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Volumn 9, Issue , 2015, Pages

The down syndrome biomarker initiative (DSBI) pilot: Proof of concept for deep phenotyping of Alzheimer's disease biomarkers in down syndrome

Author keywords

Alzheimer's disease; Amyloid; Biomarkers; Down syndrome; MRI; PET; Plasma; Retinal

Indexed keywords

AMYLOID BETA PROTEIN; APOLIPOPROTEIN E; BIOLOGICAL MARKER; FLUORODEOXYGLUCOSE F 18;

EID: 85074109354     PISSN: 16625153     EISSN: None     Source Type: Journal    
DOI: 10.3389/fnbeh.2015.00239     Document Type: Article
Times cited : (70)

References (44)
  • 1
    • 77952426708 scopus 로고    scopus 로고
    • Brain anatomy and ageing in non-demented adults with down's syndrome: An in vivo MRI study
    • Beacher, F., Daly, E., Simmons, A., Prasher, V., Morris, R., Robinson, C., et al. (2010). Brain anatomy and ageing in non-demented adults with down's syndrome: an in vivo MRI study. Psychol. Med. 40, 611-619. doi: 10. 1017/s0033291709990985
    • (2010) Psychol. Med. , vol.40 , pp. 611-619
    • Beacher, F.1    Daly, E.2    Simmons, A.3    Prasher, V.4    Morris, R.5    Robinson, C.6
  • 2
    • 0001677717 scopus 로고
    • Controlling the false discovery rate: A practical and powerful approach to multiple testing
    • Benjamini, Y., and Hochberg, Y. (1995). Controlling the false discovery rate: a practical and powerful approach to multiple testing. J. R. Stat. Soc. Series B 57, 289-300.
    • (1995) J. R. Stat. Soc. Series B , vol.57 , pp. 289-300
    • Benjamini, Y.1    Hochberg, Y.2
  • 3
    • 0025868212 scopus 로고
    • The diagnosis of dementia in the elderly. A comparison of CAMCOG (the cognitive section of CAMDEX), the AGECAT program, DSM-III, the Mini-Mental State Examination and some short rating scales
    • Blessed, G., Black, S. E., Butler, T., and Kay, D. W. (1991). The diagnosis of dementia in the elderly. A comparison of CAMCOG (the cognitive section of CAMDEX), the AGECAT program, DSM-III, the Mini-Mental State Examination and some short rating scales. Br. J. Psychiatry 159, 193-198. doi: 10.1192/bjp.159.2.193
    • (1991) Br. J. Psychiatry , vol.159 , pp. 193-198
    • Blessed, G.1    Black, S.E.2    Butler, T.3    Kay, D.W.4
  • 4
    • 64649093241 scopus 로고    scopus 로고
    • Fully-automated quantification of regional brain volumes for improved detection of focal atrophy in Alzheimer disease
    • Brewer, J. B., Magda, S., Airriess, C., and Smith, M. E. (2009). Fully-automated quantification of regional brain volumes for improved detection of focal atrophy in Alzheimer disease. AJNR Am. J. Neuroradiol. 30, 578-580. doi: 10. 3174/ajnr.a1402
    • (2009) AJNR Am. J. Neuroradiol. , vol.30 , pp. 578-580
    • Brewer, J.B.1    Magda, S.2    Airriess, C.3    Smith, M.E.4
  • 6
    • 0026493238 scopus 로고
    • Dementia in down syndrome: Methods of evaluation
    • Dalton, A. J. (1992). Dementia in down syndrome: methods of evaluation. Prog. Clin. Biol. Res. 379, 51-76.
