Intracerebroventricular administration of MK-801 increases food intake through mechanisms independent of gastric emptying

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 287, Issue 6 56-6, 2004, Pages

  Covasa, M ^a   Hung, Chun Yi ^a   Ritter, R C ^b   Burns, G A ^b  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b WASHINGTON STATE UNIVERSITY   (United States)

Author keywords

Dizolcipine; Gastric distention; Gastric tone; Satiation

Indexed keywords

DIZOCILPINE; SODIUM CHLORIDE; SUCROSE;

ANIMAL EXPERIMENT; ARTICLE; BRAIN FOURTH VENTRICLE; CONTROLLED STUDY; FEEDING; FOOD INTAKE; LOADING TEST; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RHOMBENCEPHALON; STOMACH EMPTYING; SUGAR INTAKE;

ANIMALS; DIZOCILPINE MALEATE; ENERGY INTAKE; FEEDING BEHAVIOR; GASTRIC EMPTYING; INJECTIONS, INTRAVENTRICULAR; KINETICS; MALE; RATS; RATS, SPRAGUE-DAWLEY; SODIUM CHLORIDE; SUCROSE;

EID: 8844234170     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.00471.2004     Document Type: Article

References (45)

1. Bednar I, Qian M, Qureshi GA, Kallstrom L, Johnson AE, Carrer H, and Sodersten P. Glutamate inhibits ingestive behaviour. J Neuroendocrinol 6: 403-408, 1994.
2. Berthoud HR, Earle T, Zheng H, Patterson LM, and Phifer C. Food-related gastrointestinal signals activate caudal brainstem neurons expressing both NMDA and AMPA receptors. Brain Res 915: 143-154, 2001.
3. Brenner L, Vox DP, and Ritter RC. Suppression of sham feeding by intraintestinal nutrients is not correlated with plasma cholecystokinin elevation. Am J Physiol Regul Integr Comp Physiol 264: R972-R976, 1993.
4. Broussard DL, Wiedner EB, Li X, and Altschuler SM. NMDAR1 mRNA expression in the brainstem circuit controlling esophageal peristalsis. Brain Res Mol Brain Res 27: 329-332, 1994.
5. Burns GA, Fleischmann LG, and Ritter RC. MK-801 interferes with nutrient-related signals for satiation. Appetite 30: 1-12, 1998.
6. Burns GA and Ritter RC. The non-competitive NMDA antagonist MK-801 increases food intake in rats. Pharmacol Biochem Behav 56: 145-149, 1997.
7. Burns GA and Ritter RC. Visceral afferent participation in delayed satiation following NMDA receptor blockade. Physiol Behav 65: 361-366, 1998.
8. Burns GA and Stephens KE. Expression of mRNA for the N-methyl-D-aspartate (NMDAR1) receptor and vasoactive intestinal polypeptide (VIP) co-exist in enteric neurons of the rat. J Anton Nerv Syst 55: 207-210, 1995.
9. Burns GA, Stephens KE, and Benson JA. Expression of mRNA for the N-methyl-D-aspartate (NMDAR1) receptor by the enteric neurons of the rat. Neurosci Lett 170: 87-90, 1994.
10. Covasa M, Ritter RC, and Burns GA. NMDA receptor participation in control of food intake by the stomach. Am J Physiol Regul Integr Comp Physiol 278: R1362-R1368, 2000.
11. Covasa M, Ritter RC, and Burns GA. Reduction of food intake by intestinal macronutrient infusion is not reversed by NMDA receptor blockade. Am J Physiol Regul Integr Comp Physiol 278: R345-R351, 2000.
12. Covasa M, Ritter RC, and Burns GA. Cholinergic neurotransmission participates in increased food intake induced by NMDA receptor blockade. Am J Physiol Regul Integr Comp Physiol 285: R641-R648, 2003.
