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Volumn 38, Issue 8, 2021, Pages 1137-1150

Neuro-inflammatory Sequelae of Minimal Trauma in the Non-traumatized Human Brain: A Microdialysis Study

Author keywords

brain trauma; cytokines; interleukin 6; microdialysis; neuroinflammation

Indexed keywords

AUTACOID; BIOLOGICAL MARKER;

EID: 85103953596     PISSN: 08977151     EISSN: 15579042     Source Type: Journal    
DOI: 10.1089/neu.2011.1790     Document Type: Article
Times cited : (5)

References (64)
  • 1
    • 9244260503 scopus 로고    scopus 로고
    • Attenuation of astroglial reactivity by interleukin-10
    • Balasingam, V., and Yong, V.W. (1996). Attenuation of astroglial reactivity by interleukin-10. J. Neurosci. 16, 2945?2955.
    • (1996) J. Neurosci , vol.16 , pp. 2945-2955
    • Balasingam, V.1    Yong, V.W.2
  • 2
    • 0036677420 scopus 로고    scopus 로고
    • Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12
    • Becher, B., Durell, B.G., and Noelle, R.J. (2002). Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12. J. Clin. Invest. 110, 493?497.
    • (2002) J. Clin. Invest , vol.110 , pp. 493-497
    • Becher, B.1    Durell, B.G.2    Noelle, R.J.3
  • 4
    • 15044366338 scopus 로고    scopus 로고
    • Interleukin 1beta and interleukin 6 relationship with paediatric head trauma severity and outcome
    • discussion 94
    • Chiaretti, A., Genovese, O., Aloe, L., Antonelli, A., Piastra, M., Polidori, G., and Di Rocco, C. (2005). Interleukin 1beta and interleukin 6 relationship with paediatric head trauma severity and outcome. Childs Nerv. Syst. 21, 185?193; discussion 94.
    • (2005) Childs Nerv. Syst , vol.21 , pp. 185-193
    • Chiaretti, A.1    Genovese, O.2    Aloe, L.3    Antonelli, A.4    Piastra, M.5    Polidori, G.6    Di Rocco, C.7
  • 5
    • 0036074165 scopus 로고    scopus 로고
    • Effects of blood flow on the in vivo recovery of a small diffusible molecule by microdialysis in human skin
    • Clough, G.F., Boutsiouki, P., Church, M.K., and Michel, C.C. (2002). Effects of blood flow on the in vivo recovery of a small diffusible molecule by microdialysis in human skin. J. Pharmacol. Exp. Ther. 302, 681?686.
    • (2002) J. Pharmacol. Exp. Ther , vol.302 , pp. 681-686
    • Clough, G.F.1    Boutsiouki, P.2    Church, M.K.3    Michel, C.C.4
  • 9
    • 0028322158 scopus 로고
    • Direct measurement of extracellular lactate in the human hippocampus during spontaneous seizures
    • During, M.J., Fried, I., Leone, P., Katz, A., and Spencer, D.D. (1994). Direct measurement of extracellular lactate in the human hippocampus during spontaneous seizures. J. Neurochem. 62, 2356?2361.
    • (1994) J. Neurochem , vol.62 , pp. 2356-2361
    • During, M.J.1    Fried, I.2    Leone, P.3    Katz, A.4    Spencer, D.D.5
  • 10
    • 0027262604 scopus 로고
    • Extracellular hippocampal glutamate and spontaneous seizure in the conscious human brain
    • During, M.J., and Spencer, D.D. (1993). Extracellular hippocampal glutamate and spontaneous seizure in the conscious human brain. Lancet 341, 1607?1610.
    • (1993) Lancet , vol.341 , pp. 1607-1610
    • During, M.J.1    Spencer, D.D.2
  • 11
    • 33644963942 scopus 로고    scopus 로고
    • Multiplex bead array assays: performance evaluation and comparison of sensitivity to ELISA
    • Elshal, M.F., and McCoy, J.P. (2006). Multiplex bead array assays: performance evaluation and comparison of sensitivity to ELISA. Methods 38, 317?323.
    • (2006) Methods , vol.38 , pp. 317-323
    • Elshal, M.F.1    McCoy, J.P.2
  • 12
    • 0001890895 scopus 로고
    • The next step
    • J.J. Engel JJ (ed). Raven Press: New York, pps
    • Engel, J.J., and Ojemann, G.A. (1993) The next step, in: Surgical Treatment of the Epilepsies. J.J. Engel JJ (ed.). Raven Press: New York, pps. 319?329.
