메뉴 건너뛰기




Volumn 276, Issue 3 45-3, 1999, Pages

Lateral hypothalamic NMDA receptor subunits NR2A and/or NR2B mediate eating: Immunochemical/behavioral evidence

Author keywords

Glutamate; Ifenprodil; Immunoblotting; Immunohistochemistry; Microliter injections; N methyl D aspartate

Indexed keywords

GLUTAMIC ACID; IFENPRODIL; KAINIC ACID; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; RECEPTOR SUBUNIT;

EID: 0032895861     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.1999.276.3.r880     Document Type: Article
Times cited : (42)

References (52)
  • 1
    • 0030900752 scopus 로고    scopus 로고
    • Ionotropic glutamate receptors: New types and concepts
    • Barnard, E. A. Ionotropic glutamate receptors: new types and concepts. Trends Pharmacol. Sci. 18: 141-148, 1997.
    • (1997) Trends Pharmacol. Sci. , vol.18 , pp. 141-148
    • Barnard, E.A.1
  • 2
    • 0027280380 scopus 로고
    • The lateral hypothalamic area revisited: Neuroanatomy, body weight regulation, neuroendocrinology and metabolism
    • Bernardis, L. L., and L. L. Bellinger. The lateral hypothalamic area revisited: neuroanatomy, body weight regulation, neuroendocrinology and metabolism. Neurosci. Biobehav. Rev. 17: 141-193, 1993.
    • (1993) Neurosci. Biobehav. Rev. , vol.17 , pp. 141-193
    • Bernardis, L.L.1    Bellinger, L.L.2
  • 4
    • 0028003653 scopus 로고
    • 2+ channels in rat and mouse cultured hippocampal pyramidal neurones: Comparison with N-methyl-D-aspartate receptor antagonist actions
    • 2+ channels in rat and mouse cultured hippocampal pyramidal neurones: comparison with N-methyl-D-aspartate receptor antagonist actions. Br. J. Pharmacol. 113: 499-507, 1994.
    • (1994) Br. J. Pharmacol. , vol.113 , pp. 499-507
    • Church, J.1    Fletcher, E.J.2    Baxter, K.3    MacDonald, J.F.4
  • 5
    • 0019887644 scopus 로고
    • Cerebral vasodilators
    • Cook, P., and I. James. Cerebral vasodilators. N. Engl. J. Med. 305: 1560-1564, 1981.
    • (1981) N. Engl. J. Med. , vol.305 , pp. 1560-1564
    • Cook, P.1    James, I.2
  • 6
    • 0032125677 scopus 로고    scopus 로고
    • Developmental plasticity of NR1 and NR2B subunit expression in the supraoptic nucleus of the rat hypothalamus
    • Currás, M. C., and J. Dao. Developmental plasticity of NR1 and NR2B subunit expression in the supraoptic nucleus of the rat hypothalamus. Dev. Brain Res. 109: 1-12, 1998.
    • (1998) Dev. Brain Res. , vol.109 , pp. 1-12
    • Currás, M.C.1    Dao, J.2
  • 7
    • 0030592811 scopus 로고    scopus 로고
    • Single-channel evidence for glycine and NMDA requirement in NMDA receptor activation
    • Currás, M. C., and B. S. Pallotta. Single-channel evidence for glycine and NMDA requirement in NMDA receptor activation. Brain Res. 740: 27-40, 1996.
    • (1996) Brain Res. , vol.740 , pp. 27-40
    • Currás, M.C.1    Pallotta, B.S.2
  • 9
    • 13044249433 scopus 로고    scopus 로고
    • Developmental regulation of tyrosine phosphorylation of the NMDA subunit NR2D protein in rat brain
    • Dunah, A. W., R. P. Yasuda, S. Vicini, and B. B. Wolfe. Developmental regulation of tyrosine phosphorylation of the NMDA subunit NR2D protein in rat brain. Soc. Neurosci. Abstr. 23: 933, 1997.
    • (1997) Soc. Neurosci. Abstr. , vol.23 , pp. 933
    • Dunah, A.W.1    Yasuda, R.P.2    Vicini, S.3    Wolfe, B.B.4
  • 10
    • 0032054917 scopus 로고    scopus 로고
    • The second messenger cyclic AMP elicits eating by an anatomically specific action in the perifornical hypothalamus
    • Gillard, E. R., A. M. Khan, R. S. Grewal, B. Mouradi, S. D. Wolfsohn, and B. G. Stanley. The second messenger cyclic AMP elicits eating by an anatomically specific action in the perifornical hypothalamus. J. Neurosci. 18: 2646-2652, 1998.
