Effect of stevia aqueous extract on the antidiabetic activity of saxagliptin in diabetic rats

Journal of Ethnopharmacology

Volumn 265, Issue , 2021, Pages

  Abdel Aal, Raafat A ^a   Abdel Rahman, Mahran S ^a   Al Bayoumi, Soad ^b   Ali, Laila A ^b  

^a Assiut University Faculty of Medicine   (Egypt)

^b Assiut University   (Egypt)

Author keywords

Diabetes mellitus; DPP 4; Saxagliptin; Stevia; STZ and Nicotinamide

Indexed keywords

ANTIDIABETIC AGENT; CHOLESTEROL; DIPEPTIDYL PEPTIDASE IV; GLUCOSE; GLUTATHIONE; HIGH DENSITY LIPOPROTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; NICOTINAMIDE; PLANT EXTRACT; SAXAGLIPTIN; STEVIA REBAUDIANA EXTRACT; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; ADAMANTANE; ANTILIPEMIC AGENT; ANTIOXIDANT; DIPEPTIDE; STREPTOZOCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ARTICLE; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; COLORIMETRY; COMPARATIVE STUDY; CONTROLLED STUDY; DIABETES CONTROL; ELECTROSPRAY MASS SPECTROMETRY; GLUCOSE BLOOD LEVEL; HOMEOSTASIS MODEL ASSESSMENT; INSULIN BLOOD LEVEL; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; MALE; NONHUMAN; PARTICLE SIZE; PLANT LEAF; RAT; RETENTION TIME; STEVIA REBAUDIANA; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; TISSUE HOMOGENATE; TRIACYLGLYCEROL BLOOD LEVEL; ANIMAL; CHEMISTRY; DRUG EFFECT; EXPERIMENTAL DIABETES MELLITUS; HERB DRUG INTERACTION; INSULIN RESISTANCE; ISOLATION AND PURIFICATION; PATHOPHYSIOLOGY; STEVIA; WISTAR RAT;

ADAMANTANE; ANIMALS; ANTIOXIDANTS; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; DIPEPTIDES; HERB-DRUG INTERACTIONS; HYPOGLYCEMIC AGENTS; HYPOLIPIDEMIC AGENTS; INSULIN RESISTANCE; MALE; NIACINAMIDE; PLANT EXTRACTS; RATS; RATS, WISTAR; STEVIA; STREPTOZOCIN;

EID: 85091199234     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2020.113188     Document Type: Article

References (54)

