Prostaglandin F(2α) stimulates interleukin-6 synthesis via activation of PKC in osteoblast-like cells

American Journal of Physiology - Endocrinology and Metabolism

Volumn 272, Issue 2 35-2, 1997, Pages

  Kozawa, Osamu ^a   Suzuki, Atsushi ^b   Tokuda, Haruhiko ^b   Uematsu, Toshihiko ^b  

^a GIFU UNIVERSITY   (Japan)

^b NONE

Author keywords

phosphoinositide; phospholipase C; phospholipase D; protein kinase C

Indexed keywords

CALPHOSTIN C; INTERLEUKIN 6; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHATIDYLCHOLINE; PHOSPHOLIPASE C; PHOSPHOLIPASE D; PROSTAGLANDIN F2 ALPHA; PROTEIN KINASE C; STAUROSPORINE; ENZYME INHIBITOR; NAPHTHALENE DERIVATIVE;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; MOUSE; NONHUMAN; OSTEOBLAST; PHOSPHOINOSITIDE METABOLISM; PRIORITY JOURNAL; PROTEIN INDUCTION; ANIMAL; BIOSYNTHESIS; CELL LINE; METABOLISM;

ANIMALS; CELL LINE; DINOPROST; ENZYME ACTIVATION; ENZYME INHIBITORS; INTERLEUKIN-6; MICE; NAPHTHALENES; OSTEOBLASTS; PROTEIN KINASE C; STAUROSPORINE; TETRADECANOYLPHORBOL ACETATE;

EID: 0031067808     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1997.272.2.e208     Document Type: Article

References (27)

1. Akira, S., T. Hirano, T. Taga, and T. Kishimoto. Biology of multifunctional cytokines: IL-6 and related molecules (IL-1 and TNF). FASEB J. 4: 2860-2867, 1990.
2. Billah, M. M., and J. C. Anthes. The regulation and cellular functions of phosphatidylcholine hydrolysis. Biochem. J. 269: 281-291, 1990.
3. Exton, J. H. Signaling through phosphatidylcholine breakdown. J. Biol. Chem. 265: 1-4, 1990.
4. Feyen, J. H. M., P. Elford, F. E. Di Padonova, and U. Trechsel. Interleukin-6 is produced by bone and modulated by parathyroid hormone. J. Bone Miner. Res. 4: 633-638, 1989.
5. Franchimont, N., and E. Canalis. Platelet-derived growth factor stimulates the synthesis of interleukin-6 in cells of the osteoblast lineage. Endocrinology 136: 5469-5475, 1995.
6. Helle, M., J. P. J. Brakenhoff, E. R. DeGroot, and L. A. Aarden. Interleukin-6 is involved in interleukin-1-induced activities. Eur. J. Immunol. 18: 957-959, 1988.
7. Hughes, F. J., and G. L. Howells. Interleukin-6 inhibits bone formation in vitro. Bone Miner. 21: 21-28, 1993.
8. Ishimi, Y., C. Miyaura, C. H. Jin, T. Akatsu, E. Abe, Y. Nakamura, Y. Yamaguchi, S. Yoshiki, T. Matsuda, T. Hirano, T. Kishimoto, and T. Suda. IL-6 is produced by osteoblasts and induces bone resorption. J. Immunol. 145: 3297-3303, 1990.
9. Kikuchi, A., O. Kozawa, Y. Hamamori, K. Kaibuchi, and Y. Takai. Inhibition of chemotactic peptide-induced phosphoinositide hydrolysis by phorbol esters through the activation of protein kinase C in differentiated human leukemia (HL-60) cells. Cancer Res. 46: 3401-3406, 1986.
10. Kobayashi, E., H. Nakano, M. Morimoto, and T. Tamaoki. Calphostin C (UCN-1029C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C. Biochem. Biophys. Res. Commun. 159: 548-553, 1989.
11. Kodama, H., Y. Amagai, H. Sudo, S. Kasai, and S. Yamamoto. Establishment of a clonal osteogenic cell line from newborn mouse calvaria. Jpn. J. Oral Biol. 23: 899-901, 1981.
12. 2 stimulates calcification of human osteoblastic cells. Biochem. Biophys. Res. Commun. 159: 1206-1212, 1989.
13. 45Ca-accumulation in cultures of osteoblast-like cells: possible involvement of insulin-like growth factor-I. Bone Miner. 19: 235-243, 1992.
14. 2α activates phospholipase D independently from activation of protein kinase C in osteoblast-like cells. J. Cell. Biochem. 55: 373-379, 1994.
15. Kozawa, O., K. Takatsuki, K. Kotake, M. Yoneda, Y. Oiso, and H. Saito. Possible involvement of protein kinase C in proliferation and differentiation of osteoblast-like cells. FEBS Lett. 243: 183-185, 1989.
16. Littlewood, A. J., J. Russell, G. R. Harvey, D. E. Hughes, R. G. G. Russell, and M. Gowen. The modulation of the expression of IL-6 and its receptor in human osteoblasts in vitro. Endocrinology 129: 1513-1520, 1991.
17. 2α-induced phosphoinositide hydrolysis in osteoblast-like cells. Biochem. Biophys. Res. Commun. 171: 1229-1235, 1990.
18. Nijweide, P. J., E. H. Burger, and J. H. M. Feyen. Cells of bone: proliferation, differentiation and hormonal regulation. Physiol. Rev. 66: 855-886, 1986.
19. Nishizuka, Y. Studies and perspectives of protein kinase C. Science Wash. DC 233: 305-312, 1986.
20. Nishizuka, Y. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science Wash. DC 258: 607-614, 1992.
21. Raisz, L. G., and T. J. Martin. Prostaglandins in bone and mineral metabolism. In: Bone and Mineral Research, edited by W. A. Peck. Amsterdam: Elsevier, 1984, vol. 2, p. 286-310.
22. Robinson, R. J., S. B. Doty, and R. R. Cooper. Electron microscopy of mammalian bone. In: Biological Mineralization, edited by I. Zipkin. New York: Academic, 1973, p.257-296.
23. Roodman, G. D. Interleukin-6; an osteotropic factor? J. Bone Miner. Res. 7: 475-478, 1992.
24. Sakai, T., Y. Okano, Y. Nozawa, and N. Oka. Different protein kinase C isozymes could modulate bradykinin-induced extracellular calcium-dependent and -independent increases in osteoblast-like MC3T3-E1 cells. Cell Calc. 13: 329-340, 1992.
25. Sudo, H., H. Kodama, Y. Amagai, S. Yamamoto, and S. Kasai. In vitro differentiation and calcification in a new clonal osteogenic cell line derived from newborn mouse calvaria. J. Cell Biol. 96: 191-198, 1983.
26. Tamaoki, T., H. Nomoto, I. Takahashi, Y. Kato, M. Morimoto, and F. Tomita. Staurosporine, a potent inhibitor of phospholipid/Ca++ dependent protein kinase. Biochem. Biophys. Res. Commun. 135: 397-402, 1986.
27. Van Snick, J. V. Interleukin-6: an overview. Annu. Rev. Immunol. 8: 253-297, 1990.