    • (1992) Prog. Clin. Biol. Res. , vol.379 , pp. 51-76
    • Dalton, A.J.1
  • 7
    • 0033623888 scopus 로고    scopus 로고
    • APOE epsilon 4 influences the manifestation of Alzheimer's disease in adults with down's syndrome
    • Deb, S., Braganza, J., Norton, N., Williams, H., Kehoe, P. G., Williams, J., et al. (2000). APOE epsilon 4 influences the manifestation of Alzheimer's disease in adults with down's syndrome. Br. J. Psychiatry 176, 468-472. doi: 10.1192/bjp. 176.5.468
    • (2000) Br. J. Psychiatry , vol.176 , pp. 468-472
    • Deb, S.1    Braganza, J.2    Norton, N.3    Williams, H.4    Kehoe, P.G.5    Williams, J.6
  • 8
    • 84942198358 scopus 로고    scopus 로고
    • Longitudinal plasma amyloid beta in Alzheimer's disease clinical trials
    • Epub ahead of print
    • Donohue, M. C., Moghadam, S. H., Roe, A. D., Sun, C. K., Edland, S. D., Thomas, R. G., et al. (2014). Longitudinal plasma amyloid beta in Alzheimer's disease clinical trials. Alzheimers. Dement. doi: 10.1016/j.jalz.2014.07.156 [Epub ahead of print].
    • (2014) Alzheimers. Dement
    • Donohue, M.C.1    Moghadam, S.H.2    Roe, A.D.3    Sun, C.K.4    Edland, S.D.5    Thomas, R.G.6
  • 9
    • 0346787627 scopus 로고    scopus 로고
    • Reliability and validity of an assessment instrument for anxiety, depression and mood among individuals with mental retardation
    • Esbensen, A. J., Rojahn, J., Aman, M. G., and Ruedrich, S. (2003). Reliability and validity of an assessment instrument for anxiety, depression and mood among individuals with mental retardation. J. Autism Dev. Disord. 33, 617-629. doi: 10. 1023/b:jadd.0000005999.27178.55
    • (2003) J. Autism Dev. Disord. , vol.33 , pp. 617-629
    • Esbensen, A.J.1    Rojahn, J.2    Aman, M.G.3    Ruedrich, S.4
  • 10
    • 18244406829 scopus 로고    scopus 로고
    • Whole brain segmentation: Automated labeling of neuroanatomical structures in the human brain
    • Fischl, B., Salat, D. H., Busa, E., Albert, M., Dieterich, M., Haselgrove, C., et al. (2002). Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain. Neuron 33, 341-355. doi: 10.1016/S0896-6273(02)00569-X
    • (2002) Neuron , vol.33 , pp. 341-355
    • Fischl, B.1    Salat, D.H.2    Busa, E.3    Albert, M.4    Dieterich, M.5    Haselgrove, C.6
  • 11
    • 39549083869 scopus 로고    scopus 로고
    • The observer memory questionnaire-parent form: Introducing a new measure of everyday memory for children
    • Gonzalez, L. M., Anderson, V. A., Wood, S. J., Mitchell, L. A., Heinrich, L., and Harvey, A. S. (2008). The observer memory questionnaire-parent form: introducing a new measure of everyday memory for children. J. Int. Neuropsychol. Soc. 14, 337-342. doi: 10.1017/s1355617708 08020x
    • (2008) J. Int. Neuropsychol. Soc. , vol.14 , pp. 337-342
    • Gonzalez, L.M.1    Anderson, V.A.2    Wood, S.J.3    Mitchell, L.A.4    Heinrich, L.5    Harvey, A.S.6
  • 12
    • 2442449806 scopus 로고
    • Studies in the psychology of children's drawings. II. 1928-1949
    • Goodenough, F. L., and Harris, D. (1950). Studies in the psychology of children's drawings. II. 1928-1949. Psychol. Bull. 47, 369-433. doi: 10.1037/h0058368
    • (1950) Psychol. Bull. , vol.47 , pp. 369-433
    • Goodenough, F.L.1    Harris, D.2
  • 13
    • 84867893925 scopus 로고    scopus 로고
    • Imaging brain amyloid in nondemented young adults with down syndrome using pittsburgh compound B
