-
1
-
-
0034924156
-
Epidemiology of sepsis: an update
-
(Suppl)
-
Angus DC, Wax RS. Epidemiology of sepsis: an update. Crit Care Med. 2001;29(7 Suppl):S109-S116.
-
(2001)
Crit Care Med
, vol.29
, Issue.7
, pp. S109-S116
-
-
Angus, DC1
Wax, RS.2
-
2
-
-
84857641733
-
Hospitalizations, costs, and outcomes of severe sepsis in the United States 2003 to 2007
-
Lagu T, Rothberg MB, Shieh MS, Pekow PS, Steingrub JS, Lindenauer PK. Hospitalizations, costs, and outcomes of severe sepsis in the United States 2003 to 2007. Crit Care Med. 2012;40(3):754-761.
-
(2012)
Crit Care Med
, vol.40
, Issue.3
, pp. 754-761
-
-
Lagu, T1
Rothberg, MB2
Shieh, MS3
Pekow, PS4
Steingrub, JS5
Lindenauer, PK.6
-
3
-
-
9144241208
-
Reversing established sepsis with antagonists of endogenous high-mobility group box 1
-
Yang H, et al. Reversing established sepsis with antagonists of endogenous high-mobility group box 1. Proc Natl Acad Sci U S A. 2004;101(1):296-301.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, Issue.1
, pp. 296-301
-
-
Yang, H1
-
4
-
-
74449089862
-
Targeting HMGB1 in inflammation
-
Yang H, Tracey KJ. Targeting HMGB1 in inflammation. Biochim Biophys Acta. 2010;1799(1-2):149-156.
-
(2010)
Biochim Biophys Acta
, vol.1799
, Issue.1-2
, pp. 149-156
-
-
Yang, H1
Tracey, KJ.2
-
5
-
-
79953066407
-
HMGB1 is a therapeutic target for sterile inflammation and infection
-
Andersson U, Tracey KJ. HMGB1 is a therapeutic target for sterile inflammation and infection. Ann Rev Immunol. 2011;29:139-162.
-
(2011)
Ann Rev Immunol
, vol.29
, pp. 139-162
-
-
Andersson, U1
Tracey, KJ.2
-
6
-
-
84908640980
-
High-mobility group box-1 in sterile inflammation
-
Tsung A, Tohme S, Billiar TR. High-mobility group box-1 in sterile inflammation. J Intern Med. 2014;276(5):425-443.
-
(2014)
J Intern Med
, vol.276
, Issue.5
, pp. 425-443
-
-
Tsung, A1
Tohme, S2
Billiar, TR.3
-
7
-
-
0032238463
-
Hypophysectomy, high tumor necrosis factor levels, and hemoglobinemia in lethal endotoxemic shock
-
Bloom O, Wang H, Ivanova S, Vishnubhakat JM, Ombrellino M, Tracey KJ. Hypophysectomy, high tumor necrosis factor levels, and hemoglobinemia in lethal endotoxemic shock. Shock. 1998;10(6):395-400.
-
(1998)
Shock
, vol.10
, Issue.6
, pp. 395-400
-
-
Bloom, O1
Wang, H2
Ivanova, S3
Vishnubhakat, JM4
Ombrellino, M5
Tracey, KJ.6
-
8
-
-
0036596391
-
Globin attenuates the innate immune response to endotoxin
-
Yang H, et al. Globin attenuates the innate immune response to endotoxin. Shock. 2002;17(6):485-490.
-
(2002)
Shock
, vol.17
, Issue.6
, pp. 485-490
-
-
Yang, H1
-
9
-
-
0028131671
-
Hemoglobin, a newly recognized lipopolysaccharide (LPS)-binding protein that enhances LPS biological activity
-
Kaca W, Roth RI, Levin J. Hemoglobin, a newly recognized lipopolysaccharide (LPS)-binding protein that enhances LPS biological activity. J Biol Chem. 1994;269(40):25078-25084.
-
(1994)
J Biol Chem
, vol.269
, Issue.40
, pp. 25078-25084
-
-
Kaca, W1
Roth, RI2
Levin, J.3
-
10
-
-
84945918494
-
High mobility group box protein 1 (HMGB1): The prototypical endogenous danger molecule
-
(Suppl 1)
-
Yang H, Wang H, Chavan SS, Andersson U. High mobility group box protein 1 (HMGB1): The prototypical endogenous danger molecule. Mol Med. 2015;21(Suppl 1):S6-S12.
