Initial Characterization of the SAFIR Prototype PET-MR Scanner

IEEE Transactions on Radiation and Plasma Medical Sciences

Volumn 4, Issue 5, 2020, Pages 613-621

  Ritzer, Christian ^a   Becker, Robert ^a   Buck, Alfred ^b   Commichau, Volker ^a   Debus, Jan ^c   Djambazov, Lubomir ^a   Eleftheriou, Afroditi ^b   Fischer, Jannis ^a   Fischer, Peter ^c   Ito, Mikiko ^a   Khateri, Parisa ^a   Lustermann, Werner ^a   Ritzert, Michael ^c   Röser, Ulf ^a   Rudin, Markus ^a   Sacco, Ilaria ^c   Tsoumpas, Charalampos ^d   Warnock, Geoffrey ^b   Wyss, Matthias ^b   Zagozdzinska Bochenek, Agnieszka ^a   Weber, Bruno ^b   Dissertori, Gunther ^a   more..

^a ETH ZURICH   (Switzerland)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c UNIVERSITY OF HEIDELBERG   (Germany)

^d UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

High rate PET; instrumentation; molecular imaging; multimodality imaging; positron emission tomography (PET) magnetic resonance (MR); preclinical PET insert; SAFIR; TOF PET

Indexed keywords

LUTETIUM COMPOUNDS; MAGNETIC RESONANCE; MOLECULAR IMAGING; POSITRONS; SCANNING; SIGNAL TO NOISE RATIO; YTTRIUM COMPOUNDS;

FULL WIDTHS AT HALF MAXIMUMS; HIGH RATE; HIGH RATE POSITRON EMISSION TOMOGRAPHY; INSTRUMENTATION; MAGNETIC RESONANCE SCANNERS; MULTI-MODALITY IMAGING; POSITRON EMISSION TOMOGRAPHY /MAGNETIC RESONANCE; PRECLINICAL POSITRON EMISSION TOMOGRAPHY INSERT; SAFIR; TOF-POSITRON EMISSION TOMOGRAPHY;

POSITRON EMISSION TOMOGRAPHY;

EID: 85097947583     PISSN: None     EISSN: 24697311     Source Type: Journal    
DOI: 10.1109/TRPMS.2020.2980072     Document Type: Article

References (36)