    • (1993) Surgical Treatment of the Epilepsies , pp. 319-329
    • Engel, J.J.1    Ojemann, G.A.2
  • 13
    • 0032805573 scopus 로고    scopus 로고
    • Immunohistochemical localization of interleukin-1beta, interleukin-1 receptor antagonist and interleukin-1beta converting enzyme/caspase-1 in the rat brain after peripheral administration of kainic acid
    • Eriksson, C., Van Dam, A.M., Lucassen, P.J., Bol, J.G., Winblad, B., and Schultzberg, M. (1999). Immunohistochemical localization of interleukin-1beta, interleukin-1 receptor antagonist and interleukin-1beta converting enzyme/caspase-1 in the rat brain after peripheral administration of kainic acid. Neuroscience 93, 915?930.
    • (1999) Neuroscience , vol.93 , pp. 915-930
    • Eriksson, C.1    Van Dam, A.M.2    Lucassen, P.J.3    Bol, J.G.4    Winblad, B.5    Schultzberg, M.6
  • 15
    • 0021912473 scopus 로고
    • Interleukin-1 stimulation of astroglial proliferation after brain injury
    • Giulian, D., and Lachman, L.B. (1985). Interleukin-1 stimulation of astroglial proliferation after brain injury. Science 228, 497?499.
    • (1985) Science , vol.228 , pp. 497-499
    • Giulian, D.1    Lachman, L.B.2
  • 18
    • 85027936374 scopus 로고    scopus 로고
    • The cytokine response to human traumatic brain injury: Temporal profiles and evidence for cerebral parenchymal production
    • Helmy, A., Carpenter, K.L., Menon, D.K., Pickard, J.D., and Hutchinson, P.J. (2010). The cytokine response to human traumatic brain injury: Temporal profiles and evidence for cerebral parenchymal production. J. Cereb. Blood Flow Metab. 31, 658?670.
    • (2010) J. Cereb. Blood Flow Metab , vol.31 , pp. 658-670
    • Helmy, A.1    Carpenter, K.L.2    Menon, D.K.3    Pickard, J.D.4    Hutchinson, P.J.5
  • 19
    • 20044385570 scopus 로고    scopus 로고
    • A microdialysis technique for routine measurement of macromolecules in the injured human brain
    • discussion 68?70
    • Hillman, J., Aneman, O., Anderson, C., Sjogren, F., Saberg, C., and Mellergard, P. (2005). A microdialysis technique for routine measurement of macromolecules in the injured human brain. Neurosurgery 56, 1264?1268; discussion 68?70.
    • (2005) Neurosurgery , vol.56 , pp. 1264-1268
    • Hillman, J.1    Aneman, O.2    Anderson, C.3    Sjogren, F.4    Saberg, C.5    Mellergard, P.6
  • 20
    • 34247857556 scopus 로고    scopus 로고
    • Variations in the response of interleukins in neurosurgical intensive care patients monitored using intracerebral microdialysis
    • Hillman, J., Aneman, O., Persson, M., Andersson, C., Dabrosin, C., and Mellergard, P. (2007). Variations in the response of interleukins in neurosurgical intensive care patients monitored using intracerebral microdialysis. J. Neurosurg. 106, 820?825.
    • (2007) J. Neurosurg , vol.106 , pp. 820-825
    • Hillman, J.1    Aneman, O.2    Persson, M.3    Andersson, C.4    Dabrosin, C.5    Mellergard, P.6
  • 21
    • 33644787352 scopus 로고    scopus 로고
    • Intracerebral microdialysis in neurosurgical intensive care patients utilising catheters with different molecular cut-off (20 and 100 kD)
    • discussion 24
    • Hillman, J., Milos, P., Yu, Z.Q., Sjogren, F., Anderson, C., and Mellergard, P. (2006). Intracerebral microdialysis in neurosurgical intensive care patients utilising catheters with different molecular cut-off (20 and 100 kD). Acta Neurochir. (Wien.) 148, 319?324; discussion 24.