    • (1998) J. Neurosci. , vol.18 , pp. 2646-2652
    • Gillard, E.R.1    Khan, A.M.2    Grewal, R.S.3    Mouradi, B.4    Wolfsohn, S.D.5    Stanley, B.G.6
  • 11
    • 0030871294 scopus 로고    scopus 로고
    • Stimulation of eating by the second messenger cAMP in the perifornical and lateral hypothalamus
    • Regulatory Integrative Comp. Physiol. 42
    • Gillard, E. R., A. M. Khan, A. U. Haq, R. S. Grewal, B. Mouradi, and B. G. Stanley. Stimulation of eating by the second messenger cAMP in the perifornical and lateral hypothalamus. Am. J. Physiol. 273 (Regulatory Integrative Comp. Physiol. 42): R107-R112, 1997.
    • (1997) Am. J. Physiol. , vol.273
    • Gillard, E.R.1    Khan, A.M.2    Haq, A.U.3    Grewal, R.S.4    Mouradi, B.5    Stanley, B.G.6
  • 12
    • 0031820147 scopus 로고    scopus 로고
    • Eating induced by perifornical hypothalamic cAMP is behaviorally selective and involves protein kinase activity
    • Regulatory Integrative Comp. Physiol. 44
    • Gillard, E. R., A. M. Khan, B. Mouradi, O. Nalamwar, and B. G. Stanley. Eating induced by perifornical hypothalamic cAMP is behaviorally selective and involves protein kinase activity. Am. J. Physiol. 275 (Regulatory Integrative Comp. Physiol. 44): R647-R653, 1998.
    • (1998) Am. J. Physiol. , vol.275
    • Gillard, E.R.1    Khan, A.M.2    Mouradi, B.3    Nalamwar, O.4    Stanley, B.G.5
  • 13
    • 0024215352 scopus 로고
    • Changes in lateral hypothalamic neuronal activity accompanying hyper- and hypoglycemias
    • Himmi, T., A. Boyer, and J. C. Orsini. Changes in lateral hypothalamic neuronal activity accompanying hyper- and hypoglycemias. Physiol. Behav. 44: 347-354, 1988.
    • (1988) Physiol. Behav. , vol.44 , pp. 347-354
    • Himmi, T.1    Boyer, A.2    Orsini, J.C.3
  • 15
    • 0030450983 scopus 로고    scopus 로고
    • A novel mechanism of activity-dependent NMDA receptor antagonism describes the effect of ifenprodil in rat cultured cortical neurones
    • Kew, J. N., G. Trube, and J. A. Kemp. A novel mechanism of activity-dependent NMDA receptor antagonism describes the effect of ifenprodil in rat cultured cortical neurones. J. Physiol. (Lond.) 497: 761-772, 1996.
    • (1996) J. Physiol. (Lond.) , vol.497 , pp. 761-772
    • Kew, J.N.1    Trube, G.2    Kemp, J.A.3
  • 16
    • 13044281071 scopus 로고    scopus 로고
    • 2B or not 2B: Behavioral, biochemical and immunocytochemical evidence for the involvement of the NR2B NMDA receptor subunit in lateral hypothalamic (LHA) feeding
    • Khan, A. M., B. G. Stanley, F. A. Jamal, R. K. Goel, J. Dao, E. R. Gillard, and M. C. Currás. 2B or not 2B: behavioral, biochemical and immunocytochemical evidence for the involvement of the NR2B NMDA receptor subunit in lateral hypothalamic (LHA) feeding. Soc. Neurosci. Abstr. 27: 576, 1997.
    • (1997) Soc. Neurosci. Abstr. , vol.27 , pp. 576
    • Khan, A.M.1    Stanley, B.G.2    Jamal, F.A.3    Goel, R.K.4    Dao, J.5    Gillard, E.R.6    Currás, M.C.7
  • 17
    • 13044304837 scopus 로고    scopus 로고
    • Feeding elicited by N-methyl-D-aspartate (NMDA) in the lateral hypothalamus (LHA) is suppressed by a tyrosine kinase inhibitor
    • Khan, A. M., D. S. Welsbie, A. M. Khan, C. S. Ton, J. Nikpur, E. R. Gillard, P. P. Pir, and B. G. Stanley. Feeding elicited by N-methyl-D-aspartate (NMDA) in the lateral hypothalamus (LHA) is suppressed by a tyrosine kinase inhibitor. Soc. Neurosci. Abstr. 26: 1608, 1996.