1. Aghajanyan, A., M ovsisyan, Z., Trchounian, A., Antihyperglycemic and antihyperlipidemic activity of hydroponic Stevia rebaudiana aqueous extract in hyperglycemia induced by immobilization stress in rabbits. BioMed Res. Int. 2017 (2017), 1–6 https://www.hindawi.com/journals/bmri/2017/9251358/.
2. Ahmad, U., Ahmad, R.S., Anti diabetic property of aqueous extract of Stevia rebaudiana Bertoni leaves in Streptozotocin-induced diabetes in albino rats. BMC Compl. Alternative Med. 18 (2018), 1–11 https://www.ncbi.nlm.nih.gov/pubmed/29890969.
3. Ahmad, U., Ahmad, R.S., Arshad, M.S., Musthaq, Z., H ussain, S.M., Hameed, A., Antihyperlipidemic efficacy of aqueous extract of Stevia rebaudiana Bertoni in albino rats. Lipids Health Dis. 17 (2018), 1–8 https://lipidworld.biomedcentral.com/articles/10.1186/s12944-018-0810-9.
4. Ahmed, R.H., Huri, H.Z., Al-hamodi, Z., Salem, S.D., Muniandy, S., Serum levels of soluble CD26/dipeptidyl peptidase-IV in type 2 diabetes mellitus and its association with metabolic syndrome and therapy with antidiabetic agents in Malaysian subjects. PloS One 10 (2015), 1–12 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608690/.
5. Amir Abbas, M.-B., Seyed-Alireza, E., Elham, A., Amirhossein, S., A review on the pharmacology and toxicology of steviol glycosides extracted from Stevia rebaudiana. Curr. Pharmaceut. Des. 23 (2017), 1616–1622, 10.2174/1381612822666161021142835.
6. Antunes, L.C., Elkfury, J.L., Jornada, M.N., Foletto, K.C., Bertoluci, M.C., Validation of HOMA-IR in a model of insulin-resistance induced by a high-fat diet in Wistar rats. Arch Endocrinol Metab 60 (2016), 138–142, 10.1590/2359-3997000000169.
7. Assaei, R., Mokarram, P., Dastghaib, S., Darbandi, S., Darbandi, M., Zal, F., Akmali, M., Ranjbar Omrani, G.H., Hypoglycemic effect of aquatic extract of stevia in pancreas of diabetic rats: PPARgamma-dependent regulation or antioxidant potential. Avicenna J. Med. Biotechnol. (AJMB) 8 (2016), 65–74 https://www.ncbi.nlm.nih.gov/pubmed/27141265.
8. Ayachi, H., Merad, M., Said, G., Study of interaction between dipeptidyl peptidase-4 and products extracted from the Stevia plant by molecular modeling. Int. J. Pharmaceut. Sci. Rev. Res. 23 (2013), 87–90 https://www.researchgate.net/publication/259007112.
9. Beutler, E., Duron, O., Kelly, B.M., Improved method for the determination of blood glutathione. J. Lab. Clin. Med. 61 (1963), 882–888 https://www.ncbi.nlm.nih.gov/pubmed/13967893.
10. Brownlee, M., The pathobiology of diabetic complications a unifying mechanism. diabetes 54 (2005), 1615–1625 https://diabetes.diabetesjournals.org/content/54/6/1615.long.
11. Chang, J.-C., Wu, M., Liu, I.-M., Cheng, J.-T., Increase of insulin sensitivity by stevioside in fructose-rich chow-fed rats. Horm. Metab. Res. 37 (2005), 610–616 https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-2005-870528.
12. Davidson, J.A., Advances in therapy for type 2 diabetes: GLP-1 receptor agonists and DPP-4 inhibitors. Cleve. Clin. J. Med. 76 (2009), S28–S38 https://www.ncbi.nlm.nih.gov/pubmed/19952301.
13. Duvnjak, L., Blaslov, K., Dipeptidyl peptidase-4 inhibitors improve arterial stiffness, blood pressure, lipid profile and inflammation parameters in patients with type 2 diabetes mellitus. Diabetol. Metab. Syndrome 8 (2016), 26–32 https://www.ncbi.nlm.nih.gov/pubmed/27006706.
14. Evans, J.L., Goldfine, I.D., Maddux, B.A., Grodsky, G.M., Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction?. Diabetes 52 (2003), 1–8, 10.2337/diabetes.52.1.1.