    • Handen, B. L., Cohen, A. D., Channamalappa, U., Bulova, P., Cannon, S. A., Cohen, W. I., et al. (2012). Imaging brain amyloid in nondemented young adults with down syndrome using pittsburgh compound B. Alzheimers. Dement. 8, 496-501. doi: 10.1016/j.jalz.2011.09.229
    • (2012) Alzheimers. Dement. , vol.8 , pp. 496-501
    • Handen, B.L.1    Cohen, A.D.2    Channamalappa, U.3    Bulova, P.4    Cannon, S.A.5    Cohen, W.I.6
  • 14
    • 84906660618 scopus 로고    scopus 로고
    • Cognitive functioning in relation to brain amyloid-ß in healthy adults with down syndrome
    • Hartley, S. L., Handen, B. L., Devenny, D. A., Hardison, R., Mihaila, I, Price, J. C., et al. (2014). Cognitive functioning in relation to brain amyloid-ß in healthy adults with Down syndrome. Brain 137(Pt. 9), 2556-2563. doi: 10.1093/brain/ awu173
    • (2014) Brain , vol.137 , pp. 2556-2563
    • Hartley, S.L.1    Handen, B.L.2    Devenny, D.A.3    Hardison, R.4    Mihaila, I.5    Price, J.C.6
  • 15
    • 82955198535 scopus 로고    scopus 로고
    • Predicting MCI outcome with clinically available MRI and CSF biomarkers
    • Alzheimer's Disease
    • Heister, D., Brewer, J. B., Magda, S., Blennow, K., McEvoy, L. K., and Alzheimer's Disease Neuroimaging, I. (2011). Predicting MCI outcome with clinically available MRI and CSF biomarkers. Neurology 77, 1619-1628. doi: 10.1212/wnl. 0b013e3182343314
    • (2011) Neurology , vol.77 , pp. 1619-1628
    • Heister, D.1    Brewer, J.B.2    Magda, S.3    Blennow, K.4    McEvoy, L.K.5    Neuroimaging, I.6
  • 16
    • 0028948391 scopus 로고
    • Age-related distribution of neuropathologic changes in the cerebral cortex of patients with down's syndrome. Quantitative regional analysis and comparison with Alzheimer's disease
    • Hof, P. R., Bouras, C., Perl, D. P., Sparks, D. L., Mehta, N., and Morrison, J. H. (1995). Age-related distribution of neuropathologic changes in the cerebral cortex of patients with down's syndrome. Quantitative regional analysis and comparison with Alzheimer's disease. Arch. Neurol. 52, 379-391. doi: 10. 1001/archneur.1995.00540280065020
    • (1995) Arch. Neurol. , vol.52 , pp. 379-391
    • Hof, P.R.1    Bouras, C.2    Perl, D.P.3    Sparks, D.L.4    Mehta, N.5    Morrison, J.H.6
  • 17
    • 0033039845 scopus 로고    scopus 로고
    • Neuropsychological assessment of older adults with down's syndrome: An epidemiological study using the Cambridge Cognitive Examination (CAMCOG)
    • Hon, J., Huppert, F. A., Holland, A. J., and Watson, P. (1999). Neuropsychological assessment of older adults with down's syndrome: an epidemiological study using the Cambridge Cognitive Examination (CAMCOG). Br. J. Clin. Psychol. 38, 155-165. doi: 10.1348/014466599162719
    • (1999) Br. J. Clin. Psychol. , vol.38 , pp. 155-165
    • Hon, J.1    Huppert, F.A.2    Holland, A.J.3    Watson, P.4
  • 18
    • 0028962046 scopus 로고
    • Neuropathological changes in down's syndrome hippocampal formation. Effect of age and apolipoprotein E genotype
    • Hyman, B. T., West, H. L., Rebeck, G. W., Lai, F., and Mann, D. M. (1995). Neuropathological changes in down's syndrome hippocampal formation. Effect of age and apolipoprotein E genotype. Arch. Neurol. 52, 373-378. doi: 10. 1001/archneur.1995.00540280059019
    • (1995) Arch. Neurol. , vol.52 , pp. 373-378
    • Hyman, B.T.1    West, H.L.2    Rebeck, G.W.3    Lai, F.4    Mann, D.M.5
  • 19
    • 33645117322 scopus 로고    scopus 로고
    • Reliability in multi-site structural MRI studies: Effects of gradient non-linearity correction on phantom and human data
