메뉴 건너뛰기




Volumn 3, Issue 2, 2011, Pages 242-248

Antidiabetic activity of medium-polar extract from the leaves of Stevia rebaudiana Bert. (Bertoni) on alloxan-induced diabetic rats

Author keywords

Alloxan induced diabetic rats; antidiabetic activity; benzene:acetone extract; Compositae; Stevia rebaudiana

Indexed keywords

ALLOXAN; ANTIDIABETIC AGENT; GLIBENCLAMIDE; GLUCOSE; STEVIA REBAUDIANA EXTRACT; UNCLASSIFIED DRUG;

EID: 79957540295     PISSN: None     EISSN: 09757406     Source Type: Journal    
DOI: 10.4103/0975-7406.80779     Document Type: Article
Times cited : (64)

References (45)
  • 1
    • 3843116771 scopus 로고    scopus 로고
    • Diabetes mellitus: Pathogenesis and treatment strategies
    • DOI 10.1021/jm0306273
    • Skyler JS. Diabetes mellitus: Pathogenesis and treatment strategies. J Med Chem 2004;47:4113-7. (Pubitemid 39045414)
    • (2004) Journal of Medicinal Chemistry , vol.47 , Issue.17 , pp. 4113-4117
    • Skyler, J.S.1
  • 2
    • 67649351473 scopus 로고    scopus 로고
    • Geneva: WHO Available from: Last cited on 2010 May 23
    • World Health Organization. Geneva: WHO; 2008. Diabetes, Fact sheet no. 312. Available from: http://www.who.int/mediacentre/factsheets/fs312/en/index. html. [Last cited on 2010 May 23].
    • (2008) Diabetes, Fact Sheet No. 312
  • 4
  • 6
    • 75449102208 scopus 로고    scopus 로고
    • In-vitro antimicrobial and antitumor activities of Stevia rebaudiana (Asteraceae) leaf extracts
    • Satishkumar J, Sarvanan MM, Seethalakshmi I. In-vitro antimicrobial and antitumor activities of Stevia rebaudiana (Asteraceae) leaf extracts. Trop J Pharm Res 2008;7:1143-9.
    • (2008) Trop J Pharm Res , vol.7 , pp. 1143-1149
    • Satishkumar, J.1    Sarvanan, M.M.2    Seethalakshmi, I.3
  • 8
    • 79957551655 scopus 로고    scopus 로고
    • Hepatoprotective effects of Stevia rebaudiana Bertoni leaf extract in CCl4-induced liver injury in albino rats
    • Mohan K, Robert J. Hepatoprotective effects of Stevia rebaudiana Bertoni leaf extract in CCl4-induced liver injury in albino rats. Med Arom Plant Sci Biotechnol 2009;3:59-61.
    • (2009) Med Arom Plant Sci Biotechnol , vol.3 , pp. 59-61
    • Mohan, K.1    Robert, J.2
  • 11
    • 77957324971 scopus 로고    scopus 로고
    • In-vitro anti-HIV activity of extract from Stevia rebaudiana
    • Takahashi K, Iwata Y, Mori S, Shigeta S. In-vitro anti-HIV activity of extract from Stevia rebaudiana. Antiviral Res 1998;37:A59.
    • (1998) Antiviral Res , vol.37
    • Takahashi, K.1    Iwata, Y.2    Mori, S.3    Shigeta, S.4
  • 12
    • 0032476163 scopus 로고    scopus 로고
    • The effect of stevioside on blood pressure and plasma catecholamines in spontaneously hypertensive rats
    • DOI 10.1016/S0024-3205(98)00439-1, PII S0024320598004391
    • Chan P, Xu DY, Liu JC, Chen YJ, Tomlinson B, Huang WP, et al. The effect of stevioside on blood pressure and plasma catecholamines in spontaneously hypertensive rats. Life Sci 1998;63:1679-84. (Pubitemid 28494155)
    • (1998) Life Sciences , vol.63 , Issue.19 , pp. 1679-1684
    • Chan, P.1    Xu, D.-Y.2    Liu, J.-C.3    Chen, Y.-J.4    Tomlinson, B.5    Huang, W.-P.6    Cheng, J.-T.7
  • 13
    • 0035672675 scopus 로고    scopus 로고
    • Inhibitory effect of stevioside on calcium influx to produce antihypertension
    • DOI 10.1055/s-2001-18841
    • Lee CN, Wong KL, Liu JC, Chen YJ, Cheng JT, Chan P. Inhibitory effect of stevioside on calcium influx to produce anti-hypertension. Planta Med 2001;67:796-9. (Pubitemid 34015540)
    • (2001) Planta Medica , vol.67 , Issue.9 , pp. 796-799
    • Lee, C.-N.1    Wong, K.-L.2    Liu, J.-C.3    Chen, Y.-J.4    Cheng, J.-T.5    Chan, P.6
  • 15
    • 79957556758 scopus 로고    scopus 로고
    • Available from: Last accessed on 2010 Oct 04
    • Stevia rebaudiana Bertoni. Available from: http://www. emperorsherbiologist.com/stevia.php [Last accessed on 2010 Oct 04].