-
(2015)
Mol Med
, vol.21
, pp. S6-S12
-
-
Yang, H1
Wang, H2
Chavan, SS3
Andersson, U.4
-
11
-
-
84898683559
-
A systematic nomenclature for the redox states of high mobility group box (HMGB) proteins
-
Antoine DJ, Harris HE, Andersson U, Tracey KJ, Bianchi ME. A systematic nomenclature for the redox states of high mobility group box (HMGB) proteins. Mol Med. 2014;20:135-137.
-
(2014)
Mol Med
, vol.20
, pp. 135-137
-
-
Antoine, DJ1
Harris, HE2
Andersson, U3
Tracey, KJ4
Bianchi, ME.5
-
12
-
-
84870781509
-
A Janus tale of two active high mobility group box 1 (HMGB1) redox states
-
Tang D, Billiar TR, Lotze MT. A Janus tale of two active high mobility group box 1 (HMGB1) redox states. Mol Med. 2012;18:1360-1362.
-
(2012)
Mol Med
, vol.18
, pp. 1360-1362
-
-
Tang, D1
Billiar, TR2
Lotze, MT.3
-
13
-
-
84866378556
-
Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release
-
Venereau E, et al. Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release. J Exp Med. 2012;209(9):1519-1528.
-
(2012)
J Exp Med
, vol.209
, Issue.9
, pp. 1519-1528
-
-
Venereau, E1
-
14
-
-
84860862890
-
Redox modification of cysteine residues regulates the cytokine activity of high mobility group box-1 (HMGB1)
-
Yang H, et al. Redox modification of cysteine residues regulates the cytokine activity of high mobility group box-1 (HMGB1). Mol Med. 2012;18:250-259.
-
(2012)
Mol Med
, vol.18
, pp. 250-259
-
-
Yang, H1
-
15
-
-
84878408642
-
The many faces of HMGB1: molecular structure-functional activity in inflammation, apoptosis, and chemotaxis
-
Yang H, Antoine DJ, Andersson U, Tracey KJ. The many faces of HMGB1: molecular structure-functional activity in inflammation, apoptosis, and chemotaxis. J Leukoc Biol. 2013;93(6):865-873.
-
(2013)
J Leukoc Biol
, vol.93
, Issue.6
, pp. 865-873
-
-
Yang, H1
Antoine, DJ2
Andersson, U3
Tracey, KJ.4
-
16
-
-
84966355801
-
Regulation of posttranslational modifications of HMGB1 during immune responses
-
Tang Y, et al. Regulation of posttranslational modifications of HMGB1 during immune responses. Antioxid Redox Signal. 2016;24(12):620-624.
-
(2016)
Antioxid Redox Signal
, vol.24
, Issue.12
, pp. 620-624
-
-
Tang, Y1
-
17
-
-
33745854493
-
Role of HMGB1 in apoptosis-mediated sepsis lethality
-
Qin S, et al. Role of HMGB1 in apoptosis-mediated sepsis lethality. J Exp Med. 2006;203(7):1637-1642.
-
(2006)
J Exp Med
, vol.203
, Issue.7
, pp. 1637-1642
-
-
Qin, S1
-
18
-
-
77958023093
-
A central role for free heme in the pathogenesis of severe sepsis
-
Larsen R, et al. A central role for free heme in the pathogenesis of severe sepsis. Sci Transl Med. 2010;2(51):51ra71.
-
(2010)
Sci Transl Med
, vol.2
, Issue.51
, pp. 51ra71
-
-
Larsen, R1
-
19
-
-
0014830334
-
Enhancement of Escherichia coli infection and endotoxic activity by hemoglobin and ferric ammonium citrate
-
Bornside GH, Bouis PJ Jr, Cohn I Jr. Enhancement of Escherichia coli infection and endotoxic activity by hemoglobin and ferric ammonium citrate. Surgery. 1970;68(2):350-355.
-
(1970)
Surgery
, vol.68
, Issue.2
, pp. 350-355
-
-
Bornside, GH1
Bouis, PJ2
Cohn, I3
-
20
-
-
0014244771
-
Hemoglobin as a bacterial virulence-enhancing factor in fluids produced in strangulation intestinal obstruction
-
Bornside GH, Cohn I Jr. Hemoglobin as a bacterial virulence-enhancing factor in fluids produced in strangulation intestinal obstruction. Am Surg. 1968;34(1):63-67.
