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Renal transport of calcium, magnesium, and phosphate
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Suki, W.N.1
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Novel phosphate-regulating genes in the pathogenesis of renal phosphate wasting disorders
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FGF-23 inhibits renal tubular phosphate transport and is a PHEX substrate
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Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia
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+- dependent phosphate co-transport activity and 1alpha,25-dihydroxyvitamin D3 production
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+-dependent phosphate co-transport activity and 1alpha,25-dihydroxyvitamin D3 production. J Biol Chem 2003; 278:2206-2211. This interesting study describes the effects of a mutant FGF23 protein on phosphate transporters and on vitamin D metabolism without altering PTH secretion.
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Saito, H.1
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Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism
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Shimada T, Kakitani M, Yamazaki Y, et al. Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism. J Clin Invest 2004; 113:561-568. This report provides a description of the phenotype of FGF23-null mice.
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Shimada, T.1
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Hypo and hyperphosphataemia
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Grunfeld JP, Ypersele MV, Cameron JS, et al., editors. Oxford: Oxford University Press; (in press)
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Silve C, Friedlander G. Hypo and hyperphosphataemia. In: Grunfeld JP, Ypersele MV, Cameron JS, et al., editors. Oxford textbook of clinical nephrology, 3rd ed. Oxford: Oxford University Press; 2004 (in press).
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Oxford Textbook of Clinical Nephrology, 3rd Ed.
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Silve, C.1
Friedlander, G.2
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10
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Localization of NaPi-1, a Na/Pi cotransporter, in rabbit kidney proximal tubules. II. Localization by immunohistochemistry
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Biber J, Custer M, Wemer A, et al. Localization of NaPi-1, a Na/Pi cotransporter, in rabbit kidney proximal tubules. II. Localization by immunohistochemistry. Pflugers Arch 1993; 424:210-215.
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Expression of a renal type I sodium/phosphate transporter (NaPi-1) induces a conductance in Xenopus oocytes permeable for organic and inorganic anions
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Busch AE, Schuster A, Waldegger S, et al. Expression of a renal type I sodium/phosphate transporter (NaPi-1) induces a conductance in Xenopus oocytes permeable for organic and inorganic anions. Proc Natl Acad Sci USA 1996; 93:5347-5351.
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Characterization of a murine type II sodium-phosphate cotransporter expressed in mammalian small intestine
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Hiffiker H, Hattenhauer O, Traebert M, et al. Characterization of a murine type II sodium-phosphate cotransporter expressed in mammalian small intestine. Proc Natl Acad Sci USA 1998; 95:14564-14569.
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Hiffiker, H.1
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+-dependent phosphate co-transporters by a low-phosphate diet and 1,25-dihydroxyvitamin D3
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+-dependent phosphate co-transporters by a low-phosphate diet and 1,25-dihydroxyvitamin D3. Biochem J 1999; 343 (Pt 3):705-712.
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Growth-related renal type II Na/Pi cotransporter
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Segawa H, Kaneko I, Takahashi A, et al. Growth-related renal type II Na/Pi cotransporter. J Biol Chem 2002; 277:19665-19672.
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Kaneko, I.2
Takahashi, A.3
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Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria, and skeletal abnormalities
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Beck L, Karaplis AC, Amizuka N, et al. Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria, and skeletal abnormalities. Proc Natl Acad Sci USA 1998; 95:5372-5377.
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Beck, L.1
Karaplis, A.C.2
Amizuka, N.3
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Parathyroid hormone regulation of type II sodium-phosphate cotransporters is dependent on an A kinase anchoring protein
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Khundmiri SJ, Rane MJ, Lederer ED. Parathyroid hormone regulation of type II sodium-phosphate cotransporters is dependent on an A kinase anchoring protein. J Biol Chem 2003; 278:10134-10141. This study demonstrates that NPT2a is physically associated with an A kinase anchoring protein and that this association is necessary for regulation of phosphate transport by PTH.
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J Biol Chem
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Khundmiri, S.J.1
Rane, M.J.2
Lederer, E.D.3
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Targeted disruption of the mouse NHERF-1 gene promotes internalization of proximal tubule sodium-phosphate cotransporter type IIa and renal phosphate wasting
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Shenolikar S, Voltz JW, Minkoff CM, et al. Targeted disruption of the mouse NHERF-1 gene promotes internalization of proximal tubule sodium-phosphate cotransporter type IIa and renal phosphate wasting. Proc Natl Acad Sci USA 2002; 99:11470-11475.
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Shenolikar, S.1
Voltz, J.W.2
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Interaction of the type IIa Na/Pi cotransporter with PDZ proteins
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Gisler SM, Stagljar I, Traebert M, et al. Interaction of the type IIa Na/Pi cotransporter with PDZ proteins. J Biol Chem 2001; 276:9206-9213.
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PDZ-domain interactions and apical expression of type IIa Na/P(i) cotransporters
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Hernando N, Deliot N, Gisler SM, et al. PDZ-domain interactions and apical expression of type IIa Na/P(i) cotransporters. Proc Natl Acad Sci USA 2002; 99:11957-11962.