    • Jovicich, J., Czanner, S., Greve, D., Haley, E., van der Kouwe, A., Gollub, R., et al. (2006). Reliability in multi-site structural MRI studies: effects of gradient non-linearity correction on phantom and human data. Neuroimage 30, 436-443. doi: 10.1016/j.neuroimage.2005.09.046
    • (2006) Neuroimage , vol.30 , pp. 436-443
    • Jovicich, J.1    Czanner, S.2    Greve, D.3    Haley, E.4    Van Der Kouwe, A.5    Gollub, R.6
  • 20
    • 67651040500 scopus 로고    scopus 로고
    • High-throughput, fully automated volumetry for prediction of MMSE and CDR decline in mild cognitive impairment
    • Alzheimer's Disease Neuroimaging, I
    • Kovacevic, S., Rafii, M. S., Brewer, J. B., and Alzheimer's Disease Neuroimaging, I. (2009). High-throughput, fully automated volumetry for prediction of MMSE and CDR decline in mild cognitive impairment. Alzheimer Dis. Assoc. Disord. 23, 139-145. doi: 10.1097/wad.0b013e318192e745
    • (2009) Alzheimer Dis. Assoc. Disord. , vol.23 , pp. 139-145
    • Kovacevic, S.1    Rafii, M.S.2    Brewer, J.B.3
  • 21
    • 0036368653 scopus 로고    scopus 로고
    • Relation of medial temporal lobe volumes to age and memory function in nondemented adults with down's syndrome: Implications for the prodromal phase of Alzheimer's disease
    • Krasuski, J. S., Alexander, G. E., Horwitz, B., Rapoport, S. I., and Schapiro, M. B. (2002). Relation of medial temporal lobe volumes to age and memory function in nondemented adults with down's syndrome: implications for the prodromal phase of Alzheimer's disease. Am. J. Psychiatry 159, 74-81. doi: 10.1176/appi. ajp.159.1.74
    • (2002) Am. J. Psychiatry , vol.159 , pp. 74-81
    • Krasuski, J.S.1    Alexander, G.E.2    Horwitz, B.3    Rapoport, S.I.4    Schapiro, M.B.5
  • 22
    • 0030007964 scopus 로고    scopus 로고
    • Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in down syndrome: Implications for initial events in amyloid plaque formation
    • Lemere, C. A., Blusztajn, J. K., Yamaguchi, H., Wisniewski, T., Saido, T. C., and Selkoe, D. J. (1996). Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in down syndrome: implications for initial events in amyloid plaque formation. Neurobiol. Dis. 3, 16-32. doi: 10.1006/nbdi.1996. 0003
    • (1996) Neurobiol. Dis. , vol.3 , pp. 16-32
    • Lemere, C.A.1    Blusztajn, J.K.2    Yamaguchi, H.3    Wisniewski, T.4    Saido, T.C.5    Selkoe, D.J.6
  • 23
    • 0042133117 scopus 로고    scopus 로고
    • Practitioner review: Computerized assessment of neuropsychological function in children: Clinical and research applications of the Cambridge Neuropsychological Testing Automated Battery (CANTAB)
    • Luciana, M. (2003). Practitioner review: computerized assessment of neuropsychological function in children: clinical and research applications of the Cambridge Neuropsychological Testing Automated Battery (CANTAB). J. Child. Psychol. Psychiatry 44, 649-663. doi: 10.1111/1469-7610.00152
    • (2003) J. Child. Psychol. Psychiatry , vol.44 , pp. 649-663
    • Luciana, M.1
  • 24
    • 84884614168 scopus 로고    scopus 로고
    • The national task group on intellectual disabilities and dementia practices consensus recommendations for the evaluation and management of dementia in adults with intellectual disabilities
    • American Academy of
    • Moran, J. A., Rafii, M. S., Keller, S. M., Singh, B. K., Janicki, M. P., American Academy of Developmental, M., et al. (2013). The national task group on intellectual disabilities and dementia practices consensus recommendations for the evaluation and management of dementia in adults with intellectual disabilities. Mayo Clin. Proc. 88, 831-840. doi: 10.1016/j.mayocp.2013.04.024