-
(1968)
Am Surg
, vol.34
, Issue.1
, pp. 63-67
-
-
Bornside, GH1
Cohn, I2
-
21
-
-
33846102978
-
An improved method for haptoglobin 1-1, 2-1, and 2-2 purification using monoclonal antibody affinity chromatography in the presence of sodium dodecyl sulfate
-
Yueh SC, Lai YA, Chen WL, Hsu HH, Mao SJ. An improved method for haptoglobin 1-1, 2-1, and 2-2 purification using monoclonal antibody affinity chromatography in the presence of sodium dodecyl sulfate. J Chromatogr B Analyt Technol Biomed Life Sci. 2007;845(2):210-217.
-
(2007)
J Chromatogr B Analyt Technol Biomed Life Sci
, vol.845
, Issue.2
, pp. 210-217
-
-
Yueh, SC1
Lai, YA2
Chen, WL3
Hsu, HH4
Mao, SJ.5
-
22
-
-
0032530341
-
Increased susceptibility in Hp knockout mice during acute hemolysis
-
Lim SK, et al. Increased susceptibility in Hp knockout mice during acute hemolysis. Blood. 1998;92(6):1870-1877.
-
(1998)
Blood
, vol.92
, Issue.6
, pp. 1870-1877
-
-
Lim, SK1
-
23
-
-
33750451990
-
Constitutive endocytosis of CD163 mediates hemoglobin-heme uptake and determines the noninflammatory and protective transcriptional response of macrophages to hemoglobin
-
Schaer CA, Schoedon G, Imhof A, Kurrer MO, Schaer DJ. Constitutive endocytosis of CD163 mediates hemoglobin-heme uptake and determines the noninflammatory and protective transcriptional response of macrophages to hemoglobin. Circ Res. 2006;99(9):943-950.
-
(2006)
Circ Res
, vol.99
, Issue.9
, pp. 943-950
-
-
Schaer, CA1
Schoedon, G2
Imhof, A3
Kurrer, MO4
Schaer, DJ.5
-
24
-
-
70350444860
-
The CD163-expressing macrophages recognize and internalize TWEAK: potential consequences in atherosclerosis
-
Moreno JA, et al. The CD163-expressing macrophages recognize and internalize TWEAK: potential consequences in atherosclerosis. Atherosclerosis. 2009;207(1):103-110.
-
(2009)
Atherosclerosis
, vol.207
, Issue.1
, pp. 103-110
-
-
Moreno, JA1
-
25
-
-
0035843134
-
Identification of the haemoglobin scavenger receptor
-
Kristiansen M, et al. Identification of the haemoglobin scavenger receptor. Nature. 2001;409(6817):198-201.
-
(2001)
Nature
, vol.409
, Issue.6817
, pp. 198-201
-
-
Kristiansen, M1
-
26
-
-
13444283452
-
Haptoglobin dampens endotoxin-induced inflammatory effects both in vitro and in vivo
-
Arredouani MS, Kasran A, Vanoirbeek JA, Berger FG, Baumann H, Ceuppens JL. Haptoglobin dampens endotoxin-induced inflammatory effects both in vitro and in vivo. Immunology. 2005;114(2):263-271.
-
(2005)
Immunology
, vol.114
, Issue.2
, pp. 263-271
-
-
Arredouani, MS1
Kasran, A2
Vanoirbeek, JA3
Berger, FG4
Baumann, H5
Ceuppens, JL.6
-
27
-
-
68849086892
-
Sequestration of extracellular hemoglobin within a haptoglobin complex decreases its hypertensive and oxidative effects in dogs and guinea pigs
-
Boretti FS, et al. Sequestration of extracellular hemoglobin within a haptoglobin complex decreases its hypertensive and oxidative effects in dogs and guinea pigs. J Clin Invest. 2009;119(8):2271-80.
-
(2009)
J Clin Invest
, vol.119
, Issue.8
, pp. 2271-2280
-
-
Boretti, FS1
-
28
-
-
84859712543
-
Hemoglobin-driven pathophysiology is an in vivo consequence of the red blood cell storage lesion that can be attenuated in guinea pigs by haptoglobin therapy
-
Baek JH, et al. Hemoglobin-driven pathophysiology is an in vivo consequence of the red blood cell storage lesion that can be attenuated in guinea pigs by haptoglobin therapy. J Clin Invest. 2012;122(4):1444-1458.
