Synthesis and antitrypanosomal profile of new functionalized 1,3,4-thiadiazole-2-arylhydrazone derivatives, designed as non-mutagenic megazol analogues

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 24, 2004, Pages 5967-5970

  Carvalho, Samir A ^a,b   Da Silva, Edson F ^b   Santa Rita, Ricardo M ^a,b   De Castro, Solange L ^b   Fraga, Carlos A M ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b INSTITUTO OSWALDO CRUZ   (Brazil)

Author keywords

1,3,4 Thiadiazole derivatives; Chagas' disease; Hydrazone derivatives; Megazol analogues; New trypanocidal drugs

Indexed keywords

1,3,4 THIADIAZOLE DERIVATIVE; 2 AMINO 5 (1 METHYL 5 NITRO 2 IMIDAZOLYL) 1,3,4 THIADIAZOLE; AMIDINOHYDRAZONE; ANTITRYPANOSOMAL AGENT; BENZENE; BRAZILINONE A; HYDRAZONE DERIVATIVE; NITROIMIDAZOLE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BLOOD FLOW; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; IC 50; MOLECULAR HYBRIDIZATION; MOUSE; NONHUMAN; TRYPANOSOMA CRUZI; TRYPOMASTIGOTE;

ANIMALS; HYDRAZONES; MOLECULAR STRUCTURE; MUTAGENS; PARASITIC SENSITIVITY TESTS; STRUCTURE-ACTIVITY RELATIONSHIP; THIADIAZOLES; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

TRYPANOSOMA; TRYPANOSOMA CRUZI;

EID: 8844278475     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.10.007     Document Type: Article

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