New nutraceutical combination reduces blood pressure and improves exercise capacity in hypertensive patients via a nitric oxide–dependent mechanism

Journal of the American Heart Association

Volumn 9, Issue 5, 2020, Pages

  Carrizzo, Albino ^a   Moltedo, Ornella ^b   Damato, Antonio ^a   Martinello, Katiuscia ^a   Di Pietro, Paola ^c   Oliveti, Marco ^c   Acernese, Fausto ^b   Giugliano, Giuseppe ^d   Izzo, Raffaele ^d   Sommella, Eduardo ^b   Migliarino, Serena ^e   Piazza, Ornella ^c   Izzo, Carmine ^c   Virtuoso, Nicola ^f   Strianese, Andrea ^c   Trimarco, Valentina ^f   Campiglia, Pietro ^b   Fucile, Sergio ^a,g   Puca, Annibale ^c,h   Trimarco, Bruno ^d   Vecchione, Carmine ^a,c   more..

^a IRCCS NEUROMED   (Italy)

^b UNIVERSITY OF SALERNO   (Italy)

^c UNIVERSITY OF SALERNO   (Italy)

^d UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^e SAPIENZA UNIVERSITY OF ROME   (Italy)

^f FEDERICO II UNIVERSITY HOSPITAL   (Italy)

^g SAPIENZA UNIVERSITY OF ROME   (Italy)

^h IRCCS MULTIMEDICA   (Italy)

Author keywords

Exercise capacity; Nitric oxide; Vascular biology

Indexed keywords

AKP 05; ANTIHYPERTENSIVE AGENT; BACOPA MONNIERI EXTRACT; CONNEXIN 37; CONNEXIN 43; DIURETIC AGENT; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GINKGO BILOBA EXTRACT; NITRIC OXIDE; NUTRACEUTICAL; PHOSPHOLIPASE C; PLACEBO; PROTEIN KINASE B; PROTEIN KINASE C ALPHA; RAC1 PROTEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SINECATECHINS; UNCLASSIFIED DRUG; PHOSPHATIDYLSERINE; PLANT MEDICINAL PRODUCT;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIHYPERTENSIVE ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD PRESSURE MEASUREMENT; BLOOD PRESSURE REGULATION; CALCIUM TRANSPORT; CARDIOPULMONARY EXERCISE TEST; CARDIOVASCULAR RESPONSE; CARDIOVASCULAR RISK; CASMC CELL LINE; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DOUBLE BLIND PROCEDURE; DRUG BIOAVAILABILITY; DRUG EFFICACY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; EXERCISE; FUNCTIONAL STATUS; HEART HEMODYNAMICS; HUMAN; HUMAN CELL; HUVEC CELL LINE; HYPERTENSION; IN VIVO STUDY; INTRACELLULAR SIGNALING; MAJOR CLINICAL STUDY; MESENTERIC ARTERY; MOUSE; NONHUMAN; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PHYSIOLOGICAL STRESS; RISK REDUCTION; SUPPLEMENTATION; SYSTOLIC BLOOD PRESSURE; TREATMENT DURATION; VASODILATATION; ANIMAL; BACOPA; BLOOD; CAMELLIA SINENSIS; DIETARY SUPPLEMENT; EXERCISE TEST; EXERCISE TOLERANCE; FEMALE; GINKGO BILOBA; MALE; MIDDLE AGED; PATHOPHYSIOLOGY; PHYSIOLOGY; PHYTOTHERAPY; RANDOMIZED CONTROLLED TRIAL;

ADULT; AGED; ANIMALS; BACOPA; CAMELLIA SINENSIS; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; EXERCISE TEST; EXERCISE TOLERANCE; FEMALE; GINKGO BILOBA; HUMANS; HYPERTENSION; MALE; MICE; MIDDLE AGED; NITRIC OXIDE; PHOSPHATIDYLSERINES; PHYTOTHERAPY; PLANT PREPARATIONS; REACTIVE OXYGEN SPECIES;

EID: 85079767341     PISSN: None     EISSN: 20479980     Source Type: Journal    
DOI: 10.1161/JAHA.119.014923     Document Type: Article

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