Bulk is a Determinant of Oxymetazoline Affinity for the α1A-Adrenergic Receptor

Receptors and Channels

Volumn 10, Issue 42067, 2004, Pages 109-116

  Mccune, Dan F ^a   Gaivin, Robert J ^a   Rorabaugh, Boyd R ^a   Perez, Dianne M ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Ligand Binding; Oxymetazoline; 1 Adrenergic

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR; OXYMETAZOLINE; 2 [[2 (2,6 DIMETHOXYPHENOXY)ETHYL]AMINOMETHYL] 1,4 BENZODIOXAN; 2 [[2 (4 HYDROXY 3 IODOPHENYL)ETHYL]AMINOMETHYL]TETRALONE; 5 METHYLURAPIDIL; 8 [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] 8 AZASPIRO[4.5]DECANE 7,9 DIONE; ADRENALIN; ALPHA 1A ADRENERGIC RECEPTOR; ALPHA 1B ADRENERGIC RECEPTOR; ALPHA 1D ADRENERGIC RECEPTOR; CIRAZOLINE; CLONIDINE; IODINE 125; LEUCINE; METHOXAMINE; NIGULDIPINE; PHENTOLAMINE; PHENYLALANINE; PHENYLEPHRINE; RECEPTOR SUBTYPE;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; CELL STRAIN COS1; CERCOPITHECUS; CHEMICAL STRUCTURE; DRUG ANTAGONISM; DRUG POTENTIATION; GENETICS; METABOLISM; MOLECULAR GENETICS; MUTATION; RAT; SEQUENCE ALIGNMENT; ANIMAL CELL; BINDING AFFINITY; BINDING COMPETITION; CELL MEMBRANE; CHEMICAL INTERACTION; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; HUMAN; HUMAN CELL; MOLECULAR MECHANICS; MUTAGENESIS; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN SECONDARY STRUCTURE; RECEPTOR AFFINITY; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; OXYMETAZOLINE; RATS; RECEPTORS, ADRENERGIC, ALPHA-1; SEQUENCE ALIGNMENT;

EID: 8644284919     PISSN: 10606823     EISSN: None     Source Type: Journal    
DOI: 10.3109/10606820490514923     Document Type: Article

References (19)

1. Chen, S., Xu, M., Lin, F., Lee, D., Riek, P., and Graham, R. M. 1999. J. Biol. Chem. 274: 16320 – 16330.
2. Cheng, Y., and Prusoff, W. H. 1973. Biochem. Pharmacol. 22: 3099 – 3108.
3. Cotecchia, S., Schwinn, D. A., Randall, R. R., Lefkowitz, R. J., Caron, M. G., and Kobilka, B. K. 1988. Proc. Natl. Acad. Sci. 85: 7159 – 7163.
4. Goetz, A. S., King, H. K., Ward, S. D., Ture, T. A., Rimele, T. J., and Saussy, D. L. 1995. Eur. J. Pharmacol. 272: R5 – R6.
5. Hamaguchi, N., True, T. A., Saussy, D. L., Jr., and Jeffs, P.W. 1996. Biochemistry 35: 14312 – 14317.
6. Hwa, J., Graham, R. M., and Perez, D. M. 1995. J. Biol. Chem. 270: 23189 – 23195.
7. Kenny, B. A., Chalmers, D. H., Philpott, P. C., and Naylor, A. M. 1995. Br. J. Pharmacol. 115: 981 – 986.
8. Lomasney, J. W., Cotecchia, S., Lorenz, W., Leung, W., Schwinn, D. A., Yang-Feng, T. L., Brownstein, M., Lefkowitz, R. J., and Caron, M. G. 1991. J. Biol. Chem. 272: 5261 – 5268.
9. Palczewski, K., Kumasaka, T., Hori, T., Behnke, C. A., Motoshima, H., Fox, B. A., LeTrong, I., Teller, D. C., Okada, T., Stenkamp, R. E., Yamamoto, M., and Miyano, M. 2000. Science 289: 739 – 745.
10. Perez, D. M., Piascik, M. T., and Graham, R. M. 1991. Mol. Pharmacol. 40: 876 – 883.
11. Perez, D. M., Piascik, M. T., Malik, N., Gaivin, R., and Graham, R. 1994. Mol. Pharmacol. 46: 823 – 831.
12. Piascik, M. T., Hrometz, S. L., Edelmann, S. E., Guarino, R. D., Hadley, R.W., and Brown, R. D. 1997. J. Pharmacol. Exp. Ther. 283: 854 – 868.
13. Piascik, M. T., and Perez, D. M. 2001. JPET 298: 403 – 410.
14. Sambrook, J., Fritsch, E. F., and Maniatis, T. 1989. Molecular Cloning: A Laboratory Manual, 2nd ed., Cold Spring Harbor Laboratory: Cold Spring Harbor, NY.
15. Schwinn, D. A., Lomasney, J. W., Lorenz, W., Szklut, P. J., Fremeau, R. T., Yang-Feng, T. L., Caron, M. G., Lefkowitz, R. J., and Cotecchia, S. 1990. J. Biol. Chem. 14: 8183 – 8189.
16. Testa, R., Destefani, C., Guarneri, L., Poggesi, E., Simonazzi, I., Tadei, C., and Leonardi, A. 1995. Life Sci. 57: 159 – 163.
17. Waugh, D. J. J., Gaivin, R. J., Zuscik, M. J., Gonzales-Cabrera, P., Ross, S. A., Yun, J., and Perez, D. M. 2001. JBC 276: 25366 – 25371.
18. Zhao, M., Hwa, J., and Perez, D. M. 1996. Mol. Pharmacol. 50: 1118 – 1126.
19. Zhong, H., and Minneman, K. P. 1999. Eur. J. Pharmacol. 375: 261 – 276.