    • (2006) Acta Neurochir. (Wien.) , vol.148 , pp. 319-324
    • Hillman, J.1    Milos, P.2    Yu, Z.Q.3    Sjogren, F.4    Anderson, C.5    Mellergard, P.6
  • 26
    • 0036664602 scopus 로고    scopus 로고
    • Interleukin-1beta messenger ribonucleic acid and protein levels after fluidpercussion brain injury in rats: importance of injury severity and brain temperature
    • discussion 03
    • Kinoshita, K., Chatzipanteli, K., Vitarbo, E., Truettner, J.S., Alonso, O.F., and Dietrich, W.D. (2002). Interleukin-1beta messenger ribonucleic acid and protein levels after fluidpercussion brain injury in rats: importance of injury severity and brain temperature. Neurosurgery 51, 195?203; discussion 03.
    • (2002) Neurosurgery , vol.51 , pp. 195-203
    • Kinoshita, K.1    Chatzipanteli, K.2    Vitarbo, E.3    Truettner, J.S.4    Alonso, O.F.5    Dietrich, W.D.6
  • 27
    • 0033934610 scopus 로고    scopus 로고
    • The role of tumor necrosis factor-Alpha in diffuse axonal injury following fluid-percussive brain injury in rats
    • Kita, T., Tanaka, T., Tanaka, N., and Kinoshita, Y. (2000). The role of tumor necrosis factor-Alpha in diffuse axonal injury following fluid-percussive brain injury in rats. Int. J. Legal Med. 113, 221?228.
    • (2000) Int. J. Legal Med , vol.113 , pp. 221-228
    • Kita, T.1    Tanaka, T.2    Tanaka, N.3    Kinoshita, Y.4
  • 28
    • 0034726016 scopus 로고    scopus 로고
    • Cortical interleukin-1 beta elevation after traumatic brain injury in the rat: no effect of two selective antagonists on motor recovery
    • Knoblach, S.M., and Faden, A.I. (2000). Cortical interleukin-1 beta elevation after traumatic brain injury in the rat: no effect of two selective antagonists on motor recovery. Neurosci. Lett. 289, 5?8.
    • (2000) Neurosci. Lett , vol.289 , pp. 5-8
    • Knoblach, S.M.1    Faden, A.I.2
  • 29
    • 0031713714 scopus 로고    scopus 로고
    • Interleukin-10 improves outcome and alters proinflammatory cytokine expression after experimental traumatic brain injury
    • Knoblach, S.M., and Faden, A.I. (1998). Interleukin-10 improves outcome and alters proinflammatory cytokine expression after experimental traumatic brain injury. Exp. Neurol. 153, 143?151.
    • (1998) Exp. Neurol , vol.153 , pp. 143-151
    • Knoblach, S.M.1    Faden, A.I.2
  • 30
    • 0033103686 scopus 로고    scopus 로고
    • Early neuronal expression of tumor necrosis factor-Alpha after experimental brain injury contributes to neurological impairment
    • Knoblach, S.M., Fan, L., and Faden, A.I. (1999). Early neuronal expression of tumor necrosis factor-Alpha after experimental brain injury contributes to neurological impairment. J. Neuroimmunol. 95, 115?125.
    • (1999) J. Neuroimmunol , vol.95 , pp. 115-125
    • Knoblach, S.M.1    Fan, L.2    Faden, A.I.3
  • 31
    • 0029398824 scopus 로고
    • Intrathecal and serum interleukin-6 and the acute-phase response in patients with severe traumatic brain injuries
    • Kossmann, T., Hans, V.H., Imhof, H.G., Stocker, R., Grob, P., Trentz, O., and Morganti-Kossmann, C. (1995). Intrathecal and serum interleukin-6 and the acute-phase response in patients with severe traumatic brain injuries. Shock 4, 311?317.
    • (1995) Shock , vol.4 , pp. 311-317
    • Kossmann, T.1    Hans, V.H.2    Imhof, H.G.3    Stocker, R.4    Grob, P.5    Trentz, O.6    Morganti-Kossmann, C.7
  • 32
    • 0029865078 scopus 로고    scopus 로고
    • Interleukin-6 released in human cerebrospinal fluid following traumatic brain injury may trigger nerve growth factor production in astrocytes
    • Kossmann, T., Hans, V., Imhof, H.G., Trentz, O., and Morganti- Kossmann, M.C. (1996). Interleukin-6 released in human cerebrospinal fluid following traumatic brain injury may trigger nerve growth factor production in astrocytes. Brain Res. 713, 143?152.