-
(2012)
J Clin Invest
, vol.122
, Issue.4
, pp. 1444-1458
-
-
Baek, JH1
-
29
-
-
84924225251
-
Hemoglobin-induced lung vascular oxidation, inflammation, and remodeling contribute to the progression of hypoxic pulmonary hypertension and is attenuated in rats with repeated-dose haptoglobin administration
-
Irwin DC, et al. Hemoglobin-induced lung vascular oxidation, inflammation, and remodeling contribute to the progression of hypoxic pulmonary hypertension and is attenuated in rats with repeated-dose haptoglobin administration. Free Radic Biol Med. 2015;82:50-62.
-
(2015)
Free Radic Biol Med
, vol.82
, pp. 50-62
-
-
Irwin, DC1
-
30
-
-
84921328278
-
MD-2 is required for disulfide HMGB1-dependent TLR4 signaling
-
Yang H, et al. MD-2 is required for disulfide HMGB1-dependent TLR4 signaling. J Exp Med. 2015;212(1):5-14.
-
(2015)
J Exp Med
, vol.212
, Issue.1
, pp. 5-14
-
-
Yang, H1
-
31
-
-
4544246612
-
CD163: a regulated hemoglobin scavenger receptor with a role in the anti-inflammatory response
-
Moestrup SK, Moller HJ. CD163: a regulated hemoglobin scavenger receptor with a role in the anti-inflammatory response. Ann Med. 2004;36(5):347-354.
-
(2004)
Ann Med
, vol.36
, Issue.5
, pp. 347-354
-
-
Moestrup, SK1
Moller, HJ.2
-
32
-
-
84865749056
-
alpha(1)-Acid glycoprotein up-regulates CD163 via TLR4/CD14 protein pathway: possible protection against hemolysis-induced oxidative stress
-
Komori H, et al. alpha(1)-Acid glycoprotein up-regulates CD163 via TLR4/CD14 protein pathway: possible protection against hemolysis-induced oxidative stress. J Biol Chem. 2012;287(36):30688-30700.
-
(2012)
J Biol Chem
, vol.287
, Issue.36
, pp. 30688-30700
-
-
Komori, H1
-
33
-
-
0036826682
-
IL-10 expression profiling in human monocytes
-
Williams L, Jarai G, Smith A, Finan P. IL-10 expression profiling in human monocytes. J Leukoc Biol. 2002;72(4):800-809.
-
(2002)
J Leukoc Biol
, vol.72
, Issue.4
, pp. 800-809
-
-
Williams, L1
Jarai, G2
Smith, A3
Finan, P.4
-
34
-
-
0001930725
-
Regulation of scavenger receptor CD163 expression in human monocytes and macrophages by pro- and antiinflammatory stimuli
-
Buechler C, Ritter M, Orso E, Langmann T, Klucken J, Schmitz G. Regulation of scavenger receptor CD163 expression in human monocytes and macrophages by pro- and antiinflammatory stimuli. J Leukoc Biol. 2000;67(1):97-103.
-
(2000)
J Leukoc Biol
, vol.67
, Issue.1
, pp. 97-103
-
-
Buechler, C1
Ritter, M2
Orso, E3
Langmann, T4
Klucken, J5
Schmitz, G.6
-
35
-
-
33646464894
-
Functional expression of the CD163 scavenger receptor on acute myeloid leukemia cells of monocytic lineage
-
Bachli EB, Schaer DJ, Walter RB, Fehr J, Schoedon G. Functional expression of the CD163 scavenger receptor on acute myeloid leukemia cells of monocytic lineage. J Leukoc Biol. 2006;79(2):312-318.
-
(2006)
J Leukoc Biol
, vol.79
, Issue.2
, pp. 312-318
-
-
Bachli, EB1
Schaer, DJ2
Walter, RB3
Fehr, J4
Schoedon, G.5
-
36
-
-
34250211507
-
A previously unrecognized protein-protein interaction between TWEAK and CD163: potential biological implications
-
Bover LC, et al. A previously unrecognized protein-protein interaction between TWEAK and CD163: potential biological implications. J Immunol. 2007;178(12):8183-8194.
