Mediating roles of anxiety, self-efficacy, and sleep quality on the relationship between patient-reported physician empathy and inflammatory markers in ulcerative colitis patients

Medical Science Monitor

Volumn 25, Issue , 2019, Pages 7889-7897

  Chen, Xiangfan ^a   Zhang, Yin ^b   Xu, Xianlin ^b   Wang, Wei ^a   Yan, Hong ^a   Li, Shiyue ^a   Yang, Ningxi ^c  

^a WUHAN UNIVERSITY   (China)

^b Department of Gastroenterology Huiyang Sanhe Hospital   (China)

^c HARBIN ENGINEERING UNIVERSITY   (China)

Author keywords

Colitis, Ulcerative; Empathy; Mental Health; Physician Patient Relations

Indexed keywords

BIOLOGICAL MARKER; INTERLEUKIN 6;

ADULT; ANXIETY; ARTICLE; CORRELATION ANALYSIS; DOCTOR PATIENT RELATIONSHIP; ELECTROENCEPHALOGRAM; ELECTROMYOGRAM; EMPATHY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HOSPITAL ANXIETY AND DEPRESSION SCALE; HOSPITALIZATION; HUMAN; MAJOR CLINICAL STUDY; MALE; MENTAL HEALTH; PATIENT-REPORTED OUTCOME; POLYSOMNOGRAPHY; PSYCHOLOGICAL RESILIENCE; SELF CONCEPT; SELF REPORT; SLEEP QUALITY; SLEEP TIME; STRUCTURAL EQUATION MODELING; ULCERATIVE COLITIS; ANXIETY DISORDER; CHINA; INFLAMMATION; METABOLISM; MIDDLE AGED; PATHOPHYSIOLOGY; PATIENT; PHYSICIAN; PHYSIOLOGY; PSYCHOLOGY; QUESTIONNAIRE; SLEEP;

ADULT; ANXIETY; ANXIETY DISORDERS; CHINA; COLITIS, ULCERATIVE; EMPATHY; FEMALE; HUMANS; INFLAMMATION; INTERLEUKIN-6; MALE; MIDDLE AGED; PATIENT REPORTED OUTCOME MEASURES; PATIENTS; PHYSICIAN-PATIENT RELATIONS; PHYSICIANS; SELF EFFICACY; SLEEP; SURVEYS AND QUESTIONNAIRES;

EID: 85073656593     PISSN: 12341010     EISSN: 16433750     Source Type: Journal    
DOI: 10.12659/MSM.917552     Document Type: Article

References (52)

