High serum leptin in patients with chronic graft-versus-host disease after hematopoietic stem cell transplantation

Transplantation

Volumn 78, Issue 9, 2004, Pages 1376-1383

  Tauchmanovà, Libose ^a   Matarese, Giuseppe ^b   Carella, Carlo ^c   De Rosa, Gennaro ^a   Serio, Bianca ^a   Ricci, Patrizia ^a   Lombardi, Gaetano ^a   Rotoli, Bruno ^a   Colao, Annamaria ^a   Selleri, Carmine ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b CNR   (Italy)

^c SECOND UNIVERSITY OF NAPLES   (Italy)

Author keywords

Allogeneic stem cell transplant; Chronic graft versus host disease; Interferon gamma; Leptin

Indexed keywords

C REACTIVE PROTEIN; CYTOKINE; GAMMA INTERFERON; HYDROCORTISONE; LEPTIN;

ADULT; ALLOTRANSPLANTATION; ARTICLE; AUTOTRANSPLANTATION; BODY MASS; CHRONIC DISEASE; CONTROLLED STUDY; CYTOKINE RELEASE; FEMALE; GRAFT VERSUS HOST REACTION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; MAJOR CLINICAL STUDY; MALE; NUTRITIONAL STATUS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN SYNTHESIS; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH2 CELL;

ADOLESCENT; ADULT; CD4-CD8 RATIO; CHRONIC DISEASE; CYTOKINES; FEMALE; GRAFT VS HOST DISEASE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; LEPTIN; LYMPHOCYTE CULTURE TEST, MIXED; MALE; MIDDLE AGED;

EID: 8644255846     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.TP.0000140485.20848.B7     Document Type: Article

References (46)