    • (1996) Brain Res , vol.713 , pp. 143-152
    • Kossmann, T.1    Hans, V.2    Imhof, H.G.3    Trentz, O.4    Morganti- Kossmann, M.C.5
  • 33
    • 0030939399 scopus 로고    scopus 로고
    • Interleukin-8 released into the cerebrospinal fluid after brain injury is associated with blood-brain barrier dysfunction and nerve growth factor production
    • Kossmann, T., Stahel, P.F., Lenzlinger, P.M., Redl, H., Dubs, R.W., Trentz, O., Schlag, G., and Morganti-Kossmann, M.C. (1997). Interleukin-8 released into the cerebrospinal fluid after brain injury is associated with blood-brain barrier dysfunction and nerve growth factor production. J. Cereb. Blood Flow Metab. 17, 280?289.
    • (1997) J. Cereb. Blood Flow Metab , vol.17 , pp. 280-289
    • Kossmann, T.1    Stahel, P.F.2    Lenzlinger, P.M.3    Redl, H.4    Dubs, R.W.5    Trentz, O.6    Schlag, G.7    Morganti-Kossmann, M.C.8
  • 34
    • 1442303813 scopus 로고    scopus 로고
    • IL-8 is a key mediator of neuroinflammation in severe traumatic brain injuries
    • Kushi, H., Saito, T., Makino, K., and Hayashi, N. (2003). IL-8 is a key mediator of neuroinflammation in severe traumatic brain injuries. Acta Neurochir. Suppl. 86, 347?350.
    • (2003) Acta Neurochir. Suppl , vol.86 , pp. 347-350
    • Kushi, H.1    Saito, T.2    Makino, K.3    Hayashi, N.4
  • 35
    • 0037456126 scopus 로고    scopus 로고
    • Expression of cytokines and cytokine receptors in the rat brain after kainic acid-induced seizures
    • Lehtimaki, K.A., Peltola, J., Koskikallio, E., Keranen, T., and Honkaniemi, J. (2003). Expression of cytokines and cytokine receptors in the rat brain after kainic acid-induced seizures. Brain Res. Mol. Brain Res. 110, 253?260.
    • (2003) Brain Res. Mol. Brain Res , vol.110 , pp. 253-260
    • Lehtimaki, K.A.1    Peltola, J.2    Koskikallio, E.3    Keranen, T.4    Honkaniemi, J.5
  • 36
    • 0035377436 scopus 로고    scopus 로고
    • Differential release of interleukins 6, 8, and 10 in cerebrospinal fluid and plasma after traumatic brain injury
    • Maier, B., Schwerdtfeger, K., Mautes, A., Holanda, M., Muller, M., Steudel, W.I., and Marzi, I. (2001). Differential release of interleukins 6, 8, and 10 in cerebrospinal fluid and plasma after traumatic brain injury. Shock 15, 421?426.
    • (2001) Shock , vol.15 , pp. 421-426
    • Maier, B.1    Schwerdtfeger, K.2    Mautes, A.3    Holanda, M.4    Muller, M.5    Steudel, W.I.6    Marzi, I.7
  • 37
    • 0025946766 scopus 로고
    • Increased plasma and ventricular fluid interleukin-6 levels in patients with head injury
    • McClain, C., Cohen, D., Phillips, R., Ott, L., and Young, B. (1991). Increased plasma and ventricular fluid interleukin-6 levels in patients with head injury. J. Lab. Clin. Med. 118, 225?231.
    • (1991) J. Lab. Clin. Med , vol.118 , pp. 225-231
    • McClain, C.1    Cohen, D.2    Phillips, R.3    Ott, L.4    Young, B.5
  • 38
    • 41749102224 scopus 로고    scopus 로고
    • Changes in extracellular concentrations of some cytokines, chemokines, and neurotrophic factors after insertion of intracerebral microdialysis catheters in neurosurgical patients
    • discussion 57?58
    • Mellergard, P., Aneman, O., Sjogren, F., Pettersson, P., and Hillman, J. (2008). Changes in extracellular concentrations of some cytokines, chemokines, and neurotrophic factors after insertion of intracerebral microdialysis catheters in neurosurgical patients. Neurosurgery 62, 151?157; discussion 57?58.