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Hernando, N.1
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Regulation of sodium-dependent phosphate transport in osteoclasts
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Gupta A, Guo XL, Alvarez UM, et al. Regulation of sodium-dependent phosphate transport in osteoclasts. J Clin Invest 1997; 100:538-549.
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+-Pi cotransporter (Npt2) in the osteoclast and the skeletal phenotype of Npt2-/- mice. Bone 2001; 29:467-476.
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Bone
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Gupta, A.1
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+-dependent phosphate transporters in the murine osteoclast: Cellular distribution and protein interactions
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+-dependent phosphate transporters in the murine osteoclast: cellular distribution and protein interactions. Am J Physiol Cell Physiol 2003; 284:C1633-C1644. This paper indicates that in mouse osteoclast NPT2a interacts with NHERF1 in a different manner than that reported in the kidney.
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Am J Physiol Cell Physiol
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Khadeer, M.A.1
Tang, Z.2
Tenenhouse, H.S.3
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Transmembrane topology of PiT-2, a phosphate transporter-retrovirus receptor
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Salaun C, Rodrigues P, Heard JM. Transmembrane topology of PiT-2, a phosphate transporter-retrovirus receptor. J Virol 2001; 75:5584-5592.
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In vivo expression of transcripts encoding the Glvr-1 phosphate transporter/retrovirus receptor during bone development
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Palmer G, Zhao J, Bonjour J, et al. In vivo expression of transcripts encoding the Glvr-1 phosphate transporter/retrovirus receptor during bone development. Bone 1999; 24:1-7.
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Phosphate regulation of vascular smooth muscle cell calcification
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Cell-surface receptors for gibbon ape leukemia virus and amphotropic murine retrovirus are inducible sodium-dependent phosphate symporters
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Calcium phosphate supersaturation regulates stone formation in genetic hypercalciuric stone-forming rats
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Bushinsky DA, Parker WR, Asplin JR. Calcium phosphate supersaturation regulates stone formation in genetic hypercalciuric stone-forming rats. Kidney Int 2000; 57:550-560.
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Randall's plaque of patients with nephrolithiasis begins in basement membranes of thin loops of Henle
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Evan AP, Lingeman JE, Coe FL, et al. Randall's plaque of patients with nephrolithiasis begins in basement membranes of thin loops of Henle. J Clin Invest 2003; 111:607-616. The authors performed biopsies of plaques in kidneys of idiopathic calcium stone formers and confirmed Randall's hypothesis, according to which calcium renal stones originate in the basement membranes of the thin loops of Henle as apatite crystals, and then spread from there through the interstitium to beneath the urothelium.
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J Clin Invest
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Prie D, Ravery V, Boccon-Gibod L, et al. Frequency of renal phosphate leak among patients with calcium nephrolithiasis. Kidney Int 2001; 60:272-276.
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Chau H, El-Maadawy S, McKee MD, et al. Renal calcification in mice homozygous for the disrupted type IIa Na/Pi cotransporter gene Npt2. J Bone Miner Res 2003; 18:644-657. This paper reports that NFT2a gene ablation in mice is associated with calcium renal stone formation.
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J Bone Miner Res
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Chau, H.1
El-Maadawy, S.2
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Nephrolithiasis and osteoporosis associated with hypophosphatemia caused by mutations in the type 2a sodium-phosphate cotransporter
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Prie D, Huart V, Bakouh N, et al. Nephrolithiasis and osteoporosis associated with hypophosphatemia caused by mutations in the type 2a sodium-phosphate cotransporter. N Engl J Med 2002; 347:983-991.
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Transgenic mice expressing fibroblast growth factor 23 under the control of the alpha 1(I) collagen promoter exhibit growth retardation, osteomalacia and disturbed phosphate homeostasis
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Larsson T, Marsell R, Schipani E, et al. Transgenic mice expressing fibroblast growth factor 23 under the control of the alpha 1(I) collagen promoter exhibit growth retardation, osteomalacia and disturbed phosphate homeostasis, Endocrinology 2004; 145:3087-3094, This paper describes the phenotype of a mouse strain that overexpresses FGF23.
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Endocrinology
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, pp. 3087-3094
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Larsson, T.1
Marsell, R.2
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Mansfield K, Rajpurohit R, Shapiro IM. Extracellular phosphate ions cause apoptosis of terminally differentiated epiphyseal chondrocytes. J Cell Physiol 1999; 179:276-286.
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Mansfield, K.1
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Adams CS, Mansfield K, Perlot RL, et al. Matrix regulation of skeletal cell apoptosis. Role of calcium and phosphate ions. J Biol Chem 2001; 276:20316-20322.
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Vascular calcification: In vitro evidence for the role of inorganic phosphate
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Giachelli CM. Vascular calcification: in vitro evidence for the role of inorganic phosphate. J Am Soc Nephrol 2003; 14 (suppl 4):S300-S304. This interesting paper reviews data suggesting that PiT-1 may play a central role in formation of vascular calcification in the presence of high extracellular phosphate concentration.
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(2003)
J Am Soc Nephrol
, vol.14
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Giachelli, C.M.1
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