Association of the hCLCA1 gene with childhood and adult asthma

Genes and Immunity

Volumn 5, Issue 7, 2004, Pages 540-547

  Kamada, F ^a   Suzuki, Y ^a   Shao, C ^a   Tamari, M ^b   Hasegawa, K ^b   Hirota, T ^b   Shimizu, M ^b   Takahashi, N ^b   Mao, X Q ^c   Doi, S ^d   Fujiwara, H ^d   Miyatake, A ^e   Fujita, K ^f   Chiba, Y ^g   Aoki, Y ^a   Kure, S ^a   Tamura, G ^a   Shirakawa, T ^b,c   Matsubara, Y ^a  

^a TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b INST OF PHYS AND CHEMICAL RESEARCH   (Japan)

^c KYOTO UNIVERSITY SCHOOL OF PUBLIC HEALTH   (Japan)

^d OSAKA PREFECTURAL MEDICAL CENTER FOR RESPIRATORY AND ALLERGIC DISEASES   (Japan)

^e Miyatake Asthma Clinic   (Japan)

^f UNIVERSITY OF SHIGA PREFECTURE   (Japan)

^g Sendai Red Cross Hospital   (Japan)

Author keywords

Association study; Asthma; Haplotype; hCLCA1; Japanese population; SNP

Indexed keywords

ADENINE; CALCIUM ION; CHLORIDE CHANNEL; CHLORIDE ION; CYTOSINE; GUANINE; THYMINE;

ADOLESCENT; ADULT; ARTICLE; ASTHMA; CHILD; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENE IDENTIFICATION; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SCREENING; GENETIC SUSCEPTIBILITY; GENOTYPE PHENOTYPE CORRELATION; HAPLOTYPE; HIGH RISK POPULATION; HUMAN; HUMAN CELL; JAPAN; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL SIGNIFICANCE;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ASTHMA; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; CHLORIDE CHANNELS; CONFIDENCE INTERVALS; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INFANT; LINKAGE (GENETICS); LOGISTIC MODELS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 8844239134     PISSN: 14664879     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gene.6364124     Document Type: Article

References (43)

