Excised porcine skin experimental systems to validate quantitative microdialysis methods for determination of drugs in skin after topical application

Journal of Controlled Release

Volumn 100, Issue 2, 2004, Pages 181-189

  Seki, Toshinobu ^a,b   Wang, Aiping ^a,c   Yuan, Dan ^c   Saso, Yuko ^a   Hosoya, Osamu ^a   Chono, Sumio ^a   Morimoto, Kazuhiro ^a  

^a HOKKAIDO INSTITUTE OF TECHNOLOGY   (Japan)

^b Research Institute of TTS Technology   (Japan)

^c SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Excised porcine skin; In vitro skin permeation experiment; Membrane clearance; Quantitative microdialysis; Zero net flux method

Indexed keywords

INFLOW; MICRODIALYSIS; OUTFLOW;

DIALYSIS; DRUG PRODUCTS; MASS TRANSFER; SKIN; TISSUE;

HEALTH CARE;

FLURBIPROFEN;

ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; DERMIS; DRUG CLEARANCE; DRUG DELIVERY SYSTEM; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG PENETRATION; DRUG TISSUE LEVEL; EXPERIMENTAL TEST; EXTRACELLULAR MATRIX; MICRODIALYSIS; NONHUMAN; PREDICTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SKIN; SKIN PERMEABILITY; SWINE; TECHNIQUE; VALIDATION PROCESS; ZERO NET FLUX;

ADMINISTRATION, TOPICAL; ALGORITHMS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; EXTRACELLULAR SPACE; FLURBIPROFEN; MICRODIALYSIS; PHARMACEUTICAL PREPARATIONS; SKIN; SKIN ABSORPTION; SWINE;

EID: 8544236221     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2004.08.016     Document Type: Article

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