15. Evert, A.B., Boucher, J.L., Cypress, M., Dunbar, S.A., Franz, M.J., Mayer-Davis, E.J., Neumiller, J.J., Nwankwo, R., Verdi, C.L., Urbanski, P., Yancy, W.S. Jr., Nutrition therapy recommendations for the management of adults with diabetes. Diabetes Care, 36, 2013 3821-2842 https://www.ncbi.nlm.nih.gov/pubmed/24357208.
16. Fadini, G.P., Albiero, M., Menegazzo, L., de Kreutzenberg, S.V., Avogaro, A., The increased dipeptidyl peptidase-4 activity is not counteracted by optimized glucose control in type 2 diabetes, but is lower in metformin-treated patients. Diabetes Obes. Metabol. 14 (2012), 518–522, 10.1111/j.1463-1326.2011.01550.x.
17. Farhat, G., Berset, V., Moore, L., Effects of stevia extract on postprandial glucose response, satiety and energy intake: a three-arm crossover trial. Nutrients 11 (2019), 3036–3044, 10.3390/nu11123036.
18. Feng, Y., Li, C., Liu, Y., Zhang, L., Zhang, Z., Saxagliptin attenuates diabetic nephropathy with suppressing oxidative stress by inhibiting AGEs-RAGE Axis in streptozotocin-induced diabetic rats. Am. J. Intern. Med. 6 (2018), 161–169 https://www.ncbi.nlm.nih.gov/pubmed/27006706.
19. Ford, E.S., Li, C., Sattar, N., Metabolic syndrome and incident diabetes: current state of the evidence. Diabetes Care 31 (2008), 1898–1904 https://www.ncbi.nlm.nih.gov/pubmed/18591398.
20. Fossati, P., Prencipe, L., Serum triglycerides determined colorimetrically with an enzyme that produces hydrogen peroxide. Clin. Chem. 28 (1982), 2077–2080 https://www.ncbi.nlm.nih.gov/pubmed/6812986.
21. Gallwitz, B., New treatments in the management of type 2 diabetes: a critical appraisal of saxagliptin. Diabetes, Metab. Syndrome Obes. Targets Ther. 3 (2010), 117–124, 10.2147/dmso.s4857.
22. Gargouri, M., Hamed, H., Akrouti, A., Dauvergne, X., Magne, C., El Feki, A., Effects of Spirulina platensis on lipid peroxidation, antioxidant defenses, and tissue damage in kidney of alloxan-induced diabetic rats. Appl. Physiol. Nutr. Metabol. 43 (2018), 345–354, 10.1139/apnm-2017-0461.
23. Gregersen, S., Jeppesen, P.B., Holst, J.J., Hermansen, K., Antihyperglycemic effects of stevioside in type 2 diabetic subjects. Metabolism 53 (2004), 73–76 https://www.ncbi.nlm.nih.gov/pubmed/14681845.
24. Helal, M.G., Zaki, M.M.A.F., Said, E., Nephroprotective effect of saxagliptin against gentamicin-induced nephrotoxicity, emphasis on anti-oxidant, anti-inflammatory and anti-apoptic effects. Life Sci. 208 (2018), 64–71 https://www.ncbi.nlm.nih.gov/pubmed/30012474.
25. Henry, R., Smith, S., Schwartz, S., Mudaliar, S., Deacon, C., Holst, J.J., Duan, R., Chen, R., List, J., Effects of saxagliptin on β-cell stimulation and insulin secretion in patients with type 2 diabetes. Diabetes Obes. Metabol. 13 (2011), 850–858 https://www.ncbi.nlm.nih.gov/pubmed/21554520.
26. Holst, J.J., Deacon, C.F., Vilsboll, T., Krarup, T., Madsbad, S., Glucagon-like peptide-1, glucose homeostasis and diabetes. Trends Mol. Med. 14 (2008), 161–168 https://www.ncbi.nlm.nih.gov/pubmed/18353723.
27. Jdir, H., Kolsi, R.B.A., Zouari, S., Hamden, K., Zouari, N., Fakhfakh, N., The cruciferous Diplotaxis simplex: phytochemistry analysis and its protective effect on liver and kidney toxicities, and lipid profile disorders in alloxan-induced diabetic rats. Lipids Health Dis. 16 (2017), 1–29, 10.1186/s12944-017-0492-8.
28. Jeppesen, P.B., Gregersen, S., Alstrup, K., Hermansen, K., Stevioside induces antihyperglycaemic, insulinotropic and glucagonostatic effects in vivo: studies in the diabetic Goto-Kakizaki (GK) rats. Phytomedicine 9 (2002), 9–14 https://www.ncbi.nlm.nih.gov/pubmed/11924770.
