Molecular genetics of allergic diseases

Annual Review of Immunology

Volumn 18, Issue , 2000, Pages 347-366

  Ono, Santa Jeremy ^a  

^a SCHEPENS EYE RESEARCH INSTITUTE   (United States)

Author keywords

Atopy; Genome analysis; Inflammation; Linkage

Indexed keywords

IMMUNOGLOBULIN E;

ALLERGIC DISEASE; ANAPHYLAXIS; ASTHMA; ATOPY; BEE STING; CONJUNCTIVITIS; DERMATITIS; ENVIRONMENTAL FACTOR; FOOD ALLERGY; GENETIC SUSCEPTIBILITY; GENOME; HEALTH CARE COST; HEREDITY; HUMAN; HYPERSENSITIVITY; MOLECULAR GENETICS; NONHUMAN; PRIORITY JOURNAL; REVIEW; TWINS;

ANIMALS; HUMANS; HYPERSENSITIVITY; MICE;

EID: 0034121188     PISSN: 07320582     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.immunol.18.1.347     Document Type: Review

References (67)

1. Taylor B, Broom BC. 1981. Atopy in medical students. Ann. Allergy 47:197-99
2. Sibbald B, Horn ME, Brain EA, Gregg 1. 1980. Genetic factors in childhood asthma. Thorax 35:671-74
3. Hopp RJ, Bewtra AK, Watt GD, Nair NM, Townley RG. 1984. Genetic analysis of allergic disease in twins. J. Allergy Clin. Immunol. 73:265-70
4. Luoma R, Koivikko A, Viander M. 1983. Development of asthma, allergic rhinitis and atopic dermatitis by the age of five years. A prospective study of 543 newborns. Allergy 38:339-46
5. Clausen JT, Sparck JV, Werdelin O, Larsen SO, Lundberg L. 1985. Immunogenetic studies of respiratory anaphylaxis in selectively bred guinea pigs. Inheritance of atopy, linkage to MFIC-complex. Allergy 40:15-22
6. Cookson WO ,Hopkin JM. 1988. Dominant inheritance of atopic immunoglobulin E responsiveness. Lancet 1:86-88
7. Aron Y, Desmazes-Dufeu N, Matran R, Polla BS, Dusser D, Lockhart A, Swierczewski E. 1996. Evidence of a strong, positive association between atopy and the HLA class II alleles DR4 and DR7. Clin. Exp. Allergy 26:821-28
8. Marsh DG, Ober C, Bleecker E. 1997. A genome-wide search for asthma susceptibility loci in ethnically diverse populations. Collaborative Study on the Genetics of Asthma (CSGA). Nat. Genet. 15:389-92
9. Daniels SE, Bhattacharrya S, James A, Leaves NI, Young A, Hill MR, Faux JA, Ryan GF, le Souef PN, Lathrop GM. 1996. A genome-wide search for quantitative trait loci underlying asthma. Nature 383:247-50
10. Hizawa N, Collins G, Rafnar T, Huang SK, Duffy DL, Weber JL, Freidhoff LR, Ehrlich E, Marsh DG, Beaty TH. 1998. Linkage analysis of Dermatophagoides pteronyssinus-specific IgE responsiveness with polymorphic markers on chromosome 6p21 (HLA-D region) in Caucasian families by the transmission/ disequilibrium test. Collaborative Study on the Genetics of Asthma (CSGA). J. Allergy Clin. Immunol. 102:4418
11. Lara-Marquez ML, Yunis JJ, Layrisse Z, Ortega F, Carvallo-Gil E, Montagnani S, Makhatadze NJ, Pocino M, Granja C, Yunis E. 1999. Immunogenetics of atopic asthma: association of DRB1*1101 DQA1*0501 DQB1*0301 haplotype with Dermatophagoides spp.-sensitive asthma in a sample of the Venezuelan population. Clin. Exp. Allergy 29:60-71
12. Amelung PJ, Panhuysen CI, Postma DS, Levitt RC, Koeter GH, Francomano CA, Bleecker ER, Meyers DA. 1992. Atopy and bronchial hyperresponsiveness: exclusion of linkage to markers on chromosomes 11q and 6p. Clin. Exp. Allergy 22:1077-84