    • (1996) Soc. Neurosci. Abstr. , vol.26 , pp. 1608
    • Khan, A.M.1    Welsbie, D.S.2    Khan, A.M.3    Ton, C.S.4    Nikpur, J.5    Gillard, E.R.6    Pir, P.P.7    Stanley, B.G.8
  • 18
    • 0027360286 scopus 로고
    • Characterization of the NR1, NR2A and NR2C receptor proteins
    • Köpke, A. K. E., I. Bonk, S. Sydow, H. Menke, and J. Spiess. Characterization of the NR1, NR2A and NR2C receptor proteins. Protein Sci. 2: 2066-2076, 1993.
    • (1993) Protein Sci. , vol.2 , pp. 2066-2076
    • Köpke, A.K.E.1    Bonk, I.2    Sydow, S.3    Menke, H.4    Spiess, J.5
  • 20
    • 0029093990 scopus 로고
    • Differential tyrosine phosphorylation of N-methyl-D-aspartate receptor subunits
    • Lau, L.-F., and R. L. Huganir. Differential tyrosine phosphorylation of N-methyl-D-aspartate receptor subunits. J. Biol. Chem. 270: 20036-20041, 1995.
    • (1995) J. Biol. Chem. , vol.270 , pp. 20036-20041
    • Lau, L.-F.1    Huganir, R.L.2
  • 21
    • 0028169661 scopus 로고
    • Ligand affinities at recombinant N-methyl-D-aspartate receptors depend on subunit composition
    • Laurie, D. J., and P. H. Seeburg. Ligand affinities at recombinant N-methyl-D-aspartate receptors depend on subunit composition. Eur. J. Pharmacol. 268: 335-345, 1994.
    • (1994) Eur. J. Pharmacol. , vol.268 , pp. 335-345
    • Laurie, D.J.1    Seeburg, P.H.2
  • 22
    • 0025951641 scopus 로고
    • Ifenprodil blocks N-methyl-D-aspartate receptors by a two-component mechanism
    • Legendre, P., and G. L. Westbrook. Ifenprodil blocks N-methyl-D-aspartate receptors by a two-component mechanism. Mol. Pharmacol. 40: 289-298, 1991.
    • (1991) Mol. Pharmacol. , vol.40 , pp. 289-298
    • Legendre, P.1    Westbrook, G.L.2
  • 23
    • 0022475083 scopus 로고
    • Brain monoamines and peptides: Role in control of eating behavior
    • Leibowitz, S. F. Brain monoamines and peptides: role in control of eating behavior. Federation Proc. 45: 1396-1403, 1986.
    • (1986) Federation Proc. , vol.45 , pp. 1396-1403
    • Leibowitz, S.F.1
  • 25
    • 0001111748 scopus 로고
    • A Golgi anatomy of the rodent hypothalamus
    • edited by P. J. Morgane and J. Panskepp. New York: Dekker
    • Mulhouse, O. E. A Golgi anatomy of the rodent hypothalamus. In: Handbook of the Hypothalamus. Anatomy of the Hypothalamus, edited by P. J. Morgane and J. Panskepp. New York: Dekker, 1979, vol. 1, p. 221-265.
    • (1979) Handbook of the Hypothalamus. Anatomy of the Hypothalamus , vol.1 , pp. 221-265
    • Mulhouse, O.E.1
  • 26
    • 0002699079 scopus 로고
    • Anatomical, pharmacological, and molecular diversity of native NMDA receptor subtypes
    • edited by G. L. Collingridge and J. C. Watkins. Oxford, UK: Oxford University Press
    • Monaghan, D. T., and A. L. Buller. Anatomical, pharmacological, and molecular diversity of native NMDA receptor subtypes. In: The NMDA Receptor (2nd ed.), edited by G. L. Collingridge and J. C. Watkins. Oxford, UK: Oxford University Press, 1994, p. 158-176.