    • Stevia Rebaudiana Bertoni
  • 18
    • 14944361919 scopus 로고    scopus 로고
    • Mechanism of the hypoglycemic effect of stevioside, a glycoside of Stevia rebaudiana
    • DOI 10.1055/s-2005-837775
    • Chen TH, Chen SC, Chan P, Chu YL, Yang HY, Cheng JT Mechanism of the hypoglycemic effect of stevioside, a glycoside of Stevia rebaudiana. Planta Med 2005;71:108-13. (Pubitemid 40363551)
    • (2005) Planta Medica , vol.71 , Issue.2 , pp. 108-113
    • Chen, T.-H.1    Chen, S.-C.2    Chan, P.3    Chu, Y.-L.4    Yang, H.-Y.5    Cheng, J.-T.6
  • 19
    • 3042668731 scopus 로고    scopus 로고
    • Glucose concentration in the blood of intact and alloxan-treated mice after pretreatment with commercial preparations of Stevia rebaudiana (Bertoni)
    • Raskovic A, Gavrilovic M, Jakovljevic V, Sabo J. Glucose concentration in the blood of intact and alloxan-treated mice after pretreatment with commercial preparations of Stevia rebaudiana (Bertoni). Eur J Drug Metab Pharmacokinet 2004;29:87-90. (Pubitemid 38828620)
    • (2004) European Journal of Drug Metabolism and Pharmacokinetics , vol.29 , Issue.2 , pp. 87-90
    • Raskovic, A.1    Gavrilovic, M.2    Jakovljevic, V.3    Sabo, J.4
  • 20
    • 34547439689 scopus 로고    scopus 로고
    • Comparison of two different solvents employed for pressurised fluid extraction of stevioside from Stevia rebaudiana: Methanol versus water
    • DOI 10.1007/s00216-007-1404-y
    • Pól J, Varadová Ostrá E, Karásek P, Roth M, Benešová K, Kotlaríková P, et al. Comparison of two different solvents employed for pressurised fluid extraction of stevioside from Stevia rebaudiana: methanol versus water. Anal Bioanal Chem 2007;388:1847-57. (Pubitemid 47173106)
    • (2007) Analytical and Bioanalytical Chemistry , vol.388 , Issue.8 , pp. 1847-1857
    • Pol, J.1    Varadova, O.E.2    Karasek, P.3    Roth, M.4    Benesova, K.5    Kotlarikova, P.6    Caslavsky, J.7
  • 21
    • 79957537446 scopus 로고    scopus 로고
    • Available from; [Last updated on 2009 Feb 21]. Canada: StasoSphere Base c2007-2009. Available from: http://www.chestofbooks.com/food/beverages/Alcohol- Properties/Azeotropic-Mixtures.html[Last cited on 2010 May 21]
    • Azeotropic mixtures Available from; http://www.chestofbooks.com/ [Last updated on 2009 Feb 21]. Canada: StasoSphere Base c2007-2009. Available from: http://www.chestofbooks.com/food/beverages/Alcohol-Properties/ Azeotropic-Mixtures.html[Last cited on 2010 May 21].
    • Azeotropic Mixtures
  • 22
    • 70449585629 scopus 로고    scopus 로고
    • Development and validation of high-performance thin-layer chromatographic method for determination of α-mangostin in fruit pericarp of mangosteen plant (Garcinia mangostana L.) using ultraviolet - Visible detection
    • Misra H, Dwivedi BK, Mehta D, Mehta BK, Jain DC. Development and validation of high-performance thin-layer chromatographic method for determination of α-mangostin in fruit pericarp of mangosteen plant (Garcinia mangostana L.) using ultraviolet - visible detection. Rec Nat Prod 2009;3:178-86.
