Slow-binding and competitive inhibition of 8-amino-7-oxopelargonate synthase, a pyridoxal-5'-phosphate-dependent enzyme involved in biotin biosynthesis, by substrate and intermediate analogs. Kinetic and binding studies

European Journal of Biochemistry

Volumn 259, Issue 1-2, 1999, Pages 63-70

  Ploux, Olivier ^a   Breyne, Olivier ^a   Carillon, Sophie ^a   Marquet, Andrée ^a  

^a Centre National de la Recherche Scientifique   (France)

Author keywords

8 amino 7 oxopelargonate synthase; Biotin biosynthesis; Enzyme inhibitor; Pyridoxal 5' phosphate; Slow binding inhibition

Indexed keywords

8 AMINO 7 OXO 8 PHOSPHONONONAOIC ACID; 8 AMINO 7 OXOPELARGONATE SYNTHASE; ALANINE RACEMASE; ANTIINFECTIVE AGENT; BIOTIN; DEXTRO ALANINE; ENZYME INHIBITOR; HERBICIDE; PHOSPHONIC ACID DERIVATIVE; PYRIDOXAL 5 PHOSPHATE; SERINE PALMITOYLTRANSFERASE; SYNTHETASE; TRANSFERASE; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; COMPETITIVE INHIBITION; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME CONFORMATION; ENZYME INHIBITION; ENZYME KINETICS; EQUILIBRIUM CONSTANT; NONHUMAN; PRIORITY JOURNAL; STEREOCHEMISTRY;

ACYL COENZYME A; ACYLTRANSFERASES; ALANINE; ALDEHYDES; AMINOETHYLPHOSPHONIC ACID; BIOTIN; CATALYTIC DOMAIN; DOSE-RESPONSE RELATIONSHIP, DRUG; IMINES; KINETICS; MODELS, CHEMICAL; PHOSPHONIC ACIDS; PROTEIN CONFORMATION; PYRIDOXAL PHOSPHATE; STEREOISOMERISM;

EID: 0033556075     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.1999.00006.x     Document Type: Article

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