Are β-turn mimetics mimics of β-turns?

Angewandte Chemie - International Edition

Volumn 39, Issue 5, 2000, Pages 894-896

  Müller, Gerhard ^a   Hessler, Gerhard ^a   Decornez, Helene Y ^b  

^a BAYER AG   (Germany)

^b UNIVERSITY OF NOTRE DAME   (United States)

Author keywords

Turns; Drug research; Molecular modeling; Monte Carlo simulations; Peptidomimetics

Indexed keywords

PEPTIDE;

ARTICLE; CONFORMATION; DRUG RESEARCH; MOLECULAR DYNAMICS; MOLECULAR MODEL; SIMULATION; STRUCTURE ANALYSIS; SYSTEM ANALYSIS;

EID: 0037556889     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-3773(20000303)39:5<894::AID-ANIE894>3.0.CO;2-2     Document Type: Article

References (20)

1. a) C. R. Beddell, The Design of Drugs to Macromolecular Targets, Wiley, Chichester, 1992;
2. b) K. Gubernator, H. J. Böhm, Structure-Based Ligand Design, Wiley-VCH, Weinheim, 1998;
3. c) R. E. Babine, S. L. Bender, Chem. Rev. 1997, 97, 1359-1472;
4. d) P. Veerapandian, Structure-Based Design, Dekker, New York, 1997.
5. a) J. S. Richardson, Adv. Protein Chem. 1981, 34, 167-339;
6. b) G. D. Rose, L. M. Gierasch, J. A. Smith, Adv. Protein Chem. 1985, 37, 1-109;
7. c) G. Müller, Angew. Chem. 1996, 108, 2941-2943; Angew. Chem. Int. Ed. Engl. 1996, 35, 2767-2769.
8. d) G. Müller, Angew. Chem. 1996, 108, 2941-2943; Angew. Chem. Int. Ed. Engl. 1996, 35, 2767-2769.
9. a) G. Hölzemann, Kontakte (Darmstadt) 1991, 3-12;
10. b) G. Hölzemann, Kontakte (Darmstadt) 1991, 55-63;
11. c) A. E. P. Adang, P. H. H. Hermkens, J. T. M. Linders, H. C. J. Ottenheijm, C. J. van Staveren, Recl. Trav. Chim. Pays-Bas 1994, 113, 63-78.
12. A. J. Souers, A. A. Virgilio, S. S. Schürer, J. A. Ellman, T. P. Kogan, H. E. West, W. Ankener, P. Vanderslice, Bioorg. Med. Chem. Lett. 1998, 8, 2297-2302.
13. N. Cho, M. Harada, T. Imaeda, T. Imada, H. Matsumoto, Y. Hayase, S. Sasaki, S. Furuya, N. Suzuki, S. Okubo, K. Ogi, S. Endo, H. Onda, M. Fujino, J. Med. Chem. 1998, 41, 4190-4195.
14. A. J. Souers, A. A. Virgilio, Å. Rosenquist, W. Fenuik, J. A. Ellman, J. Am. Chem. Soc. 1999, 121, 1817-1825.
15. a) G. Müller, M. Gurrath, M. Kurz, H. Kessler, Proteins Struct. Funct. Genet. 1993, 15, 235-251;
16. b) M. Gurrath, G. Müller, H. Kessler, M. Aumailley, R. Timpl, Eur. J. Biochem. 1992, 210, 911-921.
17. A comprehensive summary of β-turn mimetics: a) S. Hanessian, G. McNaughton-Smith, H.-G. Lombart, W. D. Lubell, Tetrahedron 1997, 53, 12789-12854;
18. b) P. Gillespie, J. Cicariello, G. L. Olson, Biopolymers 1991, 43, 191-217.
19. M. Venkatachalam, Biopolymers 1968, 6, 1425-1436.
20. P. Lewis, F. Momany, H. Scheraga, Biochim. Biophys. Acta 1973, 303, 211-229.