    • (2013) Mayo Clin. Proc. , vol.88 , pp. 831-840
    • Moran, J.A.1    Rafii, M.S.2    Keller, S.M.3    Singh, B.K.4    Janicki, M.P.5    Developmental, M.6
  • 25
    • 84894031575 scopus 로고    scopus 로고
    • Dementia in down's syndrome: An MRI comparison with Alzheimer's disease in the general population
    • Mullins, D., Daly, E., Simmons, A., Beacher, F., Foy, C. M., Lovestone, S., et al. (2013). Dementia in down's syndrome: an MRI comparison with Alzheimer's disease in the general population. J. Neurodev. Disord. 5:19. doi: 10.1186/1866-1955-5-19
    • (2013) J. Neurodev. Disord. , vol.5 , pp. 19
    • Mullins, D.1    Daly, E.2    Simmons, A.3    Beacher, F.4    Foy, C.M.5    Lovestone, S.6
  • 26
    • 84866138083 scopus 로고    scopus 로고
    • Down's syndrome and Alzheimer's disease: Towards secondary prevention
    • Ness, S., Rafii, M., Aisen, P., Krams, M., Silverman, W., and Manji, H. (2012). Down's syndrome and Alzheimer's disease: towards secondary prevention. Nat. Rev. Drug Discov. 11, 655-656. doi: 10.1038/nrd3822
    • (2012) Nat. Rev. Drug Discov. , vol.11 , pp. 655-656
    • Ness, S.1    Rafii, M.2    Aisen, P.3    Krams, M.4    Silverman, W.5    Manji, H.6
  • 27
    • 78650206677 scopus 로고    scopus 로고
    • Updated national birth prevalence estimates for selected birth defects in the United States, 2004-2006
    • Parker, S. E., Mai, C. T., Canfield, M. A., Rickard, R., Wang, Y., Meyer, R. E., et al. (2010). Updated national birth prevalence estimates for selected birth defects in the united states, 2004-2006. Birth Defects Res. A Clin. Mol. Teratol. 88, 1008-1016. doi: 10.1002/bdra.20735
    • (2010) Birth Defects Res. A Clin. Mol. Teratol. , vol.88 , pp. 1008-1016
    • Parker, S.E.1    Mai, C.T.2    Canfield, M.A.3    Rickard, R.4    Wang, Y.5    Meyer, R.E.6
  • 28
    • 0030753975 scopus 로고    scopus 로고
    • Low glucose metabolism during brain stimulation in older down's syndrome subjects at risk for Alzheimer's disease prior to dementia
    • Pietrini, P., Dani, A., Furey, M. L., Alexander, G. E., Freo, U., Grady, C. L., et al. (1997). Low glucose metabolism during brain stimulation in older down's syndrome subjects at risk for Alzheimer's disease prior to dementia. Am. J. Psychiatry 154, 1063-1069. doi: 10.1176/ajp.154.8.1063
    • (1997) Am. J. Psychiatry , vol.154 , pp. 1063-1069
    • Pietrini, P.1    Dani, A.2    Furey, M.L.3    Alexander, G.E.4    Freo, U.5    Grady, C.L.6
  • 29
    • 58649119608 scopus 로고    scopus 로고
    • Significant effect of APOE epsilon 4 genotype on the risk of dementia in Alzheimer's disease and mortality in persons with down syndrome
    • Prasher, V. P., Sajith, S. G., Rees, S. D., Patel, A., Tewari, S., Schupf, N., et al. (2008). Significant effect of APOE epsilon 4 genotype on the risk of dementia in Alzheimer's disease and mortality in persons with down syndrome. Int. J. Geriatr. Psychiatry 23, 1134-1140. doi: 10.1002/gps.2039
    • (2008) Int. J. Geriatr. Psychiatry , vol.23 , pp. 1134-1140
    • Prasher, V.P.1    Sajith, S.G.2    Rees, S.D.3    Patel, A.4    Tewari, S.5    Schupf, N.6
  • 30
    • 0031767811 scopus 로고    scopus 로고
    • The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS): Preliminary clinical validity
    • Randolph, C., Tierney, M. C., Mohr, E., and Chase, T. N. (1998). The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS): preliminary clinical validity. J. Clin. Exp. Neuropsychol. 20, 310-319. doi: 10.1076/jcen.20.3. 310.823