    • (2009) Rec Nat Prod , vol.3 , pp. 178-186
    • Misra, H.1    Dwivedi, B.K.2    Mehta, D.3    Mehta, B.K.4    Jain, D.C.5
  • 24
    • 34347376704 scopus 로고    scopus 로고
    • Evaluation of Antidiabetic Activity of Coldenia procumbens in Alloxan-Induced Diabetes in Rat
    • Patel N, Raval S, Goriya H, Jhala M, Joshi B. Evaluation of Antidiabetic Activity of Coldenia procumbens in Alloxan-Induced Diabetes in Rat. J Herb Pharmacother 2007;7:13-23.
    • (2007) J Herb Pharmacother , vol.7 , pp. 13-23
    • Patel, N.1    Raval, S.2    Goriya, H.3    Jhala, M.4    Joshi, B.5
  • 25
    • 0030783777 scopus 로고    scopus 로고
    • Hypoglycaemic and antihyperglycaemic effects of Trigonella foenum-graecum leaf in normal and alloxan induced diabetic rats
    • Barry JA, Hassan IA, Al-Hakiem MH. Hypoglycaemic and antihyperglycaemic effects of Trigonella foenum-graecum leaf in normal and alloxan induced diabetic rats. J Ethnopharmacol 1997;58:149-55.
    • (1997) J Ethnopharmacol , vol.58 , pp. 149-155
    • Barry, J.A.1    Hassan, I.A.2    Al-Hakiem, M.H.3
  • 26
    • 0014478342 scopus 로고
    • Determination of blood glucose using an oxidase peroxidase system with a noncarcinogenic chromogen
    • Trinder P. Determination of blood glucose using an oxidase peroxidase system with a noncarcinogenic chromogen. J Clin Pathol 1969;22:158-61.
    • (1969) J Clin Pathol , vol.22 , pp. 158-161
    • Trinder, P.1
  • 27
    • 27644534120 scopus 로고    scopus 로고
    • Antioxidant and protective effect of latex of Calotropis procera against alloxan-induced diabetes in rats
    • Roy S, Sehgal R, Padhy BM, Kumar VL. Antioxidant and protective effect of latex of Calotropis procera against alloxan-induced diabetes in rats. J Ethnopharmacol 2005;102:470-3.
    • (2005) J Ethnopharmacol , vol.102 , pp. 470-473
    • Roy, S.1    Sehgal, R.2    Padhy, B.M.3    Kumar, V.L.4
  • 28
    • 33751426123 scopus 로고    scopus 로고
    • In-vivo antidiabetic and antioxidant potential of Helichrysum plicatum spp. in streptozotocin induced diabetic rats
    • Aslan M, Orhan DD, Orhan N, Sezik E, Yesilada E. In-vivo antidiabetic and antioxidant potential of Helichrysum plicatum spp. in streptozotocin induced diabetic rats. J Ethanopharmacol 2006;109:54-9.
    • (2006) J Ethanopharmacol , vol.109 , pp. 54-59
    • Aslan, M.1    Orhan, D.D.2    Orhan, N.3    Sezik, E.4    Yesilada, E.5
  • 29
    • 0023748601 scopus 로고
    • Alloxan: History and mechanism of action
    • Lenzen S, Panten U. Alloxan: History and mechanism of action. Diabetologia 1988;31:337-42.
