equi virulence-associated protein for immunization of foals against R. equi pneumonia. Am. J. Vet. Res. 58:356-359.
21. Prescott, J. F., M. C. Patterson, V. M. Nicholson, B. Morein, and J. A. Yager. 1997. Assessment of the immunogenic potential of Rhodococcus equi virulence associated protein (VapA) in mice. Vet. Microbiol. 56:213-225.
22. Sasakawa, C., J. M. Buysse, and H. Watanabe. 1992. The large virulence plasmid of Shigella. Curr. Top. Microbiol. Immunol. 180:21-44.
23. SAS Institute, Inc. 1990. SAS/STAT user's guide, version 6. SAS, Cary, N.C.
24. Sekizaki, T., S. Takai, Y. Egawa, T. Ikeda, H. Ito, and S. Tsubaki. 1995. Sequence of the Rhodococcus equi gene encoding the virulence-associated 15-17-kDa antigens. Gene 155:135-136.
25. Tabrizi, S. N., and R. M. Robins-Browne. 1992. Influence of a 70 kilobase virulence plasmid on the ability of Yersinia enterocolitica to survive phagocytosis in vitro. Microb. Pathog. 13:171-179.
26. Takai, S., T. Anzai, Y. Sasaki, S. Tsubaki, and M. Kamada. 1993. Virulence of Rhodococcus equi isolated from lesions of infected foals. Bull. Equine Res. Inst. 30:9-14.
27. Takai, S., N. Fukunaga, K. Kamisawa, Y. Imai, Y. Sasaki, and S. Tsubaki. 1996. Expression of virulence-associated antigens of Rhodococcus equi is regulated by temperature and pH. Microbiol. Immunol. 40:591-594.
28. Takai, S., M. Iie, Y. Watanabe, S. Tsubaki, and T. Sekizaki. 1992. Virulence-associated 15- to 17-kilodalton antigens in Rhodococcus equi: temperature-dependent expression and location of the antigens. Infect. Immun. 60:2995-2997.
29. Takai, S., Y. Imai, N. Fukunaga, Y. Uchida, K. Kamisawa, Y. Sasaki, S. Tsubaki, and T. Sekizaki. 1995. Identification of virulence-associated antigens and plasmids in Rhodococcus equi from patients with AIDS. J. Infect. Dis. 172:1305-1311.
30. Takai, S., K. Koike, S. Ohbushi, C. Izumi, and S. Tsubaki. 1991. Identification of 15- to 17-kilodalton antigens associated with virulence of Rhodococcus equi. J. Clin. Microbiol. 29:439-443.
31. Takai, S., H. Madarame, C. Matsumoto, M. Inoue, Y. Sasaki, Y. Hasegawa, S. Tsubaki, and A. Nakane. 1995. Pathogenesis of Rhodococcus equi infection in mice: roles of virulence plasmids and granulomagenic activity of bacteria. FEMS Immunol. Med. Microbiol. 11:181-190.
32. Takai, S., Y. Sasaki, T. Ikeda, Y. Uchida, S. Tsubaki, and T. Sekizaki. 1994. Virulence of Rhodococcus equi isolates from patients with and without AIDS. J. Clin. Microbiol. 32:457-460.
33. Takai, S., T. Sekizaki, T. Ozawa, T. Sugawara, Y. Watanabe, and S. Tsubaki. 1991. Association between large plasmid and 15- to 17-kilodalton antigens in virulent Rhodococcus equi. Infect. Immun. 59:4056-4060.
34. Takai, S., Y. Watanabe, T. Ikeda, T. Ozawa, S. Matsukura, Y. Tamada, S. Tsubaki, and T. Sekizaki. 1993. Virulence-associated plasmids in Rhodococcus equi. J. Clin. Microbiol. 31:1726-1729.
35. Tan, C., J. F. Prescott, M. C. Patterson, and V. M. Nicholson. 1995. Molecular characterization of a lipid-modified virulence-associated protein of Rhodococcus equi and its potential in protective immunity. Can. J. Vet. Res. 59:51-59.
36. Wada, R., M. Kamada, T. Anzai, A. Nakanishi, T. Kanemaru, S. Takai, and S. Tsubaki. 1997. Pathogenicity and virulence of Rhodococcus equi in foals following intratracheal challenge. Vet. Microbiol. 56:301-312.
37. Yager, J. A., C. A. Prescott, D. P. Kramar, H. Honnah, G. A. Balson, and B. A. Croy. 1991. The effect of experimental infection with Rhodococcus equi on immunodeficient mice. Vet. Microbiol. 28:363-376.