Functional neuroimaging: An introduction to the technology, methodology, interpretation, and applications

Neuroimaging in Psychiatry

Volumn , Issue , 2003, Pages 1-50

  Russell, Tamara A ^a   Zelaya, Fernando ^a   Bressan, Rodrigo A ^a,b   Bandettini, Peter A ^c  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^c NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 85083255756     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.3109/9780203508343-2     Document Type: Chapter

References (107)

1. Bandettini PA, Wong EC, Hinks RS, Tikofsky RS, Hyde JS. Time course EPI of human brain function during task activation. Magn Reson Med 1992; 25: 390-7.
2. Ogawa S, Tank DW, Menon R et al. Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging. Proc Natl Acad Sci USA 1992; 89: 5951-5.
3. Kwong KK, Belliveau JW, Chesler DA et al. Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation. Proc Natl Acad Sci USA 1992; 89: 5675-9.
4. Menon RS, Ogawa S, Tank DW, Ugurbil K. 4 tesla gradient recalled echo characteristics of photic stimulation - induced signal changes in the human primary visual cortex. Magn Reson Med 1993; 30: 380-6.
5. Turner R, Jezzard P, Wen H et al. Functional mapping of the human visual cortex at 4 and 1.5 tesla using deoxygenation contrast EPI. Magn Reson Med 1993; 29: 277-9.
6. Gati JS, Menon RS, Ugurbil K, Rutt BK. Experimental determination of the BOLD field strength dependence in vessels and tissue. Magn Reson Med 1997; 38: 296-302.
7. Noll D. A primer on MRI and functional MRI (Version 2.1, 6/21/01). http://www.bme.umich.edu/~dnoll/primer2.pdf.
8. Lauterbur PC. Imager formation by induced local interactions. Examples employing nuclear magnetic resonance. Nature 1973; 242: 190-1.
9. Mansfield P, Grannell PK. Diffraction and microscopy in solids and liquids by NMR. Phys Rev B 1975; 12: 3618-34.
10. Cohen MS, Weisskoff RM. Ultra-fast imaging. Magn Reson Imaging 1991; 9: 1-37.
11. Howseman AM, Grootoonk S, Porter DA et al. The effect of slice order and thickness on fMRI activation data using multislice echo-planar imaging. Neuroimage 1999; 9: 363-76.
12. Rosen BR, Belliveau JW, Aronen HJ et al. Susceptibility contrast imaging of cerebral blood volume: human experience. Magn Reson Med 1991; 22: 293-9.
13. Rosen BR, Belliveau JW, Chien D. Perfusion imaging by nuclear magnetic resonance. Magn Reson Quart 1989; 5: 263-81.
14. Belliveau JW, Kennedy DN, McKinstry RC et al. Functional mapping of the human visual cortex by magnetic resonance imaging. Science 1991; 254: 716-19.
15. Williams DS, Detre JA, Leigh JS, Koretsky AS. Magnetic resonance imaging of perfusion using spin-inversion of arterial water. Proc Natl Acad Sci USA 1992; 89: 212-16.
16. Detre JA, Leigh JS, Williams DS, Koretsky AP. Perfusion imaging. Magn Reson Med 1992; 23: 37-45.
17. Kwong KK, Chesler DA, Weisskoff RM, Rosen BR. Perfusion MR imaging. In: Proceedings of SMR, 2nd Annual Meeting, San Francisco, 1994.
18. Wong EC, Buxton RB, Frank LR. Implementation of quantitative perfusion imaging techniques for functional brain mapping using pulsed arterial spin labeling. NMR Biomed 1997; 10: 237-49.
19. Kim S-G. Quantification of relative cerebral blood flow change by flow-sensitive alternating inversion recovery (FAIR) technique: application to functional mapping. Magn Reson Med 1995; 34: 293-301.
20. Ogawa S, Lee TM, Kay AR, Tank DW. Brain magnetic resonance imaging with contrast dependent on blood oxygenation. Proc Natl Acad Sci USA 1990; 87: 9868-72.
21. Turner R, LeBihan D, Moonen CTW, Despres D, Frank J. Echo-planar time course MRI of cat brain oxygenation changes. Magn Reson Med 1991; 22: 159-66.
22. Ogawa S, Lee TM. Functional brain imaging with physiologically sensitive image signals. J Magn Reson Imaging 1992; 2(Suppl): S22.
