Aglycemia and ischemia depress monosynaptic and polysynaptic reflexes in neonatal rat spinal cord in vitro by involving different types of 5-hydroxytryptamine receptors

Neuroscience Letters

Volumn 372, Issue 1-2, 2004, Pages 167-172

  Deshpande, Shripad B ^a   Jha, Archana ^a  

^a BANARAS HINDU UNIVERSITY   (India)

Author keywords

Anoxia; Hypoglycemia; Hypoxia; Serotonin receptors; Spinal cord; Synaptic transmission

Indexed keywords

5,7 DIHYDROXYTRYPTAMINE; KETANSERIN; ONDANSETRON; SEROTONIN RECEPTOR; SPIPERONE;

ANIMAL MODEL; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; DORSAL ROOT; FEMALE; HYPOGLYCEMIA; INHIBITION KINETICS; MALE; MEMBRANE POTENTIAL; MONOSYNAPTIC REFLEX; NONHUMAN; POLYSYNAPTIC REFLEX; PRIORITY JOURNAL; RAT; SPINAL CORD; VENTRAL ROOT;

ACTION POTENTIALS; ANIMALS; ANIMALS, NEWBORN; FEMALE; GLUCOSE; ISCHEMIA; MALE; RATS; RECEPTORS, SEROTONIN; REFLEX, MONOSYNAPTIC; SPINAL CORD;

EID: 8644238212     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2004.09.033     Document Type: Article

References (21)

1. D. Chesnoy-Marchais, and J.Y. Barthe Voltage-dependent block of NMDA response by 5-HT agonists in ventral spinal cord neurones Br. J. Pharmacol. 117 1996 133 141
2. L.A. Connell, and D.I. Wallis 5-Hydroxytryptamine depolarizes neonatal rat motoneurones through a receptor unrelated to an identified binding site Neuropharmacology 28 1989 625 634
3. W. Danysz, and C.G. Parsons Glycine and N-methyl-d-aspartate receptors: physiological significance and possible therapeutic applications Pharmacol. Rev. 50 1998 597 664
4. S.B. Deshpande, N.S. Pilotte, and J.E. Warnick Gender specific action of thyrotropin-releasing hormone in the mammalian spinal cord FASEB J. 1 1987 478 482
5. S.B. Deshpande, and J.E. Warnick Temperature dependence of reflex transmission in the neonatal rat spinal cord, in vitro: influence on strychnine and bicuculline sensitive inhibitions Neuropharmacology 27 1988 1033 1037
6. S.B. Deshpande, and J.E. Warnick Interaction of thyrotropin-releasing hormone and methysergide on the monosynaptic reflex in isolated mammalian spinal cord Neurosci. Lett. 116 1990 141 148
7. S.B. Deshpande, and J.E. Warnick Receptor subtypes involved in mediating serotonin-induced depression of the spinal monosynaptic reflex in vitro S.K. Manchanda W. Selvamurthy V. Mohan Kumar Advances in Physiological Sciences 1992 MacMillan India Ltd. New Delhi 631 635
8. S.B. Deshpande, and J.E. Warnick Thyrotropin-releasing hormone reverses the supersensitively depressed monosynaptic transmission by serotonin in 5,7-dihydroxytryptamine treated neonatal rats in vitro Brain Res. 655 1994 263 266
9. A. Jha, and S.B. Deshpande Aglycemia and ischemia depress the spinal synaptic transmission via the inhibitory system involving NMDA receptors Eur. J. Pharmacol. 481 2003 189 196
10. +-dependent glutamate transport J. Neurosci. 19 RC16 1999 1 9
11. + channels in ion fluxes during hypoxia of rat hippocampal slices J. Neurophysiol. 84 2000 1869 1880
12. 3H] noradrenaline and glutamate in response to simulation of ischemic conditions in rat spinal cord slice preparation: effect of NMDA and AMPA receptor antagonists Eur. J. Pharmacol. 366 1999 143 150
13. Y. Ohno, and J.E. Warnick Presynaptic activation of the spinal serotonergic system in the rat by phencyclidine in vitro J. Pharamacol. Exp. Ther. 250 1989 177 183
14. A.K. Pringle, F. Iannotti, G.J.C. Wilde, J.E. Chad, P.J. Seeley, and L.E. Sundstorm Neuroprotection by both NMDA and non-NMDA receptor antagonists in vitro ischemia Brain Res. 755 1997 36 46
15. M.S. Santos, A.J. Moreno, and A.P. Carvalho Relationships between ATP depletion, membrane potential and the release of neurotransmitters in rat nerve terminals. An in vitro study under conditions that mimic anoxia, hypoglycemia and ischemia Stroke 27 1996 941 950
16. P. Seeman, and H.H. Van Tol Dopamine receptor pharmacology Trends Pharmacol. Sci. 15 1994 264 270
17. J.N. Singh, and S.B. Deshpande Involvement of N-methyl-d-aspartate receptors for the Ptychodiscus brevis toxin-induced depression of monosynaptic and polysynaptic reflexes in neonatal rat spinal cord in vitro Neuroscience 115 2002 1189 1197
18. J.N. Singh, and S.B. Deshpande Ptychodiscus brevis toxin-induced depression of spinal reflexes involves GABA-ergic system sensitive to N-methyl-d-aspartate receptors. Brain Res. 974 2003 243 248
19. D.I. Wallis, and P. Elliott The electrophysiology of 5-HT J.R. Fozard P.R. Saxena Serotonin Molecular Biology, Receptors and Functional Effects 1991 Birkhauser Verlag Basel, Switzerland 203 219
20. D.I. Wallis, and J. Wu The pharmacology of descending responses evoked by thoracic stimulation in the neonatal rat spinal cord Arch. Pharmacol. 347 1993 643 651
21. D.I. Wallis, J. Wu, and X.C. Wang Is 5-hydroxytryptamine mediating descending inhibition in the neonatal rat spinal cord in vitro through different receptor subtypes? Eur. J. Pharmacol. 250 1993 371 377