    • (1994) The NMDA Receptor (2nd Ed.) , pp. 158-176
    • Monaghan, D.T.1    Buller, A.L.2
  • 27
    • 0000927212 scopus 로고
    • The major tyrosine-phosphorylated protein in the postsynaptic density fraction is N-methyl-D-aspartate receptor subunit 2B
    • Moon, I. S., M. L. Apperson, and M. B. Kennedy. The major tyrosine-phosphorylated protein in the postsynaptic density fraction is N-methyl-D-aspartate receptor subunit 2B. Proc. Natl. Acad. Sci. USA 91: 3954-3958, 1994.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 3954-3958
    • Moon, I.S.1    Apperson, M.L.2    Kennedy, M.B.3
  • 28
    • 0029905992 scopus 로고    scopus 로고
    • Identification of a phosphorylation site for calcium/calmodulin-dependent protein kinase II in the NR2B subunit of the N-methyl-D-aspartate receptor
    • Omkumar, R. V., M. J. Kiely, A. J. Rosenstein, K.-T. Min, and M. B. Kennedy. Identification of a phosphorylation site for calcium/calmodulin-dependent protein kinase II in the NR2B subunit of the N-methyl-D-aspartate receptor. J. Biol. Chem. 271: 31670-31678, 1996.
    • (1996) J. Biol. Chem. , vol.271 , pp. 31670-31678
    • Omkumar, R.V.1    Kiely, M.J.2    Rosenstein, A.J.3    Min, K.-T.4    Kennedy, M.B.5
  • 29
    • 0016814940 scopus 로고
    • Effects of free fatty acid on rat lateral hypothalamic neurons
    • Oomura, Y., T. Hakamura, M. Sugimori, and Y. Yamada. Effects of free fatty acid on rat lateral hypothalamic neurons. Physiol. Behav. 14: 483-486, 1975.
    • (1975) Physiol. Behav. , vol.14 , pp. 483-486
    • Oomura, Y.1    Hakamura, T.2    Sugimori, M.3    Yamada, Y.4
  • 30
    • 0014683812 scopus 로고
    • Glucose and osmosensitive neurones of rat hypothalamus
    • Oomura, Y., T. Ono, H. Ooyama, and M. J. Wayner. Glucose and osmosensitive neurones of rat hypothalamus. Nature 22: 282-284, 1969.
    • (1969) Nature , vol.22 , pp. 282-284
    • Oomura, Y.1    Ono, T.2    Ooyama, H.3    Wayner, M.J.4
  • 33
    • 0028087773 scopus 로고
    • The NMDA receptor subunits NR2A and NR2B show histological and ultrastructural localization patterns similar to those of NR1
    • Petralia, R. S., Y.-X. Wang, and R. J. Wenthold. The NMDA receptor subunits NR2A and NR2B show histological and ultrastructural localization patterns similar to those of NR1. J. Neurosci. 14: 6102-6120, 1994.
    • (1994) J. Neurosci. , vol.14 , pp. 6102-6120
    • Petralia, R.S.1    Wang, Y.-X.2    Wenthold, R.J.3
  • 34
    • 0028157362 scopus 로고
    • Light and electron microscopic distribution of the NMDA receptor subunit NMDAR1 in the rat nervous system using a selective antipeptide antibody
    • Petralia, R. S., N. Yokotani, and R. J. Wenthold. Light and electron microscopic distribution of the NMDA receptor subunit NMDAR1 in the rat nervous system using a selective antipeptide antibody. J. Neurosci. 14: 667-696, 1994.
    • (1994) J. Neurosci. , vol.14 , pp. 667-696
    • Petralia, R.S.1    Yokotani, N.2    Wenthold, R.J.3
  • 35
    • 0021604780 scopus 로고
    • The neurophysiology of feeding
    • Rolls, E. T. The neurophysiology of feeding. Int. J. Obes., Suppl. 1: 139-150, 1984.
    • (1984) Int. J. Obes., Suppl. , vol.1 , pp. 139-150
    • Rolls, E.T.1
  • 36
    • 0028988978 scopus 로고
    • D-Serine, an endogenous synaptic modulator: Localization to astrocytes and glutamate-stimulated release
    • Schell, M. J., M. E. Molliver, and S. H. Snyder. D-Serine, an endogenous synaptic modulator: localization to astrocytes and glutamate-stimulated release. Proc. Natl. Acad. Sci. USA 92: 3948-3952, 1995.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 3948-3952
    • Schell, M.J.1    Molliver, M.E.2    Snyder, S.H.3
  • 37
    • 0010673819 scopus 로고
    • Molecular biology of NMDA receptors
    • edited by G. L. Collingridge and J. C. Watkins. Oxford, UK: Oxford University Press
    • Seeburg, P. H., H. Monyer, R. Sprengel, and N. Burnashev. Molecular biology of NMDA receptors. In: The NMDA Receptor (2nd ed.), edited by G. L. Collingridge and J. C. Watkins. Oxford, UK: Oxford University Press, 1994, p. 147-157.