    • (2008) Neurosurgery , vol.62 , pp. 151-157
    • Mellergard, P.1    Aneman, O.2    Sjogren, F.3    Pettersson, P.4    Hillman, J.5
  • 40
    • 0023257978 scopus 로고
    • Interleukin-1- like activity in rat brain: sources, targets, and effect of injury
    • Nieto-Sampedro, M., and Berman, M.A. (1987). Interleukin-1- like activity in rat brain: sources, targets, and effect of injury. J. Neurosci. Res. 17, 214?219.
    • (1987) J. Neurosci. Res , vol.17 , pp. 214-219
    • Nieto-Sampedro, M.1    Berman, M.A.2
  • 41
    • 0034308079 scopus 로고    scopus 로고
    • Interleukin-6 and interleukin-1 receptor antagonist in cerebrospinal fluid from patients with recent tonic-clonic seizures
    • Peltola, J., Palmio, J., Korhonen, L., Suhonen, J., Miettinen, A., Hurme, M., Lindholm, D., and Keranen, T. (2000). Interleukin-6 and interleukin-1 receptor antagonist in cerebrospinal fluid from patients with recent tonic-clonic seizures. Epilepsy Res. 41, 205? 211.
    • (2000) Epilepsy Res , vol.41 , pp. 205-211
    • Peltola, J.1    Palmio, J.2    Korhonen, L.3    Suhonen, J.4    Miettinen, A.5    Hurme, M.6    Lindholm, D.7    Keranen, T.8
  • 42
    • 0033557201 scopus 로고    scopus 로고
    • Strongly compromised inflammatory response to brain injury in interleukin-6- deficient mice
    • Penkowa, M., Moos, T., Carrasco, J., Hadberg, H., Molinero, A., Bluethmann, H., and Hidalgo, J. (1999). Strongly compromised inflammatory response to brain injury in interleukin-6- deficient mice. Glia 25, 343?357.
    • (1999) Glia , vol.25 , pp. 343-357
    • Penkowa, M.1    Moos, T.2    Carrasco, J.3    Hadberg, H.4    Molinero, A.5    Bluethmann, H.6    Hidalgo, J.7
  • 43
    • 0034521193 scopus 로고    scopus 로고
    • Intracerebral microdialysis in clinical practice: baseline values for chemical markers during wakefulness, anesthesia, and neurosurgery
    • discussion 709?710
    • Reinstrup, P., Stahl, N., Mellergard, P., Uski, T., Ungerstedt, U., and Nordstrom, C.H. (2000). Intracerebral microdialysis in clinical practice: baseline values for chemical markers during wakefulness, anesthesia, and neurosurgery. Neurosurgery 47, 701?709; discussion 709?710.
    • (2000) Neurosurgery , vol.47 , pp. 701-709
    • Reinstrup, P.1    Stahl, N.2    Mellergard, P.3    Uski, T.4    Ungerstedt, U.5    Nordstrom, C.H.6
  • 44
    • 0037410074 scopus 로고    scopus 로고
    • Interleukin-1 and neuronal injury: mechanisms, modification, and therapeutic potential
    • Rothwell, N. (2003). Interleukin-1 and neuronal injury: mechanisms, modification, and therapeutic potential. Brain Behav. Immun. 17, 152?157.
    • (2003) Brain Behav. Immun , vol.17 , pp. 152-157
    • Rothwell, N.1
  • 47
    • 0031047431 scopus 로고    scopus 로고
    • Cytokine production in the brain following closed head injury: dexanabinol (HU-211) is a novel TNF-Alpha inhibitor and an effective neuroprotectant
    • Shohami, E., Gallily, R., Mechoulam, R., Bass, R., and Ben-Hur, T. (1997). Cytokine production in the brain following closed head injury: dexanabinol (HU-211) is a novel TNF-Alpha inhibitor and an effective neuroprotectant. J. Neuroimmunol. 72, 169?177.
    • (1997) J. Neuroimmunol , vol.72 , pp. 169-177
    • Shohami, E.1    Gallily, R.2    Mechoulam, R.3    Bass, R.4    Ben-Hur, T.5
  • 48
    • 0036674005 scopus 로고    scopus 로고
    • Association between cerebrospinal fluid interleukin-6 concentrations and outcome after severe human traumatic brain injury
    • Singhal, A., Baker, A.J., Hare, G.M., Reinders, F.X., Schlichter, L.C., and Moulton, R.J. (2002). Association between cerebrospinal fluid interleukin-6 concentrations and outcome after severe human traumatic brain injury. J. Neurotrauma 19, 929?937.