23. Frahm J, Bruhn H, Merboldt K-D, Hanicke W, Math D. Dynamic MR imaging of human brain oxygenation during rest and photic stimulation. J Magn Reson Imaging 1992; 2: 501-505.
24. Haacke EM, Lai S, Reichenbach JR et al. In vivo measurement of blood oxygen saturation using magnetic resonance imaging: a direct validation of the blood oxygen level-dependent concept in functional brain imaging. Hum Brain Mapping 1997; 5: 341-6.
25. vanZijl PCM, Eleff SM, Ulatowski JA et al. Quantitative assessment of blood flow, blood volume, and blood oxygenation effects in functional magnetic resonance imaging. Nature Med 1998; 4: 159-60.
26. Davis TL, Kwong KK, Weisskoff RM, Rosen BR. Calibrated functional MRI: mapping the dynamics of oxidative metabolism. Proc Natl Acad Sci USA 1998; 95: 1834-9.
27. Kim S-G, Ugurbil K. Comparison of blood oxygenation and cerebral blood flow effects in fMRI: estimation of relative oxygen consumption change. Magn Reson Med 1997; 38: 59-65.
28. Hoge RD, Atkinson J, Gill B, Crelier GR, Marrett S, Pike GB. Investigation of BOLD signal dependence on cerebral blood flow and oxygen consumption: the deoxyhemoglobin dilution model. Magn Reson Med 1999; 42: 849-63.
29. Hoge RD, Atkinson J, Gill B, Crelier GR, Marrett S, Pike GB. Stimulus-dependent BOLD and perfusion dynamics in human V1. Neuroimage 1999; 9: 573-85.
30. Liu TT, Luh W-M, Wong EC, Frank LR, Buxton RB. A method for dynamic measurement of blood volume with compensation for T2 changes. In: Proceedings of ISMRM 8th Annual Meeting, Denver, 2000.
31. Arthurs, OJ, Boniface, S. How well do we understand the origins of the fMRI BOLD signal? Trends Neurosci 2002; 25: 27-31
32. Attwell D, Iadeola C. The neural basis of functional brain imaging signals. Trends Neurosci 2002; 25: 621-5.
33. Pauling L, Coryell CD. The magnetic properties and structure of hemoglobin, oxyhemoglobin, and carbonmonoxyhemoglobin. Proc Natl Acad Sci USA 1936; 22: 210-16.
34. Thulborn KR, Waterton JC, Matthews PM, Radda GK. Oxygenation dependence of the transverse relaxation time of water protons in whole blood at high field. Biochim Biophys Acta 1982; 714: 265-70.
35. Yablonskiy DA. Quantitation of intrinsic magnetic susceptibility-related effects in a tissue matrix. Phantom study. Magn Reson Med 1998; 39: 417-28.
36. Ogawa S, Menon RS, Tank DW et al. Functional brain mapping by blood oxygenation level-dependent contrast magnetic resonance imaging: a comparison of signal characteristics with a biophysical model. Biophysical J 1993; 64: 803-12.
37. Boxerman JL, Hamberg LM, Rosen BR, Weisskoff RM. MR contrast due to intravascular magnetic susceptibility perturbations. Magn Reson Med 1995; 34: 555-66.
38. Kennan RP, Zhong J, Gore JC. Intravascular susceptibility contrast mechanisms in tissues. Magn Reson Med 1994; 31: 9-21.
39. Bandettini PA, Wong EC. Effects of biophysical and physiologic parameters on brain activation-induced R2* and R2 changes: simulations using a deterministic diffusion model. Int J Imaging Sys Technol 1995; 6: 134-52.
40. Weisskoff RM, Zuo CS, Boxerman JL, Rosen BR. Microscopic susceptibility variation and transverse relaxation: theory and experiment. Magn Reson Med 1994; 31: 601-10.
41. Boxerman JL, Bandettini PA, Kwong KK et al. The intravascular contribution to fMRI signal change: Monte Carlo modelling and diffusion-weighted studies in vivo. Magn Reson Med 1995; 34: 4-10.
42. Kim SG, Rostrup E, Larsson HB, Ogawa S, Paulson OB. Determination of relative CMRO2 from CBF and BOLD changes: significant increase of oxygen consumption rate during visual stimulation. Magn Reson Med 1999; 41: 1152-61.
