Hemoglobin-induced lung vascular oxidation, inflammation, and remodeling contribute to the progression of hypoxic pulmonary hypertension and is attenuated in rats with repeated-dose haptoglobin administration

Free Radical Biology and Medicine

Volumn 82, Issue , 2015, Pages 50-62

  Irwin, David C ^a   Hyen Baek, Jin ^b   Hassell, Kathryn ^c   Nuss, Rachelle ^c   Eigenberger, Paul ^a   Lisk, Christina ^a   Loomis, Zoe ^c   Maltzahn, Joanne ^a   Stenmark, Kurt R ^a   Nozik Grayck, Eva ^a   Buehler, Paul W ^a,b  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

^c UNIVERSITY OF COLORADO   (United States)

Author keywords

Freeradicals; Heme; Hemoglobin; Hemolysis; Iron; Lipid peroxidation; Sickle celldisease; Thalassemia

Indexed keywords

4 HYDROXYNONENAL; ALPHA SMOOTH MUSCLE ACTIN; BLOOD CLOTTING FACTOR 8; CD163 ANTIGEN; HAPTOGLOBIN; HEME; HEME OXYGENASE 1; HEMOGLOBIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; IRON;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL PRESSURE; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; DISEASE COURSE; HEART OUTPUT; HEART RIGHT VENTRICLE HYPERTROPHY; HEMODYNAMICS; HEMOLYSIS; HEMOLYTIC ANEMIA; HYPOBARISM; HYPOXIA; HYPOXIC PULMONARY HYPERTENSION; LIPID PEROXIDATION; LUNG ARTERY PRESSURE; LUNG BLOOD VESSEL; LUNG ENDOTHELIUM; LUNG HEMODYNAMICS; LUNG VASCULAR RESISTANCE; MACROPHAGE; MALE; MONOCYTE; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULMONARY HYPERTENSION; RAT; REPEATED DRUG DOSE; STEADY STATE; VASCULAR REMODELING; VASCULITIS; ANIMAL; BIOSYNTHESIS; CELL LINE; DISEASE MODEL; DRUG EFFECTS; LUNG; LUNG ALVEOLUS MACROPHAGE; LUNG DISEASE; METABOLISM; OXIDATION REDUCTION REACTION; PATHOLOGY; PHYSIOLOGY; PNEUMONIA; SPRAGUE DAWLEY RAT; VASCULAR DISEASE; VASCULAR RESISTANCE; VASCULARIZATION;

RATTUS;

ANIMALS; CELL LINE; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; HAPTOGLOBINS; HEMOGLOBINS; HYPERTENSION, PULMONARY; HYPERTROPHY, RIGHT VENTRICULAR; HYPOXIA; INTERCELLULAR ADHESION MOLECULE-1; IRON; LUNG; LUNG DISEASES; MACROPHAGES, ALVEOLAR; MALE; OXIDATION-REDUCTION; PNEUMONIA; RATS; RATS, SPRAGUE-DAWLEY; VASCULAR DISEASES; VASCULAR REMODELING; VASCULAR RESISTANCE;

EID: 84924225251     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2015.01.012     Document Type: Article

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