1. Ordás I, Eckmann L, Talamini M, Baumgart DC, Sandborn WJ. Ulcerative colitis. Lancet, 2012; 380: 1606–19
2. Boye B, Lundin KE, Jantschek G et al: INSPIRE study: Does stress management improve the course of inflammatory bowel disease and disease-specific quality of life in distressed patients with ulcerative colitis or Crohn’s disease? A randomized controlled trial. Inflamm Bowel Dis, 2011; 17: 1863–73
3. Hojat M: Empathy in patient care: Antecedents, development, measurement, and outcomes. New York, Springer, 2007
4. Mercer SW, Reynolds WJ: Empathy and quality of care. Br J Gen Pract, 2002; 52(Suppl.): S9–12
5. Attar HS, Chandramani S: Impact of physician empathy on migraine disability and migraineur compliance. Ann Indian Acad Neur, 2012; 15: S89–94
6. Neumann M, Bensing J, Mercer S et al: Analyzing the “nature” and “specific effectiveness” of clinical empathy: A theoretical overview and contribution towards a theory-based research agenda. Patient Educ Couns, 2009; 74: 339–46
7. Larso EB, Yao X: Clinical empathy as emotional labor in the patient-physician relationship. JAMA, 2005; 293: 1100–6
8. Hojat M, Louis DZ, Markham FW et al: Physicians’ empathy and clinical outcomes for diabetic patients. Acad Med, 2011; 86: 359–64
9. Del Canale S, Louis DZ, Maio V et al: The relationship between physician empathy and disease complications: An empirical study of primary care physicians and their diabetic patients in Parma, Italy. Acad Med, 2012; 87: 1243–49
10. Dibley L, Czuber-Dochan W, Woodward S et al: Development and psychometric properties of the Inflammatory Bowel Disease Distress Scale (IBD-DS): A new tool to measure disease-specific distress. Inflamm Bowel Dis, 2018 [Epub ahead of print]
11. Hoogendoorn C, Satpute A, Reigada L: Anxiety in pediatric IBD: A predictor for disease relapse and increased health care use. Inflamm Bowel Dis, 2016; Suppl.1: S7
12. Graff LA, Sexton KA, Walker JR et al: Validating a measure of patient self-efficacy in disease self-management using a population-based IBD cohort: The IBD Self-efficacy Scale. Inflamm Bowel Dis, 2016; 22: 2165–72
13. Izaguirre MR, Taft T, Keefer L: Validation of a self-efficacy scale for adolescents and young adults with inflammatory bowel disease. J Pediatr Gastroenterol Nutr, 2017; 65: 546–50
14. Keefer L, Kiebles JL, Taft TH: The role of self-efficacy in inflammatory bowel disease management: Preliminary validation of a disease-specific measure. Inflamm Bowel Dis, 2011; 17: 614–20
15. Ali T, Orr WC: Sleep disturbances and inflammatory bowel disease. Inflamm Bowel Dis, 2014; 20: 1986–95
16. Janelidze S, Suchankova P, Ekman A et al: Low IL-8 is associated with anxiety in suicidal patients: genetic variation and decreased protein levels. Acta Psychiatr Scand, 2015; 131: 269–78
17. Mausbach BT, von Känel R, Roepke SK et al: Self-efficacy buffers the relationship between dementia caregiving stress and circulating concentrations of the proinflammatory cytokine interleukin-6. Am J Geriatr Psychiatry, 2011; 19: 64–71
18. Abedelmalek S, Chtourou H, Aloui A et al: Effect of time of day and partial sleep deprivation on plasma concentrations of IL-6 during a short-term maximal performance. Eur J Appl Physiol, 2013; 113: 241–48
19. Mudter J, Neurath MF: IL-6 signaling in inflammatory bowel disease: Pathophysiological role and clinical relevance. Inflamm Bowel Dis, 2007; 13: 1016–23
20. Sturgeon JA, Arewasikporn A, Okun MA et al: The psychosocial context of financial stress: Implications for inflammation and psychological health. Psychosom Med, 2016; 78: 134–43
21. Hughes AE, Crowell SE, Uyeji L, Coan JA: A developmental neuroscience of borderline pathology: Emotion dysregulation and social baseline theory. J Abnorm Child Psychol, 2012; 40: 21–33
22. Anderson PF, Wescom E, Carlos RC: Difficult doctors, difficult patients: Building empathy. J Am Coll Radiol, 2016; 13: 1590–98
23. Kiecolt-Glaser JK, McGuire L, Robles TF, Glaser R: Psychoneuroimmunology: Psychological influences on immune function and health. J Consult Clin Psychol, 2002; 70: 537–47
24. Ananthakrishnan AN, Long MD, Martin CF et al: Sleep disturbance and risk of active disease in patients with Crohn’s disease and ulcerative colitis. Clin Gastroenterol Hepatol, 2013; 11: 965–71
25. Neuendorf R, Harding A, Stello N et al: Depression and anxiety in patients with inflammatory bowel disease: A systematic review. J Psychosom Res, 2016; 87: 70–80
26. Zigmond AS, Snaith RD: The Hospital Anxiety and Depression Scale. Acta Psychiatr Scand, 1983; 67: 361–70
27. Bjelland I, Hahl AA, Hauq TT, Neckelmann D: The validity of the Hospital Anxiety and Depression Scale. An undated literature review. J Psychosom Res, 2002; 52: 69–77