1. R. Becker et al., "Studies of the high rate coincidence timing response of the STiC and TOFPET ASICs for the SAFIR PET scanner, " J. Instrum., vol. 11, no. 12, 2016, Art. no. 12001.
2. R. Becker et al., "The SAFIR experiment: Concept, status and perspectives, " Nucl. Instrum. Methods Phys. Res. A, Accelerators Spectrometers Detectors Assoc. Equip., vol. 845, pp. 648-651, Feb. 2017.
3. M. Ahnen et al., "Performance measurements of the SAFIR prototype detector with the STiC ASIC readout, " IEEE Trans. Radiat. Plasma Med. Sci., vol. 2, no. 3, pp. 250-258, May 2018.
4. C. Tsoumpas, D. Visvikis, and G. Loudos, "Innovations in small-animal PET/MR imaging instrumentation, " PET Clin., vol. 11, pp. 1051-18, Apr. 2016.
5. R. Becker et al., "Monte-Carlo simulation based estimation of NECR, sensitivity, and spatial resolution of a novel preclinical PET insert for MR, " in Proc. IEEE Nucl. Sci. Symp. Med. Imag. Conf. (NSS/MIC), San Diego, CA, USA, Oct. 2015, pp. 1-3.
6. X. Zhang et al., "Subsecond total-body imaging using ultrasensitive positron emission tomography, " Proc. Nat. Acad. Sci., vol. 117, no. 5, pp. 2265-2267, 2020.
7. R. Dohle et al., "LTCC based highly integrated SiPM module with integrated liquid cooling channels for high resolution molecular imaging, " J. Microelectron. Electron. Packaging, vol. 15, no. 2, pp. 86-94, 2018.
8. I. Sacco, R. Dohle, P. Fischer, C. Piemmonte, and M. Rizert, "A compact, high-density gamma-detection module for time-of-flight measurements in PET applications, " Nucl. Instrum. Methods Phys. Res. A, Accelerators Spectrometers Detectors Assoc. Equip., vol. 824, pp. 233-236, Jul. 2016.
9. J. Fischer, "Development of pre-clinical and clinical positron emission tomography detectors, " Ph.D. dissertation, Dept. Phys., Inst. Particle Phys., ETH Zürich, Zürich, Switzerland, 2017.
10. Quad I2C Voltage, Current and Temperature Monitor, Ltc2990, Analog Devices, Norwood, MA, USA, Nov. 2018.
11. C. Ritzer et al., "Compact MR-compatible DC-DC converter module, " J. Instrum., vol. 14, pp. P09016-P09016, Sep. 2019.
12. J. Du, J. P. Schmall, M. S. Judenhofer, K. Di, Y. Yong, and S. R. Cherry, "A time-walk correction method for PET detectors based on leading edge discriminators, " IEEE Trans. Radiat. Plasma Med. Sci., vol. 1, no. 5, pp. 385-390, Sep. 2017.
13. H. M. Hudson and R. S. Larkin, "Accelerated image reconstruction using ordered subsets of projection data, " IEEE Trans. Med. Imag., vol. 13, no. 4, pp. 601-609, Dec. 1994.
14. M. Jacobson et al., "Enhanced 3D PET OSEM reconstruction using inter-update metz filtering, " Phys. Med. Biol., vol. 45, no. 8, pp. 2417-2439, Jul. 2000.
15. E. V. VDI, VDI-Wärmeatlas, 11th ed. Heidelberg, Germany: Springer, 2013.
16. C. Chang, B. J. Lee, A. M. Grant, A. N. Groll, and C. S. Levin, "Performance study of a radio-frequency field-penetrable PET insert for simultaneous PET/MRI, " IEEE Trans. Radiat. Plasma Med. Sci., vol. 2, no. 5, pp. 422-431, Sep. 2018.
17. N. Omidvari et al., "PET performance evaluation of MADPET4: A small animal PET insert for a 7 T MRI scanner, " Phys. Med. Biol., vol. 62, no. 22, pp. 8671-8692, Nov. 2017.
18. G. Stortz et al., "Performance of a PET insert for high-resolution smallanimal PET/MRI at 7 Tesla, " J. Nucl. Med., vol. 59, no. 3, pp. 536-542, 2018.
19. G. B. Ko et al., "Evaluation of a silicon photomultiplier PET insert for simultaneous PET and MR imaging, " Med. Phys., vol. 43, no. 1, pp. 72-83, 2016.
20. M. Bergeron et al., "Performance evaluation of the LabPETTM APDbased digital PET scanner, " in Proc. IEEE Nucl. Sci. Symp. Conf. Rec., vol. 6. Honolulu, HI, USA, Oct. 2007, pp. 4185-4191.