    • (2002) J. Neurotrauma , vol.19 , pp. 929-937
    • Singhal, A.1    Baker, A.J.2    Hare, G.M.3    Reinders, F.X.4    Schlichter, L.C.5    Moulton, R.J.6
  • 49
    • 0032547136 scopus 로고    scopus 로고
    • Increased interleukin-12 levels in human cerebrospinal fluid following severe head trauma
    • Stahel, P.F., Kossmann, T., Joller, H., Trentz, O., and Morganti- Kossmann, M.C. (1998). Increased interleukin-12 levels in human cerebrospinal fluid following severe head trauma. Neurosci. Lett. 249, 123?126.
    • (1998) Neurosci. Lett , vol.249 , pp. 123-126
    • Stahel, P.F.1    Kossmann, T.2    Joller, H.3    Trentz, O.4    Morganti- Kossmann, M.C.5
  • 50
    • 77449122473 scopus 로고    scopus 로고
    • How minimally invasive is microdialysis sampling? A cautionary note for cytokine collection in human skin and other clinical studies
    • A., and
    • Stenken, J.A., Church, M.K., Gill, C,A., and Clough, G.F. (2010). How minimally invasive is microdialysis sampling? A cautionary note for cytokine collection in human skin and other clinical studies. AAPS J. 12, 73?78.
    • (2010) AAPS J , vol.12 , pp. 73-78
    • Stenken, J.A.1    Church, M.K.2    Gill, C3    Clough, G.F.4
  • 51
    • 0343953483 scopus 로고    scopus 로고
    • Temporal profile of cerebrospinal fluid glutamate, interleukin-6, and tumor necrosis factor-Alpha in relation to brain edema and contusion following controlled cortical impact injury in rats
    • Stover, J.F., Schoning, B., Beyer, T.F., Woiciechowsky, C., and Unterberg, A.W. (2000). Temporal profile of cerebrospinal fluid glutamate, interleukin-6, and tumor necrosis factor-Alpha in relation to brain edema and contusion following controlled cortical impact injury in rats. Neurosci. Lett. 288, 25?28.
    • (2000) Neurosci. Lett , vol.288 , pp. 25-28
    • Stover, J.F.1    Schoning, B.2    Beyer, T.F.3    Woiciechowsky, C.4    Unterberg, A.W.5
  • 52
    • 0033178340 scopus 로고    scopus 로고
    • Exacerbation of damage and altered NF-kappaB activation in mice lacking tumor necrosis factor receptors after traumatic brain injury
    • Sullivan, P.G., Bruce-Keller, A.J., Rabchevsky, A.G., Christakos, S., Clair, D.K., Mattson, M.P., and Scheff, S.W. (1999). Exacerbation of damage and altered NF-kappaB activation in mice lacking tumor necrosis factor receptors after traumatic brain injury. J. Neurosci. 19, 6248?6256.
    • (1999) J. Neurosci , vol.19 , pp. 6248-6256
    • Sullivan, P.G.1    Bruce-Keller, A.J.2    Rabchevsky, A.G.3    Christakos, S.4    Clair, D.K.5    Mattson, M.P.6    Scheff, S.W.7
  • 54
    • 0027400847 scopus 로고
    • Increase in IL-6, IL-1 and TNF levels in rat brain following traumatic lesion. Influence of pre-and posttraumatic treatment with Ro5 4864, a peripheral-Type (p site) benzodiazepine ligand
    • Taupin, V., Toulmond, S., Serrano, A., Benavides, J., and Zavala, F. (1993). Increase in IL-6, IL-1 and TNF levels in rat brain following traumatic lesion. Influence of pre-and posttraumatic treatment with Ro5 4864, a peripheral-Type (p site) benzodiazepine ligand. J. Neuroimmunol. 42, 177?185.
    • (1993) J. Neuroimmunol , vol.42 , pp. 177-185
    • Taupin, V.1    Toulmond, S.2    Serrano, A.3    Benavides, J.4    Zavala, F.5
  • 55
    • 0036675515 scopus 로고    scopus 로고
    • Improved recovery and delayed cytokine induction after closed head injury in mice with central overexpression of the secreted isoform of the interleukin-1 receptor antagonist
    • Tehranian, R., Andell-Jonsson, S., Beni, S.M., Yatsiv, I., Shohami, E., Bartfai, T., Lundkvist, J., and Iverfeldt, K. (2002). Improved recovery and delayed cytokine induction after closed head injury in mice with central overexpression of the secreted isoform of the interleukin-1 receptor antagonist. J. Neurotrauma 19, 939?951.