1. Daser A, Daheshia M, De Sanctis GT. Genetics of allergen-induced asthma. J Allergy Clin Immunol 2001; 108: 167-174.
2. McFadden ER, Gilbert IA. Asthma. N Engl J Med 1992; 327: 1928-1937.
3. Barnes PJ. New concepts in the pathogenesis of bronchial hyperresponsiveness and asthma. J Allergy Clin Immunol 1989; 83 1013-1026.
4. Boushey HA, Fahy JV. Basic mechanisms of asthma. Environ Health Perspect 1995; 103: 229-233.
5. Barnes KC, Marsh DG. The genetics and complexity of allergy and asthma. Immunol Today 1998; 19: 325-332.
6. Steinke JW, Borish L, Rosenwasser LJ. 5. Genetics of hypersensitivity. J Allergy Clin Immunol 2003; 111: S495-S501.
7. Tattersfield AE, Knox AJ, Britton JR, Hall IP. Asthma. Lancet 2002; 360: 1313-1322.
8. Cookson WO, Moffatt MF. Genetics of asthma and allergic disease. Hum Mol Genet 2000; 9: 2359-2364.
9. Ono SJ. Molecular genetics of allergic diseases. Annu Rev Immunol 2000; 18: 347-366.
10. Nakanishi A, Morita S, Iwashita H et al. Role of gob-5 in mucus overproduction and airway hyperresponsiveness in asthma. Proc Natl Acad Sci USA 2001; 98: 5175-5180.
11. Zhou Y, Dong Q, Louahed J et al. Characterization of a calcium-activated chloride channel as a shared target of Th2 cytokine pathways and its potential involvement in asthma. Am J Respir Cell Mol Biol 2001; 25: 486-491.
12. Toda M, Tulic MK, Levitt RC, Hamid Q. A calcium-activated chloride channel (HCLCA1) is strongly related to IL-9 expression and mucus production in bronchial epithelium of patients with asthma. J Allergy Clin Immunol 2002; 109: 246-250.
13. Hashimoto K, Graham BS, Ho SB et al. Respiratory syncytial virus in allergic lung inflammation increases Muc5ac and gob-5. Am J Respir Crit Care Med 2004; 170: 306-312.
14. Miller AL, Strieter RM, Gruber AD, Ho SB, Lukacs NW. CXCR2 regulates respiratory syncytial virus-induced airway hyperreactivity and mucus overproduction. J Immunol 2003; 170: 3348-3356.
15. Agnel M, Vermat T, Culouscou JM. Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea. FEBS Lett 1999; 455: 295-301.
16. - channel proteins. Genomics 1998; 54: 200-214.
17. Cunningham SA, Awayda MS, Bubien JK et al. Cloning of an epithelial chloride channel from bovine trachea. J Biol Chem 1995; 270: 31016-31026.
18. Elble RC, Widom J, Gruber AD et al. Cloning and characterization of lung-endothelial cell adhesion molecule-1 suggest it is an endothelial chloride channel. J Biol Chem 1997; 272: 27853-27861.
19. Zhu DZ, Cheng CF, Pauli BU. Mediation of lung metastasis of murine melanomas by a lung-specific endothelial cell adhesion molecule. Proc Natl Acad Sci USA 1991; 88: 9568-9572.
20. Elble RC, Ji G, Nehrke K et al. Molecular and functional characterization of a murine calcium-activated chloride channel expressed in smooth muscle. J Biol Chem 2002; 277: 18586-18591.
21. Gandhi R, Elble RC, Gruber AD et al. Molecular and functional characterization of a calcium-sensitive chloride channel from mouse lung. J Biol Chem 1998; 273: 32096-32101.
22. Komiya T, Tanigawa Y, Hirohashi S. Cloning and identification of the gene gob-5, which is expressed in intestinal goblet cells in mice. Biochem Biophys Res Commun 1999; 255: 347-351.
23. Lee D, Ha S, Kho Y et al. Induction of mouse Ca(2+)-sensitive chloride channel 2 gene during involution of mammary gland. Biochem Biophys Res Commun 1999; 264: 933-937.
24. Pauli BU, Abdel-Ghany M, Cheng HC, Gruber AD, Archibald HA, Elble RC. Molecular characteristics and functional diversity of CLCA family members. Clin Exp Pharmacol Physiol 2000; 27: 901-905.
25. - channels. Biochim Biophys Acta 1999; 1444 418-423.
26. Gruber AD, Schreur KD, Ji HL, Fuller CM, Pauli BU. Molecular cloning and transmembrane structure of hCLCA2 from human lung, trachea, and mammary gland. Am J Physiol 1999; 276: C1261-C1270.
27. Gruber AD, Pauli BU. Clustering of the human CLCA gene family on the short arm of chromosome 1 (1p22-31). Genome 1999; 42: 1030-1032.
28. Hasegawa K, Tamari M, Shao C et al. Variations in the C3, C3aR and C5 genes affect risk for bronchial asthma and related phenotypes. Hum Genet 27 July 2004 (Epub ahead of print). DOI: 10.1007/s00439-004-1157-z.
29. Hirakawa M, Tanaka T, Hashimoto Y, Kuroda M, Takagi T, Nakamura Y. JSNP: a database of common gene variations in the Japanese population. Nucleic Acids Res 2002; 30: 158-162.
30. Lewontin RC. The interaction of selection and linkage. I. General considerations; heterotic models. Genetics 1964; 49: 49-67.
31. Hill WG, Robertson A. Linkage disequilibrium in finite populations. Theor Appl Genet 1968; 38: 226-231.
32. Niimi T, Munakata M, Keck-Waggoner CL et al. A polymorphism in the human UGRP1 gene promoter that regulates transcription is associated with an increased risk of asthma. Am J Hum Genet 2002; 70: 718-725.
33. Prokunina L, Castillejo-Lopez C, Oberg F et al. A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans. Nat Genet 2002; 32: 666-669.
34. Hegab AE, Sakamoto T, Uchida Y et al. CLCA1 gene polymorphisms in chronic obstructive pulmonary disease. J Med Genet 2004; 41: e27.
35. Guidelines for the diagnosis and management of asthma. National Heart, Lung, and Blood Institute. National Asthma Education Program. Expert Panel Report J Allergy Clin Immunol 1991; 88: 425-534.
36. Guidelines for the diagnosis and management of asthma. National Heart, Lung, and Blood Institute. Second expert panel on the management of asthma Publication 1997, 97-4051A.
37. Lyamichev V, Mast AL, Hall JG et al. Polymorphism identification and quantitative detection of genomic DNA by invasive cleavage of oligonucleotide probes. Nat Biotechnol 1999; 17: 292-296.
38. Mein CA, Barratt BJ, Dunn MG et al. Evaluation of single nucleotide polymorphism typing with invader on PCR amplicons and its automation. Genome Res 2000; 10: 330-343.
39. Fujii K, Matsubara Y, Akanuma J et al. Mutation detection by TaqMan-allele specific amplification: application to molecular diagnosis of glycogen storage disease type Ia and medium-chain acyl-CoA dehydrogenase deficiency. Hum Mutat 2000; 15: 189-196.
40. Ohnishi Y, Tanaka T, Ozaki K, Yamada R, Suzuki H, Nakamura Y. A high-throughput SNP typing system for genome-wide association studies. J Hum Genet 2001; 46: 471-477.
41. Brown CC. The validity of approximation methods for interval estimation of the odds ratio. Am J Epidemiol 1981; 113: 474-480.
42. Stephens M, Donnelly P. A comparison of bayesian methods for haplotype reconstruction from population genotype data. Am J Hum Genet 2003; 73: 1162-1169.
43. Niu T, Qin ZS, Xu X, Liu JS. Bayesian haplotype inference for multiple linked single-nucleotide polymorphisms. Am J Hum Genet 2002; 70: 157-169.