    • (1994) The NMDA Receptor (2nd Ed.) , pp. 147-157
    • Seeburg, P.H.1    Monyer, H.2    Sprengel, R.3    Burnashev, N.4
  • 38
    • 0024204883 scopus 로고
    • Feeding related lateral hypothalamic neuron responses to odors depend on food deprivation in rats
    • Shiraishi, T. Feeding related lateral hypothalamic neuron responses to odors depend on food deprivation in rats. Physiol. Behav. 44: 591-597, 1988.
    • (1988) Physiol. Behav. , vol.44 , pp. 591-597
    • Shiraishi, T.1
  • 39
    • 2642641299 scopus 로고    scopus 로고
    • Glucose-induced intracellular ion changes in sugar-sensitive hypothalamic neurons
    • Silver, I. A., and M. Erecińska. Glucose-induced intracellular ion changes in sugar-sensitive hypothalamic neurons. J. Neurophysiol. 79: 1733-1745, 1998.
    • (1998) J. Neurophysiol. , vol.79 , pp. 1733-1745
    • Silver, I.A.1    Erecińska, M.2
  • 40
    • 0030222090 scopus 로고    scopus 로고
    • Regional and subunit specific changes in NMDA receptor mRNA and immunoreactivity in mouse brain following chronic ethanol ingestion
    • Snell, L. D., K. R. Nunley, R. L. Lickteig, M. D. Browning, B. Tabakoff, and P. L. Hoffman. Regional and subunit specific changes in NMDA receptor mRNA and immunoreactivity in mouse brain following chronic ethanol ingestion. Mol. Brain Res. 40: 71-78, 1996.
    • (1996) Mol. Brain Res. , vol.40 , pp. 71-78
    • Snell, L.D.1    Nunley, K.R.2    Lickteig, R.L.3    Browning, M.D.4    Tabakoff, B.5    Hoffman, P.L.6
  • 41
    • 0030800480 scopus 로고    scopus 로고
    • NMDA receptor coagonist glycine site: Evidence for a role in lateral hypothalamic stimulation of feeding
    • Regulatory Integrative Comp. Physiol. 42
    • Stanley, B. G., B. S. Butterfield, and R. S. Grewal. NMDA receptor coagonist glycine site: evidence for a role in lateral hypothalamic stimulation of feeding. Am. J. Physiol. 273 (Regulatory Integrative Comp. Physiol. 42): R790-R796, 1997.
    • (1997) Am. J. Physiol. , vol.273
    • Stanley, B.G.1    Butterfield, B.S.2    Grewal, R.S.3
  • 42
    • 0027310839 scopus 로고
    • Lateral hypothalamic injections of glutamate, kainic acid, D,L-α-amino-3-hydroxy-5-methyl-isoxazole propionic acid or N-methyl-D-aspartic acid rapidly elicit intense eating in rats
    • Stanley, B. G., L. H. Ha, L. C. Spears, and M. G. Dee II. Lateral hypothalamic injections of glutamate, kainic acid, D,L-α-amino-3-hydroxy-5-methyl-isoxazole propionic acid or N-methyl-D-aspartic acid rapidly elicit intense eating in rats. Brain Res. 613: 88-95, 1993.
    • (1993) Brain Res. , vol.613 , pp. 88-95
    • Stanley, B.G.1    Ha, L.H.2    Spears, L.C.3    Dee II, M.G.4
  • 43
    • 0029964455 scopus 로고    scopus 로고
    • Lateral hypothalamic NMDA receptors and glutamate as physiological mediators of eating and weight control
    • Regulatory Integrative Comp. Physiol. 39
    • Stanley, B. G., V. L. Willett III, H. W. Donias, M. G. Dee II, and M. A. Duva. Lateral hypothalamic NMDA receptors and glutamate as physiological mediators of eating and weight control. Am. J. Physiol. 270 (Regulatory Integrative Comp. Physiol. 39): R443-R449, 1996.
    • (1996) Am. J. Physiol. , vol.270
    • Stanley, B.G.1    Willett III, V.L.2    Donias, H.W.3    Dee II, M.G.4    Duva, M.A.5
  • 44
    • 0027454584 scopus 로고
    • The lateral hypothalamus: A primary site mediating excitatory amino acid-elicited eating
    • Stanley, B. G., V. L. Willett III, H. W. Donias, L. H. Ha, and L. C. Spears. The lateral hypothalamus: a primary site mediating excitatory amino acid-elicited eating. Brain Res. 630: 41-49, 1993.