43. An H, Lin W, Celik A, Lee YZ. Quantitative measurements of cerebral metabolic rate of oxygen utilization using MRI: a volunteer study. NMR Biomed 2001; 14: 441-7.
44. Bandettini PA et al. Functional MRI using the BOLD approach: dynamic characteristics and data analysis methods. In D LeBihan (Ed) Diffusion and Perfusion: Magnetic Resonance Imaging (New York: Raven Press 1995) 335-49.
45. Friston KJ, Josephs O, Rees G, Turner R. Nonlinear event-related responses in fMRI. Magn Reson Med 1998; 39: 41-52.
46. Josephs O, Turner R, Friston K. Event-related fMRI. Hum Brain Mapping 1997; 5: 243-8.
47. Cohen MS. Parametric analysis of fMRI data using linear systems methods. Neuroimage 1997; 6: 93-103.
48. Glover GH. Deconvolution of impulse response in event-related BOLD fMRI. Neuroimage 1999; 9: 416-29.
49. Dale AM, Buckner RL. Selective averaging of rapidly presented individual trials using fMRI. Hum Brain Mapping 1997; 5: 329-40.
50. Savoy RL, O’Craven KM, Weisskoff RM, Davis TL, Baker J, Rosen B. Exploring the temporal boundaries of fMRI: measuring responses to very brief visual stimuli. In: Book of Abstracts, Society for Neuroscience 24th Annual Meeting; Miami, 1994.
51. Savoy RL, Bandettini PA, Weisskoff RM et al. Pushing the temporal resolution of fMRI: studies of very brief visual stimuli, onset variablity and asynchrony, and stimulus-correlated changes in noise. In: Proceedings of SMR, 3rd Annual Meeting, Nice, 1995.
52. Saad ZS, Ropella KM, Cox RW, DeYoe EA. Analysis and use of FMRI response delays. Hum Brain Mapping 2001; 13: 74-93.
53. Buckner RL, Bandettini PA, O’Craven KM et al. Detection of cortical activation during averaged single trials of a cognitive task using functional magnetic resonance imaging. Proc Natl Acad Sci USA 1996; 93: 14, 878-83.
54. Lee AT, Glover GH, Meyer CH. Discrimination of large venous vessels in time-course spiral blood-oxygen-level-dependent magntic-resonance functional neuro-imaging. Magn Reson Med 1995; 33: 745-54.
55. Saad ZS, DeYoe EA. Time delay estimates of FMRI signals: efficient algorithm & estimate variance. In: Proceedings of the 19th annual international conference of IEEE/EMBS, Chicago, 1997.
56. Binder JR, Rao SM, Hammeke TA, Frost JA, Bandettini PA, Hyde JS. Effects of stimulus rate on signal response during functional magnetic resonance imaging of auditory cortex. Cognitive Brain Res 1994; 2: 31-8.
57. Rao SM, Bandettini PA, Binder JR et al. Relationship between finger movement rate and functional magnetic resonance signal change in human primary motor cortex. J Cereb Blood Flow Metab 1996; 16: 1250-4.
58. Tootell RB, Reppas JB, Kwong KK et al. Functional analysis of human MT and related visual cortical areas using magnetic resonance imaging. J Neurosci 1995; 15: 3215-30.
59. Disbrow EA, Slutsky DA, Roberts TP, Krubitzer LA. Functional MRI at 1.5 tesla: a comparison of the blood oxygenation level-dependent signal and electrophysiology. Proc Natl Acad Sci USA 2000; 97: 9718-23.
60. Rees G, Friston K, Koch C. A direct quantitative relationship between the functional properties of human and macaque V5. Nat Neurosci 2000; 3: 716-23.
61. Heeger DJ, Huk AC, Geisler WS, Albrecht DG. Spikes versus BOLD: what does neuroimaging tell us about neuronal activity? Nat Neurosci 2000; 3: 631-3.
62. Logothetis N, Pauls J, Augath M, Trinath T, Oeltermann A. Neurophysiological investigation of the basis of the fMRI signal. Nature 2001; 412: 150-7.
63. Boynton GM, Engel SA, Glover GH, Heeger DJ. Linear systems analysis of functional magnetic resonance imaging in human V1. J Neurosci 1996; 16: 4207-21.
