Amotosalen and ultraviolet A light efficiently inactivate MERS-coronavirus in human platelet concentrates

Transfusion Medicine

Volumn 29, Issue 6, 2019, Pages 434-441

  Hashem, A M ^a,b   Hassan, A M ^a   Tolah, A M ^a   Alsaadi, M A ^a   Abunada, Q ^c   Damanhouri, G A ^b   El Kafrawy, S A ^a   Picard Maureau, M ^c   Azhar, E I ^a   Hindawi, S I ^b  

^a KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

^b Aziz University   (Saudi Arabia)

^c Cerus Europe BV   (Netherlands)

Author keywords

amotosalen; MERS CoV; pathogen inactivation; platelets; UVA

Indexed keywords

AMOTOSALEN; GENOMIC RNA; MESSENGER RNA; THROMBOCYTE CONCENTRATE; VIRUS RNA; FUROCOUMARIN DERIVATIVE;

ANIMAL CELL; APHERESIS; ARTICLE; CONTROLLED STUDY; HUMAN; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; NONHUMAN; PLAQUE ASSAY; PLATELET COUNT; REAL TIME REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SAUDI ARABIA; THROMBOCYTE TRANSFUSION; ULTRAVIOLET A RADIATION; VASCULARIZATION; VERO C1008 CELL LINE; VIRUS GENOME; VIRUS INACTIVATION; VIRUS ISOLATION; VIRUS LOAD; VIRUS PARTICLE; VIRUS REPLICATION; VIRUS TRANSMISSION; ANIMAL; BLOOD SAFETY; CHLOROCEBUS AETHIOPS; DRUG EFFECT; RADIATION RESPONSE; THROMBOCYTE; ULTRAVIOLET RADIATION; VERO CELL LINE; VIROLOGY;

ANIMALS; BLOOD PLATELETS; BLOOD SAFETY; CHLOROCEBUS AETHIOPS; FUROCOUMARINS; HUMANS; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; ULTRAVIOLET RAYS; VERO CELLS; VIRUS INACTIVATION;

EID: 85074770711     PISSN: 09587578     EISSN: 13653148     Source Type: Journal    
DOI: 10.1111/tme.12638     Document Type: Article

References (36)