13. Stephan V, Schmid V, Frischer T, Sparholt S, Forster J, Wahn V, Kuehr J. 1996. Mite allergy, clinical atopy, and restriction by HLA class II immune response genes. Pediatr. Allergy Immunol. 7:28-34
14. Holloway JW, Doull I, Begishvili B, Beasley R, Holgate ST, Howell WM. 1996. Lack of evidence of a significant association between HLA-DR, DQ and DP genotypes and atopy in families with HDM allergy. Clin. Exp. Allergy 26: 1142-49
15. Torres-Galvan MJ, Quiralte J, Blanco C, Castillo R, Carrillo T, Perez-Aciego P, Sanchez-Garcia F. 1999. Linkage of house dust mite allergy with the HLA region. Ann. Allergy Asthma Immunol. 82:198-203
16. Cookson WO, Sharp PA, Faux JA, Hopkin JM. 1989. Linkage between immunoglobulin E responses underlying asthma and rhinitis and chromosome 11q. Lancet 1:1292-95
17. Lympany P, Welsh K, MacCochrane G, Kemeny DM, Lee TH. 1992. Genetic analysis using DNA polymorphism of the linkage between chromosome 11q13 and atopy and bronchial hyperresponsiveness to methacholine. J. Allergy Clin. Immunol. 89:619-28
18. Cookson WO, Young RP, Sandford AJ, Moffatt MF, Shirakawa T, Sharp PA, Faux JA, Julier C, Nakumuura Y, Nakumura Y. 1992. Maternal inheritance of atopic IgE responsiveness On chromosome 11q [published erratum. appears in Lancet 1992 Oct 31; 340(8827):1110] [see comments]. Lancet 340:381-84
19. Sandford AJ, Shirakawa T, Moffatt MF, Daniels SE, Ra C, Faux JA, Young RP, Nakamura Y, Lathrop GM, Cookson WO. 1993. Localisation of atopy and beta subunit of high-affinity IgE receptor (Fc epsilon RI) on chromosome 11q [see comments]. Lancet 341:332-34
20. Stafford AN, Rider SH, Hopkin JM, Cookson WO, Monaco AP. 1994. A 2.8 Mb YAC contig in 11q12-q13 localizes candidate genes for atopy: Fc epsilon RI beta and CD20. Hum. Mol. Genet. 3:779-85
21. Shirakawa T, Li A, Dubowitz M, Dekker JW, Shaw AE, Faux JA, Ra C, Cookson WO, Hopkin JM. 1994. Association between atopy and variants of the beta subunit of the high-affinity immunoglobulin E receptor [see comments]. Nat. Genet. 7:125-29
22. Shirakawa T, Hashimoto T, Furuyama J, Takeshita T, Morimoto K. 1994. Linkage between severe atopy and chromosome 11q13 in Japanese families. Clin. Genet. 46:228-32
23. Sandford AJ, Moffatt MF, Daniels SE, Nakamura Y, Lathrop GM, Hopkin JM, Cookson WO. 1995. A genetic map of chromosome 11q, including the atopy locus. Eur. J. Hum. Genet. 3:188-94
24. Hill MR, James AL, Faux JA, Ryan G, Hopkin JM, le Souef P, Musk AW, Cookson WO. 1995. Fc epsilon RI-beta polymorphism and risk of atopy in a general population sample [see comments] [published erratum appears in Br. Med. J. 1995. Nov 4;311(7014):11961.] Br. Med. J. 311:776-79
25. van Herwerden L, Harrap SB, Wong ZY, Abramson MJ, Kutin JJ, Forbes AB, Raven J, Lanigan A, Walters EH. 1995. Linkage of high-affinity IgE receptor gene with bronchial hyperreactivity, even in absence of atopy [see comments]. Lancet 346:1262-65
