Microtiter plate-based microfluidic platforms: Sealing, leakage testing, and performance of a 96-well SPRI device

American Society of Mechanical Engineers, Micro-Electro Mechanical Systems Division, (Publications) MEMS

Volumn , Issue , 2006, Pages

  Park, D S ^a   Hupert, M ^a   Guy, J ^a   Datta, P ^a   Lee, J B ^b   Witek, M ^a   You, B H ^c   Soper, S A ^a   Nikitopoulos, D E ^a,c   Murphy, M C ^a,c  

^a LOUISIANA STATE UNIVERSITY   (United States)

^b The University of Texas at Dallas   (United States)

^c Louisiana State University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; LEAK DETECTION; LITHOGRAPHY; PATIENT TREATMENT; POLYCARBONATES; SEALING (CLOSING);

HOT EMBOSSING; LARGE AREA MOLD INSERT (LAMI); METALLIC MOLD; VERTICAL SIDEWALLS;

FLUIDIC DEVICES;

EID: 85196489153     PISSN: 1096665X     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1115/IMECE2006-15275     Document Type: Conference Paper

References (28)

1. Microplate Standards Development Committee (2004) For Microplates - Footprint Dimensions - ANSI/SBS 1-2004, eds. Secretariat Society for Biomolecular Screening. Danbury, CT.
2. Darvas, F., Dormán, G., Krajcsi, P., Puskás, L. G., Kovári, Z., Lörincz, Z., and Urge, L., 2004, "Recent Advances in Chemical Genomics," Current Medicinal Chemistry, 11, pp. 3119-3145.
3. Honma, K., Miyata, T., and Ochiya, T., 2004, "The Role of Atelocollagen-Based Cell Transfection Array in High-Throughput Screening of Gene Functions and in Drug Discovery," Current Drug Discovery Technologies, 1, pp. 287-294.
4. Reyes, D. R., lossifidis, D., Auroux, P.-A., and Manz, A., 2002, "Micro Total Analysis Systems. 1. Introduction, Theory, and Technology," Anal. Chem., 74, pp. 2623-2636.
5. Auroux, P.-A., Iossifidis, D., Reyes, D. R., and Manz, A., 2002, "Micro Total Analysis Systems. 2. Analytical Standard Operations and Applications," Anal. Chem., 74, pp. 2637-2652.
6. Erickson, D., and Li, D., 2004, "Integrated Microfluidic Devices," Analytica Chimica Acta, 57, pp. 11-26.
7. Lee, S. J., and Lee, S. Y., 2004, "Micro Total Analysis System (μ-TAS) in Biotechnology," Appl. Microbiol. Biotechnol., 64, pp. 289-299.
8. Huang, Y., Mather, E. L., Bell, J. L., and Madou, M., 2002, "MEMS-Based Sample Preparation for Molecular Diagnostics," Anal. Bioanal. Chem., 372, pp. 49-65.
9. Liu, J., Enzelberger, M., and Quake, S., 2002, "A Nanoliter Rotary Device for Polymerase Chain Reaction," Electrophoresis, 23(10), pp. 1531-1536.
10. Ziaie, B., Baldi, A., Lei, M., Gu, Y., and Siegel, R. A., 2004, "Hard and Soft Micromachining for BioMEMS: Review of Techniques and Examples of Applications in Microfluidics and Drug Discovery," Advanced Drug Delivery Reviews, 56, pp. 145-172.
11. Paegel, B. M., Emrich, C. A., Wedemayer, G. J., Scherer, J. R., and Mathies, R. A., 2002, "High Throughput DNA Sequencing with a Microfabricated 96-Lane Capillary Array Electrophoresis bioprocessor," Applied Biological Sciences, 99(2), pp. 574-579.
12. Qi, S., Liu, X., Ford, S., Barrows, J., Thomas, G., Kelly, K., McCandless, A., Lian, K., Goettert, J., and Soper, S. A., 2002, "Microfluidic Devices Fabricated in Poly(methyl methacrylate) Using Hot-Embossing with Integrated Sampling Capillary and Fiber Optics for Fluorescence Detection," Lab Chip, 2(2), pp. 88-95.
