Vagally-regulated gastric motor activity: Evidence for kainate and NMDA receptor mediation

European Journal of Pharmacology

Volumn 368, Issue 2-3, 1999, Pages 173-182

  Sivarao, Digavalli V ^a   Krowicki, Zbigniew K ^a   Abrahams, T Patrick ^a   Hornby, Pamela J ^a  

^a Louisiana Stt University Eye Center   (United States)

Author keywords

Dorsal vagal complex; Gastric motility; Hindbrain; Vagus

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR BLOCKING AGENT; 6,7 DINITRO 2,3 QUINOXALINEDIONE; KAINIC ACID; KAINIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; EXCITATION AND STIMULATION; MALE; MICROINJECTION; MOTONEURON NUCLEUS; NONHUMAN; PRIORITY JOURNAL; RAT; REGIONAL PERFUSION; SOLITARY TRACT NUCLEUS; STOMACH MOTILITY; STOMACH PRESSURE; VAGUS NERVE;

ANIMALS; ATROPINE; BLOOD PRESSURE; BRAIN STEM; BRONCHODILATOR AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; GASTROINTESTINAL MOTILITY; GLUTAMIC ACID; KAINIC ACID; MALE; MICROINJECTIONS; N-METHYLASPARTATE; QUINOXALINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; STOMACH; VAGUS NERVE;

EID: 0033017001     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(99)00015-1     Document Type: Article

References (42)