26. Doull IJ, Lawrence S, Watson M, Begishvili T, Beasley RW, Lampe F, Holgate T, Morton NE. 1996. Allelic association of gene markers on chromosomes 5q and 11q with atopy and bronchial hyperresponsiveness. Am. J. Respir. Crit.Care Med. 153:1280-84
27. Folster-Holst R, Moises HW, Yang L, Fritsch W, Weissenbach J, Christophers E. 1998. Linkage between atopy and the IgE high-affinity receptor gene at 11q 13 in atopic dermatitis families. Hum. Genet. 102:236-39
28. Cox HE, Moffatt MF, Faux JA, Walley AJ, Coleman R, Trembath RC, Cookson WO, Harper JI. 1998. Association of atopic dermatitis to the beta subunit of the high affinity immunoglobulin E receptor. Br. J. Dermatol. 138:182-87
29. Green SL, Gaillard MC, Song E, Dewar JB, Halkas A. 1998. Polymorphisms of the beta chain of the high-affinity immunoglobulin E receptor (Fc epsilon RI-beta) in South African black and white asthmatic and nonasthmatic individuals. Am. J. Respir. Crit. Care Med. 158:1487-92
30. Hizawa N, Freidhoff LR, Ehrlich E, Chiu YF, Duffy DL, Schou C, Dunston GM, Beaty TH, Marsh DG, Barnes KC. 1998. Genetic influences of chromosomes 5q31-q33 and 11q13 on specific IgE responsiveness to common inhaled allergens among African American families. Collaborative Study on the Genetics of Asthma (CSGA). J. Allergy Clin. Immunol. 102:449-53
31. Lympany P, Welsh KI, Cochrane GM, Kemeny DM, Lee TH. 1992. Genetic analysis of the linkage between chromosome 11q and atopy. Clin. Exp. Allergy 22:108-192
32. Brereton HM, Ruffin RE, Thompson PJ, Turner DR. 1994. Familial atopy in Australian pedigrees: adventitious linkage to chromosome 8 is not confirmed nor is there evidence of linkage to the high affinity IgE receptor. Clin. Exp. Allergy 24:868-77
33. Hizawa N, Ohe M, Kawakami 1996. [Genetic analysis of bronchial asthma in Japanese population - Fc epsilon RI beta gene and beta 2 adrenergic receptor gene]. Nippon Rinsho. 54:539-43
34. Martinati LC, Trabetti E, Casartelli A, Boner AL, Pignatti PF. 1996. Affected sib-pair and mutation analyses of the high affinity IgE receptor beta chain locus in Italian families with atopic asthmatic children. Am J. Respir. Crit. Care Med. 153(5):1682-5
35. Kofler H, Aichberger S, Ott G, Casari A, Kofler R. 1996. Lack of association between atopy and the Ile 181 Leu variant of the beta-subunit of the high-affinity immunoglobulin E receptor. Int. Arch. Allergy Immunol. 111:44-47
36. Guler ML, Gorham JD, Dietrich WF, Murphy TL, Steen RG, Parvin CA, Fenoglio D, Grupe A, Peltz G, Murphy KM. 1999. Tpml, a locus controlling IL-12 responsiveness, acts by a cell-autonomous mechanism. J. Immunol. 162:1339-47
37. Thomas NS, Wilkinson J, Holgate ST. 1997. The candidate region approach to the genetics of asthma and allergy. Am. J. Respir. Crit. Care Med. 156:5144-51
38. Noguchi E, Shibasaki M, Arinami T, Takeda K, Maki T, Miyamoto T, Kawashima T, Kobayashi K, Hamaguchi H. 1997. Evidence for linkage between asthma/atopy in childhood and chromosome 5q31-q33 in a Japanese population. Am. J. Respir. Crit. Care Med. 156:1390-93
