Piperidine-based nocaine/modafinil hybrid ligands as highly potent monoamine transporter inhibitors: Efficient drug discovery by rational lead hybridization

Journal of Medicinal Chemistry

Volumn 47, Issue 24, 2004, Pages 5821-5824

  Zhou, Jia ^a   He, Rong ^b   Johnson, Kenneth M ^c   Ye, Yanping ^c   Kozikowski, Alan P ^a,b  

^a Acenta Discovery Incorporated   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c University of Texas Medical Branch School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COCAINE; DOPAMINE TRANSPORTER; MODAFINIL; NORADRENALIN TRANSPORTER; PIPERIDINE DERIVATIVE; SEROTONIN TRANSPORTER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEPRESSION; DOPAMINE UPTAKE; DOSE RESPONSE; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; NONHUMAN; NORADRENALIN UPTAKE; POSITRON EMISSION TOMOGRAPHY; RAT; SEROTONIN UPTAKE; SLEEP APNEA SYNDROME;

ANIMALS; BENZHYDRYL COMPOUNDS; BIOLOGICAL AVAILABILITY; COCAINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; DRUG DESIGN; LIGANDS; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT MODULATORS; MEMBRANE TRANSPORT PROTEINS; MOTOR ACTIVITY; NERVE ENDINGS; NERVE TISSUE PROTEINS; NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS; PIPERIDINES; RATS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SYMPORTERS; SYNAPTOSOMES;

EID: 8644230956     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm040117o     Document Type: Article

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