    • (1998) J. Clin. Exp. Neuropsychol. , vol.20 , pp. 310-319
    • Randolph, C.1    Tierney, M.C.2    Mohr, E.3    Chase, T.N.4
  • 31
    • 84939251964 scopus 로고    scopus 로고
    • Florbetapir PET, FDG PET and MRI in down syndrome individuals with and without Alzheimer's dementia
    • Sabbagh, M. N., Chen, K., Rogers, J., Fleisher, A. S., Liebsack, C., Bandy, D., et al. (2015). Florbetapir PET, FDG PET and MRI in down syndrome individuals with and without Alzheimer's dementia. Alzheimers Dement. 11, 994-1004. doi: 10.1016/j.jalz.2015.01.006
    • (2015) Alzheimers Dement , vol.11 , pp. 994-1004
    • Sabbagh, M.N.1    Chen, K.2    Rogers, J.3    Fleisher, A.S.4    Liebsack, C.5    Bandy, D.6
  • 32
    • 81355154155 scopus 로고    scopus 로고
    • Positron emission tomography and neuropathologic estimates of fibrillar amyloid-beta in a patient with down syndrome and Alzheimer disease
    • Sabbagh, M. N., Fleisher, A., Chen, K., Rogers, J., Berk, C., Reiman, E., et al. (2011). Positron emission tomography and neuropathologic estimates of fibrillar amyloid-beta in a patient with down syndrome and Alzheimer disease. Arch. Neurol. 68, 1461-1466. doi: 10.1001/archneurol.2011.535
    • (2011) Arch. Neurol. , vol.68 , pp. 1461-1466
    • Sabbagh, M.N.1    Fleisher, A.2    Chen, K.3    Rogers, J.4    Berk, C.5    Reiman, E.6
  • 33
    • 0026473720 scopus 로고
    • Down syndrome: Differentiating mental retardation and dementia with brain imaging techniques
    • Schapiro, M. B., Azari, N. P., Grady, C. L., Haxby, J. V., and Horwitz, B. (1992b). Down syndrome: differentiating mental retardation and dementia with brain imaging techniques. Prog. Clin. Biol. Res. 379, 103-122.
    • (1992) Prog. Clin. Biol. Res. , vol.379 , pp. 103-122
    • Schapiro, M.B.1    Azari, N.P.2    Grady, C.L.3    Haxby, J.V.4    Horwitz, B.5
  • 34
    • 0026621718 scopus 로고
    • Nature of mental retardation and dementia in down syndrome: Study with PET, CT and neuropsychology
    • Schapiro, M. B., Haxby, J. V., and Grady, C. L. (1992a). Nature of mental retardation and dementia in down syndrome: study with PET, CT and neuropsychology. Neurobiol. Aging 13, 723-734. doi: 10.1016/0197-4580(92)90096-g
    • (1992) Neurobiol. Aging , vol.13 , pp. 723-734
    • Schapiro, M.B.1    Haxby, J.V.2    Grady, C.L.3
  • 35
    • 0029844434 scopus 로고    scopus 로고
    • Onset of dementia is associated with apolipoprotein E epsilon4 in down's syndrome
    • Schupf, N., Kapell, D., Lee, J. H., Zigman, W., Canto, B., Tycko, B., et al. (1996). Onset of dementia is associated with apolipoprotein E epsilon4 in down's syndrome. Ann. Neurol. 40, 799-801. doi: 10.1002/ana.410400518
    • (1996) Ann. Neurol. , vol.40 , pp. 799-801
    • Schupf, N.1    Kapell, D.2    Lee, J.H.3    Zigman, W.4    Canto, B.5    Tycko, B.6
  • 36
    • 34447275455 scopus 로고    scopus 로고
    • Elevated plasma beta-amyloid peptide Abeta(42). Levels, incident dementia and mortality in down syndrome
    • Schupf, N., Patel, B., Pang, D., Zigman, W. B., Silverman, W., Mehta, P. D., et al. (2007). Elevated plasma beta-amyloid peptide Abeta(42). levels, incident dementia and mortality in down syndrome. Arch. Neurol. 64, 1007-1013. doi: 10.1001/archneur.64.7.1007
    • (2007) Arch. Neurol. , vol.64 , pp. 1007-1013
    • Schupf, N.1    Patel, B.2    Pang, D.3    Zigman, W.B.4    Silverman, W.5    Mehta, P.D.6
  • 37
    • 0035815573 scopus 로고    scopus 로고