    • (1993) Brain Res. , vol.630 , pp. 41-49
    • Stanley, B.G.1    Willett III, V.L.2    Donias, H.W.3    Ha, L.H.4    Spears, L.C.5
  • 46
    • 0031040615 scopus 로고    scopus 로고
    • Characterization of protein kinase A and protein kinase C phosphorylation of the N-methyl-D-aspartate receptor NR1 subunit using phosphorylation site-specific antibodies
    • Tingley, W. G., M. D. Ehlers, K. Kameyama, C. Doherty, J. B. Ptak, J. T. Riley, and R. L. Huganir. Characterization of protein kinase A and protein kinase C phosphorylation of the N-methyl-D-aspartate receptor NR1 subunit using phosphorylation site-specific antibodies. J. Biol. Chem. 272: 5157-5166, 1997.
    • (1997) J. Biol. Chem. , vol.272 , pp. 5157-5166
    • Tingley, W.G.1    Ehlers, M.D.2    Kameyama, K.3    Doherty, C.4    Ptak, J.B.5    Riley, J.T.6    Huganir, R.L.7
  • 47
    • 0028302970 scopus 로고
    • Ionotropic glutamate-receptor gene expression in hypothalamus: Localization of AMPA, kainate, and NMDA receptor RNA with in situ hybridization
    • Van den Pol, A. N., I. Hermans-Borgmeyer, M. Hofer, P. Ghosh, and S. Heinemann. Ionotropic glutamate-receptor gene expression in hypothalamus: localization of AMPA, kainate, and NMDA receptor RNA with in situ hybridization. J. Comp. Neurol. 343: 428-444, 1994.
    • (1994) J. Comp. Neurol. , vol.343 , pp. 428-444
    • Van Den Pol, A.N.1    Hermans-Borgmeyer, I.2    Hofer, M.3    Ghosh, P.4    Heinemann, S.5
  • 48
    • 0027382009 scopus 로고
    • Distinct distributions of five N-methyl-D-aspartate receptor channel subunit mRNAs in the forebrain
    • Watanabe, M., Y. Inoue, K. Sakimura, and M. Mishina. Distinct distributions of five N-methyl-D-aspartate receptor channel subunit mRNAs in the forebrain. J. Comp. Neurol. 338: 377-390, 1993.
    • (1993) J. Comp. Neurol. , vol.338 , pp. 377-390
    • Watanabe, M.1    Inoue, Y.2    Sakimura, K.3    Mishina, M.4
  • 49
    • 0001201531 scopus 로고
    • The NMDA receptor concept: Origins and development
    • edited by G. L. Collingridge and J. C. Watkins. Oxford, UK: Oxford University Press
    • Watkins, J. C. The NMDA receptor concept: origins and development. In: The NMDA Receptor (2nd ed.), edited by G. L. Collingridge and J. C. Watkins. Oxford, UK: Oxford University Press, 1994, p. 1-30.
    • (1994) The NMDA Receptor (2nd Ed.) , pp. 1-30
    • Watkins, J.C.1
  • 50
    • 0030867518 scopus 로고    scopus 로고
    • Antagonism of N-methyl-D-aspartate receptors by σ site ligands: Potency, subtype-selectivity and mechanisms of inhibition
    • Whittemore, E. R., V. I. Ilyin, and R. M. Woodward. Antagonism of N-methyl-D-aspartate receptors by σ site ligands: potency, subtype-selectivity and mechanisms of inhibition. J. Pharmacol. Exp. Ther. 282: 326-338, 1997.
    • (1997) J. Pharmacol. Exp. Ther. , vol.282 , pp. 326-338
    • Whittemore, E.R.1    Ilyin, V.I.2    Woodward, R.M.3
  • 51
    • 0027525324 scopus 로고
    • Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: Selectivity and mechanisms at recombinant heteromeric receptors
    • Williams, K. Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: selectivity and mechanisms at recombinant heteromeric receptors. Mol. Pharmacol. 44: 851-859, 1993.
    • (1993) Mol. Pharmacol. , vol.44 , pp. 851-859
    • Williams, K.1
  • 52
    • 0028821024 scopus 로고
    • Pharmacological properties of recombinant N-methyl-D-aspartate (NMDA) receptors containing the ∈4 (NR2D) subunit
    • Williams, K. Pharmacological properties of recombinant N-methyl-D-aspartate (NMDA) receptors containing the ∈4 (NR2D) subunit. Neurosci. Lett. 184: 181-184, 1995.
    • (1995) Neurosci. Lett. , vol.184 , pp. 181-184
    • Williams, K.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.