1. Bekkers J.M., Stevens C.F. NMDA and non-NMDA receptors are colocalized at individual excitatory synapses in cultured rat hippocampus. Nature. 341:1989;230-233.
2. Bertolino M., Vicini S., Gillis R.A., Travagli R.A. Presynaptic alpha2-adrenoceptors inhibit excitatory synaptic transmission in rat brain stem. Am. J. Physiol. 272(3):1997;G654-G661. Part 1.
3. Broussard D.L., Li X., Altschuler S.M. Localization of GABAA alpha1 mRNA subunit in the brainstem nuclei controlling esophageal peristalsis. Molecular Brain Research. 40:1996;143-147.
4. A and NMDA receptors within the dorsal motor nucleus of the vagus nerve (DMV) of the rat. Brain Res. 763:1997;123.
5. Chen S.Y., Wang S.D., Cheng C.L., Kuo J.S., De Groat W.C., Chai C.Y. Glutamate activation of neurons in CV-reactive areas of cat brain stem affects urinary bladder motility. Am. J. Physiol. 265(34):1993;F520-F529.
6. Colombari E., Bonagamba L.G.H., Machado B.H. Mechanism of pressor and bradycardic responses to L-glutamate microinjected into the NTS of conscious rats. Am. J. Physiol. 266(35):1994;R730-R738.
7. Colombari E., Menani J.V., Talman W.T. Comissural nucleus tractus solitarius contributes to pressor responses to glutamate injected into the medial nucleus tractus solitarius of awake rats. Am. J. Physiol. 270(39):1996;R1220-R1225.
8. Depaulis A., Keay K.A., Bandler R. Quiescence and hyporeactivity evoked by activation of cell bodies in the ventrolateral midbrain periaqueductal gray of the rat. Exp. Brain Res. 99:1994;75-83.
9. El-Mas M.M., Abdel-Rahman A.A. Role of NMDA and non-NMDA receptors in the nucleus tractus solitarius in the depressant effect of ethanol on baroreflexes. J. Pharmacol. Exp. Ther. 266(2):1993;602-610.
10. Feng H.-S., Lynn R.B., Han J., Brooks F.P. Gastric effects of TRH analog and bicuculline injected into dorsal motor vagal nucleus in cats. Am. J. Physiol. 259:1990;G321-G326.
11. Galloudec E.L., Merahi N., Laguzzi R. Cardiovascular changes induced by the local application of glutamate-related drugs in the rat nucleus tractus solitarii. Brain Res. 503:1989;322-325.
12. Gordon F.J., Leone C. Non-NMDA receptors in the nucleus of the tractus solitarius play the predominant role in mediating aortic baroreceptor reflexes. Brain Res. 568:1991;319-322.
13. Greenamyre J.T., Young A.B. Synaptic localization of striatal NMDA, quisqualate and kainate receptors. Neurosci. Lett. 101(2):1989;133-137.
14. Jensen T.S., Yaksh T.L. The antinociceptive activity of excitatory amino acids in the rat brainstem: an anatomical and pharmacological analysis. Brain Res. 569:1992;255-267.
15. Kessler J.P., Cherkaoui N., Catalin D., Jean A. Swallowing responses induced by microinjection of glutamate and glutamate agonists into the nucleus tractus solitarius of ketamine-anesthetized rats. Exp. Brain Res. 83:1990;151-158.
16. Krowicki Z.K., Hornby P.J. The nucleus raphe obscurus controls pancreatic hormone secretion in the rat. Am. J. Physiol. 268:1995;E1128-E1134.
17. Krowicki, Z.K., Hornby, P.J., 1995. Hindbrain neuroactive substances controlling gastrointestinal function. In: Gaginella, T. (Ed.), Regulatory Mechanisms in Gastrointestinal Function. CRC Press, Boca Raton, FL, 1995, pp. 277-319.
18. Krowicki Z.K., Arimura A., Nathan N., Hornby P.J. Hindbrain effects of PACAP on gastric motor function in the rat. Am. J. Physiol. 272(35):1997;G1221-G1229.
19. Leone C., Gordon F.J. Is glutamate a neurotransmitter of baroreceptor information in the nucleus tractus solitarius? J. Pharmacol. Exp. Ther. 250:1989;953-962.
20. 3H ]glutamate-binding sites in the rat brain J. Neurosci. 5(11):1985;2909-2919.
21. Narita K., Yokawa T., Nishihara M., Takahashi M. Interaction between excitatory and inhibitory amino acids in the ventromedial nucleus of the hypothalamus in inducing hyper-running. Brain. Res. 603:1993;243-247.
22. Ohta H., Talman W.T. Both NMDA and non-NMDA receptors in the NTS participate in the baroreceptor reflex in rats. Am. J. Physiol. 267(36):1994;R1065-R1070.
23. Ormsbee H.S. III, Bass P. Gastroduodenal gradients in the dog after pyloroplasty. Am. J. Physiol. 230:1976;389-397.
24. Ormsbee, H.S., III., Basone, F.C., Lombardi, D.M., McCartney, L.C., 1984. In: Lancaster, R.C. (Ed.), Effects of hindbrain L-glutamate acid application on gastrointestinal motor function in the cat. Gastrointestinal Motility: Proceedings of the Ninth International Symposium on Gastrointestinal Motility, MTP, pp. 583-591.
25. Paxinos, G., Watson, C., 1986. The Rat Brain in Stereotaxic Coordinates, Academic Press, New York.
26. Petralia R.S., Wang Y.X., Wenthold R.J. Histological and ultrastructural localization of the kainate receptor subunits, KA2 and GluR6/7, in the rat nervous system using selective antipeptide antibodies. J. Comp. Neurol. 349:1994;85-110.
27. Reis D.J., Granata A.R., Perrone M.H., Talman W.T. Evidence that glutamic acid is the neurotransmitter of baroreceptor afferents terminating in the nucleus tractus solitarius (NTS). J. Auton. Nerv. Syst. 3:1981;321-334.
28. Rogers R.C., McCann M.J., Stephens R.L. Evidence for glutamate as a neurotransmitter in the gastric mechanoreceptor afferents projecting to the nucleus of the solitary tract. Soc. Neurosci. Abstr. 16:1990;865. Abstract.
29. Schwarcz R., Zaczek R., Coyle J.T. Microinjection of kainic acid into rat hippocampus. Eur. J. Pharmacol. 50(3):1978;209-220.
30. A receptors in rat hindbrain nuclei controlling gastric motor function. Neurogastroenterol. Motil. 10:1998;305-313.
31. Spencer S.E., Talman W.T. Central modulation of gastric pressure by substance P: a comparison with glutamate and acetylcholine. Brain Res. 385:1986;371-374.
32. Spencer S.E., Talman W.T. Modulation of gastric and arterial pressure by nucleus tractus solitarius in rat. Am. J. Physiol. 250:1986;R996-R1002.
33. Talman W.T., Perrone M.H., Reis D.J. Evidence for L-glutamate as the neurotransmitter of baroreceptor afferent nerve fibers. Science. 209:1980;813-815.
34. Tell F., Jean A. Rhythmic bursting patterns induced in neurons of the rat nucleus tractus solitarii, in vitro, in response to N-methyl-D-aspartate. Brain Res. 533:1990;152-156.
35. Travagli R.A., Gillis R.A., Rossiter C.D., Vicini S. Glutamate and GABA-mediated synaptic currents in neurons of the rat dorsal motor nucleus of the vagus. Am. J. Physiol. 260:1991;G531-G536.
36. Vardhan A., Kachroo A., Sapru H.N. Excitatory amino acid receptors in comissural nucleus of the NTS mediate carotid chemoreceptor responses. Am. J. Physiol. 264(33):1993;R41-R50.
37. Varner K.J., Vasquez E.C., Brody M.J. Lesions in rostral ventromedial or ventrolateral medulla block neurogenic hypertension. Hypertension. 24(1):1994;91-96.
38. Vasquez E.C., Lewis S.J., Varner K.J., Brody M.J. Chronic lesions of rostral ventrolateral medulla in spontaneously hypertensive rats. Hypertension. 19(2):1992;154-158. Suppl.
39. Washabau R.J., Fudge M., Price W.J., Barone F.C. GABA receptors in the dorsal motor nucleus of the vagus influence feline lower esophageal sphincter and gastric function. Brain Res. Bull. 38(6):1995;587-594.
40. Willis A., Mihalevich A.W.M., Neff R.A., Mendelowitz D. Three types of postsynaptic glutamatergic receptors are activated in DMNX neurons upon stimulation of NTS. Am. J. Physiol. 271(40):1996;R1614-R1619.
41. Yang H., Taché Y. PYY in brain stem nuclei induces vagal stimulation of gastric acid secretion in rats. Am. J. Physiol. 268:1995;G953-G948.
42. Yang H., Ohning G., Taché Y. TRH in dorsal vagal complex mediates acid response to excitation of raphe pallidus neurons in rats. Am. J. Physiol. 265:1993;G880-G886.