39. Castro J, Telleria JJ, Blanco-Quiros A, Linares P, Andion R. 1998. Lack of association between atopy and Rsal polymorphism within intron 2 of the Fc(epsilon)RIbeta gene in a Spanish population sample. Allergy 53:1083-86
40. Ober C, Cox 54, Abney M, Di Rienzo A, Lander ES, Changyaleket B, Gidley H, Kurtz B, Lee J, Nance IV. 1998. Genome-wide search for asthma susceptibility loci in a founder population.Collaborative Study on the Genetics of Asthma. Hum. Mol. Genet. 7:1393-98
41. Xu J, Levitt RC, Panhuysen CI, Postma DS, Taylor EW, Amelung PJ, Holroyd KJ, Bleecker ER, Meyers DA. 1995. Evidence for two unlinked loci regulating total serum IgE levels. Am. J. Hum. Genet. 57:425-30
42. Postma DS, Bleecker ER, Amelung PJ, Holroyd KJ, Xu J, Panhuysen CI, Meyers DA, Levitt RC. 1995. Genetic susceptibility to asthma - bronchial hyperresponsiveness coinherited with a major gene for atopy. N. Engl. J. Med. 333:894-900
43. Holroyd KJ, Martinati LC, Trabetti E, Scherpbier T, Eleff SM, Boner AL, Pignatti PF, Kiser MB, Dragwa CR, Hubbard F, Sullivan CD, Grasso L, Messler CJ, Huang M, Hu Y, Nicolaides NC, Buetow KH, Levitt RC. 1998. Asthma and bronchial hyperresponsiveness linked to the XY long arm pseudoautosmal region. Genomics 52(2):233-535
44. Laitinen T, Kauppi P, Ignatius J, Ruotsalainen T, Daly MJ, Kaariainen H, Kruglyak L, Laitinen H, de la Chapelle A, Lander ES. 1997. Genetic control of serum IgE levels and asthma: linkage and linkage disequilibrium studies in an isolated population. Hum. Mol. Genet. 6:2069-76
45. Kamitani A, Wong ZY, Dickson P, van Herwerden L, Raven J, Forbes AB, Abramson MJ, Walters EH, Harrap SB. 1997. Absence of genetic linkage of chromosome 5q31 with asthma and atopy in the general population. Thorax 52:8167
46. Rosenwasser LJ. Promoter polymorphism in the candidate genes, IL-4, IL-9, TGF-beta1, for atopy and asthma. Int Arch Allergy Immunol 1999 Feb-Apr; 118(2-4):268-70
47. Deleted in proof
48. Noguchi E, Shibasaki M, Arinami T, Takeda K, Yokouchi Y, Kawashima T, Yanagi H, Matsui A, Hamaguchi H. 1998. Association of asthma and the interleukin-4 promoter gene in Japanese. Chin. Exp. Allergy 28:449-53
49. Walley AJ,Cookson WO. 1996. Investigation of an interleukin-4 promoter polymorphism for associations with asthma and atopy. J. Med. Genet. 33:689-92
50. Izuhara K, Shirakawa T. 1999. Signal transduction via the interleukin-4 receptor and its correlation with atopy. Int. J. Mol. Med. 3:3-10
51. Hershey GK, Friedrich MF, Esswein LA, Thomas ML, Chatila TA. 1997. The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor. N. Engl. J. Med. 337:1720-25
52. Adra CN, Mao XQ, Kawada H, Gao PS, Korzycka B, Donate JL, Shaldon SR, Coull P, Dubowitz M, Enomoto T, Ozawa A, Syed SA, Horiuchi T, Khaeraja R, Khan R, Lin SR, Flinter F, Beales P, Hagihara A, Inoko H, Shirakawa T, Hopkin JM. 1999. Chromosome 11q13 and atopic asthma. Clin. Genet. 55(6):431-37
53. Dent AL, Shaffer AL, Yu X, Allman D, Staudt LM. 1997. Control of inflammation, cytokine expression, and germinal center formation by BCL-6. Science 276:589-92
54. Dent AL, Hu-Li J, Paul WE, Staudt LM. 1998. T helper type 2 inflammatory disease in the absence of interleukin 4 and transcription factor STAT6. Proc. Natl. Acad. Sci. USA 95:13823-28
