Preclinical valuation of anti-hyperglycemic and antioxidant action of Nirmali (Strychnos potatorum) seeds in streptozotocin-nicotinamide-induced diabetic Wistar rats: A histopathological investigation

Biomarkers and Genomic Medicine

Volumn 5, Issue 4, 2013, Pages 157-163

  Mishra, Shanti Bhushan ^a   Verma, Amita ^b   Vijayakumar, Madhavan ^c  

^a United Institute of Pharmacy   (India)

^b SAM HIGGINBOTTOM UNIVERSITY OF AGRICULTURE   (India)

^c Himalaya Health Care   (India)

Author keywords

Antidiabetic; Antioxidant; Seed extract; Streptozotocin; Strychnos potatorum

Indexed keywords

ANTIDIABETIC AGENT; ANTIOXIDANT; CATALASE; CHOLESTEROL; GLIBENCLAMIDE; GLUCOSE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; NICOTINAMIDE; PLANT EXTRACT; STREPTOZOCIN; STRYCHNOS POTATORUM EXTRACT; SUPEROXIDE DISMUTASE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG DOSE COMPARISON; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; FEMALE; GLUCOSE BLOOD LEVEL; HISTOPATHOLOGY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PLANT SEED; PRIORITY JOURNAL; RAT; SINGLE DRUG DOSE; STREPTOZOCIN DIABETES; STRYCHNOS; STRYCHNOS POTATORUM; TOXICITY TESTING; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 84890066710     PISSN: 22140247     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bgm.2013.07.010     Document Type: Article

References (24)

1. Diabetes Programme, Department of Chronic Diseases and Health Promotion. Facts and Figures Sheet-Diabetes 2006, World Health Organization, World Health Organization, Geneva, Switzerland.
2. Skyler J. Diabetes mellitus: pathogenesis and treatment strategies. J Med Chem 2004, 47:4113-4117.
3. 13C glucose breath test: a new tool for early diagnosis and follow-up of high-risk patients. Nutri J 2010, 9:25. Available at. http://www.nutritionj.com/content/9/1/25.
4. Venkatesh S., Reddy G.D., Reddy B.M., et al. Antihyperglycemic activity of Caralluma attenuata. Fitoterapia 2003, 74:274-279.
5. Saha B.P., Biswas S., Murugesan T., et al. Study on the diuretic activity of Strychnos potatorum Linn seed extract in albino rats. Phytomedicine 2001, 8:469-471.
6. Saha B.P., Biswas S., Murugesan T., et al. Antidiarrhoeal activity of Strychnos potatorum seed extract in rat. Fitoterapia 2002, 73:43-47.
7. 4-induced acute hepatic injury in experimental rats. J Ethnopharmacol 2006, 105:154-160.
8. Venkataraman S., Sanmugapriya E. Antiulcerogenic potential of Strychnos potatorum Linn seed on aspirin plus pylorus ligation-induced ulcer in experimental rats. Phytomedicine 2007, 14:360-365.
9. Venkataraman S., Sanmugapriya E. Anti-inflammatory effect of Strychnos potatorum Linn seed on acute and subacute inflammation in experimental rat models. Pharm Biol 2007, 45:435-439.
10. Ekambaram S., Perumal S.S., Subramanian V. Evaluation of antiarthritic activity of Strychnos potatorum Linn seeds in Freund's adjuvant-induced arthritic rat model. BMC Comp Alt Med 2010, 10:56. Available at. http://www.biomedcentral.com/1472-6882/10/56.
11. Kirtikar K.R., Basu B.D. Indian Medicinal Plants 2005, 1647-1649. International Book Distributors, Dehradun, India. 2nd ed.
12. Mallikharjuna P.B., Rajanna L.N., Seetharam Y.N., et al. Phytochemical studies of Strychnos potatorum L.f-a medicinal plant. e-J Chem 2007, 4:510-518.
13. Kokate C.K., Purohit A.P., Gokhale S.B. Pharmacognosy 2008, 607-611. Nirali Prakashan, Pune, India. 40 ed.
14. Guideline Number 423 for the Testing of Chemicals: Revised Draft Guideline 423 (Acute Oral Toxicity) 2000, OECD, OECD, Paris, France.
15. Sureshkumar S.V., Mishra S.H. Hepatoprotective effect of extracts from Pergularia daemia Forsk. J Ethnopharmacol 2006, 107:164-168.
16. Shirwaikar A., Rajendran K., Punitha I.S.R. Antidiabetic activity of alcoholic stem extract of Coscinium fenestratum in streptozotocin-nicotinamide-induced type 2 diabetic rats. J Ethnopharmacol 2005, 97:369-374.
17. Pari L., Murugan P. Antioxidant effect of tetrahydrocurcumin in streptozotocin-nicotinamide induced diabetic rats. Life Sci 2006, 79:1720-1728.
18. Culling C.F.A. Handbook of Histopathological and Histochemical Techniques 1974, 194-196. Butterworth and Co. Ltd., London, England. 3rd ed.
19. Mishra S.B., Verma A., Mukerjee A., et al. Antihyperglycemic activity of leaves extract of Hyptis suaveolens L. Poit in streptozotocin-induced diabetic rats. Asian Pac J Trop Med 2011, 4:689-693.
20. Chatterjea M.N., Shinde R. Text Book of Medical Biochemistry 2002, 317. Jaypee Brothers Medical Publishers, New Delhi, India.
21. Novelli M., D'Aleo V., Lupi R., et al. Reduction of oxidative stress by a new low molecular weight antioxidant improves metabolic alteration in a nonobese mouse diabetes model. Pancreas 2007, 35:e10-e17.
22. Bera T.K., Chatterjee K., Jana K., et al. Antihyperglycemic and antioxidative effect of hydro-methanolic (2:3) extract of the seed of Swietenia mahagoni (L.) Jacq. in streptozotocin-induced diabetic male albino rat: an approach through pancreas. Genomic Medicine, Biomarkers, and Health Sciences 2012, Available at, [website]. http://dx.doi.org/10.1016/j.gmbhs.2012.11.001.
23. Metwally N.S., Mohamed A.M., ELSharabasy F.S. Chemical constituents of the Egyptian Plant Anabasis articulata (Forssk) Moq and its antidiabetic effects on rats with streptozotocin induced diabetic hepatopathy. J Applied Pharm Sci 2012, 2:54-65.
24. Santhakumari P., Prakasam A., Pugalendi K.V. Modulation of oxidative stress parameters by treatment with Piper betel leaf in streptozotocin-induced diabetic rats. Ind J Pharmacol 2003, 35:373-378.