1. Al-Amri, S.S., Abbas, A.T., Siddiq, L.A., Alqhamdi, A., Al-Muhanna, M.K., Alhabbab, R.Y., Azhar, E.I. & Hashem, A.M. (2017) Immunogenicity of candidate MERS-CoV DNA vaccines based on the spike protein. Scientific Reports, 7, 44875.
2. Almekhlafi, G.A., Albarrak, M.M., Mandourah, Y. et al. (2016) Presentation and outcome of Middle East respiratory syndrome in Saudi intensive care unit patients. Critical Care, 20, 123.
3. Alshukairi, A.N., Zheng, J., Zhao, J. et al. (2018) High prevalence of MERS CoV infection in camel Workers in Saudi Arabia. MBio, 9, e01985–e01918.
4. Arabi, Y.M., Balkhy, H.H., Hayden, F.G. et al. (2017) Middle East respiratory syndrome. New England Journal of Medicine, 376, 584–594.
5. Azhar, E.I., El-Kafrawy, S.A., Farraj, S.A., Hassan, A.M., Al-Saeed, M.S., Hashem, A.M. & Madani, T.A. (2014) Evidence for camel-to-human transmission of MERS coronavirus. New England Journal of Medicine, 370, 2499–2505.
6. Benjamin, R.J., Braschler, T., Weingand, T. & Corash, L.M. (2017) Hemovigilance monitoring of platelet septic reactions with effective bacterial protection systems. Transfusion, 57, 2946–2957.
7. Candotti, D., Assennato, S.M., Laperche, S., Allain, J.P. & Levicnik-Stezinar, S. (2018) Multiple HBV transfusion transmissions from undetected occult infections: revising the minimal infectious dose. Gut, 68, 313–321.
8. Cappy, P., Barlet, V., Lucas, Q., Tinard, X., Pillonel, J., Gross, S., Tiberghien, P. and Laperche S. (2019) Transfusion of HIV-infected blood products despite highly sensitive nucleic acid testing. Transfusion, 59, 2046–2053.
9. Castro, G., Merkel, P.A., Giclas, H.E. et al. (2018) Amotosalen/UVA treatment inactivates T cells more effectively than the recommended gamma dose for prevention of transfusion-associated graft-versus-host disease. Transfusion, 58, 1506–1515.
10. Chu, H., Zhou, J., Wong, B.H. et al. (2016) Middle East respiratory syndrome coronavirus efficiently infects human primary T lymphocytes and activates the extrinsic and intrinsic apoptosis pathways. The Journal of Infectious Diseases, 213, 904–914.
11. Chu, H., Zhou, J., Wong, B.H. et al. (2014) Productive replication of Middle East respiratory syndrome coronavirus in monocytederived dendritic cells modulates innate immune response. Virology, 454-455, 197–205.
12. Cid, J., Escolar, G. & Lozano, M. (2012) Therapeutic efficacy of platelet components treated with amotosalen and ultraviolet a pathogen inactivation method: results of a meta-analysis of randomized controlled trials. Vox Sanguinis, 103, 322–330.
13. Corman, V.M., Albarrak, A.M., Omrani, A.S. et al. (2016) Viral shedding and antibody response in 37 patients with MERS-coronavirus infection. Clinical Infectious Diseases, 62, 477–483.
14. Eickmann, M., Gravemann, U., Handke, W., Tolksdorf, F., Reichenberg, S., Müllert, T.H. & Seltsam, A. (2018) Inactivation of Ebola virus and Middle East respiratory syndrome coronavirus in platelet concentrates and plasma by ultraviolet C light and methylene blue plus visible light, respectively. Transfusion, 58, 2202–2207.
15. Hashem, A.M., Algaissi, A., Agrawal, A., Al-amri, S.S., Alhabbab, R.Y., Sohrab, S.S., Almasoud, A., Alharbi, N.K., Peng, B.H., Russell, M., Li, X., Tseng, C.T. (2019) A highly immunogenic, protective and safe adenovirus-based vaccine expressing MERS-CoV S1-CD40L fusion protein in transgenic human DPP4 mouse model. The Journal of Infectious Diseases, 220, 1558–1567. https://doi.org/10.1093/infdis/jiz137
16. Hindawi, S.I., Hashem, A.M., Damanhouri, G.A., El-Kafrawy, S.A., Tolah, A.M., Hassan, A.M. & Azhar, E.I. (2018) Inactivation of Middle East respiratory syndrome-coronavirus in human plasma using amotosalen and ultraviolet a light. Transfusion, 58, 52–59.
17. Jutzi, M., Mansouri, B., Rueesch, M., Amsler, L. & Buser, A. (2018) Nationwide implementation of pathogen inactivation for all platelet concentrates in Switzerland. Transfusion Medicine and Hemotherapy, 45, 151–156.
18. Keil, S.D., Bowen, R. & Marschner, S. (2016) Inactivation of Middle East respiratory syndrome coronavirus (MERS-CoV) in plasma products using a riboflavin-based and ultraviolet light-based photochemical treatment. Transfusion, 56, 2948–2552.
19. Kim, S.Y., Park, S.J., Cho, S.Y. et al. (2016) Viral RNA in blood as Indicator of severe outcome in Middle East respiratory syndrome coronavirus infection. Emerging Infectious Diseases, 22, 1813–1816.
20. Lanteri, M.C., Kleinman, S.H., Glynn, S.A., Musso, D., Hoots, W.K., Custer, B.S., Sabino, E.C. & Busch, M.P. (2016) Zika virus: a new threat to the safety of the blood supply with worldwide impact and implications. Transfusion, 56, 1907–1914.
21. Lessler, J., Salje, H., Van Kerkhove, M.D. et al. (2016) Estimating the severity and subclinical burden of Middle East respiratory syndrome coronavirus infection in the Kingdom of Saudi Arabia. American Journal of Epidemiology, 83, 657–663.
22. Mackay, I.M. & Arden, K.E. (2015) Middle East respiratory syndrome: an emerging coronavirus infection tracked by the crowd. Virus Research, 202, 60–88.
23. Memish, Z.A., Assiri, A.M. & Al-Tawfiq, J.A. (2014) Middle East respiratory syndrome coronavirus (MERS-CoV) viral shedding in the respiratory tract: an observational analysis with infection control implications. International Journal of Infectious Diseases, 29, 307–308.
24. Min, C.K., Cheon, S., Ha, N.Y. et al. (2016) Comparative and kinetic analysis of viral shedding and immunological responses in MERS patients representing a broad spectrum of disease severity. Scientific Reports, 6, 25359.
25. Müller, M.A., Meyer, B., Corman, V.M. et al. (2015) Presence of Middle East respiratory syndrome coronavirus antibodies in Saudi Arabia: a nationwide, cross-sectional, serological study. Lancet Infectious Diseases, 15, 629.
26. Musso, D., Richard, V., Broult, J. & Cao-Lormeau, V.M. (2014) Inactivation of dengue virus in plasma with amotosalen and ultraviolet a illumination. Transfusion, 54, 2924–2930.
27. Pinna, D., Sampson-Johannes, A., Clementi, M., Poli, G., Rossini, S., Lin, L. & Vicenzi, E. (2005) Amotosalen photochemical inactivation of severe acute respiratory syndrome coronavirus in human platelet concentrates. Transfusion Medicine, 15, 269–276.
28. Prowse, C. (2013) Component pathogen inactivation: a critical review. Vox Sanguinis, 104, 183–199.
29. Santa Maria, F., Laughhunn, A., Lanteri, M.C., Aubry, M., Musso, D. & Stassinopoulos, A. (2017) Inactivation of Zika virus in platelet components using amotosalen and ultraviolet a illumination. Transfusion, 57, 2016–2025.
30. Schlenke, P. (2014) Pathogen inactivation Technologies for Cellular Blood Components: an update. Transfusion Medicine and Hemotherapy, 41, 309–325.
31. Shehata, M.M., Gomaa, M.R., Ali, M.A. & Kayali, G. (2016) Middle East respiratory syndrome coronavirus: a comprehensive review. Frontiers of Medicine, 10, 120–136.
32. Stramer, S.L. (2014) Current perspectives in transfusion-transmitted infectious diseases: emerging and re-emerging infections. ISBT Science Series, 9, 30–36.
33. Vairo, F., Mammone, A., Lanini, S. et al. (2018) Local transmission of chikungunya in Rome and the Lazio region, Italy. PLoS One, 13, e0208896.
34. World Health Organization. Middle East respiratory syndrome coronavirus (MERS-CoV). [cited 2019 May 30] https://www.who.int/emergencies/mers-cov/en/.
35. Zaki, A.M., van, Boheemen, S., Bestebroer, T.M., Osterhaus, A.D. & Fouchier, R.A. (2012) Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia. New England Journal of Medicine, 367, 1814–1820.
36. Zhou, J., Chu, H., Li, C. et al. (2014) Active replication of Middle East respiratory syndrome coronavirus and aberrant induction of inflammatory cytokines and chemokines in human macrophages: implications for pathogenesis. The Journal of Infectious Diseases, 209, 1331–1342.