64. Vazquez AL, Noll DC. Nonlinear aspects of the BOLD response in functional MRI. Neuroimage 1998; 7: 108-18.
65. Buxton RB, Wong EC, Frank LR. A biomechanical interpretation of the BOLD signal time course: the balloon model. In: Proceedings of the ISMRM, 5th Annual Meeting, Vancouver, 1997.
66. Frahm J, Krüger G, Merboldt K-D, Kleinschmidt A. Dynamic uncoupling and recoupling of perfusion and oxidative metabolism during focal activation in man. Magn Reson Med 1996; 35: 143-8.
67. Busatto GF, Pilowsky LS. Neuroreceptor imaging with PET and SPET: research and clinical applications. In: (Kerwin R, ed) Neurobiology and Psychiatry - Neuroimaging. (Cambridge University Press: Cambridge, 1995) 111-24.
68. Fugita M., Innis RB. In vivo molecular imaging: ligand development and research application. In: (Davis KL, Charney D, Coyle JT, Nemeroff CB, eds) Psychopharmacology: the Fifth Generation of Progress. (Raven Press Ltd: New York, 2002) 411-25.
69. Meikle SR, Dahlbom M. Positron emission tomography. In: (Murray IPC, Ell PJ, eds) Nuclear Medicine in Clinical Diagnosis and Treatment. (Churchill Livingstone: London, 1998) 1603-16.
70. Walker B, Jarrit P. Basic physics of nuclear medicine. In: (Murray IPC, Ell PJ, eds) Nuclear Medicine in Clinical Diagnosis and Treatment. (Churchill Livingstone: London, 1998) 1445-58.
71. Reba RC. PET and SPECT: opportunities and challenges for psychiatry. J Clin Psychiatry 1993; 54: 26-32.
72. Mallison RT. Positron and single photon emission tomography. In: (Bloom FE, Kupfer DJ, eds) Psychopharmacology: the Fourth Generation of Progress. (Raven Press Ltd: New York, 1994) 865-79.
73. Eberl S, Zimmerman RE. Nuclear medicine imaging instrumentation. In: (Murray IPC, Ell PJ, eds) Nuclear Medicine in Clinical Diagnosis and Treatment. (Churchill Livingstone: London, 1998) 1559-69.
74. Westera G, Buck A, Burger C, Leenders KL, von Schulthess GK, Schubiger AP. Carbon-11 and iodine-123 labelled iomazenil: a direct PET-SPET comparison. Eur J Nucl Med 1996; 23: 5-12.
75. Pike VW. Positron-emitting radioligand for studies in vivo - probes for human psychopharmacology. J Psychopharmacol 1993; 7: 139-58.
76. Halldin C, Gulyas B, Langer O, Farde L. Brain radioligands - state of the art and new trends. Q J Nucl Med 2001; 45: 139-52.
77. Mintun MA, Raichle ME, Kilbourn MR, Wooten GF, Welch MJ. A quantitative model for the in vivo assessment of drug binding sites with positron emission tomography. Ann Neurol 1984; 15: 217-27.
78. Laruelle M. The role of model-based methods in the development of single scan techniques. Nucl Med Biol 2000; 27: 637-42.
79. Carson RE. Precision and accuracy considerations of physiological quantitation in PET. J Cereb Blood Flow Metab 1991; 11: A45-A50.
80. Laruelle M, Abi-Dargham A, al Tikriti MS et al. SPECT quantification of [123I]iomazenil binding to benzodiazepine receptors in nonhuman primates: II. Equilibrium analysis of constant infusion experiments and correlation with in vitro parameters. J Cereb Blood Flow Metab 1994; 14: 453-65.
81. Laruelle M, Baldwin RM, Rattner Z et al. SPECT quantification of [123I]iomazenil binding to benzodiazepine receptors in nonhuman primates: I. Kinetic modeling of single bolus experiments. J Cereb Blood Flow Metab 1994; 14: 439-52.
82. Logan J, Volkow ND, Fowler JS et al. Effects of blood flow on [11C]raclopride binding in the brain: model simulations and kinetic analysis of PET data. J Cereb Blood Flow Metab 1994; 14: 995-1010.
83. Lammertsma AA, Hume SP. Simplified reference tissue model for PET receptor studies. Neuroimage 1996; 4: 153-8.
84. Carson RE, Channing MA, Blasberg RG et al. Comparison of bolus and infusion methods for receptor quantitation: application to [18F]cyclofoxy and positron emission tomography. J Cereb Blood Flow Metab 1993; 13: 24-42.