    • (1988) Diabetologia , vol.31 , pp. 337-342
    • Lenzen, S.1    Panten, U.2
  • 30
    • 0023770113 scopus 로고
    • Free radicals and diabetes
    • DOI 10.1016/0891-5849(88)90036-6
    • Oberley LW. Free radicals and diabetes. Free Radic Biol Med 1988;5:113-24. (Pubitemid 18263730)
    • (1988) Free Radical Biology and Medicine , vol.5 , Issue.2 , pp. 113-124
    • Oberley, L.W.1
  • 31
    • 0019812690 scopus 로고
    • Streptozotocin and alloxan induce DNA strand breaks and poly(ADP-ribose) synthetase in pancreatic islets
    • Yamamoto H, Uchigata Y, Okamoto H. Streptozotocin and Alloxan induce DNA strand breaks and poly (ADP-ribose) synthetase in pancreatic islets. Nature 1981;294:284-6. (Pubitemid 12221500)
    • (1981) Nature , vol.294 , Issue.5838 , pp. 284-286
    • Yamamoto, H.1    Uchigata, Y.2    Okamoto, H.3
  • 32
    • 1842373814 scopus 로고    scopus 로고
    • Comparative toxicity of alloxan, N-alkylalloxans and ninhydrin to isolated pancreatic islets in vitro
    • DOI 10.1677/joe.0.1550283
    • Jorns A, Munday R, Tiedge M, Lenzen S. Comparative toxicity of alloxan, N-alkyl-alloxans and ninhydrin to isolated pancreatic islets in-vitro. J Endocrinol 1997;155:283-93. (Pubitemid 27475824)
    • (1997) Journal of Endocrinology , vol.155 , Issue.2 , pp. 283-293
    • Jorns, A.1    Munday, R.2    Tiedge, M.3    Lenzen, S.4
  • 33
    • 0022472816 scopus 로고
    • Mechanisms of nitrosourea-induced β-cell damage. Alterations in DNA
    • LeDoux SP, Woodley SE, Patton NJ, Wilson GL. Mechanism of notrosourea-induced β-cells damage - alterations in DNA. Diabetes 1986;35:866-72. (Pubitemid 16014437)
    • (1986) Diabetes , vol.35 , Issue.8 , pp. 866-872
    • LeDoux, S.P.1    Woodley, S.E.2    Patton, N.J.3    Wilson, G.L.4
  • 34
    • 0035691617 scopus 로고    scopus 로고
    • The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas
    • Szkudelski T. The mechanism of alloxan and streptozotocin action in B-cells of the rat pancreas. Physiol Res 2001;50:537-46. (Pubitemid 34087272)
    • (2001) Physiological Research , vol.50 , Issue.6 , pp. 537-546
    • Szkudelski, T.1
  • 35
    • 0025073589 scopus 로고
    • Traditional plant treatments for diabetes. Studies in normal and streptozotocin diabetic mice
    • DOI 10.1007/BF00405106
    • Swanston-Flatt SK, Day C, Bailey CJ, Flatt PR. Traditional plant treatments for diabetes: Studies in normal and streptozotocin diabetic mice. Diabetologia 1990;33:462-4. (Pubitemid 20254867)
    • (1990) Diabetologia , vol.33 , Issue.8 , pp. 462-464
    • Swanston-Flatt, S.K.1    Day, C.2    Bailey, C.J.3    Flatt, P.R.4
  • 36
    • 0034457043 scopus 로고    scopus 로고
    • Impaired insulin-stimulated expression of the glycogen synthase gene in skeletal muscle of type 2 diabetic patients is acquired rather than inherited
    • DOI 10.1210/jc.85.4.1584
    • Huang X, Vaag A, Hanson M, Weng J, Laurila E, Groop L. Impaired insulin stimulated expression of the glycogen synthase gene in sekeletal muscle of type 2 diabetic patient is acquired rather than inherited. J Clin Endocrinol Metab 2000;85:1584-90. (Pubitemid 32289504)
    • (2000) Journal of Clinical Endocrinology and Metabolism , vol.85 , Issue.4 , pp. 1584-1590
    • Huang, X.1    Vaag, A.2    Hansson, M.3    Weng, J.4    Laurila, E.S.A.5    Groop, L.6
  • 38
    • 34447518411 scopus 로고    scopus 로고
    • Stevioside counteracts the glyburide-induced desensitization of the pancreatic beta-cell function in mice: Studies in vitro
    • DOI 10.1016/j.metabol.2006.08.009, PII S0026049506003052
    • Chen J, Jeppesen PB, Nordentoft I, Hermansen K. Stevioside counteracts the glyburide-induced desensitization of the pancreatic beta-cell function in mice: studies in-vitro. Metabolism 2006;55:1674-80. (Pubitemid 44827136)
    • (2006) Metabolism: Clinical and Experimental , vol.55 , Issue.12 , pp. 1674-1680
    • Chen, J.1    Jeppesen, P.B.2    Nordentoft, I.3    Hermansen, K.4
  • 39
    • 4544319977 scopus 로고    scopus 로고
    • Rebaudioside A potently stimulates insulin secretion from isolated mouse islets: Studies on the dose-, glucose-, and calcium-dependency
    • DOI 10.1016/j.metabol.2004.04.014, PII S0026049504002100
    • Abudula R, Jeppesen PB, Rolfsen SE, Xiao J, Hermansen K. Rebaudioside A potentially stimulates insulin secretion from isolated mouse islets: Studies on the dose-, glucose-, and calcium-dependency. Metabolism 2004;53:1378-81. (Pubitemid 39222103)
    • (2004) Metabolism: Clinical and Experimental , vol.53 , Issue.10 , pp. 1378-1381
    • Abudula, R.1    Jeppesen, P.B.2    Rolfsen, S.E.D.3    Xiao, J.4    Hermansen, K.5
  • 40
    • 85056051405 scopus 로고    scopus 로고
    • The diterpene glycoside, Rebaudioside A, does not improve glycemic control or affect blood pressure after eight weeks treatment in the Goto-Kakizaki rats
    • Dyrskog SE, Jeppesen PB, Chen J, Christensen LP, Hermansen K. The diterpene glycoside, Rebaudioside A, does not improve glycemic control or affect blood pressure after eight weeks treatment in the Goto-Kakizaki rats. Rev Diabet Stud 2005;2:84-91.