55. Szabo SJ, Jacobson NG, DigheAS, Gubler U, Murphy KM. 1995. Developmental commitment to the Th2 lineage by extinction of IL-12 signaling. Immunity 2:665-75
56. Gorham JD, Guler ML, Murphy KM. 1997. Genetic control of interleukin 12 responsiveness: implications for disease pathogenesis. J. Mol. Med. 75:502-11
57. Hizawa N, Freidhoff LIZ, Chiu YF, Ehrlich E, Luehr CA, Anderson JL, Duffy DL, Dunston GM, Weber JL, Huang SK. 1998. Genetic regulation of Dermatophagoides pteronyssinus-specific IgE responsiveness: a genome-wide multipoint linkage analysis in families recruited through 2 asthmatic sibs. Collaborative Study on the Genetics of Asthma (CSGA). J. Allergy Clin. Immunol. 102:436-42
58. Wilkinson J, Thomas NS, Morton N, Holgate ST. 1999. Candidate gene and mutational analysis in asthma and atopy. Int. Arch. Allergy Immunol. 118:265-67
59. Wilkinson J, Grimley S, Collins A, Thomas NS, Holgate ST, Morton N. 1998. Linkage of asthma to markers on chromosome 12 in a sample of 240 families using quantitative phenotype scores. Genomics 53:251-59
60. Dewar JC, Wheatley AP, Venn A, Morrison JF, Britton J, Hall IP. 1998. Beta2-adrenoceptor polymorphisms are in linkage disequilibrium, but are not associated with asthma in an adult population. Clin. Exp. Allergy 28:442-48
61. Dewar JC, Wilkinson J, Wheatley A, Thomas NS, Doull I, Morton N, Lio P, Harvey JF, Liggett SB, Holgate ST. 1997. The glutamine 27 beta2-adrenoceptor polymorphism is associated with elevated IgE levels in asthmatic families. J. Allergy Clin. Immunol. 100:261-65
62. Ohe M, Munakata M. Hizawa N, Itoh A, Doi I, Yamaguchi E, Homma Y, Kawakami Y. 1995. Beta 2 adrenergic receptor gene restriction fragment length polymorphism and bronchial asthma. Thorax 50:353-59
63. Ismail A, Bousaffara R, Kaziz J, Zili J, el Kamel A, Tahar Sfar M, Remadi S, Chouchane L. 1997. Polymorphism in transporter antigen peptides gene (TAP1) associated with atopy in Tunisians. J. Allergy Clin. Immunol. 99:216-23
64. Noguchi E, Shibasaki M, Arinami T, Takeda K, Kobayashi K, Matsui A, Hamaguchi H. 1998. Evidence for linkage between the development of asthma in childhood and the T-cell receptor beta chain gene in Japanese. Genomics 47:121-24
65. Nickel RG, Saitta FP, Freidhoff LIZ, Yu XY, Ehrlich E, Barnes KC, Beaty T, Huang SK. 1999. Positional candidate gene approach and functional genomics strategy in atopy gene discovery. Int. Arch. Allergy Immunol. 118:282-84
66. Kawashima T, Noguchi E, Arinami T, Kobayashi K, Otsuka F, Hamaguchi H. 1998. No evidence for an association between a variant of the mast cell chymase gene and atopic dermatitis based on case-control and haplotype-relative-risk analyses. Hum. Hered. 48:271-74
67. Mao XQ, Shirakawa T, Yoshikawa T, Yoshikawa K, Kawai M, Sasaki S, Enomoto T, Hashimoto T, Furuyama J, Hopkin JM. 1996. Association between genetic variants of mast-cell chymase and eczema [see comments] [published erratum appears in Lancet 1997 Jan 4;349(9044):64]. Lancet 348:581-83