13. Covasa M, Ritter RC, and Burns GA. NMDA receptor blockade attenuates CCK-induced reduction of real feeding but not sham feeding. Am J Physiol Regul Integr Comp Physiol 286: R826-R831, 2004.
14. Jahng JW and Houpt TA. MK801 increases feeding and decreases drinking in nondeprived, freely feeding rats. Pharmacol Biochem Behav 68: 181-186, 2001.
15. Kaplan JM, Siemers W, and Grill HJ. Effect of oral versus gastric delivery on gastric emptying of corn oil emulsions. Am J Physiol Regul Integr Comp Physiol 273: R1263-R1270, 1997.
16. Khan AM, Curras MC, Dao J, Jamal FA, Turkowski CA, Goel RK, Gillard ER, Wolfsohn SD, and Stanley BG. Lateral hypothalamic NMDA receptor subunits NR2A and/or NR2B mediate eating: immunochemical/behavioral evidence. Am J Physiol Regul Integr Comp Physiol 276: R880-R891, 1999.
17. Khan AM, Stanley BG, Bozzetti L, Chin C, Stivers C, and Curras-Collazo MC. N-methyl-D-aspartate receptor subunit NR2B is widely expressed throughout the rat diencephalon: an immunohistochemical study. J Comp Neurol 428: 428-449, 2000.
18. Kirchgessner AL. Glutamate in the enteric nervous system. Curr Opin Pharmacol 1: 591-596, 2001.
19. Kirchgessner AL, Liu MT, and Alcantara F. Excitotoxicity in the enteric nervous system. J Neurosci 17: 8804-8816, 1997.
20. Ladenheim EE, Wohn A, White WO, Schwartz GJ, and Moran TH. Inhibition of gastric emptying by bombesin-like peptides is dependent upon cholecystokinin-A receptor activation. Regul Pept 84: 101-106, 1999.
21. Li JL, Ohishi H, Kaneko T, Shigemoto R, Neki A, Nakanishi S, and Mizuno N. Immunohistochemical localization of a metabotropic glutamate receptor, mGluR7, in ganglion neurons of the rat; with special reference to the presence in glutamatergic ganglion neurons. Neurosci Lett 204: 9-12, 1996.
22. Liddle RA, Green GM, Conrad CK, and Williams JA. Proteins but not amino acids, carbohydrates, or fats stimulate cholecystokinin secretion in the rat. Am J Physiol Gastrointest Liver Physiol 251: G243-G248, 1986.
23. Liu MT, Rothstein JD, Gershon MD, and Kirchgessner AL. Glutamatergic enteric neurons. J Neurosci 17: 4764-4784, 1997.
24. Nakanishi S. Molecular diversity of glutamate receptors and implications for brain function. Science 258: 597-603, 1992.
25. Ninan I and Kulkarni SK. Dopamine receptor sensitive effect of dizocilpine on feeding behaviour. Brain Res 812: 157-163, 1998.
26. Petralia RS, Yokotani N, and Wenthold RJ. Light and electron microscope distribution of the NMDA receptor subunit NMDAR1 in the rat nervous system using a selective anti-peptide antibody. J Neurosci 14: 667-696, 1994.
27. Ren J, Hu HZ, Liu S, Xia Y, and Wood JD. Glutamate modulates neurotransmission in the submucosal plexus of guinea-pig small intestine. Neuroreport 10: 3045-3048, 1999.
28. Rothstein JD, Martin L, Levey AI, Dykes-Hoberg M, Jin L, Wu D, Nash N, and Kuncl RW. Localization of neuronal and glial glutamate transporters. Neuron 13: 713-725, 1994.
29. Saha S, Batten TF, and McWilliam PN. Glutamate-immunoreactivity in identified vagal afferent terminals of the cat: a study combining horseradish peroxidase tracing and postembedding electron microscopic immunogold staining. Exp Physiol 80: 193-202, 1995.