29. Jeppesen, P.B., Gregersen, S., Rolfsen, S., Jepsen, M., Colombo, M., Agger, A., Xiao, J., Kruhoffer, M., Orntoft, T., Hermansen, K., Antihyperglycemic and blood pressure-reducing effects of stevioside in the diabetic Goto-Kakizaki rat. Metabolism 52 (2003), 372–378 https://www.ncbi.nlm.nih.gov/pubmed/12647278.
30. Kuanlin, C., Tiejun, Z., Jian, W., Qing, M., Saxagliptin upregulates nesfatin-1 secretion and ameliorates insulin resistance and metabolic profiles in type 2 diabetes mellitus. Metab. Syndr. Relat. Disord. 16 (2018), 336–341 https://www.liebertpub.com/doi/abs/10.1089/met.2018.0010.
31. Lamers, D., Famulla, S., Wronkowitz, N., Hartwig, S., Lehr, S., Ouwens, D.M., Eckardt, K., Kaufman, J.M., Ryden, M., Muller, S., Hanisch, F.-G., Ruige, J., Arner, P., Sell, H., Eckel, J., Dipeptidyl peptidase 4 is a novel adipokine potentially linking obesity to the metabolic syndrome. Diabetes 60 (2011), 1917–1925 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121429/.
32. Maki, K., Curry, L., Reeves, M., Toth, P., Mckenney, J., Farmer, M., Schwartz, S., Lubin, B., Boilean, A., Dicklin, M., Chronic consumption of rebaudioside A, a steviol glycoside, in men and women with type 2 diabetes mellitus. Food Chem. Toxicol. 46 (2008), S47–S53 https://www.ncbi.nlm.nih.gov/pubmed/18555575.
33. Mishra, N., An Analysis of antidiabetic activity of Stevia rebaudiana extract on diabetic patient. J. Nat. Sci. Res. 1 (2011), 1–10 https://www.iiste.org/Journals/index.php/JNSR/article/view/1215.
34. Mishra, S.B., Verma, A., Vijayakumar, M., Preclinical valuation of anti-hyperglycemic and antioxidant action of Nirmali (Strychnos potatorum) seeds in streptozotocin-nicotinamide-induceddiabetic Wistar rats: a histopathological investigation. Biomarkers and Genomic Medicine 5 (2013), 157–163 https://www.sciencedirect.com/science/article/pii/S2214024713000683.
35. Misra, H., Soni, M., Silawat, N., Metha, D., Metha, B.K., Jain, D.C., Antidiabetic activity of medium-polar extract from the leaves of Stevia rebaudiana Bert. (Bertoni) on alloxan-induced diabetic rats. J. Pharm. BioAllied Sci. 3 (2011), 242–248 https://www.ncbi.nlm.nih.gov/pubmed/21687353.
36. Monami, M., Vitale, V., Ambrosio, M.L., Bartoli, N., Toffanello, G., Raggianti, B., Monami, F., Marchionni, N., Mannucci, E., Effects on lipid profile of dipeptidyl peptidase 4 inhibitors, pioglitazone, acarbose, and sulfonylureas: meta-analysis of placebo-controlled trials. Adv. Ther. 29 (2012), 736–746 https://link.springer.com/article/10.1007%2Fs12325-012-0045-5.
37. Mossa, A.H., Swelam, E.S., Mohafrash, S.M.M., Sub-chronic exposure to fipronil induced oxidative stress, biochemical and histopathological changes in the liver and kidney of male albino rats. Toxicol Rep 2 (2015), 775–784 https://www.ncbi.nlm.nih.gov/pubmed/28962413.
38. Ohkawa, H., Ohishi, N., Yagi, K., Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 95 (1979), 351–358 https://www.ncbi.nlm.nih.gov/pubmed/36810.
39. Park, J.E., Cha, Y.S., Stevia rebaudiana Bertoni extract supplementation improves lipid and carnitine profiles in C57BL/6J mice fed a high-fat diet. J. Sci. Food Agric. 90 (2010), 1099–1105 https://www.ncbi.nlm.nih.gov/pubmed/20393989.
40. Poucher, S.M., Cheetham, S., Francis, J., Zinker, B., Kirby, M., Vickers, S.P., Effects of saxagliptin and sitagliptin on glycaemic control and pancreatic β-cell mass in a streptozotocin-induced mouse model of type 2 diabetes. Diabetes Obes. Metabol. 14 (2012), 918–926, 10.1111/j.1463-1326.2012.01619.x.