    • (2005) Rev Diabet Stud , vol.2 , pp. 84-91
    • Dyrskog, S.E.1    Jeppesen, P.B.2    Chen, J.3    Christensen, L.P.4    Hermansen, K.5
  • 41
    • 54249120793 scopus 로고    scopus 로고
    • Rebaudioside A directly stimulates insulin secretion from pancreatic beta cells: A glucose-dependent action via inhibition of ATP-sensitive K+-channels
    • Abudula R, Matchkov VV, Jeppesen PB, Nilsson H, Aalkjaer C, Hermansen K. Rebaudioside A directly stimulates insulin secretion from pancreatic beta cells: A glucose-dependent action via inhibition of ATP-sensitive K+-channels. Diabetes Obes Metab 2008;10:1074-85.
    • (2008) Diabetes Obes Metab , vol.10 , pp. 1074-1085
    • Abudula, R.1    Matchkov, V.V.2    Jeppesen, P.B.3    Nilsson, H.4    Aalkjaer, C.5    Hermansen, K.6
  • 42
    • 0042051715 scopus 로고    scopus 로고
    • Metabolism of stevioside and rebaudioside A from Stevia rebaudiana extracts by human microflora
    • Gardana C, Simonetti P, Canzi E, Zanchi R, Pietta P. Metabolism of stevioside and rebaudioside A from Stevia rebaudiana extracts by human microflora. J Agric Food Chem 2003;51:6618-22.
    • (2003) J Agric Food Chem , vol.51 , pp. 6618-6622
    • Gardana, C.1    Simonetti, P.2    Canzi, E.3    Zanchi, R.4    Pietta, P.5
  • 43
    • 79957545133 scopus 로고    scopus 로고
    • by eustas Maladeta, no. 20, 22300 Barbastro, Huesca, Spain: Available from: Last assessed on 2009 Nov 18
    • Geuns JM. Steviol glycosides as food additive, Summary of new applications by eustas Maladeta, no. 20, 22300 Barbastro, Huesca, Spain: European Stevia Association; 2007. Available from: http://www.eustas.org/ Steviol-glycosides-summary-application.pdf. [Last assessed on 2009 Nov 18].
    • (2007) Steviol Glycosides As Food Additive, Summary of New Applications
    • Geuns, J.M.1
  • 44
    • 0038064401 scopus 로고    scopus 로고
    • Absorption and metabolism of glycosidic sweeteners of stevia mixture and their aglycone, steviol, in rats and humans
    • DOI 10.1016/S0278-6915(03)00039-5
    • Koyama E, Sakai N, Ohori Y, Kitazawa K, Izawa O, Kakegawa K, et al. Absorption and metabolism of glycosidic sweeteners of stevia mixture and their aglycone, steviol, in rats and humans. Food Chem Toxicol 2003;41:875-83. (Pubitemid 36555893)
    • (2003) Food and Chemical Toxicology , vol.41 , Issue.6 , pp. 875-883
    • Koyama, E.1    Sakai, N.2    Ohori, Y.3    Kitazawa, K.4    Izawa, O.5    Kakegawa, K.6    Fujino, A.7    Ui, M.8
  • 45
    • 69249239031 scopus 로고    scopus 로고
    • Steviol effect, a glycoside of Stevia rebaudiana, on glucose clearances in rats
    • Melis MS, Rocha ST, Augusto A. Steviol effect, a glycoside of Stevia rebaudiana, on glucose clearances in rats. Braz J Biol 2009;69:371-4.
    • (2009) Braz J Biol , vol.69 , pp. 371-374
    • Melis, M.S.1    Rocha, S.T.2    Augusto, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.