-
(2007)
J Immunol
, vol.178
, Issue.12
, pp. 8183-8194
-
-
Bover, LC1
-
37
-
-
77950627035
-
Scavenger receptor CD163, a Jack-of-all-trades and potential target for cell-directed therapy
-
Van Gorp H, Delputte PL, Nauwynck HJ. Scavenger receptor CD163, a Jack-of-all-trades and potential target for cell-directed therapy. Mol Immunol. 2010;47(7-8):1650-1660.
-
(2010)
Mol Immunol
, vol.47
, Issue.7-8
, pp. 1650-1660
-
-
Van Gorp, H1
Delputte, PL2
Nauwynck, HJ.3
-
38
-
-
20944436774
-
The N-terminal domain of thrombomodulin sequesters high-mobility group-B1 protein, a novel antiinflammatory mechanism
-
Abeyama K, et al. The N-terminal domain of thrombomodulin sequesters high-mobility group-B1 protein, a novel antiinflammatory mechanism. J Clin Invest. 2005;115(5):1267-1274.
-
(2005)
J Clin Invest
, vol.115
, Issue.5
, pp. 1267-1274
-
-
Abeyama, K1
-
39
-
-
84901334017
-
RAGE regulates the metabolic and inflammatory response to high-fat feeding in mice
-
Song F, et al. RAGE regulates the metabolic and inflammatory response to high-fat feeding in mice. Diabetes. 2014;63(6):1948-1965.
-
(2014)
Diabetes
, vol.63
, Issue.6
, pp. 1948-1965
-
-
Song, F1
-
40
-
-
63149171602
-
CD24 and Siglec-10 selectively repress tissue damage-induced immune responses
-
Chen GY, Tang J, Zheng P, Liu Y. CD24 and Siglec-10 selectively repress tissue damage-induced immune responses. Science. 2009;323(5922):1722-1725.
-
(2009)
Science
, vol.323
, Issue.5922
, pp. 1722-1725
-
-
Chen, GY1
Tang, J2
Zheng, P3
Liu, Y.4
-
41
-
-
0033538467
-
HMG-1 as a late mediator of endotoxin lethality in mice
-
Wang H, et al. HMG-1 as a late mediator of endotoxin lethality in mice. Science. 1999;285(5425):248-251.
-
(1999)
Science
, vol.285
, Issue.5425
, pp. 248-251
-
-
Wang, H1
-
42
-
-
3042850403
-
Recombinant HMGB1 with cytokine-stimulating activity
-
Li J, et al. Recombinant HMGB1 with cytokine-stimulating activity. J Immunol Methods. 2004;289(1-2):211-223.
-
(2004)
J Immunol Methods
, vol.289
, Issue.1-2
, pp. 211-223
-
-
Li, J1
-
43
-
-
77955403878
-
A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release
-
Yang H, et al. A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release. Proc Natl Acad Sci U S A. 2010;107(26):11942-11947.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, Issue.26
, pp. 11942-11947
-
-
Yang, H1
-
44
-
-
0014143707
-
Rapid determination of total hemoglobin as hemiglobin cyanide in blood containing carboxyhemoglobin
-
Rice EW. Rapid determination of total hemoglobin as hemiglobin cyanide in blood containing carboxyhemoglobin. Clin Chim Acta. 1967;18(1):89-91.
-
(1967)
Clin Chim Acta
, vol.18
, Issue.1
, pp. 89-91
-
-
Rice, EW.1
-
45
-
-
84906829514
-
TLR4-dependent activation of dendritic cells by an HMGB1-derived peptide adjuvant
-
Saenz R, et al. TLR4-dependent activation of dendritic cells by an HMGB1-derived peptide adjuvant. J Transl Med. 2014;12:211.
-
(2014)
J Transl Med
, vol.12
, pp. 211
-
-
Saenz, R1
-
46
-
-
84942431410
-
Aspirin's active metabolite salicylic acid targets high mobility group box 1 to modulate inflammatory responses
-
Choi HW, et al. Aspirin's active metabolite salicylic acid targets high mobility group box 1 to modulate inflammatory responses. Mol Med. 2015;21:526-535.
-
(2015)
Mol Med
, vol.21
, pp. 526-535
-
-
Choi, HW1
|