41. Rajasekaran, T., Ramakrishna, A., Udaya Sankar, K., Giridhar, P., Ravishankar, G.A., Analysis of predominant steviosides inStevia rebaudianaBertoni by liquid chromatography/electrospray ionization-mass spectrometry. Food Biotechnol. 22 (2008), 179–188, 10.1080/08905430802043255.
42. Richmond, W., Preparation and properties of a cholesterol oxidase from Nocardia sp. and its application to the enzymatic assay of total cholesterol in serum. Clin. Chem. 19 (1973), 1350–1356 https://www.ncbi.nlm.nih.gov/pubmed/4757363.
43. Rotimi, S.O., Rotimi, O.A., Adelani, I.B., Onuzulu, C., Obi, P., Okungbaye, R., Stevioside modulates oxidative damage in the liver and kidney of high fat/low streptozocin diabetic rats. Heliyon, 4, 2018, e00640 1-20 https://www.ncbi.nlm.nih.gov/pubmed/29872771.
44. Sharma, N., Mogra, R., Upadhyay, B., Effect of stevia extract intervention on lipid profile. Stud. Ethno-Med. 3 (2009), 137–140, 10.1080/09735070.2009.11886351.
45. Shivana, N., Naika, M., Khanum, F., Kaul, V.K., Antioxidant, anti-diabetic and renal protective properties of Stevia rebaudiana. J. Diabet. Complicat. 27 (2013), 103–113 https://www.ncbi.nlm.nih.gov/pubmed/23140911.
46. Simmons, R.A., Developmental origins of diabetes: the role of oxidative stress. Best Pract. Res. Clin. Endocrinol. Metabol. 26 (2012), 917–922, 10.1016/j.freeradbiomed.2005.12.018.
47. Soejarto, D.D., Kinghorn, A.D., Farnsworth, N.R., Potential sweetening agents of plant origin. III. Organoleptic evaluation of Stevia leaf herbarium samples for sweetness. J. Nat. Prod. 45 (1982), 590–599 https://www.ncbi.nlm.nih.gov/pubmed/7153776.
48. Song, Y., Manson, J.E., Tinker, L., Howard, B.V., Kuller, L.H., Nathan, L., Rifal, N., Liu, S., Insulin sensitivity and insulin secretion determined by homeostasis model assessment and risk of diabetes in a multiethnic cohort of women. The women's health initiative observational study. Diabetes Care 30 (2007), 1747–1752 https://www.ncbi.nlm.nih.gov/pubmed/17468352.
49. Sudha, T., Devi, D.A., Kaviarasan, L., Antihyperlipidemic effect of Stevia rebaudiana on alloxan induced diabetic rats. Asian Journal of Pharmacy and Technology 7 (2017), 202–208 https://www.researchgate.net/publication/325531033.
50. Thornberry, N.A., Gallwitz, B., Mechanism of action of inhibitors of dipeptidyl-peptidase-4 (DPP-4). Best Pract. Res. Clin. Endocrinol. Metabol. 23 (2009), 479–486 http://www.sciencedirect.com/science/article/pii/S1521690X09000232.
51. Trinder, P., Determination of glucose in blood using glucose oxidase with an alternative oxygen acceptor. Ann. Clin. Biochem. 6 (1969), 24–27 https://journals.sagepub.com/doi/10.1177/000456326900600108.
52. Varga, T., Somogyi, A., Barna, G., Wichmann, B., Nagy, G., Rácz, K., Selmeci, L., Firneisz, G., Higher serum DPP-4 enzyme activity and decreased lymphocyte CD26 expression in type 1 diabetes. Pathol. Oncol. Res. 17 (2011), 925–936, 10.1007/s12253-011-9404-9.
53. Whiting, D.R., Guariguata, L., Weil, C., Shaw, J., IDF Diabetes Atlas: global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Res. Clin. Pract. 94 (2011), 311–321 https://www.sciencedirect.com/science/article/abs/pii/S0168822711005912.
54. Wieland, H., Seidel, D., A simple specific method for precipitation of low density lipoproteins. J. Lipid Res. 24 (1983), 904–909 https://www.ncbi.nlm.nih.gov/pubmed/6631224.