1. Friedman JM, Halaas JL. Leptin and the regulation of body weight in mammals. Nature 1998; 395: 763.
2. Konopleva M, Mikhail A, Estrov Z, et al. Expression and function of leptin receptor isoforms in myeloid leukemia and myelodysplastic syndromes: proliferative and anti-apoptotic activities. Blood 1999; 93: 1668.
3. Matarese G, Sanna V, Fontana S, et al. Leptin as a novel therapeutic target for immune intervention. Curr Drug Targets Inflamm Allergy 2002; 1: 13.
4. Fantuzzi G, Faggioni R. Leptin in the regulation of immunity, inflammation, and hematopoiesis. J Leukoc Biol 2000; 68: 437.
5. Kratzsch J, Lammert A, Bottner A, et al. Circulating soluble leptin receptor and free leptin index during childhood, puberty, and adolescence. J Clin Endocrinol Metab 2002; 87: 4587.
6. Moran O, Phillip M. Leptin: obesity, diabetes and other peripheral effects. Pediatr Diabetes 2003; 4: 101.
7. Zimmermann-Belsing T, Brabant G, Holst JJ, et al. Circulating leptin and thyroid dysfunction. Eur J Endocrinol 2003; 149: 257.
8. Bokarewa M, Bokarew D, Hultgren O, et al. Leptin consumption in the inflamed joints of patients with rheumatoid arthritis. Ann Rheum Dis 2003; 62: 952.
9. Schroth M, Kratzsch J, Groschl M, et al. Increased soluble leptin receptor in children with nephrotic syndrome. J Clin Endocrinol Metab 2003; 88: 5497.
10. Sanna V, Di Giacomo A, La Cava A, et al. Leptin surge precedes onset of autoimmune encephalomyelitis and correlates with development of pathogenic T cell responses. J Clin Invest 2003; 111: 241.
11. Faggioni R, Feingold KR, Grunfeld C. Leptin regulation of the immune response and the immunodeficiency of malnutrition. FASEB J 2001; 15: 2565.
12. Bruun JM, Pedersen SB, Kristensen K, et al. Effects of pro-inflammatory cytokines and chemokines on leptin production in human adipose tissue in vitro. Mol Cell Endocrinol 2002; 190: 91.
13. Lord GM, Matarese G, Howard JK, et al. Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature 1998; 394: 897.
14. Faggioni R, Jones-Carson J, Reed DA, et al. Leptin-deficient (ob/ob) mice are protected from T cell-mediated hepatotoxicity: role of tumor necrosis factor alpha and IL-18. Proc Natl Acad Sci USA 2000; 97: 2367.
15. Matarese G, Di Giacomo A, Sanna V, et al. Requirement for leptin in induction and progression of experimental autoimmune encephalomyelitis. J Immunol 2001; 166: 5909.
16. Winnicki M, Phillips BG, Accurso V, et al. Independent association between plasma leptin levels and heart rate in heart transplant recipients. Circulation 2001; 104: 384.
17. Kagan A, Haran N, Leshinsky L, et al. Serum concentrations of leptin in heart, liver and kidney transplant recipients. Isr Med Assoc J 2001; 4: 213.
18. Couto-Silvia AC, Trivin C, Esperou H, et al. Changes in height, weight and plasma leptin after bone marrow transplantation. Bone Marrow Transpl 2000; 26: 1205.
19. Imamura M, Tsutsumi Y, Miura Y, et al. Immune reconstitution and tolerance after allogeneic hematopoietic stem cell transplantation. Hematology 2003; 8: 19.
20. Porrata LF, Litzow MR, Markovic SN. Immune reconstitution after autologous hematopoietic stem cell transplantation. Mayo Clin Proc 2001; 76: 407.
21. Dagogo-Jack S, Umamaheswaran I, Askari H, et al. Leptin response to glucocorticoid occurs at physiological doses and is abolished by fasting. Obes Res 2003; 11: 232.
22. Williams LB, Fawcett RL, Waechter AS, et al. Leptin production in adipocytes from morbidly obese subjects: stimulation by dexamethasone, inhibition with troglitazone, and influence of gender. J Clin Endocrinol Metab 2000; 85: 2678.
23. Mantzoros CS. Role of leptin in reproduction. Ann N Y Acad Sci 2000; 900: 174.
24. Gomez JM, Maravall FJ, Gomez N, et al. Interactions between serum leptin, the insulin-like growth factor-I system, and sex, age, anthropometric and body composition variables in a healthy population randomly selected. Clin Endocrinol 2003; 58: 213.
25. Considine RV. Regulation of leptin production. Rev Endocr Metab Disord 2001; 2: 357.
26. Tauchmanova L, Selleri C, De Rosa G, et al. High prevalence of endocrine dysfunction in long-term survivors after allogeneic bone marrow transplantation for hematologic diseases. Cancer 2002; 95: 1076.
27. Bruserud O, Huang TS, Glejen N, et al. Leptin in human acute myelogeneous leukaemia: studies of in vitro levels and in vitro effects on native functional leukaemia blasts. Haematologica 2002; 87: 562-563.
28. Lee SJ, Klein JP, Barren AJ, et al. Severity of chronic graft-versus-host disease: association with treatment-related mortality and relapse. Blood 2002; 100: 406.
29. Lee SJ, Vogelsang G, Flowers ME. Chronic graft-versus-host disease. Biol Blood Marrow Transpl 2003; 9: 215.
30. Kitawaki J, Kusuki I, Koshiba H, et al. Leptin directly stimulates aromatase activity in human luteinized granulosa cells. Mol Hum Reprod 1999; 5: 708.
31. Brann DW, De Sevilla L, Zamorano PL, et al. Regulation of leptin gene expression and secretion by steroid hormones. Steroids 1999; 64: 659.
32. Di Carlo C, Tommaselli GA, Pisano G, et al. Serum leptin levels in postmenopausal women: effects of transdermal hormone replacement therapy. Menopause 2000; 7: 36.
33. Matarese G, La Cava A, Sanna V, et al. Balancing susceptibility to infection and autoimmunity: a role for leptin? Trends Immunol 2002; 23: 182.
34. Maruna P, Gurlich R, Frasko R, et al. Serum leptin levels in septic men correlate well with C-reactive protein (CRP) and TNF-alpha but not with BMI. Physiol Res 2001; 50: 589.
35. Sturmer T, Brenner H, Koenig W, et al. Severity and extent of osteoarthritis and low grade systemic inflammation as assessed by high sensitivity C reactive protein. Ann Rheum Dis 2004; 63: 200.
36. Clark FJ, Gregg R, Piper K, et al. Chronic graft-versus-host disease is associated with increased numbers of peripheral blood CD4+CD25high regulatory T cells. Blood 2004; 103: 2410.
37. Xystrakis E, Bernard I, Dejean AS, et al. Alloreactive CD4 T lymphocytes responsible for acute and chronic graft-versus-host disease are contained within the CD45RChigh but not the CD45RClow subset. Eur J Immunol 2004; 34: 408.
38. Ferrara JL. Cytokine dysregulation as a mechanism of graft-versus-host disease. Curr Opin Immunol 1993; 5: 794.
39. Fowler DH, Gress RE. Th2 and Tc2 cells in the regulation of GVHD, GVL, and graft rejection: considerations for the allogeneic transplantation therapy of leukemia and lymphoma. Leuk Lymphoma 2000; 38: 221.
40. Korholz D, Banning U, Bonig H, et al. The role of interleukin-10 (IL-10) in IL-15-mediated T-cell responses. Blood 1997; 90: 4513.
41. Tanaka J, Imamura M, Kasai M, et al. The important balance between cytokines derived from type 1 and type 2 helper T cells in the control of graft-versus-host disease. Bone Marrow Transpl 1997; 19: 571.
42. Teshima T, Ferrara IL. Understanding the alloresponse: new approaches to graft-versus-host disease prevention. Semin Hematol 2002; 39: 15.
43. Parkman R. Chronic graft-versus-host disease. Cun Opin Hematol 1998; 5: 22.
44. Bruun JM, Pedersen SB, Kristensen K, et al. Effects of pro-inflammatory cytokines and chemokines on leptin production in human adipose tissue in vitro. Mol Cell Endocrinol 2002; 190: 91.
45. Sanchez-Margalet V, Martin-Romero C, Santos-Alvarez J, et al. Role of leptin as an immunomodulator of blood mononuclear cells: mechanisms of action. Clin Exp Immunol 2003; 133: 11.
46. Fujita Y, Murakami M, Ogawa Y, et al. Leptin inhibits stress-induced apoptosis of T lymphocytes. Clin Exp Immunol 2002; 128: 21.