Viral RNA in blood as indicator of severe outcome in middle east respiratory syndrome coronavirus infection

Emerging Infectious Diseases

Volumn 22, Issue 10, 2016, Pages 1813-1816

  Kim, So Yeon ^a   Park, Sun Jae ^a   Cho, Sook Young ^a   Cha, Ran Hui ^a   Jee, Hyeon Gun ^a   Kim, Gayeon ^a   Shin, Hyoung Shik ^a   Kim, Yeonjae ^a   Jung, Yu Mi ^a   Yang, Jeong Sun ^b   Kim, Sung Soon ^b   Cho, Sung Im ^c   Kim, Man Jin ^c   Lee, Jee Soo ^c   Lee, Seung Jun ^c   Seo, Soo Hyun ^c   Park, Sung Sup ^c   Seong, Moon Woo ^c  

^a National Medical Center   (South Korea)

^b Korea Centers for Disease Control and Prevention   (South Korea)

^c Seoul National University College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS RNA;

ADULT; AGED; ARTICLE; BLOOD ANALYSIS; CLINICAL ARTICLE; CLINICAL FEATURE; CORONAVIRUS INFECTION; FEMALE; FEVER; GENE AMPLIFICATION; HOSPITAL ADMISSION; HUMAN; MALE; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; OUTCOME ASSESSMENT; PATIENT MONITORING; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SURVIVAL RATE; VIRUS LOAD; BLOOD; EPIDEMIC; EVALUATION STUDY; GENETICS; MIDDLE AGED; PROGNOSIS; SOUTH KOREA; VERY ELDERLY; VIROLOGY; YOUNG ADULT;

ADULT; AGED; AGED, 80 AND OVER; CORONAVIRUS INFECTIONS; DISEASE OUTBREAKS; FEMALE; HUMANS; MALE; MIDDLE AGED; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; PATIENT OUTCOME ASSESSMENT; PROGNOSIS; REPUBLIC OF KOREA; RNA, VIRAL; YOUNG ADULT;

EID: 84988504884     PISSN: 10806040     EISSN: 10806059     Source Type: Journal    
DOI: 10.3201/eid2210.160218     Document Type: Article

References (15)

1. Zaki AM, van Boheemen S, Bestebroer TM, Osterhaus AD, Fouchier RA. Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia. N Engl J Med. 2012;367:1814–20. http://dx.doi.org/10.1056/NEJMoa1211721
2. Zumla A, Hui DS, Perlman S. Middle East respiratory syndrome. Lancet. 2015;386:995–1007. http://dx.doi.org/10.1016/S0140-6736(15)60454-8
3. Majumder MS, Kluberg SA, Mekaru SR, Brownstein JS. Mortality risk factors for Middle East respiratory syndrome outbreak, South Korea, 2015. Emerg Infect Dis. 2015;21:2088–90. http://dx.doi.org/10.3201/eid2111.151231
4. Feikin DR, Alraddadi B, Qutub M, Shabouni O, Curns A, Oboho IK, et al. Association of higher MERS-CoV virus load with severe disease and death, Saudi Arabia, 2014. Emerg Infect Dis. 2015;21:2029–35. http://dx.doi.org/10.3201/eid2111.150764
5. World Health Organization. Laboratory testing for Middle East respiratory syndrome coronavirus. Interim guidance (revised) [cited 2015 Oct 15]. http://apps.who.int/iris/bitstream/10665/176982/1/WHO_MERS_LAB_15.1_eng.pdf
6. Chan JF, Chan KH, Choi GK, To KK, Tse H, Cai JP, et al. Differential cell line susceptibility to the emerging novel human betacoronavirus 2c EMC/2012: implications for disease pathogenesis and clinical manifestation. J Infect Dis. 2013;207:1743–52. http://dx.doi.org/10.1093/infdis/jit123
7. Chu H, Zhou J, Wong BH, Li C, Chan JF, Cheng ZS, et al. Middle East respiratory syndrome coronavirus efficiently infects human primary T lymphocytes and activates the extrinsic and intrinsic apoptosis pathways. J Infect Dis. 2016;213:904–14. http://dx.doi.org/10.1093/infdis/jiv380
8. Guery B, Poissy J, el Mansouf L, Séjourné C, Ettahar N, Lemaire X, et al.; MERS-CoV study group. Clinical features and viral diagnosis of two cases of infection with Middle East respiratory syndrome coronavirus: a report of nosocomial transmission. Lancet. 2013;381:2265–72. http://dx.doi.org/10.1016/S0140-6736(13)60982-4
9. Drosten C, Seilmaier M, Corman VM, Hartmann W, Scheible G, Sack S, et al. Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection. Lancet Infect Dis. 2013;13:745–51. http://dx.doi.org/10.1016/S1473-3099(13)70154-3
10. Poissy J, Goffard A, Parmentier-Decrucq E, Favory R, Kauv M, Kipnis E, et al.; MERS-CoV Biology Group. Kinetics and pattern of viral excretion in biological specimens of two MERS-CoV cases. J Clin Virol. 2014;61:275–8. Erratum in: J Clin Virol. 2015, 63:94. http://dx.doi.org/10.1016/j.jcv.2014.07.002
11. Korea Centers for Disease Control and Prevention. Middle East respiratory syndrome coronavirus outbreak in the Republic of Korea, 2015. Osong Public Health Res Perspect. 2015; 6:269–78. Erratum in: Osong Public Health Res Perspect. 2016. http://dx.doi.org/10.1016/j.phrp.2015.08.006
12. Corman VM, Eckerle I, Bleicker T, Zaki A, Landt O, Eschbach-Bludau M, et al. Detection of a novel human coronavirus by real-time reverse-transcription polymerase chain reaction. Euro Surveill. 2012;17:20285.
13. Lu X, Whitaker B, Sakthivel SK, Kamili S, Rose LE, Lowe L, et al. Real-time reverse transcription–PCR assay panel for Middle East respiratory syndrome coronavirus. J Clin Microbiol. 2014;52:67–75. http://dx.doi.org/10.1128/JCM.02533-13
14. Corman VM, Albarrak AM, Omrani AS, Albarrak MM, Farah ME, Almasri M, et al. Viral shedding and antibody response in 37 patients with Middle East respiratory syndrome coronavirus infection. Clin Infect Dis. 2016;62:477–83.
15. Ng EK, Hui DS, Chan KC, Hung EC, Chiu RW, Lee N, et al. Quantitative analysis and prognostic implication of SARS coronavirus RNA in the plasma and serum of patients with severe acute respiratory syndrome. Clin Chem. 2003;49:1976–80. http://dx.doi.org/10.1373/clinchem.2003.024125