    • (2002) J. Neurotrauma , vol.19 , pp. 939-951
    • Tehranian, R.1    Andell-Jonsson, S.2    Beni, S.M.3    Yatsiv, I.4    Shohami, E.5    Bartfai, T.6    Lundkvist, J.7    Iverfeldt, K.8
  • 56
    • 0028982742 scopus 로고
    • Interleukin-1 receptor antagonist inhibits neuronal damage caused by fluid percussion injury in the rat
    • Toulmond, S., and Rothwell, N.J. (1995). Interleukin-1 receptor antagonist inhibits neuronal damage caused by fluid percussion injury in the rat. Brain Res. 671, 261?266.
    • (1995) Brain Res , vol.671 , pp. 261-266
    • Toulmond, S.1    Rothwell, N.J.2
  • 59
    • 0030540952 scopus 로고    scopus 로고
    • Comparison of seizure related amino acid release in human epileptic hippocampus versus a chronic, kainate rat model of hippocampal epilepsy
    • Wilson, C.L., Maidment, N.T., Shomer, M.H., Behnke, E.J., Ackerson, L., Fried, I., and Engel, J, Jr. (1996). Comparison of seizure related amino acid release in human epileptic hippocampus versus a chronic, kainate rat model of hippocampal epilepsy. Epilepsy Res. 26, 245?254.
    • (1996) Epilepsy Res , vol.26 , pp. 245-254
    • Wilson, C.L.1    Maidment, N.T.2    Shomer, M.H.3    Behnke, E.J.4    Ackerson, L.5    Fried, I.6    Engel, J7
  • 60
    • 0742288542 scopus 로고    scopus 로고
    • Raised parenchymal interleukin-6 levels correlate with improved outcome after traumatic brain injury
    • Winter, C.D., Pringle, A.K., Clough, G.F., and Church,M.K. (2004). Raised parenchymal interleukin-6 levels correlate with improved outcome after traumatic brain injury. Brain 127, 315?320.
    • (2004) Brain , vol.127 , pp. 315-320
    • Winter, C.D.1    Pringle, A.K.2    Clough, G.F.3    Church, M.K.4
  • 61
    • 0025820808 scopus 로고
    • Detection of interleukin-1 and interleukin-6 in adult rat brain, following mechanical injury, by in vivo microdialysis: evidence of a role for microglia in cytokine production
    • Woodroofe, M.N., Sarna, G.S., Wadhwa, M., Hayes, G.M., Loughlin, A.J., Tinker, A., and Cuzner, M.L. (1991). Detection of interleukin-1 and interleukin-6 in adult rat brain, following mechanical injury, by in vivo microdialysis: evidence of a role for microglia in cytokine production. J. Neuroimmunol. 33, 227?236.
    • (1991) J. Neuroimmunol , vol.33 , pp. 227-236
    • Woodroofe, M.N.1    Sarna, G.S.2    Wadhwa, M.3    Hayes, G.M.4    Loughlin, A.J.5    Tinker, A.6    Cuzner, M.L.7
  • 62
    • 0026474397 scopus 로고
    • Expression of interleukin (IL)-1 beta, IL-6 and their respective receptors in the normal rat brain and after injury
    • Yan, H.Q., Banos, M.A., Herregodts, P., Hooghe, R., and Hooghe-Peters, E.L. (1992). Expression of interleukin (IL)-1 beta, IL-6 and their respective receptors in the normal rat brain and after injury. Eur. J. Immunol. 22, 2963?2971.
    • (1992) Eur. J. Immunol , vol.22 , pp. 2963-2971
    • Yan, H.Q.1    Banos, M.A.2    Herregodts, P.3    Hooghe, R.4    Hooghe-Peters, E.L.5
  • 64
    • 0034144269 scopus 로고    scopus 로고
    • Chemokines: A new classification system and their role in immunity
    • Zlotnik, A., and Yoshie, O. (2000). Chemokines: A new classification system and their role in immunity. Immunity 12, 121?127.
    • (2000) Immunity , vol.12 , pp. 121-127
    • Zlotnik, A.1    Yoshie, O.2


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