28. Christodoulou C, Michopoulos J, Tournikioti K et al: Hospital Anxiety and Depression Scale. A quantitative analysis in medical outpatients, psychiatric outpatients and normal subjects. Psychiatriki, 2010; 21: 279–86
29. Nam S, Tin D, Bain L et al: Clinical utility of the Hospital Anxiety and Depression Scale (HADS) for an outpatient fibromyalgia education program. Clin Rheumatol, 2014; 33: 685–92
30. Schwarzer R, Jerusalem M: Generalized self-efficacy scale. In: Weinman J, Wright S, Johnston M (eds.), Measures in health psychology: A user’s portfolio causal and control beliefs. Windsor, UK: NFER-NELSON, 1995; 35
31. Zhang JX, Schwarzer R: Measuring optimistic self-beliefs: A Chinese adaptation of the General Self-Efficacy Scale. Psychologia, 1995; 38: 174–81
32. Available from: http://www.caremeasure.org/CAREEng.pdf
33. Mercer SW, Maxwell M, Heaney D, Watt GC: The consultation and relational empathy (CARE) measure: Development and preliminary validation and reliability of an empathy-based consultation process measure. Fam Pract, 2004; 21: 699–705
34. Hojat M, Mangione S, Nasca TJ et al: The Jefferson Scale of Physician Empathy: Development and preliminary psychometric data. Educ Psychol Meas, 2001; 61: 349–65
35. Šter MP, SeliČ P: Assessing empathic attitudes in medical students: The re-validation of the Jefferson Scale of empathy-student version report. Zdr Varst, 2015; 54: 282–92
36. Williams B, Sifris A, Lynch M: A psychometric appraisal of the Jefferson Scale of Empathy using law students. Psychol Res Behav Manag, 2016; 9: 171–78
37. Costa P, de Carvalho-Filho MA, Schweller M et al: Measuring medical students’ empathy: Exploring the underlying constructs of and associations between two widely used self-report instruments in five countries. Acad Med, 2017; 92: 860–67
38. Cánovas L, Carrascosa AJ, García M et al: Empathy study group impact of empathy in the patient-doctor relationship on chronic pain relief and quality of life: A prospective study in Spanish pain clinics. Pain Med, 2018; 19: 1304–14
39. Thompson C, Barforoshi S, Kell C et al: Uncovering the patient experience: Empathy mapping promotes patient-centered care for improved heart failure patient outcomes. J Card Fail, 2016; 22: S87–88
40. Yang NX, Xiao H, Cao YN et al: Influence of oncology nurses’ empathy on lung cancer patients’ cellular immunity. Psychol Res Behav Manag, 2018; 11: 279–87
41. Yang NX, Xiao H, Wang W et al: Effects of doctors’ empathy abilities on the cellular immunity of patients with advanced prostate cancer treated by orchiectomy: The mediating role of patients’ stigma and self-efficacy. Patient Prefer Adher, 2018; 12: 1305–14
42. Yang NX, Cao YN, Li XY et al: Mediating effects of patients’ stigma and self-efficacy on relationships between doctors’ empathy abilities and patients’ cellular immunity in male breast cancer patients. Med Sci Monit, 2018; 24: 3978–86
43. De Moor K: The doctor’s role of witness and companion: Medical and literary ethics of care in AIDS physicians’ memoirs. Lit Med, 2003; 22: 208–29
44. Parker PA, Davis JW, Latini DM et al: Relationship between illness uncertainty, anxiety, fear of progression and quality of life in men with favourable-risk prostate cancer undergoing active surveillance. BJU Int, 2016; 117: 469–77
45. Jubraj B, Barnett NL, Grimes L et al: Why we should understand the patient experience: Clinical empathy and medicines optimisation. Int J Pharm Pract, 2016; 24: 367–70
46. Vanuytsel T, van Wanrooy S, Vanheel H et al: Psychological stress and corticotropin-releasing hormone increase intestinal permeability in humans by a mast cell-dependent mechanism. Gut, 2014; 63: 1293–99
47. Gierloff MJ: Positive emotions and immune response to influenza in medically stable older adults. Dissertations: Loyola University Chicago, 2012; 302
48. Abedelmalek S, Chtourou H, Aloui A et al: Effect of time of day and partial sleep deprivation on plasma concentrations of IL-6 during a short-term maximal performance. Eur J Appl Physiol, 2013; 113: 241–48
49. Bandura A, Adams NE: Analysis of self-efficacy theory of behavior change. Cognitive Therapy and Research, 1977; 1: 287–310
50. van Santen A, Vreeburg SA, Van der Does AJ et al: Psychological traits and the cortisol awakening response: results from the Netherlands Study of Depression and Anxiety. Psychoneuroendocrinology, 2011; 36: 240–48
51. Cardinali DP, Srinivasan V, Brzezinski A, Brown GM: Melatonin and its analogs in insomnia and depression. J Pineal Res, 2012; 52: 365–75
52. Charon R: Narrative medicine: A model for empathy, reflection, profession, and trust. JAMA, 2001; 286: 1897–902