30. Schwartz GJ, Netterville LA, McHugh PR, and Moran TH. Gastric loads potentiate inhibition of food intake produced by a cholecystokinin analogue. Am J Physiol Regul Integr Comp Physiol 261: R1141-R1146, 1991.
31. Sengupta JN, Petersen J, Peles S, and Shaker R. Response properties of antral mechanosensitive afferent fibers and effects of ionotropic glutamate receptor antagonists. Neuroscience 125: 711-723, 2004.
32. Shinozaki H, Gotoh Y, and Ishida M. Selective N-methyl-D-aspartate (NMDA) antagonists increase gastric motility in the rat. Neurosci Lett 113: 56-61, 1990.
33. Sivarao DV, Krowicki ZK, Abrahams TP, and Hornby PJ. Vagally-regulated gastric motor activity: evidence for kainate and NMDA receptor mediation. Eur J Pharmacol 368: 173-182, 1999.
34. Tamura CS and Ritter RC. Intestinal capsaicin transiently attenuates suppression of sham feeding by oleate. Am J Physiol Regul Integr Comp Physiol 267: R561-R568, 1994.
35. Treece BR, Covasa M, Ritter RC, and Burns GA. Delay in meal termination follows blockade of N-methyl-D-aspartate receptors in the dorsal hindbrain. Brain Res 810: 34-40, 1998.
36. Treece BR, Ritter RC, and Burns GA. Lesions of the dorsal vagal complex abolish increases in meal size induced by NMDA receptor blockade. Brain Res 872: 37-43, 2000.
37. Vezzani A, Serafini R, Stasi MA, Caccia S, Conti I, Tridico RV, and Samanin R. Kinetics of MK-801 and its effect on quinolinic acid-induced seizures and neurotoxicity in rats. J Pharmacol Exp Ther 249: 278-283, 1989.
38. Walls EK, Phillips RJ, Wang FB, Holst MC, and Powley TL. Suppression of meal size by intestinal nutrients is eliminated by celiac vagal deafferentation. Am J Physiol Regul Integr Comp Physiol 269: R1410-R1419, 1995.
39. Walls EK, Wang FB, Holst MC, Phillips RJ, Voreis JS, Perkins AR, Pollard LE, and Powley TL. Selective vagal rhizotomies: a new dorsal surgical approach used for intestinal deafferentations. Am J Physiol Regul Integr Comp Physiol 269: R1279-R1288, 1995.
40. Wang YH, Bosy TZ, Yasuda RP, Grayson DR, Vicini S, Pizzorusso T, and Wolfe BB. Characterization of NMDA receptor subunit-specific antibodies: distribution of NR2A and NR2B receptor subunits in rat brain and ontogenic profile in the cerebellum. J Neurochem 65: 176-183, 1995.
41. Yox DP and Ritter RC. Capsaicin attenuates suppression of sham feeding induced by intestinal nutrients. Am J Physiol Regul Integr Comp Physiol 255: R569-R574, 1988.
42. Yox DP, Stokesberry H, and Ritter RC. Fourth ventricular capsaicin attenuates suppression of sham feeding induced by intestinal nutrients. Am J Physiol Regul Integr Comp Physiol 260: R681-R687, 1991.
43. Yox DP, Stokesberry H, and Ritter RC. Vagotomy attenuates suppression of sham feeding induced by intestinal nutrients. Am J Physiol Regul Integr Comp Physiol 260: R503-R508, 1991.
44. Zhang X and Fogel R. Involvement of glutamate in gastrointestinal vago-vagal reflexes initiated by gastrointestinal distention in the rat. Auton Neurosci 103: 19-37, 2003.
45. Zheng H, Kelly L, Patterson LM, and Berthoud HR. Effect of brain stem NMDA-receptor blockade by MK-801 on behavioral and fos responses to vagal satiety signals. Am J Physiol Regul Integr Comp Physiol 277: R1104-R1111, 1999.