13. Witek, M. A., Llopis, S. D., Wheatley, A., McCarley, R. M., and Soper, S. A., 2006, "Purification and Preconcentration of Genomic DNA from Whole Cell Lysates Using Photoactivated Polycarbonate (PPC) Microfluidic Chips," Nucleic Acid Research, 34(10), e74.
14. Kim, D. S., Lee, S. H., Ahn, C. H., Lee, T. Y., and Kwon, T. H., 2006, "Disposable Integrated Microfluidic Biochip for Blood Typing by Plastic Microinjection Moulding," Lab Chip, 6, pp. 794-802.
15. Heckele, M., and Schomburg, W. K., 2004, "Review of Micro Molding of Thermoplastic Polymers", J. Micromech. Microeng., 14, pp. R1-R14.
16. Gerlach, A., Knebel, G., Guber, A. E., Heckele, M., Herrmann, D., Muslija, A., and Schaller, Th., 2002, "Microfabrication of Single-Use Plastic Microfluidic Devices for High-Throughput Screening and DNA Analysis," Microsystem Technologies, 7(5-6), pp. 265-268.
17. Gerlach, A., Knebel, G., Guber, A. E., Heckele, M., Herrmann, D., Muslija, A., and Schaller, Th., 2002, "High-Density Plastic Microfluidic Platforms for Capillary Electrophoresis Separation and High-Throughput Screening," Sensors and Materials, 14(3), pp. 119-128.
18. Guber, A. E., Heckele, M., Herrmann, D., Muslija, A., Salie, V., Eichhorn, L., Gietzelt, T., Hoffmann, W., Hauser, P. C., Tanyanyiwa, J., Gerlach, A., Gottschlich, N., and Knebel, G., 2004, "Microfluidic Lab-on-a-Chip Systems Based on Polymers-Fabrication and Application," Chemical Engineering Journal, 101, pp. 447-453.
19. Xu, Y., Vaidya, B., Patel, A. B., Ford, S. M., McCarley, R. L., and Soper, S. A., 2003, "Solid-Phase Reversible Immobilization in Microfluidic Chips for the Purification of Dye-Labeled DNA Sequencing Fragments," Anal. Chem., 75(13), pp. 2975-2984.
20. Hupert, M. L., Guy, W. J., Llopis, S. D., Situma, C., Rani, S., Nikitopoulos, D. E., and Soper, S. A., 2006, "High-Precision Micromilling for Low-Cost Fabrication of Metal Mold Masters," Proc. of SPIE, Vol. 6112, 61220B.
21. US Patent No. 4882245, Gelorme, Cox, Guterrez, "Photoresist composition and printed circuit board and package made therith," November 1989, IBM.
22. Lorenz, H., Despont, M., Fahrni, N., Brugger, J., Renaud, P., and Vettiger, P., 1998, "High Aspect Ratio, Ultrathick, Negative-Tone Near-UV Photoresist and its Applications for MEMS," Sens. Actuators A-phys, 64(1), pp. 33-39.
23. Kim, K. S., 2004, "High Aspect Ratio Microstructures and Their Applications to MEMS," Ph. D. dissertation, The University of Texas at Dallas, Richardson, TX, USA.
24. Jeong, S. J., 2005, "UV-LIGA Micro-Fabrication of Inertia Type Electrostatic Transducers and Their Application," Ph. D. dissertation, Louisiana State University, Baton Rouge, LA, USA.
25. http://discheminc.com/PAPERS/STGT2405.pdf.
26. Mekaru, H., Yamada, T., Yan, S., and Hattori, T., 2004, "Microfabrication by Hot Embossing and Injection Molding at LASTI," Microsystem Technologies, 10, pp. 682-688.
27. Witek, M. A., Wei, S., Vaidya, B., Adams, A. A., Zhu, L., Stryjewski, W., McCarley, R. L., and Soper, S. A., 2004, "Cell Transport via Electromigration in Polymer-Based Microfluidic Devices," Lab Chip, 4, pp. 464472.
28. Datta, P., Xu, F., Gurung, S., Soper, S. A., and Goettert, J., 2006, "Polymeric Waveguides for Orthogonal Near Surface Fluorescent Excitation," Proc. of SPIE, Vol. 6112, p. 611208.