85. Farde L, Hall H, Ehrin E, Sedvall G. Quantitative analysis of D2 dopamine receptor binding in the living human brain by PET. Science 1986; 231: 258-61.
86. Carson RE. PET physiological measurements using constant infusion. Nucl Med Biol 2000; 27: 657-60.
87. Innis RB, al Tikriti MS, Zoghbi SS et al. SPECT imaging of the benzodiazepine receptor: feasibility of in vivo potency measurements from stepwise displacement curves. J Nucl Med 1991; 32: 1754-61.
88. Friston KJ, Price CJ, Fletcher P, Moore C, Frackowiak RSJ, Dolan RJ. The trouble with cognitive subtraction. Neuroimage 1996; 4: 97-104.
89. Bandettini PA, Jesmanowicz A, Wong EC, Hyde JS. Processing strategies for time-course data sets in functional MRI of the human brain. Magn Reson Med 1993; 30: 161-73.
90. Bandettini PA. Magnetic resonance imaging of human brain activation using endogenous susceptibility contrast. PhD Thesis, Milwaukee: Medical College of Wisconsin, 1995.
91. Engel SA, Glover GH, Wandell BA. Retinotopic organization in human visual cortex and the spatial precision of functional MRI. Cerebral Cortex 1997; 7: 181-92.
92. Sereno MI, Dale AM, Reppas JR et al. Functional MRI reveals borders of multiple visual areas in humans. Science 1995; 268: 889-93.
93. DeYoe EA, Carman G, Bandettini P et al. Mapping striate and extrastriate areas in human cerebral cortex. Proc Natl Acad Sci USA 1996; 93: 2382-6.
94. Servos P, Zacks J, Rumelhart DE, Glover GH. Somatotopy of the human arm using fMRI. Neuroreport 1998; 9: 605-9.
95. Talavage TM, Ledden PJ, Sereno MI, Benson RR, Rosen BR. Preliminary fMRI evidence for tonotopicity in human auditory cortex. Neuroimage 1996; 3: S355.
96. Zarahn E, Aguirre G, D’Esposito M. A trial-based experimental design for fMRI. Neuroimage 1997; 6: 122-38.
97. Clark VP, Maisog JM, Haxby JV. fMRI study of face perception and memory using random stimulus sequences. J Neurophysiol 1998; 79: 3257-65.
98. Dale A, Buckner R. Selective averaging of individual trials using fMRI. In: Third International Conference on Functional Mapping of the Human Brain, Copenhagen, 1997.
99. McCarthy G, Luby M, Gore J, Goldman-Rakic P. Infrequent events transiently activate human prefrontal and parietal cortex as measured by functional MRI. J Neurophysiol 1997; 77: 1630-4.
100. Schacter DL, Buckner RL, Koutstaal W, Dale AM, Rosen BR. Late onset of anterior prefrontal activity during true and false recognition: an event-related fMRI study. Neuroimage 1997; 6: 259-69.
101. Dale AM. Optimal experimental design for event-related fMRI. Hum Brain Mapping 1999; 8: 109-14.
102. Burock MA, Buckner RL, Woldorff MG, Rosen BR, Dale AM. Randomized event-related experimental designs allow for extremely rapid presentation rates using functional MRI. Neuroreport 1998; 9: 3735-9.
103. Liu TT, Frank LR, Wong EC, Buxton RB. Detection power, estimation efficiency, and predictability in event-related fMRI. Neuroimage 2001; 13: 759-73.
104. Birn RM, Cox RW, Bandettini PA. Detection versus estimation in event-related fMRI: choosing the optimal stimulus timing. Neuroimage 2002; 15: 252-64.
105. Courtney SM, Ungerleider LG, Keil K, Haxby JV. Transient and sustained activity in a distributed neural system for human working memory. Nature 1997; 386: 608-11.
106. Patterson J, Bandettini P, Ungerleider LG. Simultaneous skin conductance measurement and fMRI during cognitive tasks: correlations of skin conductance activity with ventromedial prefrontal cortex (PFC) and orbitofrontal cortex (OFC) activity. In: Proceedings of Human Brain Mapping, San Antonio, 2000.
107. Shergill SS, Bullmore E, Simmons A, Murray R, McGuire P. Functional anatomy of auditory verbal imagery in schizophrenic patients with auditory hallucinations. Am J Psychiatry 2000; 157: 1691-3.