21. Y. Wang, J. Seidel, B. M. Tsui, J. J. Vaquero, and M. G. Pomper, "Performance evaluation of the GE healthcare eXplore VISTA dualring small-animal PET scanner, " J. Nucl. Med., vol. 47, no. 11, pp. 1891-1900, 2006.
22. W.-H. Wong et al., "Engineering and performance (NEMA and animal) of a lower-cost higher-resolution animal PET/CT scanner using photomultiplier-quadrant-sharing detectors, " J. Nucl. Med., vol. 53, no. 11, pp. 1786-1793, 2012.
23. D. Schug et al., "Initial PET performance evaluation of a preclinical insert for PET/MRI with digital SiPM technology, " Phys. Med. Biol., vol. 61, no. 7, pp. 2851-2878, Apr. 2016.
24. J. E. Mackewn et al., "PET performance evaluation of a pre-clinical SiPM-based MR-compatible PET scanner, " IEEE Trans. Nucl. Sci., vol. 62, no. 3, pp. 784-790, Jun. 2015.
25. S. España, R. Marcinkowski, V. Keereman, S. Vandenberghe, and R. Van Holen, "DigiPET: Sub-millimeter spatial resolution small-animal PET imaging using thin monolithic scintillators, " Phys. Med. Biol., vol. 59, no. 13, pp. 3405-3420, Jun. 2014.
26. H. S. Yoon et al., "Initial results of simultaneous PET/MRI experiments with an MRI-compatible silicon photomultiplier PET scanner, " J. Nucl. Med., vol. 53, no. 4, pp. 608-614, 2012.
27. N. Belcari et al., "Design and detector performance of the PET component of the TRIMAGE PET/MR/EEG scanner, " IEEE Trans. Radiat. Plasma Med. Sci., vol. 3, no. 3, pp. 292-301, May 2019.
28. C. Ritzer, P. Hallen, D. Schug, and V. Schulz, "Intercrystal scatter rejection for pixelated PET detectors, " IEEE Trans. Radiat. Plasma Med. Sci., vol. 1, no. 2, pp. 191-200, Mar. 2017.
29. A. Phunpueok, W. Chewpraditkul, V. Thongpool, and D. Aphairaj, "Comparison of photofraction for LuYAP:Ce, LYSO:Ce and BGO crystals in gamma ray detection, " in Proc. 15th Int. Conf. Int. Acad. Phys. Sci., Pathumthani, Thailand, Dec. 2012, pp. 1-5.
30. Y. Shao, S. R. Cherry, S. Siegel, and R. W. Silverman, "A study of intercrystal scatter in small scintillator arrays designed for high resolution PET imaging, " IEEE Trans. Nucl. Sci., vol. 43, no. 3, pp. 1938-1944, Jun. 1996.
31. N. Zeraatkar, M. R. Ay, S. Sarkar, P. Geramifar, and A. Rahmim, "Quantitative investigation of inter-crystal scatter and penetration in the GE discovery RX PET/CT scanner using Monte Carlo simulations, " in Proc. IEEE Nucl. Sci. Symp. Med. Imag. Conf., Knoxville, TN, USA, Oct. 2010, pp. 2403-2408.
32. J. Clerk-Lamalice, M. Bergeron, C. Thibaudeau, R. Fontaine, and R. Lecomte, "Evaluation of easily implementable inter-crystal scatter recovery schemes in high-resolution PET imaging, " in Proc. IEEE Nucl. Sci. Symp. Med. Imag. Conf. Rec. (NSS/MIC), Anaheim, CA, USA, Oct. 2012, pp. 2196-2199.
33. M. Rafecas, G. Böning, B. J. Pichler, E. Lorenz, M. Schwaiger, and S. I. Ziegler, "Inter-crystal scatter in a dual layer, high resolution LSOAPD positron emission tomograph, " Phys. Med. Biol., vol. 48, no. 7, pp. 821-848, Mar. 2003.
34. G. D. Hutchins, M. A. Miller, V. C. Soon, and T. Receveur, "Small animal PET imaging, " ILAR J., vol. 49, no. 1, pp. 54-65, Jan. 2008.
35. J.-C. Tseng, O. J. Kelada, and J. D. Peterson, Preclinical In Vivo Imaging PET 101: Best Practices for Preclinical 18 F-FDG PET Imaging, PerkinElmer, Inc., Hopkinton, MA, USA, 2017.
36. P. Khateri, J. Fischer, W. Lustermann, C. Tsoumpas, and G. Dissertori, "Implementation of cylindrical PET scanners with block detector geometry in STIR, " EJNMMI Phys., vol. 6, no. 1, p. 15, Jul. 2019.