    • Elevated plasma amyloid beta-peptide 1-42 and onset of dementia in adults with down syndrome
    • Schupf, N., Patel, B., Silverman, W., Zigman, W. B., Zhong, N., Tycko, B., et al. (2001). Elevated plasma amyloid beta-peptide 1-42 and onset of dementia in adults with down syndrome. Neurosci. Lett. 301, 199-203. doi: 10.1016/s0304-3940(01)01657-3
    • (2001) Neurosci. Lett. , vol.301 , pp. 199-203
    • Schupf, N.1    Patel, B.2    Silverman, W.3    Zigman, W.B.4    Zhong, N.5    Tycko, B.6
  • 38
    • 78349266860 scopus 로고    scopus 로고
    • Change in plasma Ass peptides and onset of dementia in adults with down syndrome
    • Schupf, N., Zigman, W. B., Tang, M. X., Pang, D., Mayeux, R., Mehta, P., et al. (2010). Change in plasma Ass peptides and onset of dementia in adults with down syndrome. Neurology 75, 1639-1644. doi: 10.1212/wnl. 0b013e3181fb448b
    • (2010) Neurology , vol.75 , pp. 1639-1644
    • Schupf, N.1    Zigman, W.B.2    Tang, M.X.3    Pang, D.4    Mayeux, R.5    Mehta, P.6
  • 40
    • 0031987382 scopus 로고    scopus 로고
    • A nonparametric method for automatic correction of intensity nonuniformity in MRI data
    • Sled, J. G., Zijdenbos, A. P., and Evans, A. C. (1998). A nonparametric method for automatic correction of intensity nonuniformity in MRI data. IEEE Trans. Med. Imaging. 17, 87-97. doi: 10.1109/42.668698
    • (1998) IEEE Trans. Med. Imaging. , vol.17 , pp. 87-97
    • Sled, J.G.1    Zijdenbos, A.P.2    Evans, A.C.3
  • 41
    • 84875888388 scopus 로고    scopus 로고
    • A comparison of the Cambridge Automated Neuropsychological Test Battery (CANTAB) with "traditional" neuropsychological testing instruments
    • Smith, P. J., Need, A. C., Cirulli, E. T., Chiba-Falek, O., and Attix, D. K. (2013). A comparison of the Cambridge Automated Neuropsychological Test Battery (CANTAB) with "traditional" neuropsychological testing instruments. J. Clin. Exp. Neuropsychol. 35, 319-328. doi: 10.1080/13803395.2013. 771618
    • (2013) J. Clin. Exp. Neuropsychol. , vol.35 , pp. 319-328
    • Smith, P.J.1    Need, A.C.2    Cirulli, E.T.3    Chiba-Falek, O.4    Attix, D.K.5
  • 42
    • 23244449128 scopus 로고    scopus 로고
    • Social care. Shared issues. Interview by stuart shepherd
    • Sparrow, S., and Havis, Y. (2005). Social care. Shared issues. Interview by stuart shepherd. Health Serv. J. 115, 32-33.
    • (2005) Health Serv. J. , vol.115 , pp. 32-33
    • Sparrow, S.1    Havis, Y.2
  • 43
    • 82655173747 scopus 로고    scopus 로고
    • Testing the right target and right drug at the right stage
    • Sperling, R. A., Jack, C. R. Jr., and Aisen, P. S. (2011). Testing the right target and right drug at the right stage. Sci. Transl. Med. 3:111cm133. doi: 10. 1126/scitranslmed.3002609
    • (2011) Sci. Transl. Med. , vol.3 , pp. 111cm133
    • Sperling, R.A.1    Jack, C.R.2    Aisen, P.S.3
  • 44
    • 1842683970 scopus 로고    scopus 로고
    • Age-related cortical grey matter reductions in non-demented down's syndrome adults determined by MRI with voxel-based morphometry
    • Teipel, S. J., Alexander, G. E., Schapiro, M. B., Möller, H. J., Rapoport, S. I., and Hampel, H. (2004). Age-related cortical grey matter reductions in non-demented down's syndrome adults determined by MRI with voxel-based morphometry. Brain 127, 811-824. doi: 10.1093/brain/ awh101
    • (2004) Brain , vol.127 , pp. 811-824
    • Teipel, S.J.1    Alexander, G.E.2    Schapiro, M.B.3    Möller, H.J.4    Rapoport, S.I.5    Hampel, H.6


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